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11.发明授权公开(公告)号：US12018051B2
公开(公告)日：2024-06-25
申请号：US18162530
申请日：2023-01-31
发明人： Peter Collins , Bo Liang , Shirin Munir , Anne Schaap Nutt , Ursula Buchholz , Natalie Mackow , Peter Kwong , Barney Graham , Jason McLellan
IPC分类号： C07K14/005 , A61K39/12 , A61K39/155 , A61P31/14 , A61K39/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/155 , A61P31/14 , A61K2039/5254 , A61K2039/5256 , A61K2039/575 , A61K2039/70 , C07K2319/03 , C07K2319/033 , C12N2760/00022 , C12N2760/18534 , C12N2760/18571 , C12N2760/18622 , C12N2760/18634 , C12N2760/18641 , C12N2760/18643 , C12N2760/18671 , C12N2760/18722 , C12N2760/18734 , C12N2760/18741 , C12N2760/18743 , C12N2760/18771
摘要： Recombinant paramyxoviruses including a viral genome encoding a heterologous gene are provided. In several embodiments, the recombinant paramyxovirus is a recombinant parainfluenza virus, such as a recombinant PIV3 including a viral genome encoding a heterologous respiratory syncytial virus F ectodomain linked to the transmembrane domain and the cytoplasmic tail of the F protein from the PIV3. Nucleic acid molecules including the genome of a recombinant paramyxoviruses are also provided. The recombinant viruses may advantageously be used in vaccine formulations, such as for vaccines against parainfluenza virus and respiratory syncytial virus.
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公开(公告)号：US10858400B2
公开(公告)日：2020-12-08
申请号：US15633578
申请日：2017-06-26
发明人： Peter Kwong , Barney Graham , Jason McLellan , Man Chen , Baoshan Zhang , Tongqing Zhou , Michael Gordon Joyce , Yongping Yang
IPC分类号： C07K14/005
摘要： Disclosed are immunogens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the immunogens and methods of producing the immunogens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the immunogen to the subject.
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13.发明公开公开(公告)号：US20230287055A1
公开(公告)日：2023-09-14
申请号：US18162530
申请日：2023-01-31
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Ser.
发明人： Peter Collins , Bo Liang , Shirin Munir , Anne Schaap Nutt , Ursula Buchholz , Natalie Mackow , Peter Kwong , Barney Graham , Jason McLellan
IPC分类号： C07K14/005 , A61K39/12 , A61P31/14 , A61K39/155
CPC分类号： C07K14/005 , A61K39/12 , A61P31/14 , A61K39/155 , A61K2039/5256
摘要： Recombinant paramyxoviruses including a viral genome encoding a heterologous gene are provided. In several embodiments, the recombinant paramyxovirus is a recombinant parainfluenza virus, such as a recombinant PIV3 including a viral genome encoding a heterologous respiratory syncytial virus F ectodomain linked to the transmembrane domain and the cytoplasmic tail of the F protein from the PIV3. Nucleic acid molecules including the genome of a recombinant paramyxoviruses are also provided. The recombinant viruses may advantageously be used in vaccine formulations, such as for vaccines against parainfluenza virus and respiratory syncytial virus.
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14.发明申请公开(公告)号：US20200277338A1
公开(公告)日：2020-09-03
申请号：US16877319
申请日：2020-05-18
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic
发明人： Peter Collins , Bo Liang , Shirin Munir , Anne Schaap Nutt , Ursula Buchholz , Natalie Mackow , Peter Kwong , Barney Graham , Jason McLellan
IPC分类号： C07K14/005 , A61K39/12 , A61P31/14 , A61K39/155
摘要： Recombinant paramyxoviruses including a viral genome encoding a heterologous gene are provided. In several embodiments, the recombinant paramyxovirus is a recombinant parainfluenza virus, such as a recombinant PIV3 including a viral genome encoding a heterologous respiratory syncytial virus F ectodomain linked to the transmembrane domain and the cytoplasmic tail of the F protein from the PIV3. Nucleic acid molecules including the genome of a recombinant paramyxoviruses are also provided. The recombinant viruses may advantageously be used in vaccine formulations, such as for vaccines against parainfluenza virus and respiratory syncytial virus.
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公开(公告)号：US20170298101A1
公开(公告)日：2017-10-19
申请号：US15633578
申请日：2017-06-26
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Serv
发明人： Peter Kwong , Barney Graham , Jason McLellan , Man Chen , Baoshan Zhang , Tongqing Zhou
IPC分类号： C07K14/005
CPC分类号： C07K14/005 , C07K2319/03 , C07K2319/21 , C07K2319/40 , C07K2319/50 , C07K2319/70 , C12N2760/18522 , C12N2760/18534
摘要： Disclosed are immunogens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the immunogens and methods of producing the immunogens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the immunogen to the subject.
