公开(公告)号：US20150219603A1

公开(公告)日：2015-08-06

申请号：US14612532

申请日：2015-02-03

Applicant: Waters Technologies Corporation

Inventor： Michael R. Jackson ,  Christopher Seith ,  Joshua A. Shreve

IPC: G01N30/34 ,  F04B49/06

CPC classification number: G01N30/34 ,  F04B23/04 ,  F04B49/065

Abstract: Described is a method of generating a flow having a composition gradient such as a mobile phase gradient for liquid chromatography. A pair of pumps is operated such that the initiations of pump strokes for one pump are controlled to occur between the initiations of pump strokes for the other pump so that the sequences of pump strokes fort the two pumps are interspersed in time. Initiations of the pump strokes of the second pump are offset in time relative to initiations of the pump strokes of the first pump such that variations in the flow rates of the first and second pumps due to initiation do not overlap in time. The volume of liquid contributed by a pump stroke is controlled according to the relative contribution of the respective pump to the composition gradient.

Abstract translation: 描述了产生具有组成梯度的流的方法，例如用于液相色谱的流动相梯度。 一对泵被操作，使得一个泵的泵冲程的启动被控制在另一个泵的泵冲程的启动之间发生，使得两个泵的泵冲程顺序分散在时间上。 第二泵的泵冲程的启动在时间上相对于第一泵的泵冲程的启动而偏移，使得由于起动引起的第一和第二泵的流量的变化在时间上不重叠。 根据相应泵对组成梯度的相对贡献来控制由泵冲程贡献的液体体积。

公开(公告)号：US10159913B2

公开(公告)日：2018-12-25

申请号：US15333876

申请日：2016-10-25

Applicant: Waters Technologies Corporation

Inventor： Michael R. Jackson ,  Christopher Seith ,  Senthil Bala ,  Colin Fredette ,  Maruth Sok ,  Carlos Gomez ,  Joshua A. Shreve

IPC: B01D19/00 ,  B01D15/40 ,  G01N30/14 ,  G01N30/84

Abstract: Methods, systems and apparatus are provided for degassing a supersaturated solution. An example degasser is described having a continuous body of gas-permeable tubing to remove an amount of a gas from the supersaturated solution below the gas's saturation point in the supersaturated solution. The degasser can be connected to at least one of a fraction collector or a detector. The example degasser is sized and/or positioned to cause a change in pressure (ΔP) across the degasser to drive removal of a dissolved gas from a supersaturated solution passing through the degasser. As a result of the reduction of gas, efficiencies in system flow and fraction collection are achieved.

公开(公告)号：US20180106770A1

公开(公告)日：2018-04-19

申请号：US15565347

申请日：2016-04-07

Applicant: Waters Technologies Corporation

Inventor： Michael R. Jackson ,  Christopher Seith ,  Senthil Bala ,  Colin Fredette

IPC: G01N30/84 ,  G01N30/80 ,  G01N30/62 ,  G01N30/32 ,  G01N30/30 ,  B01D15/24

CPC classification number: G01N30/84 ,  B01D15/24 ,  B01D15/40 ,  G01N30/30 ,  G01N30/32 ,  G01N30/62 ,  G01N30/80 ,  G01N30/82

Abstract: The present disclosure relates to methodologies, systems and apparatus for cooling a supersaturated or mixed-phase solution to increase the solubility of gases dissolved therein. In a fluid chromatography system, the mobile phase may include a pressurized mixture including a gas, such as CO2, and prior to fraction collection and/or detection a portion of the gas is extracted via a gas/liquid separator. Cooling the substantially liquid phase eluent exiting the gas/liquid separator increases the solubility of any remnant gas still dissolved within the eluent. The increased solubility of the remnant gas prevents out gassing, provides more consistent flow of the eluent through the system, and results in more efficient collection and analysis of a desired sample.

