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    METHOD FOR COATING ALUMINUM WHEEL, AND ALUMINUM WHEEL
    3.
    发明申请
    METHOD FOR COATING ALUMINUM WHEEL, AND ALUMINUM WHEEL 有权
    铝合金轮毂和铝合金轮毂的方法

    公开(公告)号：US20130313888A1

    公开(公告)日：2013-11-28

    申请号：US13979205

    申请日：2012-01-01

    申请人： Junya Uemura ,  Toru Shimizu ,  Koji Murakami ,  Tatsuya Oguri ,  Masafumi Maeda

    发明人： Junya Uemura ,  Toru Shimizu ,  Koji Murakami ,  Tatsuya Oguri ,  Masafumi Maeda

    IPC分类号： B60B19/00

    CPC分类号： B60B19/00 ,  B05D7/14 ,  B05D7/16 ,  B05D7/53 ,  B05D2202/25 ,  B05D2502/00 ,  B05D2504/00 ,  B60B23/04 ,  B60B23/10 ,  B60B25/20 ,  B82Y30/00 ,  C08K3/36 ,  C09D5/08 ,  C09D133/08 ,  C09D163/00 ,  C09D163/04 ,  C23C22/361 ,  B05D2420/01

    摘要： The present invention provides a method for coating an aluminum wheel using a coating composition capable of forming a coating film having a superior cosmetic property as well as an anticorrosive property much enough for preventing corrosion even in the use in an area where the coating film is susceptible to salt damage, and an aluminum wheel obtained by the method. A method for coating an aluminum wheel including applying an anticorrosive coating composition onto the aluminum wheel, and thereafter applying a clear coating composition to form a transparent multilayer coating film, wherein the anticorrosive coating composition contains an acrylic resin (1) having a weight average molecular weight of 50,000 to 140,000, a glass transition point of 20 to 50° C., a hydroxyl value of 10 to 50 mgKOH/g, and an acid value of 10 to 40 mgKOH/g, and an epoxy resin (2) having an epoxy equivalent of 210 to 1,000 g/eq and contains the epoxy resin (2) in an amount of 5 to 20 parts by weight on the solid matter basis to 100 parts by weight of the solid matter of the acrylic resin (1).

    摘要翻译： 本发明提供一种涂覆铝轮的方法，该涂料组合物能够形成具有优异的化妆品性质的涂膜以及即使在涂膜易感的区域中也能防止腐蚀的耐腐蚀性 受到盐损害，并通过该方法获得的铝合金轮毂。 一种涂覆铝轮的方法，包括在铝轮上涂覆防腐涂料组合物，然后施加透明涂料组合物以形成透明多层涂膜，其中防腐涂料组合物含有具有重均分子量的丙烯酸树脂（1） 重量为50,000〜140,000，玻璃化转变点为20〜50℃，羟值为10〜50mgKOH / g，酸值为10〜40mgKOH / g，环氧树脂（2）具有 环氧当量为210〜1000g / eq，相对于丙烯酸树脂（1）的固体成分100重量份，以固体成分计含有5〜20重量份的环氧树脂（2）。

    FIBROSIS INHIBITOR
    4.
    发明申请
    FIBROSIS INHIBITOR 有权
    纤维蛋白酶抑制剂

    公开(公告)号：US20110015211A1

    公开(公告)日：2011-01-20

    申请号：US12919885

    申请日：2009-02-26

    申请人： Koji Murakami ,  Takuya Toramoto

    发明人： Koji Murakami ,  Takuya Toramoto

    IPC分类号： A61K31/4965 ,  C07D241/20 ,  A61P35/00 ,  A61P17/02 ,  A61P25/28 ,  A61P13/12 ,  A61P1/18 ,  A61P19/00

    CPC分类号： C07D241/20 ,  A61K31/4965

    摘要： [Object] The main object of the present invention is to provide a fibrosis inhibitor.[Solving Means] The present invention relates to a fibrosis inhibitor containing the heterocyclic derivative represented by the following general formula (1) or a pharmaceutically acceptable salt thereof as an active ingredient; In the formula (1), R1 and R2 are the same or different and each represents an optionally substituted aryl; R3 and R4 are the same or different and each represents hydrogen atom or alkyl; R5 represents hydrogen atom, alkyl or halogen atom; Y represents N or N→O; A represents NR6, and R6 represents hydrogen atom, alkyl, etc.; D represents alkylene or alkenylene which is optionally substituted with hydroxy; E represents phenylene or a single bond; G represents O, S, etc.; and Q represents carboxy, alkoxycarbonyl, etc.