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公开(公告)号：US20140348865A1
公开(公告)日：2014-11-27
申请号：US14344589
申请日：2012-09-07
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Ser. , University of Maryland, Baltimore , University of Washington
发明人： Peter Kwong , Jason McLellan , Marie Pancera , Jason Gorman , Mallika Sastry , Kaifan Dai , Tongqing Zhou , John Mascola , Gary Nabel , Masaru Kanekiyo , Yongping Yang , Jiang Zhu , Lai-Xi Wang , William Schief , Chris Carrico , Mohammed Amin
IPC分类号： C07K14/005 , C12N7/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , C12N7/00 , C12N2740/16011 , C12N2740/16034 , C12N2740/16134
摘要： Disclosed are HIV immunogens. Also disclosed are nucleic acids encoding these immunogens and methods of producing these antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a human immunodeficiency type 1 (HIV-1) infection in a subject.
摘要翻译： 披露的是艾滋病毒免疫原。 还公开了编码这些免疫原的核酸和产生这些抗原的方法。 还公开了在受试者中产生免疫应答的方法。 在一些实施方案中，该方法是用于治疗或预防受试者中的人类免疫缺陷1型（HIV-1）感染的方法。
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17.发明公开公开(公告)号：US20240309053A1
公开(公告)日：2024-09-19
申请号：US18665309
申请日：2024-05-15
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Servic
发明人： Peter Collins , Bo Liang , Shirin Munir , Anne Schaap Nutt , Ursula Buchholz , Natalie Mackow , Peter Kwong , Barney Graham , Jason McLellan
IPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/155 , A61P31/14
CPC分类号： C07K14/005 , A61K39/12 , A61K39/155 , A61P31/14 , A61K2039/5254 , A61K2039/5256 , A61K2039/575 , A61K2039/70 , C07K2319/03 , C07K2319/033 , C12N2760/00022 , C12N2760/18534 , C12N2760/18571 , C12N2760/18622 , C12N2760/18634 , C12N2760/18641 , C12N2760/18643 , C12N2760/18671 , C12N2760/18722 , C12N2760/18734 , C12N2760/18741 , C12N2760/18743 , C12N2760/18771
摘要： Recombinant paramyxoviruses including a viral genome encoding a heterologous gene are provided. In several embodiments, the recombinant paramyxovirus is a recombinant parainfluenza virus, such as a recombinant PIV3 including a viral genome encoding a heterologous respiratory syncytial virus F ectodomain linked to the transmembrane domain and the cytoplasmic tail of the F protein from the PIV3. Nucleic acid molecules including the genome of a recombinant paramyxoviruses are also provided. The recombinant viruses may advantageously be used in vaccine formulations, such as for vaccines against parainfluenza virus and respiratory syncytial virus.
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公开(公告)号：US20140271699A1
公开(公告)日：2014-09-18
申请号：US14207372
申请日：2014-03-12
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Serv
发明人： Peter Kwong , Barney Graham , Jason McLellan , Jeffrey Boyington , Ivelin Stefanov Georgiev , Michael Gordon Joyce , Masaru Kanekiyo , Marie Pancera , Cinque Soto , Sanjay Srivatsan , Baoshan Zhang
IPC分类号： C07K14/005
CPC分类号： C07K14/005 , C07K2319/03 , C07K2319/21 , C07K2319/40 , C07K2319/50 , C07K2319/70 , C12N2760/18522 , C12N2760/18534
摘要： Disclosed are immunogens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the immunogens and methods of producing the immunogens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the immunogen to the subject.
摘要翻译： 公开了包含以预设构象稳定的重组RSV F蛋白的免疫原。 还公开了编码免疫原的核酸和产生免疫原的方法。 还公开了在受试者中产生免疫应答的方法。 在一些实施方案中，该方法是通过向受试者施用治疗有效量的免疫原来治疗或预防受试者RSV感染的方法。
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公开(公告)号：US20230348571A1
公开(公告)日：2023-11-02
申请号：US17917174
申请日：2021-04-06
申请人： VANDERBILT UNIVERSITY , BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , TRUSTEES OF DARTMOUTH COLLEGE
发明人： Ivelin Stefanov Georgiev , Andrea R. Shiakolas , Kevin J. Kramer , James E. Crowe, Jr. , Robert Carnahan , Nianshuang Wang , Daniel Wrapp , Jason McLellan
CPC分类号： C07K16/1003 , A61P31/14 , A61K2039/505
摘要： The present disclosure relates to antibodies and uses thereof for treating, preventing, and detecting coronavirus infection.
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公开(公告)号：US12077563B2
公开(公告)日：2024-09-03
申请号：US18411284
申请日：2024-01-12
发明人： Jason McLellan , Ching-Lin Hsieh , Scott Rush , Nianshuang Wang
IPC分类号： C07K14/08 , C07K14/115 , C07K14/135
CPC分类号： C07K14/08
摘要： Provided herein are engineered hMPV F proteins. In some aspects, the engineered F proteins exhibit enhanced conformational stability and/or antigenicity. Methods are also provided for use of the engineered F proteins as diagnostics, in screening platforms, and/or in vaccine compositions.
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