-
公开(公告)号：US20160035549A1
公开(公告)日：2016-02-04
申请号：US14776910
申请日：2014-03-07
申请人： THERMO FINNIGAN LLC
发明人： Michael W. SENKO , Justin BLETHROW , Shannon Eliuk DIXON , Tonya SECOND , Vladimir ZABROUSKOV , Eric HEMENWAY
IPC分类号： H01J49/00
CPC分类号： H01J49/0031 , H01J49/005 , H01J49/009 , H01J49/061
摘要： A hybrid mass spectrometer design and architecture, and methods of operating mass spectrometers are disclosed. According to one operating method, an analysis time is determined for each one of a plurality of ion species to be analyzed in an ordered sequence, and an injection time is calculated for at least some of the ion species based on an analysis time of a preceding ion species in the ordered list. The method enables more efficient utilization of analyzer time.
摘要翻译： 公开了混合质谱仪设计和结构以及操作质谱仪的方法。 根据一种操作方法，以有序序列确定要分析的多个离子种类中的每一种的分析时间，并且基于前面的分析时间为至少一些离子种类计算注入时间 有序列表中的离子物种。 该方法可以更有效地利用分析仪的时间。
-
公开(公告)号：US20150364303A1
公开(公告)日：2015-12-17
申请号：US14741360
申请日：2015-06-16
申请人： Thermo Finnigan LLC
发明人： Philip M. REMES , Michael W. SENKO
CPC分类号： H01J49/0031 , H01J49/38 , H01J49/4245 , H01J49/4265
摘要： A method is disclosed for operating a mass spectrometer having a Fourier Transform (FT) analyzer, such as an orbital electrostatic trap mass analyzer, to avoid peak coalescence and/or other phenomena arising from frequency-shifting caused by ion-ion interactions. Ions of a first group are mass analyzed, for example in a quadrupole ion trap analyzer, to generate a mass spectrum. The estimated frequency shift of the characteristic periodic motion in the FT analyzer is calculated for one or more ion species of interest based on the intensities of adjacent (closely m/z-spaced) ion species. If the estimated frequency shift(s) for the one or more ion species exceeds a threshold, then a target ion population for an FT analyzer scan is adjusted downwardly to a value that produces a shift of acceptable value. An analytical scan of a second ion group is performed at the adjusted target ion population.
摘要翻译： 公开了一种用于操作具有诸如轨道静电阱质量分析仪的傅立叶变换（FT）分析仪的质谱仪以避免由离子 - 离子相互作用引起的频率偏移引起的峰值聚结和/或其他现象的方法。 质量分析第一组的离子，例如在四极离子阱分析仪中，以产生质谱。 基于相邻（接近m / z-间隔）的离子种类的强度，计算出FT分析仪中特征周期运动的估计频移，用于一种或多种感兴趣的离子种类。 如果一个或多个离子物质的估计频率偏移超过阈值，则将FT分析仪扫描的目标离子群体向下调整到产生可接受值的偏移的值。 在调整的目标离子群体上进行第二离子组的分析扫描。
-
公开(公告)号：US20150179420A1
公开(公告)日：2015-06-25
申请号：US14137723
申请日：2013-12-20
申请人： Thermo Finnigan LLC
发明人： Michael W. SENKO
CPC分类号： H01J49/06
摘要： A sample ionization system includes at least an ionization source disposed at an ion source end of a charged particle analyzer, for selectably generating first ions in an analyzing mode of operation and second ions in a cleaning mode of operation. The first ions are one of positively and negatively charged and the second ions are the other one of positively and negatively charged. The second ions are directed through the charged particle analyzer toward a surface of an ion optic component, for at least partially neutralizing a buildup of charge caused by the first ions impinging on the surface of the at least one ion optic component.
摘要翻译： 样品电离系统至少包括设置在带电粒子分析仪的离子源端处的电离源，用于在分析操作模式中选择性地产生第一离子，并在清洁操作模式中产生第二离子。 第一离子是带正电荷和负电荷的第二离子，而第二离子是带正电荷和带负电荷的另一个离子。 第二离子被引导通过带电粒子分析仪朝向离子光学部件的表面，用于至少部分地中和由第一离子撞击在至少一个离子光学部件的表面上引起的电荷积累。
-
14.发明申请公开(公告)号：US20140264007A1
公开(公告)日：2014-09-18
申请号：US14216507
申请日：2014-03-17
申请人： THERMO FINNIGAN LLC
发明人： Philip M. REMES , Michael W. SENKO , Michael W. BELFORD , Jae C. SCHWARTZ , Jean-Jacques DUNYACH , Berg TEHLIRIAN
IPC分类号： H01J49/00
CPC分类号： H01J49/0031
摘要： A method is described for identifying the occurrence and location of charging of ion optic devices arranged along the ion path of a mass spectrometer. The method includes repeatedly performing a sequence of introducing a beam of discharge ions to a location on the ion path, and subsequently measuring the intensities of opposite-polarity sample ions delivered to a mass analyzer, with the discharge ions being delivered to a location further downstream in the ion path at each successive sequence.
