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72 条记录 (耗时 0.039 秒)

    Eye therapy system
    11.
    发明授权
    Eye therapy system 失效

    公开(公告)号：US08545487B2

    公开(公告)日：2013-10-01

    申请号：US12315829

    申请日：2008-12-05

    申请人： David Muller ,  Thomas Ryan

    发明人： David Muller ,  Thomas Ryan

    IPC分类号： A61B17/22

    CPC分类号： A61F9/0079 ,  A61B18/18 ,  A61B18/1815 ,  A61F9/013 ,  A61F2009/00853 ,  A61F2009/00872 ,  A61N5/062 ,  A61N2005/0661

    摘要： Heat is generated in corneal fibrils in a cornea of an eye according to a selected pattern. The heat causes the corneal fibrils corresponding to the selected pattern to transition from a first structure to a second structure. The second structure provides a desired reshaping of the cornea. A cross-linking agent is then activated in the region of corneal fibrils according to the selected pattern. The cross-linking agent prevents the corneal fibrils from changing from the second structure. Thus, embodiments stabilize corneal tissue and improve its biomechanical strength after desired structural changes have been achieved in the corneal tissue. Accordingly, the embodiments help to preserve the desired reshaping of the cornea.

    CYTOKINES AS PROGNOSTIC MARKERS OF RESPIRATORY-TRACT INFECTION FOLLOWING MAJOR SURGERY
    14.
    发明申请
    CYTOKINES AS PROGNOSTIC MARKERS OF RESPIRATORY-TRACT INFECTION FOLLOWING MAJOR SURGERY 审中-公开
    细胞因子作为主要手术后呼吸道感染的预防标记

    公开(公告)号：US20120129176A1

    公开(公告)日：2012-05-24

    申请号：US13132127

    申请日：2009-11-30

    申请人： Thomas Ryan ,  Mary White ,  Owen Ross McManus ,  Dermot Kelleher ,  Patrick Stordeur ,  Vincent Young

    发明人： Thomas Ryan ,  Mary White ,  Owen Ross McManus ,  Dermot Kelleher ,  Patrick Stordeur ,  Vincent Young

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/158 ,  G16B20/00 ,  G16H50/30

    摘要： The invention relates to the use of a certain subset of cytokine markers as prognostic variables of infection status in an individual, and especially as prognostic markers of a patients developing severe infection such as pneumonia, and respiratory tract infection following surgery. The subset of cytokine markers consists of the interleukin cytokines IL-2, IL-7, IL-23, IL-27, and IL-IO, and Interferon-γ (INFγ) and Tissue Necrosis Factor-α (TNFα). The markers may be employed as individual prognostic variables of infection status, or they may be used in pairs or other combinations. Generally, the abundance of the markers is correlated with infection status by means of an absolute pre-operative value of biomarker abundance, ratio's of pre-operative to post-operative biomarker abundance, or ratio values for pairs of certain biomarkers within the subset. Typically, cytokine abundance is expressed in terms of mRNA copy number wherein the copy numbers are ideally normalised to a house keeping gene and quantification of mRNA copy number is determined by RT-PCR containing reference serial dilutions of cytokine specific cDNA.

    摘要翻译： 本发明涉及某些亚细胞因子标记物在个体中作为感染状态的预后变量的用途，特别是作为手术后发生严重感染如肺炎和呼吸道感染的患者的预后标志物。 细胞因子标志物亚群由IL-2，IL-7，IL-23，IL-27和IL-10以及干扰素-γ（INFγ）和组织坏死因子-α（TNFα）组成。 标记物可以用作感染状态的个体预后变量，或者它们可以成对使用或其它组合使用。 通常，标记物的丰度与生物标志物丰度的绝对术前价值，手术前与术后生物标志物丰度的比值或子集内特定生物标志物对的比值相关联于感染状态。 通常，细胞因子丰度以mRNA拷贝数表示，其中拷贝数理想地归一化为保存基因，并且通过含有细胞因子特异性cDNA的参考连续稀释度的RT-PCR测定mRNA拷贝数的定量。

    Eye therapy system
    15.
    发明申请
    Eye therapy system 失效
    眼科治疗系统

    公开(公告)号：US20090149842A1

    公开(公告)日：2009-06-11

    申请号：US12315829

    申请日：2008-12-05

    申请人： David Muller ,  Thomas Ryan

    发明人： David Muller ,  Thomas Ryan

    IPC分类号： A61B18/20

    CPC分类号： A61F9/0079 ,  A61B18/18 ,  A61B18/1815 ,  A61F9/013 ,  A61F2009/00853 ,  A61F2009/00872 ,  A61N5/062 ,  A61N2005/0661

