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1.发明授权O- or S-substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity 失效O-或S-取代的四氢萘衍生物，其具有类视黄醇和/或维生素A拮抗剂样生物活性公开(公告)号：US06855832B2
公开(公告)日：2005-02-15
申请号：US10269270
申请日：2002-10-11
申请人： Vidyasagar Vuligonda , Min Teng , Richard L. Beard , Alan T. Johnson , Yuan Lin , Roshantha A. Chandraratna
发明人： Vidyasagar Vuligonda , Min Teng , Richard L. Beard , Alan T. Johnson , Yuan Lin , Roshantha A. Chandraratna
IPC分类号： A01N33/26 , A61K31/655 , C07C61/10 , C07C61/16 , C07C62/00 , C07C69/02 , C07C69/587 , C07C69/76 , C07C69/95 , C07C233/81 , C07C245/10 , C07C251/44 , C07C291/00 , C07C309/65 , C07C317/44 , C07C323/55 , C07D211/70 , C07D211/78 , C07D211/82 , C07D277/30 , C07D309/12 , C07D311/00 , C07D311/04 , C07D317/20 , C07D317/24 , C07D317/26 , C07D333/24 , C07D335/04 , C07D339/08 , C07D409/10 , C09B29/033 , C09B29/09 , C09B29/22 , C09B29/36
CPC分类号： C07D339/08 , C07C69/587 , C07C69/734 , C07C69/76 , C07C233/81 , C07C235/66 , C07C245/10 , C07C251/44 , C07C309/65 , C07C317/44 , C07C323/55 , C07C2602/10 , C07D277/30 , C07D309/12 , C07D317/20 , C07D317/24 , C07D317/26 , C07D333/24 , C07D409/10
摘要： Compounds of the formula where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.
摘要翻译： 符号具有本申请中描述的含义的化合物具有类视黄醇样或类视黄醇拮抗剂样的生物活性。
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公开(公告)号：US06720425B2
公开(公告)日：2004-04-13
申请号：US10314758
申请日：2002-12-09
申请人： Alan T. Johnson , Min Teng , Vidyasagar Vuligonda , Richard L. Beard , Samuel J. Gillett , Tien T. Duong , Roshantha A. Chandraratna
发明人： Alan T. Johnson , Min Teng , Vidyasagar Vuligonda , Richard L. Beard , Samuel J. Gillett , Tien T. Duong , Roshantha A. Chandraratna
IPC分类号： C07D21304
CPC分类号： C07D317/24 , C07C69/587 , C07C69/76 , C07C233/81 , C07C245/10 , C07C251/44 , C07C309/65 , C07C317/44 , C07C323/55 , C07C2602/10 , C07D277/30 , C07D309/12 , C07D317/20 , C07D317/26 , C07D333/24 , C07D339/08 , C07D409/10
摘要： Compounds of the formula where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.
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3.发明申请Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity 失效具有类视黄醇和/或维生素A拮抗剂的生物活性的烷基或芳基取代的二氢萘衍生物公开(公告)号：US20020173631A1
公开(公告)日：2002-11-21
申请号：US10141655
申请日：2002-05-08
发明人： Alan T. Johnson , Min Teng , Vidyasagar Vuligonda , Richard L. Beard , Samuel J. Gillett , Tien T. Duong , Roshantha A. Chandraratna
IPC分类号： C07D213/63 , C09B029/00
CPC分类号： C07D317/24 , C07C69/587 , C07C69/76 , C07C233/81 , C07C245/10 , C07C251/44 , C07C309/65 , C07C317/44 , C07C323/55 , C07C2602/10 , C07D277/30 , C07D309/12 , C07D317/20 , C07D317/26 , C07D333/24 , C07D339/08 , C07D409/10
摘要： Compounds of the formula 1 where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.
