公开(公告)号：US20120164160A1

公开(公告)日：2012-06-28

申请号：US13306545

申请日：2011-11-29

申请人： Ugur Sahin ,  Özlem Türeci ,  Dirk Usener ,  Stefan Fritz ,  Christoph Uherek ,  Gunda Brandenburg ,  Harald-Gerhard Geppert ,  Anja Kristina Schröder ,  Phillippe Thiel

发明人： Ugur Sahin ,  Özlem Türeci ,  Dirk Usener ,  Stefan Fritz ,  Christoph Uherek ,  Gunda Brandenburg ,  Harald-Gerhard Geppert ,  Anja Kristina Schröder ,  Phillippe Thiel

IPC分类号： C07K16/30 ,  C12N5/00 ,  C12N5/16 ,  A61P35/04 ,  A61K39/395

CPC分类号： C07K16/18 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6807 ,  A61K47/6809 ,  A61K47/6813 ,  A61K47/6821 ,  A61K47/6823 ,  A61K47/6829 ,  A61K47/6851 ,  A61K47/6859 ,  A61K47/6863 ,  A61K47/6869 ,  A61K51/1063 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/3046 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76

摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD1 8, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.

摘要翻译： 本发明提供了可用作治疗和/或预防与表达CLD18的细胞相关疾病的治疗剂的抗体，包括肿瘤相关疾病如胃癌，食管癌，胰腺癌，肺癌，卵巢癌，结肠癌，肝癌， 头颈癌，胆囊癌。

公开(公告)号：US09044382B2

公开(公告)日：2015-06-02

申请号：US11596649

申请日：2005-05-18

申请人： Özlem Türeci ,  Ugur Sahin ,  Michael Koslowski ,  Stefan Fritz ,  Harald-Gerhard Geppert

发明人： Özlem Türeci ,  Ugur Sahin ,  Michael Koslowski ,  Stefan Fritz ,  Harald-Gerhard Geppert

IPC分类号： A61K6/00 ,  C07K14/47 ,  C07K14/705 ,  C07K16/30 ,  C12N9/88 ,  G01N33/574 ,  A61K49/00 ,  A61K39/00

CPC分类号： A61K6/00 ,  A61K47/6851 ,  A61K49/00 ,  A61K2039/505 ,  C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  C07K16/28 ,  C07K16/30 ,  C07K16/303 ,  C07K16/3046 ,  C07K16/3076 ,  C07K16/44 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/73 ,  C07K2317/75 ,  C12N9/88 ,  C12Y406/01002 ,  G01N33/57496

摘要： According to the invention, gene products expressed in a tumor-associated manner and the nucleic acids coding therefor were identified. The invention relates to the therapy and diagnosis of diseases wherein said gene products expressed in a tumor-associated manner are aberrantly expressed. The invention also relates to proteins, polypeptides and peptides which are expressed in a tumor associated manner and to nucleic acids coding therefor.

摘要翻译： 根据本发明，鉴定了以肿瘤相关方式表达的基因产物和其编码的核酸。 本发明涉及疾病的治疗和诊断，其中以肿瘤相关方式表达的所述基因产物被异常表达。 本发明还涉及以肿瘤相关方式表达的蛋白质，多肽和肽以及编码它们的核酸。

公开(公告)号：US08716455B2

公开(公告)日：2014-05-06

申请号：US12197960

申请日：2008-08-25

申请人： Ugur Sahin ,  Özlem Türeci ,  Michael Koslowski

发明人： Ugur Sahin ,  Özlem Türeci ,  Michael Koslowski

IPC分类号： C07K16/00

CPC分类号： C07K16/30 ,  A61K38/00 ,  A61K39/00 ,  A61K39/39558 ,  A61K48/00 ,  C07K14/4748 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/3053 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2317/76 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/574

摘要： The invention relates to the identification of genetic products that are expressed in association with a tumor and the nucleic acid coding therefor. The invention relates to the therapy and diagnosis of diseases in which said genetic products that are expressed in association with a tumor are expressed in an aberrant manner. The invention also relates to proteins, polypeptides, and peptides which are expressed in association with a tumor and the nucleic acids coding therefor.