    摘要： Heat is generated in corneal fibrils in a cornea of an eye according to a selected pattern. The heat causes the corneal fibrils corresponding to the selected pattern to transition from a first structure to a second structure. The second structure provides a desired reshaping of the cornea. A cross-linking agent is then activated in the region of corneal fibrils according to the selected pattern. The cross-linking agent prevents the corneal fibrils from changing from the second structure. Thus, embodiments stabilize corneal tissue and improve its biomechanical strength after desired structural changes have been achieved in the corneal tissue. Accordingly, the embodiments help to preserve the desired reshaping of the cornea.

    摘要翻译： 根据选定的图案，在角膜的角膜原纤维中产生热量。 热量导致对应于所选图案的角膜原纤维从第一结构转变到第二结构。 第二种结构提供了所需的角膜重塑。 然后根据所选择的图案，在角膜原纤维区域中激活交联剂。 交联剂防止角膜原纤维从第二结构改变。 因此，在角膜组织中已经实现所需的结构变化之后，实施例可稳定角膜组织并提高其生物力学强度。 因此，这些实施例有助于保持期望的角膜重塑。

    Electrosurgical instrument and method for transecting an organ
    18.
    发明授权
    Electrosurgical instrument and method for transecting an organ 有权
    电外科手术器具和器官截面法

    公开(公告)号：US07135018B2

    公开(公告)日：2006-11-14

    申请号：US10674453

    申请日：2003-09-30

    申请人： Thomas Ryan ,  Rebecca Leibowitz ,  Roddi J. Simpson ,  James S. Gatewood

    发明人： Thomas Ryan ,  Rebecca Leibowitz ,  Roddi J. Simpson ,  James S. Gatewood

    IPC分类号： A61F18/04

    CPC分类号： A61B18/14 ,  A61B2017/4216 ,  A61B2018/1407 ,  A61B2018/144 ,  A61B2018/1475

    摘要： An electrosurgical instrument and method is provided for transecting an organ. The electrosurgical instrument includes an introducer having a channel therein, and a conductive wire positioned in and deployable from the channel. A deployment device on the introducer is capable of moving the conductive wire between an undeployed position wherein it is substantially positioned within the channel, and a deployed position wherein a portion is deployed from and positioned outside of the channel and has a substantially looped configuration. A capture element at the distal end of the introducer can secure the distal end of the wire to the introducer, and the deployment device can subsequently move the wire toward the undeployed position to thereby cinch the conductive wire.

    摘要翻译： 提供一种用于横切器官的电外科手术器械和方法。 电外科器械包括其中具有通道的引导器，以及定位在通道中并且可从通道展开的导线。 引导器上的展开装置能够在其基本上位于通道内的未展开位置之间移动导电线，并且其中部分从通道展开并位于通道外部并且具有基本上环状的构造。 引导器远端处的捕获元件可以将导线的远端固定到导引器，并且展开装置随后可以将电线移向未部署的位置，从而使导线束紧。

    System and method for measuring middleware response time
    19.
    发明申请
    System and method for measuring middleware response time 有权
    用于测量中间件响应时间的系统和方法

    公开(公告)号：US20050055439A1

    公开(公告)日：2005-03-10

    申请号：US10750009

    申请日：2003-12-30

    申请人： Anthony Piccirilli ,  Kevin Loesch ,  Thomas Ryan

    发明人： Anthony Piccirilli ,  Kevin Loesch ,  Thomas Ryan

    IPC分类号： G06F15/173 ,  H04L12/24 ,  H04L12/26

    CPC分类号： H04L43/062 ,  H04L41/22 ,  H04L43/045 ,  H04L43/0852 ,  H04L43/106 ,  H04L43/16 ,  H04L47/283

    摘要： System and method for monitoring middleware performance is described herein. A route time for a sample message transmitted along a predetermined network route is determined and at least one queue residency time is determined. The at least one queue residency time reflects an amount of time an actual application message is stored in at least one respective local production queue located along the network route. Middleware response time is calculated according to the route time and the at least one queue residency time.

    摘要翻译： 本文描述了用于监控中间件性能的系统和方法。 确定沿着预定网络路由发送的采样消息的路由时间，并确定至少一个队列驻留时间。 至少一个队列驻留时间反映实际应用消息存储在沿着网络路由位于至少一个相应的本地生产队列中的时间量。 中间件响应时间根据路由时间和至少一个队列驻留时间计算。