公开(公告)号：US20170136389A1

公开(公告)日：2017-05-18

申请号：US15333876

申请日：2016-10-25

Applicant: Waters Technologies Corporation

Inventor： Michael R. Jackson ,  Christopher Seith ,  Senthil Bala ,  Colin Fredette ,  Maruth Sok ,  Carlos Gomez ,  Joshua A. Shreve

IPC: B01D19/00 ,  G01N30/14 ,  B01D15/40

CPC classification number: B01D15/40 ,  B01D19/0031 ,  G01N30/84 ,  G01N2030/8423

Abstract: Methods, systems and apparatus are provided for degassing a supersaturated solution. An example degasser is described having a continuous body of gas-permeable tubing to remove an amount of a gas from the supersaturated solution below the gas's saturation point in the supersaturated solution. The degasser can be connected to at least one of a fraction collector or a detector. The example degasser is sized and/or positioned to cause a change in pressure (ΔP) across the degasser to drive removal of a dissolved gas from a supersaturated solution passing through the degasser. As a result of the reduction of gas, efficiencies in system flow and fraction collection are achieved.

公开(公告)号：US20150298027A1

公开(公告)日：2015-10-22

申请号：US14687290

申请日：2015-04-15

Applicant: Waters Technologies Corporation

Inventor： Michael R. Jackson ,  Christopher Seith ,  Steven J. Ciavarini ,  Kara O'Donnell ,  John Angelosanto ,  John Leason

IPC: B01D19/00 ,  B01D15/08

CPC classification number: B01D19/0073 ,  B01D15/08 ,  B01D15/16 ,  B01D19/0036 ,  B01D19/0063 ,  B01D19/0068 ,  G01N30/14 ,  G01N30/26 ,  G01N30/34

Abstract: Described is a method for vacuum degassing of a liquid such as a solvent for a liquid chromatography system. The method includes modulating application of a vacuum to a fluid channel of a degasser so that each volume of a liquid drawn from the degasser experiences a residence time that is equal to the residence times of the other volumes. The residence time is determined as a time that the volume resides in the fluid channel under application of the vacuum and to a magnitude of the applied vacuum. The method is advantageous for use with liquid chromatography systems where differences in the diffusion rates of solvents into the degasser vacuum can otherwise introduce error into the composition gradient of a mobile phase.

Abstract translation: 描述了液体如液相色谱系统的溶剂的真空脱气方法。 该方法包括调节对脱气机的流体通道施加真空，使得从脱气器抽出的每个体积的液体经历等于其它体积的停留时间的停留时间。 停留时间被确定为在施加真空时体积位于流体通道中的时间以及施加的真空度的大小。 该方法有利于与液相色谱系统一起使用，其中溶剂进入脱气机真空的扩散速率差异可能会将误差引入流动相的组成梯度。

公开(公告)号：US20150042089A1

公开(公告)日：2015-02-12

申请号：US14382850

申请日：2013-02-01

Applicant: Waters Technologies Corporation

Inventor： Kurt D. Joudrey ,  Sylvain Cormier ,  James Usowicz ,  Emily J. Berg ,  Christopher Seith

IPC: F16L19/06 ,  G01N30/60

CPC classification number: F16L19/061 ,  G01N30/6026

Abstract: A fitting for coupling fluidic paths, such as high pressure fluidic paths in liquid chromatography systems, includes a compression nut, a tube assembly and a compression member. The compression nut has a threaded outer surface to engage a threaded bore of a receiving port and the tube assembly has an outer surface and an end face to contact a sealing surface of the receiving port. The compression member is pre-staked to the outer surface of the tube assembly at a predetermined distance from the end face and has a tapered surface to engage a surface of the receiving port. The predetermined distance permits the tube assembly to be inserted into the receiving port so that the end face makes contact with the sealing surface without the tapered surface engaging a surface of the receiving port and so that the threaded outer surface of the compression nut engages the threaded bore.

Abstract translation: 用于耦合流体路径（例如液相色谱系统中的高压流体路径）的配件包括压缩螺母，管组件和压缩构件。 压缩螺母具有螺纹外表面以接合接收端口的螺纹孔，并且管组件具有外表面和端面以接触接收端口的密封表面。 压缩构件预先固定在距离端面一预定距离的管组件的外表面上，并且具有锥形表面以接合接收端口的表面。 预定距离允许管组件插入到接收端口中，使得端面与密封表面接触，而锥形表面接合接收端口的表面，并且使得压缩螺母的螺纹外表面接合螺纹 孔。