公开(公告)号：US10266815B2

公开(公告)日：2019-04-23

申请号：US14911630

申请日：2014-08-13

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： Justin Bloomfield Siegel ,  David Baker ,  Ingrid Swanson Pultz

IPC: C12N9/52 ,  C12N9/64 ,  A61K38/00

Abstract: The invention provides compositions and methods for treating celiac sprue.

公开(公告)号：US10248758B2

公开(公告)日：2019-04-02

申请号：US14759308

申请日：2014-02-07

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： David Baker ,  Neil King ,  Jacob Bale ,  William Sheffler

IPC: G06F19/18 ,  C07K14/00 ,  G01N33/68 ,  G06F19/16 ,  G06F19/12 ,  C07K14/195 ,  B82Y5/00

Abstract: Synthetic nanostructures, proteins that are useful, for example, in making synthetic nanostructures, and methods for designing such synthetic nanostructures are disclosed herein.

公开(公告)号：US20180137234A1

公开(公告)日：2018-05-17

申请号：US15813872

申请日：2017-11-15

Applicant: University of Washington

Inventor： David Baker ,  Jorge Fallas ,  George Ueda ,  William H. Sheffler ,  Vanessa Nguyen

IPC: G06F19/12 ,  A61K38/03

CPC classification number: G16B5/00 ,  A61K38/03 ,  C07K14/00 ,  G16B15/30

Abstract: Described herein are polypeptides capable of self-assembling to form homo-oligomers, and methods for designing such polypeptides.

公开(公告)号：US09707280B2

公开(公告)日：2017-07-18

申请号：US15006341

申请日：2016-01-26

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： Justin Siegel ,  David Baker ,  Sydney Rin Anna Gordon ,  Ingrid Swanson Pultz ,  Elizabeth Joy Stanley ,  Sarah Jane Wolf

IPC: A61K38/48 ,  C12N9/50

CPC classification number: A61K38/482 ,  A61K38/48 ,  C12N9/50 ,  C12N9/52 ,  C12Y304/21

Abstract: The invention provides compositions and methods for treating celiac sprue.

公开(公告)号：US09630994B2

公开(公告)日：2017-04-25

申请号：US14930792

申请日：2015-11-03

Applicant: UNIVERSITY OF WASHINGTON

Inventor： David Baker ,  Jacob B. Bale ,  Neil P. King ,  William H. Sheffler ,  Daniel Ellis

IPC: A61K38/16 ,  C07K14/00

CPC classification number: C07K14/00

Abstract: Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using such synthetic nanostructures are disclosed herein.

公开(公告)号：US09388217B2

公开(公告)日：2016-07-12

申请号：US14384901

申请日：2013-03-12

Applicant: University of Washington through its Center for Commercialization

Inventor： David Baker ,  Timothy A. Whitehead ,  Sarel Fleishman

IPC: A61K38/00 ,  A61K38/16 ,  A61K38/10 ,  C07K14/00 ,  C07K7/08 ,  G01N33/53 ,  G01N33/569

CPC classification number: C07K14/00 ,  A61K38/00 ,  C07K7/08 ,  G01N33/56983 ,  G01N2333/11

Abstract: Polypeptides that recognize and are strong binders to Influenza A hemagglutinin and can be used, for example, to treat and/or limit development of an influenza infection are disclosed. Isolated nucleic acids encoding the polypeptides of the invention, recombinant expression vectors comprising the nucleic acids encoding the polypeptides of the invention operatively linked to a suitable control sequence, and recombinant host cells comprising the recombinant expression vectors of the invention are disclosed. Antibodies that selectively bind to the polypeptides of the invention, and pharmaceutical compositions comprising one or more polypeptides according to the invention and a pharmaceutically acceptable carrier are disclosed. Additionally, methods for treating and/or limiting an influenza infection, methods for diagnosing an influenza infection, or monitoring progression of an influenza infection, methods for identifying candidate influenza vaccines, and methods for identifying candidate compounds for treating, limiting, and/or diagnosing influenza infection are disclosed.

