公开(公告)号：US20150364302A1

公开(公告)日：2015-12-17

申请号：US14742115

申请日：2015-06-17

Applicant: Thermo Finnigan LLC

Inventor： Oleg SILIVRA ,  Harald OSER ,  Joshua T. MAZE ,  Terry OLNEY ,  Alan E. SCHOEN

IPC: H01J49/00 ,  H01J49/42

CPC classification number: H01J49/005 ,  H01J49/4215 ,  H01J49/4225 ,  H01J49/429

Abstract: A collision cell has a plurality of rod electrodes arranged in opposed pairs around an axial centerline and a plurality of drag vanes arranged in the interstitial spaces between the rod electrodes. Operating the collision cell includes, applying a rod offset voltage to the rod electrodes, and varying an offset voltage applied to the drag vanes to identify a vane offset voltage with a maximum intensity for the transition. The method further includes varying a drag field by adjusting the voltages applied to drag vane terminals in opposite directions to identify a drag field value with a cross talk below a cross talk threshold, varying the vane offset voltage by adjusting the voltages applied to the drag vane terminals to maximize the intensity of the transition while preserving the drag field, and operating the collision cell at the vane offset voltage and drag field to monitor the transition.

Abstract translation: 碰撞单元具有围绕轴向中心线相对排列的多个杆电极以及布置在杆电极之间的间隙空间中的多个牵引叶片。 操作碰撞单元包括：向杆电极施加杆偏移电压，以及改变施加到牵引叶片的偏移电压，以识别具有用于转变的最大强度的叶片偏移电压。 该方法还包括通过调整施加到相反方向上的牵引叶片端子的电压来改变阻力场，以通过串扰低于串扰阈值来识别阻力场值，通过调节施加到牵引叶片的电压来改变叶片偏移电压 终端，以最大化过渡的强度，同时保持拖曳场，并且在叶片偏移电压和阻力场处操作碰撞单元以监视转换。

公开(公告)号：US20170207075A1

公开(公告)日：2017-07-20

申请号：US15001667

申请日：2016-01-20

Applicant: Thermo Finnigan LLC

Inventor： Scott T. QUARMBY ,  Edward B. McCAULEY ,  Joshua T. MAZE

IPC: H01J49/24 ,  H01J49/16

CPC classification number: H01J49/24 ,  H01J49/0013 ,  H01J49/0404 ,  H01J49/165 ,  H01J2237/182

Abstract: A mass spectrometer system can include an ion source, a vacuum chamber; a mass analyzer within the vacuum chamber, a transfer tube between the ion source and the vacuum chamber, a transfer tube heater, and a vacuum pump. The mass spectrometer system can be configured to reduce the pump speed of the vacuum pump in response to receiving a transfer tube swap instruction; lower the temperature of the transfer tube to below a first threshold; operating the vacuum pump at the reduced pump speed while the transfer tube is replaced with a second transfer tube; heating the second transfer tube to a temperature above a pump down temperature; and increasing the pump speed of the vacuum pump after the temperature of the second transfer tube exceeds a second threshold.

公开(公告)号：US20220068621A1

公开(公告)日：2022-03-03

申请号：US17011359

申请日：2020-09-03

Applicant: Thermo Finnigan LLC

Inventor： Michael W. SENKO ,  Joshua T. MAZE ,  Scott T. QUARMBY

IPC: H01J43/22 ,  H01J49/02

Abstract: An electron multiplier includes a series of discrete electron emissive surfaces or a continuous electron emissive resistive surface configured to provide an electron amplification chain; and a housing surrounding the series of electron emissive surfaces or the continuous electron emissive resistive surface and separating the environment inside the housing from the environment outside the housing. The housing includes an electron-transparent, gas-impermeable barrier configured to allow electrons to pass through into the housing to reach a first discrete electron emissive surface of the series of discrete electron emissive surfaces or a first portion of the continuous electron emissive resistive surface.

公开(公告)号：US20180182605A1

公开(公告)日：2018-06-28

申请号：US15389118

申请日：2016-12-22

Applicant: Thermo Finnigan LLC

Inventor： Nicholas T. MOLLISON ,  Jaime A. CARRERA ,  Joshua T. MAZE ,  Scott T. QUARMBY

IPC: H01J49/06

CPC classification number: H01J49/067 ,  H01J49/04

Abstract: A mass spectrometry system includes an ion optics stack defining a central longitudinal axis. The ion optics stack includes a circular lens aperture of a first diameter and a circular alignment target having a second diameter. The second diameter is less than the first diameter. The circular alignment target is positioned such that when the ion optics stack is in alignment, the circular lens aperture and circular alignment target appear concentric to an unaided viewer when viewed along the central longitudinal axis of the ion optics stack.

