摘要:
A novel bicyclo derivative represented by the following general formula (1), or a pharmaceutically acceptable salt thereof, acts as an effective DPP-IV inhibitor: One example is (2S,4S)-1-[[N-(4-methylbicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile).
摘要:
The invention relates to substituted benzylthiazolidine-2,4-dione derivatives represented by a general formula (1) wherein R1 denotes a chlorine atom, bromine atom, nitro group, trifluoromethoxy group, ethoxy group, propoxy group or isopropoxy group, and R2 denotes a hydrogen atom or chlorine atom, their medicinally acceptable salts, their hydrates and a process for preparing them.
摘要翻译:本发明涉及由通式(1)表示的取代的苄基噻唑烷-2,4-二酮衍生物,其中R 1表示氯原子,溴原子,硝基,三氟甲氧基,乙氧基,丙氧基或异丙氧基, R 2表示氢原子或氯原子,其药学上可接受的盐,它们的水合物及其制备方法。
摘要:
The invention provides novel substituted benzylthiazolidine-2,4-dione derivatives which increase the transactivation action of receptor as a ligand of human peroxisome proliferator-activated receptor (PPAR) and exhibit the blood glucose-decreasing action and lipid-decreasing action, and a process for preparing them. The invention relates to substituted benzylthiazolidine-2,4-dione derivatives represented by the general formula (1) [wherein A denotes a phenyl group which is unsubstituted or may have substituents, phenoxy group which is unsubstituted or may have substituents or benzyloxy group which is unsubstituted or may have substituents], their medicinally acceptable salts, their hydrates and a process for preparing them.
摘要:
The present invention provides novel N-benzyldioxothiazolidylbenzamide derivatives that improve the insulin resistance and have potent hypoglycemic and lipid-lowering effects and processes for preparing the same, and relates to N-benzyldioxothiazolidylbenzamide derivatives characterized by being represented by a general formula (1) ##STR1## [wherein R.sup.1 and R.sup.2 denote identically or differently hydrogen atoms, lower alkyl groups with carbon atoms of 1 to 4, lower alkoxy groups with carbon atoms of 1 to 3, lower haloalkyl groups with carbon atoms of 1 to 3, lower haloalkoxy groups with carbon atoms of 1 to 3, halogen atoms, hydroxyl groups, nitro groups, amino groups which may be substituted with lower alkyl group(s) with carbon atoms of 1 to 3 or hetero rings, or R.sup.1 and R.sup.2 link to form a methylenedioxy group, R.sup.3 denotes a lower alkoxy group with carbon atoms of 1 to 3, hydroxyl group or halogen atom, and dotted line indicates double bond or single bond in combination with solid line], and processes for preparing the same.
摘要:
An ion conductive material containing a compound which comprises a resonance structure group which contains an atom of the Vb group in the Periodic Table serving as an anionic site and is bonded to an electron attractive organic group through an atom of the VIb group in the Periodic Table, and a counter ion selected from the group consisting of metal ions and a hydrogen ion. This material is useful as an electrolyte of a cell since it is excellent in high voltage stability.
摘要:
An electrical connection construction for connecting conductive members of an internal circuit of an electrical connection box and wires of a wiring harness, in which the wires of the wiring harness are inserted into the electrical connection box through openings formed on the electrical connection box such that conductors of the wires of the wiring harness are connected to the conductive members of the internal circuit of the electrical connection box, respectively by a joining member.
摘要:
A humidity sensor and a method for producing the same, in which an insulating film is first formed on a substrate. A first sensing film is formed on a first electrode to be separated by a space from the insulating film. A second sensing film of the same material as the first sensing film is again formed on the first sensing film and the insulating film, the space therebetween being filled with the second sensing film. Thus a uniform surface etching of the second sensing film is effected, to obtain a continuous flat film layer composed of the sensing film and the insulating film with a continuous flat surface, and in which a second electrode is formed on at least the sensing film.
摘要:
A method of gas carburizing and hardening a steel article and a continuous furnace therefor. The method includes the steps of carburizing the article in a carburizing atmosphere at atmospheric pressure, heating the article in a vacuum for a predetermined period of time, and hardening the article.
摘要:
A driving apparatus includes a first transmission mechanism receiving mechanical power from an engine output shaft by a first input shaft, a second transmission mechanism receiving the mechanical power from the engine output shaft and a motor by a second input shaft, and a first clutch capable of engaging the engine output shaft with the first input shaft. When performing cranking of an internal-combustion engine, an ECU selects a gear position of the first transmission mechanism and the second transmission mechanism to reduce speed of the mechanical power received by the second input shaft and transmit the power to the first input shaft, and puts the first clutch into an engaging state. The speed of the mechanical power from the motor is reduced by the first and second transmission mechanisms to increase torque, and power is transmitted to the engine output shaft through the first clutch.
摘要:
A vehicle driving apparatus that can execute cranking of an internal combustion engine by transmitting a mechanical power from a rotor of a motor to an engine output shaft without executing an engaging/disengaging operation of a clutch. A driving apparatus of a hybrid vehicle includes a first speed change mechanism capable of receiving mechanical power from an engine output shaft by a first input shaft and transmitting the mechanical power to drive wheels, a second speed change mechanism capable of receiving the mechanical power from the engine output shaft and a rotor by a second input shaft engaged with the rotor and transmitting the mechanical power to the drive wheels, a first clutch capable of engaging the engine output shaft with the first input shaft, and a second clutch capable of engaging the engine output shaft with the second input shaft, wherein the second clutch is placed in an engaged state when operation force for executing an engaging/disengaging operation is not applied to the second clutch.