利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

27 条记录 (耗时 0.039 秒)

    BIOREACTOR FOR GROWING BIOLOGICAL MATERIALS SUPPORTED ON A LIQUID SURFACE
    11.
    发明申请
    BIOREACTOR FOR GROWING BIOLOGICAL MATERIALS SUPPORTED ON A LIQUID SURFACE 审中-公开
    生物反应器，用于生长液体表面上支持的生物材料

    公开(公告)号：US20070094926A1

    公开(公告)日：2007-05-03

    申请号：US11469675

    申请日：2006-09-01

    申请人： R. Branson ,  Keith Everett ,  Bob Hester ,  Timothy Vickers

    发明人： R. Branson ,  Keith Everett ,  Bob Hester ,  Timothy Vickers

    IPC分类号： A01G31/06

    CPC分类号： C12M21/02 ,  C12M23/14 ,  C12M23/24 ,  C12M23/44 ,  C12M23/48 ,  Y10S47/06

    摘要： A bioreactor assembly of the present invention for holding a media and supporting growth of a plurality of plants. The assembly includes a light source and a container having a light transmissive wall structure and defining a reservoir. A major axis of the reservoir is substantially horizontal allowing the reservoir to be filled with media to a partial level and to define a relatively large surface area for support of the plants. The assembly may also include clamps to secure and seal separate wall structure portions of the container together, and end caps to the wall portions, to define an aseptic environment. As another option, the clamps may define openings therethrough that allow passage of various devices for measuring and controlling bioreactor function such as a gas supply nozzle, a gas exit nozzle, an air temperature probe, a pH probe, a sampling drain, a gas composition probe and a media temperature probe.

    摘要翻译： 本发明的用于保持培养基并支持多种植物生长的生物反应器组件。 组件包括光源和具有透光壁结构并限定储存器的容器。 储存器的长轴基本上是水平的，允许储存器被填充到局部水平的介质并且限定用于支撑植物的相对大的表面积。 组件还可以包括用于将容器的分离的壁结构部分固定并密封在一起的夹具以及将端盖封闭到壁部分，以限定无菌环境。 作为另一选择，夹具可以限定穿过其中的开口，其允许用于测量和控制生物反应器功能的各种装置的通过，例如气体供应喷嘴，气体出口喷嘴，空气温度探针，pH探针，取样排水口，气体组成 探头和介质温度探头。

    Reagents and methods for modulating gene expression through RNA mimicry
    12.
    发明授权
    Reagents and methods for modulating gene expression through RNA mimicry 失效
    通过RNA模拟调节基因表达的试剂和方法

    公开(公告)号：US06368863B1

    公开(公告)日：2002-04-09

    申请号：US09255899

    申请日：1999-02-23

    申请人： David J. Ecker ,  Thomas W. Bruice ,  Timothy Vickers

    发明人： David J. Ecker ,  Thomas W. Bruice ,  Timothy Vickers

    IPC分类号： C12N1511

    CPC分类号： A61K31/70 ,  A61K31/7105 ,  A61K38/00 ,  C07H21/00 ,  C07K14/005 ,  C12N15/1132 ,  C12N15/67 ,  C12N15/85 ,  C12N2310/13 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2740/16322 ,  C12Q1/68 ,  C12Q1/6897 ,  C12Q1/703 ,  C12N2310/3521

    摘要： Methods for modulating expression of a gene are provided. The methods comprise the steps of selecting a portion of an RNA coded by the gene, wherein the RNA is capable of interacting with a protein, preparing an oligonucleotide or oligonucleotide analog to mimic the portion of the RNA, and contacting cells containing the gene with the oligonucleotide or oligonucleotide analog. Methods of treating a disease are also provided. The methods comprise selecting a portion of an RNA coded by a gene whose expression is believed to be responsible for the disease, preparing an oligonucleotide or oligonucleotide analog to mimic the portion, and contacting an organism suspected of having the disease with the oligonucleotide or oligonucleotide analog.

