公开(公告)号：US08501251B2

公开(公告)日：2013-08-06

申请号：US12354445

申请日：2009-01-15

申请人： Martin Clunies ,  James Ross ,  Ian Ross

发明人： Martin Clunies ,  James Ross ,  Ian Ross

IPC分类号： A23K1/18 ,  A23K1/00 ,  A23B7/10 ,  A23L1/20 ,  A23L1/325

CPC分类号： A23K50/30 ,  A23K20/158 ,  A23K20/30

摘要： A premix for hog feed and a method of feeding a hog that produces DHA and EPA enriched pork while avoiding or reducing negative effects to the taste, color, texture, aroma, pH and shelf life which are significant enough to make the pork unacceptable to consumers. One embodiment of the method of feeding a hog involves feeding a hog over several days with a hog feed supplemented with the premix. The premix includes marine-sourced docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) and plant-sourced alpha-linolenic acid (ALA). The hogs are fed until their total DHA, EPA and ALA intakes are in a certain range per kilogram of the hog's weight. The hogs are then slaughtered and processed into pork products. This results in pork with an enrichment of omega-3 EFAs in the range of about 2.5% to about 4.5% of fat.

摘要翻译： 用于猪饲料的预混物和喂养产生DHA和EPA富含猪肉的猪的方法，同时避免或减少对味道，颜色，质地，香气，pH和保质期的负面影响，这足以使猪肉不能被消费者接受 。 喂养猪的方法的一个实施例涉及用补充有预混物的猪饲料喂养几天的猪。 预混物包括海洋来源的二十二碳六烯酸（DHA）和二十碳五烯酸（EPA）和植物来源的α-亚麻酸（ALA）。 喂养猪直到它们的总DHA，EPA和ALA摄入量在每千克猪的重量上在一定范围内。 然后将猪屠宰并加工成猪肉产品。 这导致猪肉富含ω-3 EFAs在脂肪的约2.5％至约4.5％的范围内。

公开(公告)号：US20100120626A1

公开(公告)日：2010-05-13

申请号：US12615778

申请日：2009-11-10

申请人： James Ross ,  Edgar A. Brown ,  Swaminathan Rajaraman ,  Mark G. Allen ,  Bruce Wheeler

发明人： James Ross ,  Edgar A. Brown ,  Swaminathan Rajaraman ,  Mark G. Allen ,  Bruce Wheeler

IPC分类号： C40B30/00 ,  B32B37/00 ,  C40B60/12 ,  C12N13/00

CPC分类号： C12N13/00 ,  B32B2535/00 ,  C12M1/42 ,  G01N33/4836 ,  G01N33/48728 ,  G01N33/48735 ,  Y10T156/10

摘要： Provided herein are apparatus and methods relating to the development of instrumentation for high throughput network electrophysiology and cellular analysis. More specifically, provided herein are multiwell microelectrode arrays (MEAs) and methods for the development of such an apparatus in an inexpensive fashion with a flexible, ANSI/SBS-compliant (American National Standards Institute/Society for Biomolecular Screening) format. Microelectrode arrays are a grid of tightly spaced microelectrodes useful for stimulating and sensing electrically active cells, networks and tissue. The techniques described herein relate to the use of microfabrication in combination with certain large-area processes that have been employed to achieve multiwell MEAs in ANSI/SBS-compliant culture well formats, which are also transparent for inverted/backside microscopy compatibility. These multiwell MEAs can be used to investigate two and three-dimensional networks of electrically active cells and tissue such as cardiac, neural, and muscular in a high throughput fashion. Also being ANSI/SBS-compliant, they are compatible with machinery and robotics developed for the pharmaceutical industry for drug screening applications.

摘要翻译： 本文提供了与开发用于高通量网络电生理学和细胞分析的仪器相关的装置和方法。 更具体地，本文提供了多孔微电极阵列（MEA）和用于以便宜的方式开发这种装置的方法，其具有柔性的符合ANSI / SBS（美国国家标准学会/生物分子筛选学会）的格式。 微电极阵列是用于刺激和感测电活性细胞，网络和组织的紧密间隔的微电极的网格。 本文所述的技术涉及使用微加工与已经用于实现符合ANSI / SBS的培养孔格式的多孔MEA的某些大面积方法的组合，其对于倒置/背面显微镜兼容性也是透明的。 这些多孔MEA可用于以高通量方式研究电活性细胞和组织如心脏，神经和肌肉的两维和三维网络。 同样符合ANSI / SBS标准，它们与制药行业开发用于药物筛选应用的机械和机器人兼容。

公开(公告)号：US20070268133A1

公开(公告)日：2007-11-22

申请号：US11646170

申请日：2006-12-27

申请人： Michael Sanchez ,  James Parker ,  James Ross ,  Charles Beason ,  Thomas Dayton

