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公开(公告)号：US20140348865A1
公开(公告)日：2014-11-27
申请号：US14344589
申请日：2012-09-07
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Ser. , University of Maryland, Baltimore , University of Washington
发明人： Peter Kwong , Jason McLellan , Marie Pancera , Jason Gorman , Mallika Sastry , Kaifan Dai , Tongqing Zhou , John Mascola , Gary Nabel , Masaru Kanekiyo , Yongping Yang , Jiang Zhu , Lai-Xi Wang , William Schief , Chris Carrico , Mohammed Amin
IPC分类号： C07K14/005 , C12N7/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , C12N7/00 , C12N2740/16011 , C12N2740/16034 , C12N2740/16134
摘要： Disclosed are HIV immunogens. Also disclosed are nucleic acids encoding these immunogens and methods of producing these antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a human immunodeficiency type 1 (HIV-1) infection in a subject.
摘要翻译： 披露的是艾滋病毒免疫原。 还公开了编码这些免疫原的核酸和产生这些抗原的方法。 还公开了在受试者中产生免疫应答的方法。 在一些实施方案中，该方法是用于治疗或预防受试者中的人类免疫缺陷1型（HIV-1）感染的方法。
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2.发明公开公开(公告)号：US20230287055A1
公开(公告)日：2023-09-14
申请号：US18162530
申请日：2023-01-31
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Ser.
发明人： Peter Collins , Bo Liang , Shirin Munir , Anne Schaap Nutt , Ursula Buchholz , Natalie Mackow , Peter Kwong , Barney Graham , Jason McLellan
IPC分类号： C07K14/005 , A61K39/12 , A61P31/14 , A61K39/155
CPC分类号： C07K14/005 , A61K39/12 , A61P31/14 , A61K39/155 , A61K2039/5256
摘要： Recombinant paramyxoviruses including a viral genome encoding a heterologous gene are provided. In several embodiments, the recombinant paramyxovirus is a recombinant parainfluenza virus, such as a recombinant PIV3 including a viral genome encoding a heterologous respiratory syncytial virus F ectodomain linked to the transmembrane domain and the cytoplasmic tail of the F protein from the PIV3. Nucleic acid molecules including the genome of a recombinant paramyxoviruses are also provided. The recombinant viruses may advantageously be used in vaccine formulations, such as for vaccines against parainfluenza virus and respiratory syncytial virus.
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公开(公告)号：US09738703B2
公开(公告)日：2017-08-22
申请号：US14864705
申请日：2015-09-24
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , University of Washington
发明人： John Mascola , Richard Wyatt , Xueling Wu , Yuxing Li , Carl-Magnus Hogerkorp , Mario Roederer , Zhi-yong Yang , Gary Nabel , Peter Kwong , Tongqing Zhou , Mark Connors , William Schief
CPC分类号： C07K16/1063 , A61K39/42 , A61K45/06 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2740/10011 , C12N2740/16011 , C12N2740/16111
摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-1 gp120. Monoclonal neutralizing antibodies also are disclosed that specifically bind to HIV-1 gp41. The identification of these antibodies, and the use of these antibodies are also disclosed. Methods are also provided for enhancing the binding and neutralizing activity of any antibody using epitope scaffold probes.
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公开(公告)号：US10035845B2
公开(公告)日：2018-07-31
申请号：US15661867
申请日：2017-07-27
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , University of Washington
发明人： John Mascola , Richard Wyatt , Xueling Wu , Yuxing Li , Carl-Magnus Hogerkorp , Mario Roederer , Zhi-yong Yang , Gary Nabel , Peter Kwong , Tongqing Zhou , Mark Connors , William Schief
IPC分类号： A61K39/395 , A61K39/00 , C07K16/24 , C07K16/00 , C07K16/28 , C07K16/10 , A61K39/42 , A61K45/06
CPC分类号： C07K16/1063 , A61K39/42 , A61K45/06 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2740/10011 , C12N2740/16011 , C12N2740/16111
摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-1 gp120. Monoclonal neutralizing antibodies also are disclosed that specifically bind to HIV-1 gp41. The identification of these antibodies, and the use of these antibodies are also disclosed. Methods are also provided for enhancing the binding and neutralizing activity of any antibody using epitope scaffold probes.
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公开(公告)号：US20170369558A1
公开(公告)日：2017-12-28
申请号：US15661867
申请日：2017-07-27
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Serv , University of Washington
发明人： John Mascola , Richard Wyatt , Xueling Wu , Yuxing Li , Carl-Magnus Hogerkorp , Mario Roederer , Zhi-yong Yang , Gary Nabel , Peter Kwong , Tongqing Zhou , Mark Connors , William Schief
CPC分类号： C07K16/1063 , A61K39/42 , A61K45/06 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2740/10011 , C12N2740/16011 , C12N2740/16111
摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-1 gp120. Monoclonal neutralizing antibodies also are disclosed that specifically bind to HIV-1 gp41. The identification of these antibodies, and the use of these antibodies are also disclosed. Methods are also provided for enhancing the binding and neutralizing activity of any antibody using epitope scaffold probes.
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公开(公告)号：US20160009789A1
公开(公告)日：2016-01-14
申请号：US14864705
申请日：2015-09-24
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Serv , University of Washington
发明人： John Mascola , Richard Wyatt , Xueling Wu , Yuxing Li , Carl-Magnus Hogerkorp , Mario Roederer , Zhi-yong Yang , Gary Nabel , Peter Kwong , Tongqing Zhou , Mark Connors , William Schief
CPC分类号： C07K16/1063 , A61K39/42 , A61K45/06 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2740/10011 , C12N2740/16011 , C12N2740/16111
摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-1 gp120. Monoclonal neutralizing antibodies also are disclosed that specifically bind to HIV-1 gp41. The identification of these antibodies, and the use of these antibodies are also disclosed. Methods are also provided for enhancing the binding and neutralizing activity of any antibody using epitope scaffold probes.
摘要翻译： 公开了特异性结合HIV-1 gp120的CD4结合位点的单克隆中和抗体。 还公开了特异性结合HIV-1 gp41的单克隆中和抗体。 还公开了这些抗体的鉴定，以及这些抗体的用途。 还提供了用于增强使用表位支架探针的任何抗体的结合和中和活性的方法。
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