公开(公告)号：US20210072204A1

公开(公告)日：2021-03-11

申请号：US17082787

申请日：2020-10-28

Applicant: Thermo Finnigan LLC

Inventor： Joshua T. MAZE ,  Scott T. QUARMBY

IPC: G01N30/86 ,  H01J49/00 ,  G01N30/72 ,  H01J49/16

Abstract: A mass spectrometry system having a simplified control interface includes a processor and a memory. The memory includes instructions that when executed cause the processor to perform the steps of providing a user interface including a plurality of adjustment elements for adjusting at least one results effective parameter and at least one sample descriptive parameter; determining a plurality of instrument control parameters based on the at least one results effective parameter and the at least one sample descriptive parameter; and analyzing a sample while operating according to the plurality of instrument control parameters.

公开(公告)号：US20180188217A1

公开(公告)日：2018-07-05

申请号：US15394240

申请日：2016-12-29

Applicant: Thermo Finnigan LLC

Inventor： Joshua T. MAZE ,  Scott T. QUARMBY

IPC: G01N30/86 ,  H01J49/00 ,  G01N30/72 ,  H01J49/16

CPC classification number: G01N30/8658 ,  G01N30/7266 ,  H01J49/00 ,  H01J49/0036 ,  H01J49/167

Abstract: A mass spectrometry system having a simplified control interface includes a processor and a memory. The memory includes instructions that when executed cause the processor to perform the steps of providing a user interface including a plurality of adjustment elements for adjusting at least one results effective parameter and at least one sample descriptive parameter; determining a plurality of instrument control parameters based on the at least one results effective parameter and the at least one sample descriptive parameter; and analyzing a sample while operating according to the plurality of instrument control parameters.

公开(公告)号：US20180019111A1

公开(公告)日：2018-01-18

申请号：US15678368

申请日：2017-08-16

Applicant: Thermo Finnigan LLC

Inventor： Scott T. QUARMBY ,  Edward B. McCAULEY ,  Joshua T. MAZE

IPC: H01J49/24 ,  H01J49/16

CPC classification number: H01J49/24 ,  H01J49/0013 ,  H01J49/0404 ,  H01J49/165 ,  H01J2237/182

Abstract: A mass spectrometer system can include an ion source, a vacuum chamber; a mass analyzer within the vacuum chamber, a transfer tube between the ion source and the vacuum chamber, a transfer tube heater, and a vacuum pump. The mass spectrometer system can be configured to reduce the pump speed of the vacuum pump in response to receiving a transfer tube swap instruction; lower the temperature of the transfer tube to below a first threshold; operating the vacuum pump at the reduced pump speed while the transfer tube is replaced with a second transfer tube; heating the second transfer tube to a temperature above a pump down temperature; and increasing the pump speed of the vacuum pump after the temperature of the second transfer tube exceeds a second threshold.

公开(公告)号：US20220276210A1

公开(公告)日：2022-09-01

申请号：US17747373

申请日：2022-05-18

Applicant: Thermo Finnigan LLC

Inventor： Joshua T. MAZE ,  Scott T. QUARMBY

IPC: G01N30/86 ,  H01J49/00 ,  G01N30/72 ,  H01J49/16

Abstract: A mass spectrometry system having a simplified control interface includes a processor and a memory. The memory includes instructions that when executed cause the processor to perform the steps of providing a user interface including a plurality of adjustment elements for adjusting at least one results effective parameter and at least one sample descriptive parameter; determining a plurality of instrument control parameters based on the at least one results effective parameter and the at least one sample descriptive parameter; and analyzing a sample while operating according to the plurality of instrument control parameters.

公开(公告)号：US20210020424A1

公开(公告)日：2021-01-21

申请号：US16512617

申请日：2019-07-16

Applicant: Thermo Finnigan LLC

Inventor： David GONZALEZ ,  Nathaniel L. SANDERS ,  Joshua T. MAZE

IPC: H01J49/16 ,  H01J49/26

Abstract: A method for removing deposits in a mass spectrometer ion source housing includes delivering a liquid from a liquid source to a surface within the ion source housing. The surface including an ultrasonic transducer embedded within the surface. The method further includes activating the ultrasonic transducer to ultrasonically remove the deposit.

公开(公告)号：US20200020513A1

公开(公告)日：2020-01-16

申请号：US16032782

申请日：2018-07-11

Applicant: Thermo Finnigan LLC

Inventor： Joshua T. MAZE ,  Edward B. McCAULEY ,  Scott T. QUARMBY

IPC: H01J43/16 ,  H01J43/10 ,  H01J49/00 ,  H01J49/02 ,  H01J49/40 ,  H01J49/42

Abstract: An ion detector includes a first stage dynode configured to receive an ion beam and generate electrons, a photon source arranged to provide photons to the first stage dynode, the photons of sufficient energy to cause the first stage dynode to emit photoelectrons, an electron multiplier configured to receive the electrons or the photoelectrons from the first stage dynode and generate an output proportional to the number of electrons or photoelectrons, and a controller. The controller is configured to receive the output generated in response to the photoelectrons; calculate a gain curve of the detector based on the output; and set a voltage of the electron multiplier or the first stage dynode to achieve a target gain for the ion beam.