发明人： Michael Sanchez ,  James Parker ,  James Ross ,  Charles Beason ,  Thomas Dayton

IPC分类号： G08B23/00

CPC分类号： G06Q50/22 ,  A61B34/20 ,  A61B34/25 ,  A61B50/10 ,  A61B90/13 ,  A61B90/98 ,  A61B2034/2051 ,  A61B2090/0805 ,  A61B2090/378 ,  A61B2090/3925 ,  G06F19/00 ,  G06K2017/009 ,  G06Q10/08 ,  G08B13/2462 ,  G16H40/20

摘要： A system for tracking and locating surgical items and objects in an operating room environment that incorporates two-stage functionality. A first stage provides mechanisms for tracking objects using radio frequency (RF) tags that are positioned on or in conjunction with every surgical item and object so as to be tracked by a number of RF transceivers located about the operating room. In addition to integrating RF ID components, the tags integrate hard spherical components that are easily identifiable by ultrasonic detection. If an object is “lost” from the tracking system functionality (RF tracking), the system operator may review a last known location and movement path presented on a display and thereafter utilize an ultrasonic sub-system in a localized area to detect the exact location of the missing object or item. Narrowing the location of a “lost” object is facilitated by the use of one or more LED laser pointers that are directed through the last known path of the object and to its last known location.

摘要翻译： 一种用于在手术室环境中跟踪和定位手术物品和物体的系统，其包含两阶段功能。 第一阶段提供用于使用射频（RF）标签跟踪对象的机制，所述射频（RF）标签位于每个手术物品和物体上或与每个外科物品和物体相结合，以便被位于手术室周围的多个RF收发器跟踪。 除了集成RF ID组件之外，标签还集成了通过超声波检测容易识别的硬球形部件。 如果物体从跟踪系统功能（RF跟踪）“丢失”，则系统操作者可以检查呈现在显示器上的最后一个已知位置和移动路径，然后利用局部区域中的超声子系统来检测确切位置 的遗漏对象或项目。 通过使用一个或多个LED激光指针来缩小“丢失”对象的位置，这些LED指示器被引导通过物体的最后已知路径和其最后的已知位置。

公开(公告)号：US20070149959A1

公开(公告)日：2007-06-28

申请号：US11318142

申请日：2005-12-23

申请人： Russell DeLonzor ,  James Ross ,  Mathew Nalipinski ,  Keith Turner ,  David Foster ,  Tom Oakley ,  Michael Cane

发明人： Russell DeLonzor ,  James Ross ,  Mathew Nalipinski ,  Keith Turner ,  David Foster ,  Tom Oakley ,  Michael Cane

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B2018/00041 ,  A61B2018/00577 ,  A61B2018/0268 ,  A61B2018/0281

摘要： A cryoprobe for use in cryosurgery and other applications comprising a rigid outer tube, an inner coolant inlet tube a short rigid penetrating segment extending distally from the distal end of the outer tube and a helical-shaped baffle having a heating element disposed about the outer surface of the inlet tube. The baffle is adapted to produce turbulent fluid flow improving heat transfer and is able to warm target tissue during rapid freezing and thawing cycles.

摘要翻译： 一种用于冷冻手术和其他应用的冷冻探针，包括刚性外管，内部冷却剂入口管，从外管远端向远端延伸的短的刚性穿透段，以及螺旋形挡板，其具有围绕外表面设置的加热元件 的入口管。 挡板适于产生改善热传递的湍流流体流动，并且能够在快速冷冻和解冻循环期间温热目标组织。

公开(公告)号：US06467303B2

公开(公告)日：2002-10-22

申请号：US09750236

申请日：2000-12-26

申请人： James Ross

发明人： James Ross

IPC分类号： F25B3904

CPC分类号： F25B40/04 ,  F25B2341/0014 ,  F25B2400/16

摘要： A passive desuperheater for a vapor compression refrigeration system is disclosed. The passive desuperheater includes a chamber having two inlets and an outlet, the first inlet for introducing superheated gas into the chamber, the second inlet for introducing cool liquid refrigerant into the chamber and the outlet for outputting the desuperheated gas. The flow of cool liquid refrigerant into the chamber is generated by a gravity drop, resulting in the mixing of the liquid refrigerant with the superheated gas, such that desuperheated gas is output at the outlet. In an alternative embodiment, the hot discharge gas is input through the bottom of a shell and tube condenser and then exposed to the cool liquid refrigerant in the condenser. The desuperheater according to the present invention also can be used to remove oil from the hot discharge gas during desuperheating. Desuperheating can also be obtained by passing the superheated gas through a pipe immersed in the cool liquid refrigerant.