Abstract translation: 公开了识别并且是甲型流感血凝素的强粘合剂并且可用于例如治疗和/或限制流感感染发展的多肽。 公开了编码本发明多肽的分离的核酸，包含编码可操作地连接到合适的对照序列的本发明的多肽的核酸的重组表达载体和包含本发明的重组表达载体的重组宿主细胞。 公开了选择性结合本发明的多肽的抗体以及包含一种或多种本发明的多肽和药学上可接受的载体的药物组合物。 另外，用于治疗和/或限制流感感染的方法，用于诊断流感感染的方法或监测流感感染的进展，用于鉴定候选流感疫苗的方法以及用于鉴定用于治疗，限制和/或诊断的候选化合物的方法 流行性感冒被披露。

公开(公告)号：US20150037870A1

公开(公告)日：2015-02-05

申请号：US14181458

申请日：2014-02-14

Applicant: UNIVERSITY OF WASHINGTON

Inventor： David Baker ,  Alexandre Zanghellini ,  Justin Siegel ,  Jennifer Saint-Clair

IPC: C12N9/90 ,  C12N9/16

CPC classification number: C12N9/90 ,  C12N9/16 ,  C12Y301/08002 ,  C12Y503/03001

Abstract: The present invention provides enzyme catalysts for Diels-Alder reactions, including intermolecular Diels-Alder reactions, as well as protein scaffolds for making such enzyme catalysts. In other aspects, the invention provides methods of making the enzyme catalysts, including by de novo computational design. The present invention thereby provides enzyme catalysts capable of catalyzing a desired Diels-Alder reaction, including with a specified or desired stereo-selectivity.

Abstract translation: 本发明提供了用于Diels-Alder反应的酶催化剂，包括分子间Diels-Alder反应，以及用于制备这种酶催化剂的蛋白质支架。 在其他方面，本发明提供了制备酶催化剂的方法，包括通过重新计算设计。 因此，本发明提供能够催化所需Diels-Alder反应的酶催化剂，包括具有指定或期望的立体选择性。

公开(公告)号：US12240880B2

公开(公告)日：2025-03-04

申请号：US17698553

申请日：2022-03-18

Applicant: UNIVERSITY OF WASHINGTON ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

Inventor： Daniel Adriano Silva Manzano ,  Shawn Yu ,  Umut Ulge ,  David Baker ,  Kenan Christopher Garcia ,  Jamie Spangler ,  Carl Walkey

IPC: C07K14/55 ,  A61K38/00 ,  A61K47/60 ,  A61K47/62 ,  C07K14/54

Abstract: De novo designed polypeptides that bind to IL-2 receptor βc heterodimer (IL-2Rβc), IL-4 receptor αc heterodimer (IL-4Rαc), or IL-13 receptor α subunit (IL-13Rα) are disclosed, as are methods for using and designing the polypeptides.

公开(公告)号：US20230374075A1

公开(公告)日：2023-11-23

申请号：US18319343

申请日：2023-05-17

Applicant: University of Washington

Inventor： David Baker ,  Ryanne Ballard ,  Asim Bera ,  Christine Kang ,  Alex Kang ,  Xinting Li ,  Hannah Nguyen ,  Meerit Said ,  Patrick Salveson ,  William H. Sheffler ,  Shunzhi Wang

IPC: C07K7/64 ,  C07K17/14 ,  B01J31/16

CPC classification number: C07K7/64 ,  C07K17/14 ,  B01J31/1691

Abstract: Cyclic peptides including the amino acid sequence selected from SEQ ID NO:1-6, multimers thereof, and metal organic frameworks including the cyclic peptides or multimers thereof are provided.

公开(公告)号：US20230313167A1

公开(公告)日：2023-10-05

申请号：US18174041

申请日：2023-02-24

Applicant: University of Washington ,  University of Utah Research Foundation

Inventor： Neil King ,  Wesley Sundquist ,  Joerg Votteler ,  Yang Hsia ,  David Baker ,  Jacob Bale ,  Marc Lajoie ,  Gabriel Butterfield ,  Elizabeth Gray ,  Daniel Stetson

IPC: C12N9/88 ,  C07K14/00 ,  C07K14/435

CPC classification number: C12N9/88 ,  C07K14/00 ,  C07K14/435 ,  C12Y401/02014 ,  C07K2319/03 ,  C07K2319/06 ,  C07K2319/735

Abstract: The application discloses multimeric assemblies including multiple oligomeric substructures, where each oligomeric substructure includes multiple proteins that self-interact around at least one axis of rotational symmetry, where each protein includes one or more polypeptide-polypeptide interface (“O interface”); and one or more polypeptide domain that is capable of effecting membrane scission and release of an enveloped multimeric assembly from a cell by recruiting the ESCRT machinery to the site of budding by binding to one or more proteins in the eukaryotic ESCRT complex (“L domain”); and where the multimeric assembly includes one or more subunits comprising one or more polypeptide domain that is capable of interacting with a lipid bilayer (“M domain”), as well as membrane-enveloped versions of the multimeric assemblies.