摘要翻译： 符号具有本申请中描述的含义的式的化合物具有类视黄醇样或维生素A拮抗剂样生物活性。
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4.发明授权O- or S- substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity 失效O-或S-取代的四氢萘衍生物，其具有类视黄醇和/或维生素A拮抗剂样生物活性
公开(公告)号：US5741896A
公开(公告)日：1998-04-21
申请号：US667664
申请日：1996-06-21
申请人： Vidyasagar Vuligonda , Min Teng , Richard L. Beard , Alan T. Johnson , Yuan Lin , Roshantha A. Chandraratna
发明人： Vidyasagar Vuligonda , Min Teng , Richard L. Beard , Alan T. Johnson , Yuan Lin , Roshantha A. Chandraratna
IPC分类号： A01N33/26 , A61K31/655 , C07C61/10 , C07C61/16 , C07C62/00 , C07C69/02 , C07C69/587 , C07C69/76 , C07C69/95 , C07C233/81 , C07C245/10 , C07C251/44 , C07C291/00 , C07C309/65 , C07C317/44 , C07C323/55 , C07D211/70 , C07D211/78 , C07D211/82 , C07D277/30 , C07D309/12 , C07D311/00 , C07D311/04 , C07D317/20 , C07D317/24 , C07D317/26 , C07D333/24 , C07D335/04 , C07D339/08 , C07D409/10 , C09B29/033 , C09B29/09 , C09B29/22 , C09B29/36
CPC分类号： C07D339/08 , C07C233/81 , C07C235/66 , C07C245/10 , C07C251/44 , C07C309/65 , C07C317/44 , C07C323/55 , C07C69/587 , C07C69/734 , C07C69/76 , C07D277/30 , C07D309/12 , C07D317/20 , C07D317/24 , C07D317/26 , C07D333/24 , C07D409/10 , C07C2102/10
摘要： Compounds of the formula ##STR1## where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.
摘要翻译： 符号具有本申请中描述的含义的式“IMAGE”的化合物具有类视黄醇样或维生素A拮抗剂样的生物活性。
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5.发明申请NOVEL SULPHUR CONTAINING LIPIDS FOR USE AS FOOD SUPPLEMENT OR AS MEDICAMENT 审中-公开含有新鲜的含硫脂肪作为食物补充剂或作为药物使用公开(公告)号：US20170029368A1
公开(公告)日：2017-02-02
申请号：US15040260
申请日：2016-02-10
IPC分类号： C07C323/54 , C07C323/55
CPC分类号： C07C323/54 , A23L33/12 , C07C317/44 , C07C323/52 , C07C323/55 , C07C323/56 , C07C323/61 , C07C2601/04
摘要： The present disclosure relates to lipid compounds of the general formula (I): (I) wherein R1 is selected from a C10-C22 alkyl, a C10-C22 alkenyl having 1-6 double bonds, and a C10-C22 alkynyl having 1-6 triple bonds; R2 and R3 are the same or different substituents; Y is selected from sulphur, sulfoxide, and sulfone; and X represents a carboxylic acid or a derivative thereof, a carboxylic ester, a carboxylic anhydride or a carboxamide; or a pharmaceutically acceptable salt, complex or solvate thereof. The disclosure also relates to pharmaceutical compositions and lipid compositions comprising such compounds, and to such compounds for use as medicaments or for use in therapy, in particular for the treatment of diseases related to the cardiovascular, metabolic and inflammatory disease area.
摘要翻译： 本公开内容涉及通式（I）的脂质化合物：（I）其中R 1选自C 10 -C 22烷基，具有1-6个双键的C 10 -C 22烯基和具有1-6个碳原子的C 10 -C 22炔基， 6个三键; R2和R3是相同或不同的取代基; Y选自硫，亚砜和砜; X表示羧酸或其衍生物，羧酸酯，羧酸酐或羧酰胺; 或其药学上可接受的盐，复合物或溶剂合物。 本公开还涉及包含这种化合物的药物组合物和脂质组合物，以及用作药物或用于治疗，特别是用于治疗与心血管，代谢和炎性疾病区域有关的疾病的化合物。
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公开(公告)号：US20150011627A1
公开(公告)日：2015-01-08
申请号：US14496488
申请日：2014-09-25
IPC分类号： C07C62/38 , C07C229/50 , C07C255/47 , C07C323/55 , C07C317/44 , C07C291/10 , C07C235/78
CPC分类号： A61K35/44 , A61K31/56 , A61K35/12 , C07C61/29 , C07C62/32 , C07C62/38 , C07C229/50 , C07C235/78 , C07C255/47 , C07C291/10 , C07C317/44 , C07C323/55 , C07C2603/52 , C07J63/008 , C07J71/0005
摘要： The present invention provides triterpenoids produced from natural compounds such as oleanolic acid, ursolic acid, betulinic acid, and hederagenin.
