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11.发明申请公开(公告)号：US20060068377A1
公开(公告)日：2006-03-30
申请号：US11273229
申请日：2005-11-14
CPC分类号： G06K9/00127 , B01J2219/00693 , B01J2219/00702 , C12Q1/6806 , G01N1/2813 , G01N1/312 , G01N15/1475 , G01N21/6428 , G01N21/6458 , G01N33/5005 , G01N35/1002 , G01N35/1011 , G01N2015/1006 , G01N2035/1034 , G06K9/0014 , G06T7/0012 , G06T2207/30024
摘要： A computer controlled method for detecting and diagnosing a rare cell type in a tissue sample is provided, said method comprising treating the tissue sample such that it generates a first signal indicative of the presence at a location of a rare cell, detecting the first signal, treating the location at which the first signal is detected to generate a second signal indicative of a diagnostically useful cellular characteristic and detecting the second signal. The first signal can be morphological or a color present in a sought cell either before or after staining. The second signal can be generated by in situ PCR or PCR in situ hybridization. In one preferred embodiment, the rare cell type is a fetal cell in a maternal blood tissue sample, said sample consisting of a smear of unenriched maternal blood. In another embodiment, the method is used to diagnose or genotype cancer cells in a blood or tissue biopsy sample.
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12.发明申请公开(公告)号：US20060056016A1
公开(公告)日：2006-03-16
申请号：US11225460
申请日：2005-09-13
IPC分类号： G02B21/00
CPC分类号： G02B21/16 , G01N21/6458 , G02B21/082 , G02B21/34
摘要： The contrast of an image produced by epifluorescence microscopy may be increased by placing a high-pass dichroic reflecting film behind the sample. The reflecting film reflects the emission light emitted by the fluorescent tags in the sample back through the objective lens while allowing the shorter wavelength excitation light to pass through the sample holder.
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公开(公告)号：US07902814B2
公开(公告)日：2011-03-08
申请号：US12330104
申请日：2008-12-08
申请人： Triantafyllos Tafas , Yash Agarwal , Youngmin Kim , Wei Guo , Richard Eberle , Joseph Turgeon , Michael Kilpatrick , Petros Tsipouras
发明人： Triantafyllos Tafas , Yash Agarwal , Youngmin Kim , Wei Guo , Richard Eberle , Joseph Turgeon , Michael Kilpatrick , Petros Tsipouras
IPC分类号： G01R31/302
CPC分类号： G02B21/24
摘要： A displaceable light-tight enclosure system housing an automated robotic microscope having electronically controllable components and an image capture device. The enclosure system includes a device(s) for displacement, an externally viewable monitor, and a plurality of electrical power receptacles. The light-tight enclosure system also incorporates an anti-fall support leg that may be extended from the enclosure.
摘要翻译： 容纳具有电子可控组件和图像捕获装置的自动机器人显微镜的可置换的不透光外壳系统。 外壳系统包括用于移动的装置，外部可观察的监视器和多个电力插座。 不透光的外壳系统还包括可从外壳延伸的防跌落支撑腿。
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公开(公告)号：US20090280496A1
公开(公告)日：2009-11-12
申请号：US12486646
申请日：2009-06-17
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6841 , C12Q1/6886 , G06T7/0012 , G06T2207/30024 , C12Q2563/107
摘要： A non-invasive method for determining the developmental age of a fetus or detecting cancer cells in a sample is provided. The method utilizes, for example, a sample of blood from a pregnant female and telomeric nucleic acid probes.
摘要翻译： 提供了用于确定胎儿的发育年龄或检测样品中的癌细胞的非侵入性方法。 该方法使用例如来自孕妇和端粒核酸探针的血液样品。
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15.发明申请公开(公告)号：US20080317566A1
公开(公告)日：2008-12-25
申请号：US11833517
申请日：2007-08-03
申请人： Tibor Virag , Yash Agarwal , Wei Guo , Richard Eberle , Young Min Kim , Michael Kilpatrick , Petros Tsipouras , Triantafyllos Tafas
发明人： Tibor Virag , Yash Agarwal , Wei Guo , Richard Eberle , Young Min Kim , Michael Kilpatrick , Petros Tsipouras , Triantafyllos Tafas
IPC分类号： B65H1/00
CPC分类号： G02B21/34 , G01N35/026 , G01N35/04 , G01N2035/0425 , G01N2035/0427 , Y10S359/90
摘要： An automated cassette and slide handling system is disclosed which organizes microscope slides in cassettes, automatically and sequentially removes individual slides from their respective cassettes, positioned each slide under the microscope as provided by the protocol, and after examination returns the slide to its proper cassette.