摘要翻译： 公开了一种用于蒸气压缩制冷系统的被动式过热降温器。 被动过热降温器包括具有两个入口和出口的室，用于将过热气体引入室的第一入口，用于将冷却的液体制冷剂引入室中的第二入口和用于输出过热气体的出口。 冷却液体制冷剂流入室内的流动是通过重力下降产生的，导致液体制冷剂与过热气体的混合，从而在出口处输出过热气体。 在替代实施例中，热放电气体通过壳管冷凝器的底部输入，然后暴露于冷凝器中的冷液体制冷剂。 根据本发明的过热降温器还可以用于在过热期间从热放电气体中除去油。 过热也可以通过使过热气体通过浸入冷液体制冷剂中的管道获得。

公开(公告)号：US5560474A

公开(公告)日：1996-10-01

申请号：US290618

申请日：1994-08-15

申请人： Barry Thomas ,  James Ross ,  Andrew S. Panto ,  W. Roy Rinehart

发明人： Barry Thomas ,  James Ross ,  Andrew S. Panto ,  W. Roy Rinehart

IPC分类号： H01H31/00

CPC分类号： H01H31/00

摘要： The apparatus includes contact blades at different elevations on a utility pole rotatable between electrical connection and disconnection positions vis-a-vis contact members. To rotate the contact blades, an electromechanical linear actuator extends a clevis and crank arm to rotate a vertically extending shaft coupled to another crank and a lever arm to rotate the insulators on which the contact blades are mounted. The linear actuators are carried by support structure high on the utility pole and, by rotating the vertical shafts, the insulators and contact blades at each phase are simultaneously rotated.

摘要翻译： 该装置包括在电连接和相对于接触构件的断开位置之间可旋转的电线杆上的不同高度的接触片。 为了旋转接触叶片，机电线性致动器延伸U形夹和曲柄臂以使连接到另一个曲柄和杠杆臂的垂直延伸的轴旋转以旋转其上安装有接触叶片的绝缘体。 线性致动器由电线杆上的支撑结构承载，并且通过旋转垂直轴，每相的绝缘子和接触片同时旋转。

公开(公告)号：US09290756B2

公开(公告)日：2016-03-22

申请号：US12615778

申请日：2009-11-10

申请人： James Ross ,  Edgar A. Brown ,  Swaminathan Rajaraman ,  Mark G. Allen ,  Bruce Wheeler

发明人： James Ross ,  Edgar A. Brown ,  Swaminathan Rajaraman ,  Mark G. Allen ,  Bruce Wheeler

IPC分类号： G01N33/487 ,  C12N13/00 ,  C12M1/42 ,  G01N33/483

CPC分类号： C12N13/00 ,  B32B2535/00 ,  C12M1/42 ,  G01N33/4836 ,  G01N33/48728 ,  G01N33/48735 ,  Y10T156/10

摘要： Provided herein are apparatus and methods relating to the development of instrumentation for high throughput network electrophysiology and cellular analysis. More specifically, provided herein are multiwell microelectrode arrays (MEAs) and methods for the development of such an apparatus in an inexpensive fashion with a flexible, ANSI/SBS-compliant (American National Standards Institute/Society for Biomolecular Screening) format. Microelectrode arrays are a grid of tightly spaced microelectrodes useful for stimulating and sensing electrically active cells, networks and tissue. The techniques described herein relate to the use of microfabrication in combination with certain large-area processes that have been employed to achieve multiwell MEAs in ANSI/SBS-compliant culture well formats, which are also transparent for inverted/backside microscopy compatibility. These multiwell MEAs can be used to investigate two and three-dimensional networks of electrically active cells and tissue such as cardiac, neural, and muscular in a high throughput fashion. Also being ANSI/SBS-compliant, they are compatible with machinery and robotics developed for the pharmaceutical industry for drug screening applications.

摘要翻译： 本文提供了与开发用于高通量网络电生理学和细胞分析的仪器相关的装置和方法。 更具体地，本文提供了多孔微电极阵列（MEA）和用于以便宜的方式开发这种装置的方法，其具有柔性的符合ANSI / SBS（美国国家标准协会/生物分子筛选学会）的格式。 微电极阵列是用于刺激和感测电活性细胞，网络和组织的紧密间隔的微电极的网格。 本文所述的技术涉及使用微加工与已经用于实现符合ANSI / SBS的培养孔格式的多孔MEA的某些大面积方法的组合，其对于倒置/背面显微镜兼容性也是透明的。 这些多孔MEA可用于以高通量方式研究电活性细胞和组织如心脏，神经和肌肉的两维和三维网络。 同样符合ANSI / SBS标准，它们与制药行业开发用于药物筛选应用的机械和机器人兼容。

