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    Chromatography column assembly
    15.
    发明授权
    Chromatography column assembly 有权

    公开(公告)号：US10802002B2

    公开(公告)日：2020-10-13

    申请号：US15990097

    申请日：2018-05-25

    Applicant: Waters Technologies Corporation

    Inventor： Joseph D. Michienzi ,  Keith Fadgen ,  Wade P. Leveille ,  Raymond P. Fisk ,  Frank John Marszalkowski, Jr.

    IPC: G01N30/60 ,  B01D15/10 ,  B01D15/22 ,  B05B5/16 ,  G01N30/72 ,  B01D15/18

    Abstract: Described is a chromatographic column assembly that includes an outer tube comprising a metal, a first conduit disposed within the outer tube, a second conduit disposed within the outer tube, and a first joint located between the first conduit and the second conduit. The outer tube is deformed by a first uniform radial crimp at a longitudinal location along the outer tube that surrounds the first conduit on a first side of the first joint, and a second uniform radial cramp at a longitudinal location along the outer tube that surrounds the second conduit on a second side of the first joint. The first and second uniform radial cramps form a fluid-tight seal between the first conduit and the second conduit and each have a substantially flat base region over which a diameter of the outer tube is reduced for a non-zero longitudinal length.

    RECONFIGURABLE FLUIDIC MANIFOLD FOR A LIQUID CHROMATOGRAPHY SYSTEM
    16.
    发明申请
    RECONFIGURABLE FLUIDIC MANIFOLD FOR A LIQUID CHROMATOGRAPHY SYSTEM 审中-公开

    公开(公告)号：US20200064312A1

    公开(公告)日：2020-02-27

    申请号：US16545590

    申请日：2019-08-20

    Applicant: Waters Technologies Corporation

    Inventor： Jeffrey Musacchio ,  Keith Fadgen ,  Joseph D. Michienzi ,  Stanislaw Koziol

    IPC: G01N30/16

    Abstract: Described is a fluidic manifold that includes a block formed of multiple layers each bonded to at least one adjacent layer at a layer interface. Bonding may be achieved using a diffusion bonding process. The block includes one or more attachment surfaces and at least two fluidic channels. Each fluidic channel is at least partially disposed at one of the layer interfaces and has a first end at one of the attachment surfaces. Each attachment surface includes an attachment feature at the first end of one of the fluidic channels to enable a fluidic coupling of the two fluidic channels through a fluidic component. Attachment features include, for example, a compression fitting coupling body adapted to receive a conventional seal, such as a ferrule and compression screw, and a fitting body that permits a face seal or gasket seal between the fluidic component and the block.

    MODULAR EXTRACTION VESSEL AND ASSOCIATED METHODS
    18.
    发明申请
    MODULAR EXTRACTION VESSEL AND ASSOCIATED METHODS 审中-公开

    公开(公告)号：US20190275442A1

    公开(公告)日：2019-09-12

    申请号：US15915847

    申请日：2018-03-08

    Applicant: Waters Technologies Corporation

    Inventor： Michael O. Fogwill ,  Keith Fadgen ,  Scott Kelley ,  Joseph D. Michienzi

    IPC: B01D11/02

    Abstract: Exemplary embodiments are directed to a method for diffusing fluid flow within a modular extraction vessel. A modular extraction vessel can be assembled using a plurality of extraction vessel chambers, and each extraction vessel chamber is associated with at least one diffuser element. An extracting solvent is introduced into the modular extraction vessel, and the extracting solvent flows through the extraction vessel chambers. By flowing through the extraction vessel chambers and diffusers, the flow path of the extracting solvent is diffused along an extraction path.

    INTEGRATED PRESSURE CONTROL DEVICE AND COLLECTION VESSEL FOR COMPRESSIBLE FLUID EXTRACTION
    19.
    发明申请
    INTEGRATED PRESSURE CONTROL DEVICE AND COLLECTION VESSEL FOR COMPRESSIBLE FLUID EXTRACTION 审中-公开

    公开(公告)号：US20190257442A1

    公开(公告)日：2019-08-22

    申请号：US16277737

    申请日：2019-02-15

    Applicant: Waters Technologies Corporation

    Inventor： Michael O. Fogwill ,  Keith Fadgen ,  Scott Kelley ,  Joseph D. Michienzi

    IPC: F16K31/126 ,  F16K7/17

    Abstract: A pressure control device for use with a compressible fluid extraction system is provided, which includes a body portion integrated with a first vessel, and a pressure control element configured to control a first pressure of a second vessel upstream of the first vessel, wherein a decompression event occurs at a point of decompression proximate an outlet of the pressure control element of the pressure control device, wherein an analyte soluble in an extraction solvent stream at the first pressure but has reduced solubility in the extraction solvent stream at the pressure resulting from the decompression event drops out of solution and into the first vessel at the point of decompression Furthermore, an associated extraction system and method is also provided.

    METHOD AND APPARATUS FOR INJECTING A CHROMATOGRAPHIC SAMPLE
    20.
    发明申请
    METHOD AND APPARATUS FOR INJECTING A CHROMATOGRAPHIC SAMPLE 审中-公开

    公开(公告)号：US20190170706A1

    公开(公告)日：2019-06-06

    申请号：US16098280

    申请日：2017-05-04

    Applicant: Waters Technologies Corporation

    Inventor： Martin Gilar ,  Richard W. Andrews ,  Peyton C. Beals ,  Thomas McDonald ,  Keith Fadgen ,  Jordan Kornfeld ,  Geoff Gerhardt ,  Sylvain Cormier

    IPC: G01N30/24 ,  G01N30/06

    Abstract: A method for injecting a diluted sample in a chromatography system includes merging a flow of a sample and a flow of a diluent to form a flow of a diluted sample. A dilution ratio of the diluted sample equals a sum of the volumetric flow rates of the sample and the diluent divided by the volumetric flow rate of the sample. The diluted sample is stored in a holding element before injection into a chromatographic system flow. Sample dilution occurs under low pressure relative to the chromatographic flow thereby allowing lower pressure sample and diluent syringes to be used. Other benefits include reduced compressibility and a reduction in leaks due to the lower pressure operation. The method avoids problems associated with manual techniques which can introduce errors due, for example, to loss of sample, sample precipitation and adsorption of sample to vials.

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