摘要翻译： 描述了一种用于识别沿着质谱仪的离子路径布置的离子光学器件的充电的发生和位置的方法。 该方法包括重复执行将放电离子束引入到离子路径上的位置的顺序，随后测量输送到质量分析器的反极性样品离子的强度，其中放电离子被递送到更下游的位置 在每个连续序列的离子路径中。
-
公开(公告)号：US20220199392A1
公开(公告)日：2022-06-23
申请号：US17539851
申请日：2021-12-01
申请人： THERMO FINNIGAN LLC
发明人： Michael W. SENKO
IPC分类号： H01J49/42
摘要： An ion separation apparatus comprises: (a) first and second ion carpets, each comprising: a substrate having first and second faces; and a set of electrodes disposed on or beneath the first face, wherein a configuration of a first plurality of the set of electrodes defines at least one group of circle sectors; (b) an ion exit aperture passing through one ion carpet; and (c) one or more power supplies configured to provide radio frequency voltages to a first subset of the electrodes of each ion carpet, to provide electrical potential differences across electrodes of the first subset of electrodes of each ion carpet, and to provide time-varying voltages to the first plurality of electrodes of each ion carpet that migrate through the sectors as a traveling wave, wherein the ion carpets are disposed parallel to one another with a gap therebetween, the first faces facing one another across the gap.
-
公开(公告)号：US20210142993A1
公开(公告)日：2021-05-13
申请号：US16678879
申请日：2019-11-08
申请人： Thermo Finnigan LLC
发明人： Michael W. SENKO , Philip M. REMES
摘要： A method of operating a mass spectrometer that allows for high-speed operation is disclosed. The method consists in separating the various steps needed to produce a mass spectrum into three or more conceptual stages in a pipeline, such that the instrument is performing steps to process more than two precursor-ion species simultaneously. In general, the number of stages in the pipeline should at least one more and, preferably, at least two more than the number of buffering storage devices in the instrument. The presently-taught methods and apparatus allow for nearly 100% duty cycle of ion accumulation for precursors of interest.
-
公开(公告)号：US20190122879A1
公开(公告)日：2019-04-25
申请号：US16222010
申请日：2018-12-17
申请人： Thermo Finnigan LLC
CPC分类号： H01J49/4245 , H01J49/0031 , H01J49/426 , H01J49/4275
摘要： A method of operating an electrostatic trapping mass analyzer, comprising: introducing a sample of ions into a trapping region of the mass analyzer, wherein a trapping field within the trapping region is such that the ions exhibit radial motion with respect to a central longitudinal axis of the trapping region while undergoing harmonic motion in a dimension defined by the central longitudinal axis, the frequency of harmonic motion of a particular ion being a function of its mass-to-charge ratio; superimposing a modulation field onto the trapping field within the trapping region, the modulation field acting to either increase or reduce the harmonic motion energies of the ions by an amount varying according to the frequency of harmonic motion; and acquiring a mass spectrum of the ions in the trapping region by measuring a signal representative of an image current induced by the harmonic motion of the ions.
-
公开(公告)号：US20180068838A1
公开(公告)日：2018-03-08
申请号：US15811530
申请日：2017-11-13
申请人： Thermo Finnigan LLC
发明人： Michael W. SENKO , Justin BLETHROW , Shannon Eliuk DIXON , Tonya SECOND , Vladimir ZABROUSKOV , Eric HEMENWAY
CPC分类号： H01J49/0031 , H01J49/005 , H01J49/009 , H01J49/061
摘要： A hybrid mass spectrometer design and architecture, and methods of operating mass spectrometers are disclosed. According to one operating method, an analysis time is determined for each one of a plurality of ion species to be analyzed in an ordered sequence, and an injection time is calculated for at least some of the ion species based on an analysis time of a preceding ion species in the ordered list. The method enables more efficient utilization of analyzer time.
-
公开(公告)号：US20220246414A1
公开(公告)日：2022-08-04
申请号：US17606386
申请日：2020-04-22
摘要： Apparatus and methods for performing charge detection mass spectrometry for measurement of the mass of a single ion of interest are disclosed. The ion of interest is caused to undergo harmonic oscillatory movement in the trapping field of an electrostatic trap, such that an image current detector generates a time-varying signal representative of the ion's oscillatory movement. This time-varying signal (transient) is processed (e.g., via a Fourier transform) to derive the ion's frequency and consequently determine the ion's mass-to-charge ratio (m/z). Ion charge is determined by construction of a Selective Temporal Overview of Resonant Ion (STORI) plot, which tracks the temporal evolution of signals attributable to the ion of interest, and where the slope of the STORI plot is related to the charge. The STORI plot may also be employed to identify ion decay events during transient acquisition and/or the presence of multiple ions of the same mass or non-resolvable ions.
-
公开(公告)号：US20220068621A1
公开(公告)日：2022-03-03
申请号：US17011359
申请日：2020-09-03
申请人： Thermo Finnigan LLC
摘要： An electron multiplier includes a series of discrete electron emissive surfaces or a continuous electron emissive resistive surface configured to provide an electron amplification chain; and a housing surrounding the series of electron emissive surfaces or the continuous electron emissive resistive surface and separating the environment inside the housing from the environment outside the housing. The housing includes an electron-transparent, gas-impermeable barrier configured to allow electrons to pass through into the housing to reach a first discrete electron emissive surface of the series of discrete electron emissive surfaces or a first portion of the continuous electron emissive resistive surface.
-
-
-
-
-
-
-
-
-
搜索结果
24 条记录 (耗时 0.013 秒)