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11.发明申请公开(公告)号：US20200377578A1
公开(公告)日：2020-12-03
申请号：US16919576
申请日：2020-07-02
Applicant: UCB Biopharma SPRL
Inventor： David Paul Humphreys , Daniel John Lightwood , Kerry Louise Tyson , David Edward Ormonde Knight , Karine Jeannine Madeleine Hervé , Joanne Elizabeth Compson , Matthew Jon Timothy Page , Andrew Charles Payne , Nicola Louise Fisher , Brendon MacKenzie , Matthew Cox
IPC: C07K16/12 , A61K39/40 , A61K45/06 , G01N33/569 , G01N33/573 , G01N33/68
Abstract: This present invention describes the derivation and selection of antibodies capable of neutralising the major exotoxins; TcdA and TcdB of Clostridium difficile. The invention also describes novel neutralisation and antigen binding properties of individual Mabs and mixtures thereof.
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公开(公告)号：US10730952B2
公开(公告)日：2020-08-04
申请号：US15326499
申请日：2015-07-16
Applicant: UCB BIOPHARMA SPRL
Inventor： Helene Margaret Finney , Stephen Edward Rapecki , Michael John Wright , Kerry Louise Tyson
Abstract: The present disclosure relates to a multispecific molecule comprising a binding domain specific to the antigen CD45 and a binding domain specific to the antigen CD79a and/or CD79b, compositions comprising same and use of each in treatment, for example treatment of autoimmune disease.
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公开(公告)号：US10344081B2
公开(公告)日：2019-07-09
申请号：US15742070
申请日：2016-07-05
Applicant: UCB BIOPHARMA SPRL
Inventor： Kerry Louise Tyson , Terence Seward Baker , Georges Mairet-Coello , Patrick Downey , Jean-Philippe Courade , David Edward Ormonde Knight
Abstract: The present invention relates to Tau-binding antibodies and binding fragments thereof.
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公开(公告)号：US09957320B2
公开(公告)日：2018-05-01
申请号：US15180916
申请日：2016-06-13
Applicant: UCB BIOPHARMA SPRL
Inventor： Neil Gozzard , Alastair David Griffiths Lawson , Daniel John Lightwood , Roger Thomas Palframan , Bryan John Smith , Kerry Louise Tyson
IPC: C07K16/24 , A61K39/395 , A61K9/00 , A61K39/00
CPC classification number: C07K16/244 , A61K9/0078 , A61K39/395 , A61K39/3955 , A61K2039/505 , A61K2039/544 , C07K2317/24 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human IL-13, therapeutic uses of the antibody molecules and methods for producing antibody molecules.
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公开(公告)号：US09499603B2
公开(公告)日：2016-11-22
申请号：US14802076
申请日：2015-07-17
Applicant: UCB Biopharma SPRL
Inventor： Kerry Louise Tyson
IPC: C07K16/00 , C07K14/705 , C07K16/28
CPC classification number: C07K14/70503 , C07K16/2818 , C07K2317/24 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/92
Abstract: A humanised agonistic antibody which binds human PD-1 comprising a heavy chain and a light chain wherein the variable domain of the heavy chain comprises the sequence given in SEQ ID NO:1 for CDR-H1, the sequence given in SEQ ID NO:2 for CDR-H2 and the sequence given in SEQ ID NO:3 for CDR-H3 and the variable domain of the light chain comprises the sequence given in SEQ ID NO:4 for CDR-L1, the sequence given in SEQ ID NO:5 for CDR-L2 and the sequence given in SEQ ID NO:7 for CDR-L3. The invention also extends to therapeutic uses of the antibody molecules, compositions and methods for producing said antibody molecules.