    摘要翻译： 本发明的主要目的在于提供纤维化抑制剂。 本发明涉及含有下述通式（1）表示的杂环衍生物或其药学上可接受的盐作为有效成分的纤维化抑制剂。 在式（1）中，R 1和R 2相同或不同，表示任选取代的芳基; R3和R4相同或不同，各自表示氢原子或烷基; R5代表氢原子，烷基或卤素原子; Y表示N或N→O; A表示NR6，R6表示氢原子，烷基等; D表示任选被羟基取代的亚烷基或亚烯基; E表示亚苯基或单键; G代表O，S等; Q表示羧基，烷氧基羰基等。

    Novel Cyclic Amino Benzoic Acid Derivative
    5.
    发明申请
    Novel Cyclic Amino Benzoic Acid Derivative 失效
    新型环状氨基苯甲酸衍生物

    公开(公告)号：US20070249580A1

    公开(公告)日：2007-10-25

    申请号：US11659854

    申请日：2005-08-11

    申请人： Masahiro Nomura ,  Yasuo Takano ,  Kazuhiro Yumoto ,  Takehiro Shinozaki ,  Shigeki Isogai ,  Koji Murakami

    发明人： Masahiro Nomura ,  Yasuo Takano ,  Kazuhiro Yumoto ,  Takehiro Shinozaki ,  Shigeki Isogai ,  Koji Murakami

    IPC分类号： A61K31/426 ,  A61K31/445 ,  A61K31/5375 ,  A61K31/55 ,  A61P3/10 ,  C07D211/36 ,  C07D223/00 ,  C07D277/02 ,  C07D413/00

    CPC分类号： C07D417/12 ,  C07D211/22 ,  C07D211/26 ,  C07D211/42 ,  C07D211/56 ,  C07D211/60

    摘要： The present invention relates to cyclic amino benzoic acid derivatives which are effective in therapy of lipid metabolism abnormality, diabetes and the like as a human peroxisome proliferators-activated receptor (PPAR) agonist, in particular, as an agonist against human PPARα isoform, and addition salts thereof, and pharmaceutical compositions containing these compounds. A cyclic amino benzoic acid derivative represented by the general formula (1) [wherein a ring Ar represents an aryl group which may have substituent, or the like; Y represents a C1-C4 alkylene, C2-C4 alkenylene, C2-C4 alkynylene, or the like; Z represents an oxygen atom, sulfur atom or —(CH2)n— (n represents 0, 1 or 2); X represents a hydrogen atom, halogen atom, lower alkyl group which may be substituted with a halogen atom, or the like; R represents a hydrogen atom or lower alkyl group, and —COOR substitutes for an ortho position or metha position of binding position of ring W] or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明涉及作为人类过氧化物酶体增殖物激活受体（PPAR）激动剂的脂质代谢异常的治疗有效的环状氨基苯甲酸衍生物，特别是作为对人PPARα同种型的激动剂的添加 其盐，以及含有这些化合物的药物组合物。 由通式（1）表示的环状氨基苯甲酸衍生物[其中环Ar表示可具有取代基的芳基等; Y表示C 1 -C 4亚烷基，C 2 -C 4亚烯基，C 2 C 3 -C 4亚炔基等; Z表示氧原子，硫原子或 - （CH 2 CH 2）n - （n表示0,1或2）。 X表示氢原子，卤素原子，可被卤素原子取代的低级烷基等; R代表氢原子或低级烷基，-COOR代替环W的结合位置的邻位或甲基位置]或其药学上可接受的盐。

    Substituted benzylthiazolidine-2,4-dione derivatives
    7.
    发明授权
    Substituted benzylthiazolidine-2,4-dione derivatives 失效
    取代的苄基噻唑烷-2,4-二酮衍生物

    公开(公告)号：US06780431B1

    公开(公告)日：2004-08-24

    申请号：US10049937

    申请日：2002-02-20

    申请人： Mashiro Nomura ,  Koji Murakami ,  Masaki Tsunoda ,  Yukie Takahashi

    发明人： Mashiro Nomura ,  Koji Murakami ,  Masaki Tsunoda ,  Yukie Takahashi

    IPC分类号： A61K31426

    CPC分类号： C07D277/34

    摘要： The invention relates to substituted benzylthiazolidine-2,4-dione derivatives represented by a general formula (1) wherein R1 denotes a chlorine atom, bromine atom, nitro group, trifluoromethoxy group, ethoxy group, propoxy group or isopropoxy group, and R2 denotes a hydrogen atom or chlorine atom, their medicinally acceptable salts, their hydrates and a process for preparing them.