摘要翻译： 本发明涉及与肿瘤相关表达的遗传产物的鉴定及其编码的核酸。 本发明涉及以异常方式表达与肿瘤相关表达的所述遗传产物的疾病的治疗和诊断。 本发明还涉及与肿瘤相关的表达的蛋白质，多肽和肽以及编码它们的核酸。

公开(公告)号：US20120014948A1

公开(公告)日：2012-01-19

申请号：US13184719

申请日：2011-07-18

申请人： Ugur Sahin ,  Özlem Türeci ,  Michael Koslowski

发明人： Ugur Sahin ,  Özlem Türeci ,  Michael Koslowski

IPC分类号： A61K39/395 ,  A61P35/00

CPC分类号： C07K16/30 ,  A61K38/00 ,  A61K39/00 ,  A61K39/39558 ,  A61K48/00 ,  C07K14/4748 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/3053 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2317/76 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/574

摘要： The invention relates to the identification of genetic products that are expressed in association with a tumor and the nucleic acid coding therefor. The invention relates to the therapy and diagnosis of diseases in which the genetic products that are expressed in association with a tumor are expressed in an aberrant manner. The invention also relates to proteins, polypeptides, and peptides which are expressed in association with a tumor and the nucleic acids coding therefor.

摘要翻译： 本发明涉及与肿瘤相关表达的遗传产物的鉴定及其编码的核酸。 本发明涉及以异常方式表达与肿瘤相关表达的遗传产物的疾病的治疗和诊断。 本发明还涉及与肿瘤相关的表达的蛋白质，多肽和肽以及编码它们的核酸。

公开(公告)号：US08088913B2

公开(公告)日：2012-01-03

申请号：US12096216

申请日：2006-12-07

申请人： Ugur Sahin ,  Özlem Türeci ,  Michael Koslowski

发明人： Ugur Sahin ,  Özlem Türeci ,  Michael Koslowski

IPC分类号： C07H21/04 ,  C07H21/02 ,  C12N15/63 ,  A61K48/00

CPC分类号： C12N15/1138 ,  C07K14/4748 ,  C12N15/1137 ,  C12N2310/14 ,  C12Y301/03048

摘要： The present invention is directed to siRNA molecules which specifically target and cause RNAi-induced degradation of mRNA from TPTE genes, so that the protein product of the TPTE gene is not produced or is produced in reduced amounts. The siRNA compounds and compositions of the invention are useful for treating diseases which require inhibition of TPTE expression for their treatment, in particular cancer pathologies. The present invention also includes methods which make possible to assess and/or prognose the metastatic behavior of a cancer disease and/or the occurrence of a relapse of cancer.

摘要翻译： 本发明涉及特异性靶向并引起来自TPTE基因的mRNA的RNAi诱导的降解的siRNA分子，使得TPTE基因的蛋白质产物不产生或以减少的量产生。 本发明的siRNA化合物和组合物可用于治疗需要抑制TPTE表达以治疗，特别是癌症病症的疾病。 本发明还包括使得有可能评估和/或预测癌症疾病的转移行为和/或癌症复发的方法。

公开(公告)号：US20080193454A1

公开(公告)日：2008-08-14

申请号：US11596106

申请日：2005-05-11

申请人： Ozlem Tureci ,  Ugur Sahin ,  Sandra Schneider ,  Gerd Helftenbein ,  Volker Schluter ,  Dirk Usener ,  Philippe Thiel

发明人： Ozlem Tureci ,  Ugur Sahin ,  Sandra Schneider ,  Gerd Helftenbein ,  Volker Schluter ,  Dirk Usener ,  Philippe Thiel

IPC分类号： A61K39/395 ,  C12N15/11 ,  C12Q1/68 ,  C12Q1/02 ,  C12N5/06 ,  A61K31/70 ,  A61P43/00 ,  C07K14/00 ,  A61K35/12 ,  G01N33/574 ,  C07K16/18

CPC分类号： A61K39/39558 ,  A61K39/395 ,  A61K45/06 ,  C07K14/4748 ,  C07K16/28 ,  C07K16/30 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156 ,  G01N33/53

摘要： The invention relates to the identification of gene products that are the result of tumor-associated expression and the nucleic acids encoding the same. The invention also relates to the therapy and diagnosis of diseases wherein these gene products are the result of an aberrant tumor-associated expression. The invention also relates to the proteins, polypeptides and peptides that are the result of tumor-associated expression and to the nucleic acids encoding the same.

摘要翻译： 本发明涉及作为肿瘤相关表达的结果的基因产物的鉴定和编码其的核酸。 本发明还涉及其中这些基因产物是异常肿瘤相关表达的结果的疾病的治疗和诊断。 本发明还涉及作为肿瘤相关表达的结果的蛋白质，多肽和肽以及编码其的核酸。

公开(公告)号：US20090221674A1

公开(公告)日：2009-09-03

申请号：US12096216

申请日：2006-12-07

申请人： Ugur Sahin ,  Özlem Türeci ,  Michael Koslowski

发明人： Ugur Sahin ,  Özlem Türeci ,  Michael Koslowski

IPC分类号： A61K31/7105 ,  C12N15/11 ,  C12N15/00 ,  C12Q1/68 ,  G01N33/574 ,  C12Q1/02

CPC分类号： C12N15/1138 ,  C07K14/4748 ,  C12N15/1137 ,  C12N2310/14 ,  C12Y301/03048

摘要： The present invention is directed to siRNA molecules which specifically target and cause RNAi-induced degradation of mRNA from TPTE genes, so that the protein product of the TPTE gene is not produced or is produced in reduced amounts. The siRNA compounds and compositions of the invention are useful for treating diseases which require inhibition of TPTE expression for their treatment, in particular cancer pathologies. The present invention also includes methods which make possible to assess and/or prognose the metastatic behaviour of a cancer disease and/or the occurrence of a relapse of cancer.