公开(公告)号：US07461882B2

公开(公告)日：2008-12-09

申请号：US11271450

申请日：2005-11-11

申请人： Yoonsu Choi ,  Mark G. Allen ,  James Ross ,  Stephen P. DeWeerth

发明人： Yoonsu Choi ,  Mark G. Allen ,  James Ross ,  Stephen P. DeWeerth

IPC分类号： B25J15/12 ,  B25J7/00

CPC分类号： C25D1/00 ,  B25J7/00 ,  B81C99/002 ,  Y10S294/902

摘要： Apparatus and processes are disclosed that provide a microfabricated microtool having a mechanically actuated manipulating mechanism. The microtool comprises a tweezer having flexible arms, and an actuating mechanism. A biological, electrical, or mechanical component is grasped, cut, sensed, or measured by the flexible arms. The actuating mechanism requires no electric power and is achieved by the reciprocating motion of a smooth, rigid microstructure applied against the flexible arms of the microtool. In certain implementations, actuator motion is controlled distally by a tethered cable. A process is also disclosed for producing a microtool, and in particular, by micropatterning. Photolithography may be used to form micro-molds that pattern the microtool or components of the microtool. In certain implementations, the tweezer and actuating mechanism are produced fully assembled. In other implementations, the tweezer and actuating mechanism are produced separately and assembled together.

摘要翻译： 公开了提供具有机械致动的操纵机构的微加工微型工具的装置和方法。 微型工具包括具有柔性臂的镊子和致动机构。 通过柔性臂来抓住，切割，感测或测量生物，电或机械部件。 致动机构不需要电力，并且通过向微型工具的柔性臂施加的光滑的刚性微结构的往复运动来实现。 在某些实施方案中，致动器运动由系留电缆远程控制。 还公开了一种用于生产微型工具，特别是通过微图案化的方法。 可以使用光刻法来形成对微型工具或微型工具的组件进行图案化的微型模具。 在某些实施方案中，镊子和致动机构被完全组装。 在其他实施方式中，镊子和致动机构分开制造并组装在一起。

公开(公告)号：US20080284187A1

公开(公告)日：2008-11-20

申请号：US11851579

申请日：2007-09-07

申请人： Yoonsu Choi ,  Mark G. Allen ,  James Ross ,  Stephen P. DeWeerth

发明人： Yoonsu Choi ,  Mark G. Allen ,  James Ross ,  Stephen P. DeWeerth

IPC分类号： B66C1/00

CPC分类号： C25D1/00 ,  B25J7/00 ,  B81C99/002 ,  Y10S294/902

摘要： Apparatus and processes are disclosed that provide a microfabricated microtool having a mechanically actuated manipulating mechanism. The microtool comprises a tweezer having flexible arms, and an actuating mechanism. A biological, electrical, or mechanical component is grasped, cut, sensed, or measured by the flexible arms. The actuating mechanism requires no electric power and is achieved by the reciprocating motion of a smooth, rigid microstructure applied against the flexible arms of the microtool. In certain implementations, actuator motion is controlled distally by a tethered cable. A process is also disclosed for producing a microtool, and in particular, by micropatterning. Photolithography may be used to form micro-molds that pattern the microtool or components of the microtool. In certain implementations, the tweezer and actuating mechanism are produced fully assembled. In other implementations, the tweezer and actuating mechanism are produced separately and assembled together.

摘要翻译： 公开了提供具有机械致动的操纵机构的微加工微型工具的装置和方法。 微型工具包括具有柔性臂的镊子和致动机构。 通过柔性臂来抓住，切割，感测或测量生物，电或机械部件。 致动机构不需要电力，并且通过向微型工具的柔性臂施加的光滑的刚性微结构的往复运动来实现。 在某些实施方案中，致动器运动由系留电缆远程控制。 还公开了一种用于生产微型工具，特别是通过微图案化的方法。 可以使用光刻法来形成对微型工具或微型工具的组件进行图案化的微型模具。 在某些实施方案中，镊子和致动机构被完全组装。 在其他实施方式中，镊子和致动机构分开制造并组装在一起。

公开(公告)号：US20070149958A1

公开(公告)日：2007-06-28

申请号：US11317970

申请日：2005-12-23

申请人： Russell DeLonzor ,  James Ross ,  Mathew Nalipinski ,  Keith Turner ,  David Foster ,  Tom Oakley ,  Michael Cane

发明人： Russell DeLonzor ,  James Ross ,  Mathew Nalipinski ,  Keith Turner ,  David Foster ,  Tom Oakley ,  Michael Cane

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B2018/0231 ,  A61B2018/0262 ,  A61B2018/0293

摘要： A cryoprobe having an exhaust heater placed in fluid communication with exhausting cryogen to heat the cryogen prior to being vented to the atmosphere.

摘要翻译： 具有排气加热器的冷冻探针放置成与排出的冷冻剂流体连通，以在排放到大气之前加热冷冻剂。