    摘要翻译： 本发明涉及由通式（1）表示的取代的苄基噻唑烷-2,4-二酮衍生物，其中R 1表示氯原子，溴原子，硝基，三氟甲氧基，乙氧基，丙氧基或异丙氧基， R 2表示氢原子或氯原子，其药学上可接受的盐，它们的水合物及其制备方法。

    Substituted benzylthiazolidine-2, 4-dione derivatives
    8.
    发明授权
    Substituted benzylthiazolidine-2, 4-dione derivatives 失效
    取代的苄基噻唑烷-2,4-二酮衍生物

    公开(公告)号：US06734199B1

    公开(公告)日：2004-05-11

    申请号：US10049904

    申请日：2002-02-20

    申请人： Hiroyuki Miyachi ,  Masahiro Nomura ,  Takahiro Tanase ,  Koji Murakami ,  Masaki Tsunoda

    发明人： Hiroyuki Miyachi ,  Masahiro Nomura ,  Takahiro Tanase ,  Koji Murakami ,  Masaki Tsunoda

    IPC分类号： A61K31426

    CPC分类号： C07D277/34

    摘要： The invention provides novel substituted benzylthiazolidine-2,4-dione derivatives which increase the transactivation action of receptor as a ligand of human peroxisome proliferator-activated receptor (PPAR) and exhibit the blood glucose-decreasing action and lipid-decreasing action, and a process for preparing them. The invention relates to substituted benzylthiazolidine-2,4-dione derivatives represented by the general formula (1) [wherein A denotes a phenyl group which is unsubstituted or may have substituents, phenoxy group which is unsubstituted or may have substituents or benzyloxy group which is unsubstituted or may have substituents], their medicinally acceptable salts, their hydrates and a process for preparing them.

    摘要翻译： 本发明提供新的取代的苄基噻唑烷-2,4-二酮衍生物，其增加受体作为人过氧化物酶体增殖物激活受体（PPAR）的配体的反式激活作用，并显示出降血糖作用和降脂作用， 本发明涉及由通式（1）表示的取代的苄基噻唑烷-2,4-二酮衍生物[其中A表示未取代或可具有取代基的苯基，未取代或可具有取代基的苯氧基或 未取代或可具有取代基的苄氧基，其药学上可接受的盐，它们的水合物及其制备方法。

    N-benzyldioxothiazolidylbenzamide derivatives and process for producing the same
    9.
    发明授权
    N-benzyldioxothiazolidylbenzamide derivatives and process for producing the same 有权
    N-苄基二氧代噻唑烷基苯甲酰胺衍生物及其制造方法

    公开(公告)号：US6147101A

    公开(公告)日：2000-11-14

    申请号：US482268

    申请日：2000-01-13

    申请人： Toshio Maeda ,  Masahiro Nomura ,  Katsuya Awano ,  Susumu Kinoshita ,  Hiroya Satoh ,  Koji Murakami ,  Masaki Tsunoda

    发明人： Toshio Maeda ,  Masahiro Nomura ,  Katsuya Awano ,  Susumu Kinoshita ,  Hiroya Satoh ,  Koji Murakami ,  Masaki Tsunoda

    IPC分类号： C07D277/34 ,  C07D417/12 ,  A61K31/426

    CPC分类号： C07D417/12 ,  C07D277/34

    摘要： The present invention provides novel N-benzyldioxothiazolidylbenzamide derivatives that improve the insulin resistance and have potent hypoglycemic and lipid-lowering effects and processes for preparing the same, and relates to N-benzyldioxothiazolidylbenzamide derivatives characterized by being represented by a general formula (1) ##STR1## [wherein R.sup.1 and R.sup.2 denote identically or differently hydrogen atoms, lower alkyl groups with carbon atoms of 1 to 4, lower alkoxy groups with carbon atoms of 1 to 3, lower haloalkyl groups with carbon atoms of 1 to 3, lower haloalkoxy groups with carbon atoms of 1 to 3, halogen atoms, hydroxyl groups, nitro groups, amino groups which may be substituted with lower alkyl group(s) with carbon atoms of 1 to 3 or hetero rings, or R.sup.1 and R.sup.2 link to form a methylenedioxy group, R.sup.3 denotes a lower alkoxy group with carbon atoms of 1 to 3, hydroxyl group or halogen atom, and dotted line indicates double bond or single bond in combination with solid line], and processes for preparing the same.

    摘要翻译： 本发明提供了改善胰岛素抵抗并具有强效降血糖和降脂作用的新型N-苄基二硫代噻唑烷基苯甲酰胺衍生物及其制备方法，涉及以通式（1）表示的N-苄基二硫代噻唑烷基苯甲酰胺衍生物[其中 R1和R2表示相同或不同的氢原子，碳原子数为1〜4的低级烷基，碳原子数1〜3的低级烷氧基，碳原子数1〜3的低级卤代烷基，碳原子数为1〜 1至3，卤素原子，羟基，硝基，可被具有1至3个碳原子的低级烷基取代的氨基或杂环，或R 1和R 2连接形成亚甲二氧基，R 3表示 碳原子数为1〜3的低级烷氧基，羟基或卤素原子，虚线表示双键或单键与实线组合]，工序 准备相同。