    摘要翻译： 提供调节基因表达的方法。 所述方法包括选择由该基因编码的RNA的一部分的步骤，其中所述RNA能够与蛋白质相互作用，制备寡核苷酸或寡核苷酸类似物以模拟RNA部分，并将含有该基因的细胞与 寡核苷酸或寡核苷酸类似物。 还提供了治疗疾病的方法。 所述方法包括选择由被认为是对该疾病负责的基因编码的RNA的一部分，制备寡核苷酸或寡核苷酸类似物以模拟该部分，并将疑似患有疾病的生物与寡核苷酸或寡核苷酸类似物 。

    Reagents and methods for modulating gene expression through RNA mimicry
    13.
    发明授权
    Reagents and methods for modulating gene expression through RNA mimicry 失效
    通过RNA模拟调节基因表达的试剂和方法

    公开(公告)号：US5874564A

    公开(公告)日：1999-02-23

    申请号：US461418

    申请日：1995-06-05

    申请人： David J. Ecker ,  Thomas W. Bruice ,  Timothy Vickers

    发明人： David J. Ecker ,  Thomas W. Bruice ,  Timothy Vickers

    IPC分类号： C12Q1/68 ,  C12Q1/70 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C12Q1/6897 ,  C12Q1/703

    摘要： Expression of genes may be modulated by employment of compositions which are capable of RNA mimicry. A portion of RNA coded by the gene whose expression is to be modulated is selected which is capable of interacting with one or more proteins. An oligonucleotide or oligonucleotide analog is then prepared in such a way as to mimic the portion of the RNA. Cells containing the gene are then contacted with the oligonucleotide or oligonucleotide analog to effect the modulation. Therapeutic compositions and methods, especially for the treatment of human immunodeficiency, are disclosed.

    摘要翻译： 可以通过使用能够进行RNA模拟的组合物来调节基因的表达。 选择由其表达被调节的基因编码的RNA的一部分，其能够与一种或多种蛋白质相互作用。 然后制备寡核苷酸或寡核苷酸类似物，以模拟RNA的部分。 然后将含有该基因的细胞与寡核苷酸或寡核苷酸类似物接触以进行调节。 公开了治疗组合物和方法，特别是用于治疗人类免疫缺陷。

    METHODS OF DETERMINING POTENCY OF CHEMICALLY-SYNTHESIZED OLIGONUCLEOTIDES
    18.
    发明申请
    METHODS OF DETERMINING POTENCY OF CHEMICALLY-SYNTHESIZED OLIGONUCLEOTIDES 有权
    确定化学合成寡核苷酸的方法

    公开(公告)号：US20120077276A1

    公开(公告)日：2012-03-29

    申请号：US13311366

    申请日：2011-12-05

    申请人： Walter F. Lima ,  Timothy Vickers ,  Stanley T. Crooke

    发明人： Walter F. Lima ,  Timothy Vickers ,  Stanley T. Crooke

    IPC分类号： G01N33/50

    CPC分类号： C12Q1/6876 ,  C12N15/111 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2320/10 ,  Y10T436/143333

    摘要： Provided herein are methods for determining potency of RNAi agents. Such methods include, but are not limited to, cell-based and cell-free assays that measure binding of an RNAi agent with Ago2 or that measure Ago2 activity in the presence of such RNAi agents. Also provided are assays that determine potency of RNAi agents by assessing their ability to compete with other RNAi agents, including control RNAi agents, for binding and/or activation of Ago2.

    摘要翻译： 本文提供了确定RNAi剂效力的方法。 这样的方法包括但不限于测量RNAi剂与Ago2的结合或在这种RNAi剂存在下测量Ago2活性的基于细胞和无细胞的测定。 还提供了通过评估其与其他RNAi试剂（包括对照RNAi试剂）竞争与Ago2结合和/或激活的能力来测定RNAi试剂的效力的测定法。