摘要翻译： 本发明提供由天然化合物如齐墩果酸，熊果酸，桦木酸和雌雄agen素生产的三萜类化合物。
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公开(公告)号：US20130303607A1
公开(公告)日：2013-11-14
申请号：US13466456
申请日：2012-05-08
IPC分类号： C07C69/757 , A61P39/00 , A61K31/215 , C07C61/29 , A61K31/19
CPC分类号： A61K35/44 , A61K31/56 , A61K35/12 , C07C61/29 , C07C62/32 , C07C62/38 , C07C229/50 , C07C235/78 , C07C255/47 , C07C291/10 , C07C317/44 , C07C323/55 , C07C2603/52 , C07J63/008 , C07J71/0005
摘要： The present invention provides triterpenoids produced from natural compounds such as oleanolic acid, ursolic acid, betulinic acid, and hederagenin.
摘要翻译： 本发明提供由天然化合物如齐墩果酸，熊果酸，桦木酸和雌雄agen素生产的三萜类化合物。
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公开(公告)号：US07605178B2
公开(公告)日：2009-10-20
申请号：US11774411
申请日：2007-07-06
申请人： David W. Old , Vinh X. Ngo
发明人： David W. Old , Vinh X. Ngo
IPC分类号： A61K47/14 , A61K31/5575 , C07C69/612
CPC分类号： C07C323/55 , C07C229/32 , C07C233/50 , C07C2601/08 , C07D213/70 , C07D213/74 , C07D215/26 , C07D215/40 , C07D217/04 , C07D257/04 , C07D277/56 , C07D307/64 , C07D307/68 , C07D307/79 , C07D333/34 , C07D333/38 , C07D333/62
摘要： Disclosed herein are compounds of the formula therapeutic methods, compositions, and medicaments related thereto are also disclosed.
摘要翻译： 本文公开了下式的化合物，还公开了与之相关的治疗方法，组合物和药物。
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9.发明申请Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity 失效具有类视黄醇和/或维生素A拮抗剂的生物活性的烷基或芳基取代的二氢萘衍生物公开(公告)号：US20040127469A1
公开(公告)日：2004-07-01
申请号：US10731448
申请日：2003-12-09
发明人： Alan T. Johnson , Min Teng , Vidyasagar Vuligonda , Richard L. Beard , Samuel J. Gillett , Tien T. Duong , Roshantha A. Chandraratna
IPC分类号： A61K031/655 , C07D215/16
CPC分类号： C07D317/24 , C07C69/587 , C07C69/76 , C07C233/81 , C07C245/10 , C07C251/44 , C07C309/65 , C07C317/44 , C07C323/55 , C07C2602/10 , C07D277/30 , C07D309/12 , C07D317/20 , C07D317/26 , C07D333/24 , C07D339/08 , C07D409/10
摘要： Compounds of the formula 1 where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.
摘要翻译： 其中符号具有本申请中描述的含义的式的化合物具有类视黄醇样或维生素A拮抗剂样生物活性。
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公开(公告)号：US20030187235A1
公开(公告)日：2003-10-02
申请号：US10314758
申请日：2002-12-09
发明人： Alan T. Johnson , Min Teng , Vidyasagar Vuligonda , Richard L. Beard , Samuel J. Gillett , Tien T. Duong , Roshantha A. Chandraratna
IPC分类号： C07F007/02 , C07D333/42 , C07D277/38 , C07D237/02 , C07D263/48
CPC分类号： C07D317/24 , C07C69/587 , C07C69/76 , C07C233/81 , C07C245/10 , C07C251/44 , C07C309/65 , C07C317/44 , C07C323/55 , C07C2602/10 , C07D277/30 , C07D309/12 , C07D317/20 , C07D317/26 , C07D333/24 , C07D339/08 , C07D409/10
摘要： Compounds of the formula 1 where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.
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