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Patent Agency Ranking
公开(公告)号：US20160289323A1
公开(公告)日：2016-10-06
申请号：US15180916
申请日：2016-06-13
Applicant: UCB BIOPHARMA SPRL
Inventor： Neil Gozzard , Alastair David Griffiths Lawson , Daniel John Lightwood , Roger Thomas Palframan , Bryan John Smith , Kerry Louise Tyson
IPC: C07K16/24 , A61K9/00 , A61K39/395
CPC classification number: C07K16/244 , A61K9/0078 , A61K39/395 , A61K39/3955 , A61K2039/505 , A61K2039/544 , C07K2317/24 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human IL-13, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
Abstract translation: 本发明涉及对人IL-13的抗原决定簇具有特异性的抗体分子，抗体分子的治疗用途以及产生所述抗体分子的方法。
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公开(公告)号：US20160068586A1
公开(公告)日：2016-03-10
申请号：US14802076
申请日：2015-07-17
Applicant: UCB Biopharma SPRL
Inventor： Kerry Louise Tyson
IPC: C07K14/705
CPC classification number: C07K14/70503 , C07K16/2818 , C07K2317/24 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/92
Abstract: A humanised agonistic antibody which binds human PD-1 comprising a heavy chain and a light chain wherein the variable domain of the heavy chain comprises the sequence given in SEQ ID NO:1 for CDR-H1, the sequence given in SEQ ID NO:2 for CDR-H2 and the sequence given in SEQ ID NO:3 for CDR-H3 and the variable domain of the light chain comprises the sequence given in SEQ ID NO:4 for CDR-L1, the sequence given in SEQ ID NO:5 for CDR-L2 and the sequence given in SEQ ID NO:7 for CDR-L3. The invention also extends to therapeutic uses of the antibody molecules, compositions and methods for producing said antibody molecules.
Abstract translation: 结合包含重链和轻链的人PD-1的人源化激动抗体，其中重链的可变结构域包含SEQ ID NO：1中针对CDR-H1给出的序列，SEQ ID NO：2中给出的序列 对于CDR-H2和CDR-H3的SEQ ID NO：3中给出的序列，轻链的可变结构域包含SEQ ID NO：4中针对CDR-L1给出的序列，SEQ ID NO：5中给出的序列 对于CDR-L2和针对CDR-L3的SEQ ID NO：7中给出的序列。 本发明还延伸到抗体分子的治疗用途，用于产生所述抗体分子的组合物和方法。
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公开(公告)号：US11692041B2
公开(公告)日：2023-07-04
申请号：US15743761
申请日：2016-07-15
Applicant: UCB Biopharma SPRL
Inventor： Helene Margaret Finney , Stephen Edward Rapecki , Kerry Louise Tyson , Michael John Wright
CPC classification number: C07K16/289 , C07K16/18 , C07K16/2803 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/55 , C07K2317/622 , C07K2317/624 , C07K2317/64 , C07K2317/76 , C07K2317/90
Abstract: The present disclosure relates to constructs, such as antibody molecules comprising a binding domain specific to CD45, said binding domain comprising SEQ ID NO: 1, 2, 3 and/or SEQ ID NO: 4, 5 and 6. The disclosure also extends to pharmaceutical compositions comprising said constructs and use of the constructs/compositions in treatment.
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公开(公告)号：US10370447B2
公开(公告)日：2019-08-06
申请号：US15326501
申请日：2015-07-16
Applicant: UCB BIOPHARMA SPRL
Inventor： Helene Margaret Finney , Stephen Edward Rapecki , Michael John Wright , Kerry Louise Tyson
Abstract: The present disclosure relates to multispecific molecule comprising a binding domain specific to the antigen CD22 and a binding domain specific to the antigen CD79a and/or CD79b, compositions comprising the same and use of both in treatment, for example the treatment of autoimmune disease.
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20.发明申请公开(公告)号：US20190233530A1
公开(公告)日：2019-08-01
申请号：US16379844
申请日：2019-04-10
Applicant: UCB BIOPHARMA SPRL , BIOGEN MA INC.
Inventor： Linda C. Burkly , Janine L. Ferrant-Orgettas , Ellen A. Garber , Yen-Ming Hsu , Lihe Su , Frederick R. Taylor , Ralph Adams , Derek Thomas Brown , Andrew George Popplewell , Martyn Kim Robinson , Anthony Shock , Kerry Louise Tyson
IPC: C07K16/28 , A61K39/395 , A61K45/06
CPC classification number: C07K16/2875 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/40 , C07K2317/52 , C07K2317/55 , C07K2317/71 , C07K2317/734 , C07K2317/76 , C07K2317/92
Abstract: This invention provides binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind a CD154 (CD40L) protein. This invention also provides a chimeric, humanized or fully human antibody, antibody derivative or antibody fragment that specifically binds to an epitope to which a humanized Fab fragment comprising a variable heavy chain sequence according to SEQ ID NO: 1 and comprising a variable light chain sequence according to SEQ ID NO: 2 specifically binds. CD154 binding proteins of this invention may elicit reduced effector function relative to a second anti-CD154 antibody. CD154 binding proteins of this invention are useful in diagnostic and therapeutic methods, such as in the treatment and prevention of diseases including those that involve undesirable immune responses that are mediated by CD154-CD40 interactions.
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