公开(公告)号：US20230085899A1

公开(公告)日：2023-03-23

申请号：US17810591

申请日：2022-07-01

Applicant: The Board of Regents of The University of Texas System

Inventor： Jinming GAO ,  David BOOTHMAN ,  Kejin ZHOU ,  Xiaonan HUANG ,  Yiguang WANG

IPC: C08F293/00 ,  C07D311/92 ,  A61K47/58 ,  A61K47/62 ,  A61K9/127 ,  A61K49/00 ,  A61K31/352 ,  A61P35/00 ,  C08F299/02 ,  A61K47/69 ,  C08G81/02 ,  G01N33/58 ,  A61K9/50 ,  A61K31/337 ,  A61K31/704 ,  A61K9/107 ,  A61K47/68

Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

公开(公告)号：US20200325265A1

公开(公告)日：2020-10-15

申请号：US16814803

申请日：2020-03-10

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming GAO ,  David BOOTHMAN ,  Kejin ZHOU ,  Xiaonan HUANG ,  Yiguang WANG

IPC: C08F299/02 ,  A61K9/107 ,  A61P35/00

Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

公开(公告)号：US20170121279A1

公开(公告)日：2017-05-04

申请号：US15265064

申请日：2016-09-14

Applicant: The Board of Regents of the University of Texas System

Inventor： Daniel J. SIEGWART ,  Kejin ZHOU

IPC: C07C321/14 ,  A61K31/7125 ,  A61K47/20 ,  C07D295/15 ,  A61K47/22

CPC classification number: C07C321/14 ,  A61K9/5146 ,  A61K31/7125 ,  A61K47/20 ,  A61K47/22 ,  A61K47/59 ,  C07C323/52 ,  C07D295/15

Abstract: Modular dendrimers with cationic groups and lipophilic groups are provided herein. In some aspects, the dendrimers provided herein may be formulated in compositions which contain a nucleic acid and one or more helper excipients. In some aspects, these compositions may also be used to treat diseases or disorders with a therapeutic nucleic acid.

公开(公告)号：US20240391869A1

公开(公告)日：2024-11-28

申请号：US18800894

申请日：2024-08-12

Applicant: The Board of Regents of The University of Texas System

Inventor： Daniel J. SIEGWART ,  Kejin ZHOU

IPC: C07C321/14 ,  A61K9/51 ,  A61K31/7105 ,  A61K31/7125 ,  A61K47/20 ,  A61K47/22 ,  A61K47/59 ,  A61K47/60 ,  A61K47/69 ,  A61K48/00 ,  C07C323/52 ,  C07D295/15

Abstract: Modular dendrimers with cationic groups and lipophilic groups are provided herein. In some aspects, the dendrimers provided herein may be formulated in compositions which contain a nucleic acid and one or more helper excipients. In some aspects, these compositions may also be used to treat diseases or disorders with a therapeutic nucleic acid.

公开(公告)号：US20240010614A1

公开(公告)日：2024-01-11

申请号：US18335974

申请日：2023-06-15

Applicant: The Board of Regents of The University of Texas System

Inventor： Daniel J. SIEGWART ,  Kejin ZHOU

IPC: C07C321/14 ,  A61K47/59 ,  C07C323/52 ,  A61K9/51 ,  A61K47/69 ,  A61K47/60 ,  A61K31/7105 ,  A61K48/00 ,  A61K31/7125 ,  A61K47/20 ,  A61K47/22 ,  C07D295/15

CPC classification number: C07C321/14 ,  A61K47/59 ,  C07C323/52 ,  A61K9/5146 ,  A61K47/6931 ,  A61K47/60 ,  A61K9/513 ,  A61K31/7105 ,  A61K48/0041 ,  A61K31/7125 ,  A61K47/20 ,  A61K47/22 ,  C07D295/15

Abstract: Modular dendrimers with cationic groups and lipophilic groups are provided herein. In some aspects, the dendrimers provided herein may be formulated in compositions which contain a nucleic acid and one or more helper excipients. In some aspects, these compositions may also be used to treat diseases or disorders with a therapeutic nucleic acid.

公开(公告)号：US20220257792A1

公开(公告)日：2022-08-18

申请号：US17566666

申请日：2021-12-30

Applicant: The Board of Regents of The University of Texas System

Inventor： Daniel J. SIEGWART ,  Kejin ZHOU

IPC: A61K48/00 ,  A61K9/127 ,  A61K31/7105 ,  A61K47/34

Abstract: Disclosed herein are methods for modulating an amount or activity of a gene or a gene product in a cell. The methods herein may comprise contacting a cell with a therapeutic agent assembled with a lipid composition, which lipid composition may comprise a dendrimer or dendron which may comprise one or more degradable diacyl group, in which may result in modulating the amount or activity of the gene or the gene product in the cell. The therapeutic agent modulating a gene or gene product in a cell may be sufficient to treat a disease or disorder in a subject. Further disclosed herein are pharmaceutical compositions, kits, and lipid compositions for modulating an amount or activity of a gene or a gene product in a cell.