摘要翻译： 本发明涉及特异性靶向并引起来自TPTE基因的mRNA的RNAi诱导的降解的siRNA分子，使得TPTE基因的蛋白质产物不被产生或以减少的量产生。 本发明的siRNA化合物和组合物可用于治疗需要抑制TPTE表达以治疗，特别是癌症病症的疾病。 本发明还包括使得有可能评估和/或预测癌症疾病的转移行为和/或癌症复发的方法。

公开(公告)号：US08637012B2

公开(公告)日：2014-01-28

申请号：US13296620

申请日：2011-11-15

申请人： Ugur Sahin ,  Özlem Türeci ,  Michael Koslowski

发明人： Ugur Sahin ,  Özlem Türeci ,  Michael Koslowski

IPC分类号： A61K39/395 ,  A61K39/00

CPC分类号： C07K16/3076 ,  A61K47/48569 ,  A61K47/549 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/18 ,  C07K16/30 ,  C07K16/3023 ,  C07K16/3046 ,  C07K2317/30 ,  C07K2317/34 ,  G01N33/57484

摘要： The invention relates to the identification of genetic products expressed in association with tumors and to coding nucleic acids for the expressed products. An embodiment of the invention also relates to the therapy and diagnosis of disease in which the genetic products are aberrantly expressed in association with tumors, proteins, polypeptides and peptides which are expressed in association with tumors, and to the nucleic acids coding for the polypeptides, peptides and proteins.

摘要翻译： 本发明涉及与肿瘤相关表达的遗传产物的鉴定和用于表达产物的编码核酸。 本发明的一个实施方案还涉及其中遗传产物与肿瘤相关表达的肿瘤，蛋白质，多肽和肽异常表达的疾病的治疗和诊断，以及编码多肽的核酸， 肽和蛋白质。

公开(公告)号：US20120258091A1

公开(公告)日：2012-10-11

申请号：US13296620

申请日：2011-11-15

申请人： Ugur Sahin ,  Özlem Türeci ,  Michael Koslowski

发明人： Ugur Sahin ,  Özlem Türeci ,  Michael Koslowski

IPC分类号： A61K39/395 ,  A61P35/00 ,  C07K16/30

CPC分类号： C07K16/3076 ,  A61K47/48569 ,  A61K47/549 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/18 ,  C07K16/30 ,  C07K16/3023 ,  C07K16/3046 ,  C07K2317/30 ,  C07K2317/34 ,  G01N33/57484

摘要： The invention relates to the identification of genetic products expressed in association with tumors and to coding nucleic acids for the expressed products. An embodiment of the invention also relates to the therapy and diagnosis of disease in which the genetic products are aberrantly expressed in association with tumors, proteins, polypeptides and peptides which are expressed in association with tumors, and to the nucleic acids coding for the polypeptides, peptides and proteins.

摘要翻译： 本发明涉及与肿瘤相关表达的遗传产物的鉴定和用于表达产物的编码核酸。 本发明的一个实施方案还涉及其中遗传产物与肿瘤相关表达的肿瘤，蛋白质，多肽和肽异常表达的疾病的治疗和诊断，以及编码多肽的核酸， 肽和蛋白质。

公开(公告)号：US09175088B2

公开(公告)日：2015-11-03

申请号：US12765251

申请日：2010-04-22

申请人： Ugur Sahin ,  Özlem Türeci ,  Michael Koslowski

发明人： Ugur Sahin ,  Özlem Türeci ,  Michael Koslowski

IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/02 ,  C07H21/04 ,  C07K16/30 ,  C07K14/47

CPC分类号： C12Q1/6886 ,  C07K14/4748 ,  C07K16/30 ,  C12Q2600/118 ,  C12Q2600/158

摘要： The present technology relates to genetic products the expression of which is associated with cancer diseases. The present technology also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.

摘要翻译： 本技术涉及与癌症疾病相关的遗传产物。 本技术还涉及遗传产物表达或异常表达，特别是癌症疾病的疾病的治疗和诊断。