摘要翻译： 公开了一种自动化的盒式磁带和幻灯片处理系统，其在盒中组织显微镜幻灯片，自动地并且顺序地从其各自的盒中移除各个幻灯片，每个幻灯片根据协议设置在显微镜下放置，并且在检查后将幻灯片返回到其正确的盒。
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16.发明申请SYSTEM AND METHOD FOR INCREASING THE CONTRAST OF AN IMAGE PRODUCED BY AN EPIFLUORESCENCE MICROSCOPE 审中-公开用于增加由差异显微镜产生的图像的对比度的系统和方法公开(公告)号：US20080106743A1
公开(公告)日：2008-05-08
申请号：US11970198
申请日：2008-01-07
CPC分类号： G02B21/16 , G01N21/6458 , G02B21/082 , G02B21/34
摘要： The contrast of an image produced by epifluorescence microscopy may be increased by placing a dichroic reflector behind the sample. The dichroic reflector reflects the emission light emitted by the fluorescent tags in the sample back through the objective lens while allowing the shorter wavelength excitation light to pass through the sample holder.
摘要翻译： 通过在荧光显微镜下产生的图像的对比可以通过在样品后面放置二向色反射镜来增加。 二向色反射镜通过物镜反射由样品中的荧光标签发射的发射光，同时允许较短波长的激发光通过样品保持器。
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17.发明申请公开(公告)号：US20080100911A1
公开(公告)日：2008-05-01
申请号：US11970189
申请日：2008-01-07
IPC分类号： G02B21/06
CPC分类号： G02B21/16 , G01N21/6458 , G02B21/082 , G02B21/34
摘要： The contrast of an image produced by epifluorescence microscopy may be increased by placing a dichroic reflector behind the sample. The dichroic reflector reflects the emission light emitted by the fluorescent tags in the sample back through the objective lens while allowing the shorter wavelength excitation light to pass through the sample holder.
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公开(公告)号：US20070212720A1
公开(公告)日：2007-09-13
申请号：US11685740
申请日：2007-03-13
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6841 , C12Q1/6886 , G06T7/0012 , G06T2207/30024 , C12Q2563/107
摘要： A non-invasive method for determining the developmental age of a fetus or detecting cancer cells in a sample is provided. The method utilizes, for example, a sample of blood from a pregnant female and telomeric nucleic acid probes.
摘要翻译： 提供了用于确定胎儿的发育年龄或检测样品中的癌细胞的非侵入性方法。 该方法使用例如来自孕妇和端粒核酸探针的血液样品。
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19.发明申请公开(公告)号：US20060068375A1
公开(公告)日：2006-03-30
申请号：US11272612
申请日：2005-11-14
CPC分类号： G06K9/00127 , B01J2219/00693 , B01J2219/00702 , C12Q1/6806 , G01N1/2813 , G01N1/312 , G01N15/1475 , G01N21/6428 , G01N21/6458 , G01N33/5005 , G01N35/1002 , G01N35/1011 , G01N2015/1006 , G01N2035/1034 , G06K9/0014 , G06T7/0012 , G06T2207/30024
摘要： A computer controlled method for detecting and diagnosing a rare cell type in a tissue sample is provided, said method comprising treating the tissue sample such that it generates a first signal indicative of the presence at a location of a rare cell, detecting the first signal, treating the location at which the first signal is detected to generate a second signal indicative of a diagnostically useful cellular characteristic and detecting the second signal. The first signal can be morphological or a color present in a sought cell either before or after staining. The second signal can be generated by in situ PCR or PCR in situ hybridization. In one preferred embodiment, the rare cell type is a fetal cell in a maternal blood tissue sample, said sample consisting of a smear of unenriched maternal blood. In another embodiment, the method is used to diagnose or genotype cancer cells in a blood or tissue biopsy sample.
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20.发明授权Device and method for detecting and localizing cells by means of photosensitive waveguides 失效用于通过光敏波导检测和定位电池的装置和方法公开(公告)号：US06759663B2
公开(公告)日：2004-07-06
申请号：US10182210
申请日：2002-07-22
IPC分类号： G01N2164
CPC分类号： G01N21/7703 , G01N21/6428
摘要： The present invention provides devices and methods for detection of particles, such as biological cells, in samples using a photosensitive waveguide. The photosensitive waveguide changes its transmissivity in a detectable manner in response to controlling radiation emitted from the particles. In preferred embodiments, the waveguide is two-dimensional and the position of the particles as well as their presence is obtained by scanning the waveguide in two non-parallel directions. The provided devices are preferably used to locate labeled cells. The present invention also includes control systems and methods for detecting and locating cells using the devices provided.
摘要翻译： 本发明提供用于在使用光敏波导的样品中检测诸如生物细胞的颗粒的装置和方法。 响应于控制从颗粒发射的辐射，光敏波导以可检测的方式改变其透射率。 在优选实施例中，波导是二维的，并且颗粒的位置以及它们的存在是通过在两个非平行方向扫描波导而获得的。 所提供的装置优选用于定位标记的细胞。 本发明还包括使用所提供的装置来检测和定位单元的控制系统和方法。
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