公开(公告)号：US20210198410A1

公开(公告)日：2021-07-01

申请号：US17198006

申请日：2021-03-10

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming GAO ,  David BOOTHMAN ,  Kejin ZHOU ,  Xiaonan HUANG ,  Yiguang WANG

IPC: C08F293/00 ,  C07D311/92 ,  A61K47/58 ,  A61K47/62 ,  A61K9/127 ,  A61K49/00 ,  A61K31/352 ,  A61P35/00 ,  C08F299/02 ,  A61K47/69 ,  C08G81/02 ,  G01N33/58 ,  A61K9/50 ,  A61K31/337 ,  A61K31/704 ,  A61K9/107 ,  A61K47/68

Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

公开(公告)号：US20160220706A1

公开(公告)日：2016-08-04

申请号：US15072522

申请日：2016-03-17

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Jinming Gao ,  David BOOTHMAN ,  Kejin ZHOU ,  Xiaonan HUANG ,  Yiguang WANG

IPC: A61K49/00 ,  A61K47/48 ,  A61K31/337 ,  A61K31/704 ,  C08F293/00 ,  A61K9/107

CPC classification number: C08F293/005 ,  A61K9/1075 ,  A61K9/1273 ,  A61K9/5031 ,  A61K31/337 ,  A61K31/352 ,  A61K31/704 ,  A61K47/58 ,  A61K47/62 ,  A61K47/6811 ,  A61K47/6845 ,  A61K49/0032 ,  A61K49/005 ,  A61K49/0054 ,  A61K49/0056 ,  A61K49/0082 ,  C07D311/92 ,  C08F220/34 ,  C08F2438/01

Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

Abstract translation: 本文提供了包含亲水性聚合物链段和疏水性聚合物链段的嵌段共聚物，其中所述亲水性聚合物链段包含选自以下的聚合物：聚（环氧乙烷）（PEO），聚（甲基丙烯酸酯磷脂酰胆碱）（MPC） 和聚乙烯吡咯烷酮（PVP），其中疏水性聚合物链段包含其中R'是-H或-CH 3，其中R是-NR 1 R 2，其中R 1和R 2是烷基，其中R 1和R 2相同或不同，其中R 1和R 2 一起具有5至16个碳，其中R 1和R 2可以任选地连接形成环，其中n为1至约10，并且其中x为总共约20至约200。 还提供了用于治疗和诊断应用的pH敏感性胶束组合物。

公开(公告)号：US20160220681A1

公开(公告)日：2016-08-04

申请号：US14962422

申请日：2015-12-08

Applicant: The Board of Regents of the University of Texas System

Inventor： Daniel J. SIEGWART ,  Jing HAO ,  Kejin ZHOU ,  Jason MILLER ,  Petra KOS ,  Lian XUE

IPC: A61K47/34 ,  A61K47/24 ,  A61K31/713 ,  C08G65/48 ,  C08G63/91 ,  A61K47/28 ,  A61K47/22

CPC classification number: A61K47/34 ,  A61K9/0019 ,  A61K9/5153 ,  A61K31/713 ,  A61K47/22 ,  A61K47/24 ,  A61K47/28 ,  C08G63/688 ,  C08G63/912 ,  C08G65/48 ,  C12N15/113 ,  C12N2310/14

Abstract: Polymers produced by ring opening polymerization which comprises an amino group that can be used in compositions to deliver a nucleic acid such as a miRNA or a siRNA. In some embodiments, compositions which comprise the polymers described herein and a nucleic acid are also provided herein. In some embodiments, these compositions are used to silence one or more genes in vivo or treat a disease or disorder.

Abstract translation: 通过开环聚合制备的聚合物，其包含可用于递送核酸如miRNA或siRNA的组合物中的氨基。 在一些实施方案中，本文还提供了包含本文所述的聚合物和核酸的组合物。 在一些实施方案中，这些组合物用于在体内沉默一种或多种基因或治疗疾病或病症。

公开(公告)号：US20130330278A1

公开(公告)日：2013-12-12

申请号：US13827197

申请日：2013-03-14

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming GAO ,  Kejin ZHOU ,  Baran SUMER

IPC: A61K49/00 ,  G01N21/64

CPC classification number: A61K49/0054 ,  A61K49/0032 ,  A61K49/0082 ,  G01N21/6486 ,  G01N33/502

Abstract: The present invention relates to pH-tunable, highly activatable multicolored fluorescent nanoplatforms and methods of using the nanoplatforms in a variety of applications including, but not limited to, investigating fundamental cell physiological processes such as pH regulation in endocytic vesicles, endosome/lysosome maturation, and effect of pH on receptor cycling and trafficking of subcellular organelles.

Abstract translation: 本发明涉及pH可调节的，高活性的多色荧光纳米平台，以及在各种应用中使用纳米平台的方法，包括但不限于研究基本细胞生理过程，如内吞泡囊中的pH调节，内体/溶酶体成熟， 以及pH对受体循环和运输亚细胞器的影响。