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    Magnetic resonance imaging of a medical device and proximate body tissue
    11.
    发明授权
    Magnetic resonance imaging of a medical device and proximate body tissue 有权
    医疗器械和邻近身体组织的磁共振成像

    公开(公告)号：US07483732B2

    公开(公告)日：2009-01-27

    申请号：US10826960

    申请日：2004-04-15

    申请人： Sheng-Ping Zhong ,  Michael N Helmus ,  Scott R. Smith ,  Bruce E. Hammer

    发明人： Sheng-Ping Zhong ,  Michael N Helmus ,  Scott R. Smith ,  Bruce E. Hammer

    IPC分类号： A61B5/05 ,  G01V3/00

    CPC分类号： G01R33/285

    摘要： Medical devices incorporate therein imaging materials having selected MRI detectable nuclei to provide useful magnetic resonance images of the medical devices and proximate body tissue. Also, a method generates MRI images of such a medical device, and involves performing first and second MRI processes on a body portion including at least a portion of the medical device to obtain, respectively, first and second image data. The first MRI process is adapted to detect MRI detectable nuclei present in the proximate body tissue, and the second MRI process is adapted to detect the selected MRI detectable nuclei contained in the device's imaging material. The selected MRI detectable nuclei incorporated in the imaging material is not the same nuclei that the first MRI process is adapted to detect. The second image data are combined with the first image data to produce image data for the medical device and the proximate body tissue.

    摘要翻译： 医疗装置包括具有选定的MRI可检测核的成像材料，以提供医疗装置和邻近身体组织的有用的磁共振图像。 此外，一种方法产生这种医疗装置的MRI图像，并且涉及在包括医疗装置的至少一部分的主体部分上执行第一和第二MRI处理，以分别获得第一和第二图像数据。 第一MRI过程适于检测存在于邻近身体组织中的MRI可检测核，并且第二MRI过程适于检测包含在装置的成像材料中的所选择的MRI可检测核。 在成像材料中并入的所选择的MRI检测核并不是第一个MRI过程适用于检测的核。 第二图像数据与第一图像数据组合以产生用于医疗装置和邻近身体组织的图像数据。

    Magnetic resonance imaging of a medical device and proximate body tissue
    14.
    发明申请
    Magnetic resonance imaging of a medical device and proximate body tissue 有权
    医疗器械和邻近身体组织的磁共振成像

    公开(公告)号：US20050240098A1

    公开(公告)日：2005-10-27

    申请号：US10826960

    申请日：2004-04-15

    申请人： Sheng-Ping Zhong ,  Michael Helmus ,  Scott Smith ,  Bruce Hammer

    发明人： Sheng-Ping Zhong ,  Michael Helmus ,  Scott Smith ,  Bruce Hammer

    IPC分类号： G01R33/28 ,  A61B5/05

    CPC分类号： G01R33/285

    摘要： Medical devices incorporate therein imaging materials having selected MRI detectable nuclei to provide useful magnetic resonance images of the medical devices and proximate body tissue. Also, a method generates MRI images of such a medical device, and involves performing first and second MRI processes on a body portion including at least a portion of the medical device to obtain, respectively, first and second image data. The first MRI process is adapted to detect MRI detectable nuclei present in the proximate body tissue, and the second MRI process is adapted to detect the selected MRI detectable nuclei contained in the device's imaging material. The selected MRI detectable nuclei incorporated in the imaging material is not the same nuclei that the first MRI process is adapted to detect. The second image data are combined with the first image data to produce image data for the medical device and the proximate body tissue.

    摘要翻译： 医疗装置包括具有选定的MRI可检测核的成像材料，以提供医疗装置和邻近身体组织的有用的磁共振图像。 此外，一种方法产生这种医疗装置的MRI图像，并且涉及在包括医疗装置的至少一部分的主体部分上执行第一和第二MRI处理，以分别获得第一和第二图像数据。 第一MRI过程适于检测存在于邻近身体组织中的MRI可检测核，并且第二MRI过程适于检测包含在装置的成像材料中的所选择的MRI可检测核。 在成像材料中并入的所选择的MRI检测核并不是第一个MRI过程适用于检测的核。 第二图像数据与第一图像数据组合以产生用于医疗装置和邻近身体组织的图像数据。

    Substrates, particularly medical devices, provided with bio-active/biocompatible coatings
    16.
    发明授权
    Substrates, particularly medical devices, provided with bio-active/biocompatible coatings 有权
    基材，特别是医疗器械，具有生物活性/生物相容性涂层

    公开(公告)号：US6099563A

    公开(公告)日：2000-08-08

    申请号：US209328

    申请日：1998-12-11

    申请人： Sheng-Ping Zhong

    发明人： Sheng-Ping Zhong

    IPC分类号： A61M25/00 ,  A61L29/00 ,  A61L29/08 ,  A61L29/16 ,  A61L31/00 ,  A61L31/10 ,  A61L31/16 ,  C03C17/32 ,  C08J7/04 ,  C08L33/02 ,  C08L75/00 ,  C08L75/04 ,  C09D201/00 ,  A61I2/00 ,  A61L27/00 ,  A61L33/00

    CPC分类号： A61L31/16 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/208 ,  A61L2300/21 ,  A61L2300/236 ,  A61L2300/25 ,  A61L2300/42 ,  A61L2300/608 ,  A61L2300/61 ,  Y10S623/92

    摘要： Disclosed is a method of enhancing the biocompatibility of a substrate by providing the substrate with a continuous bio-active surface coating. This method includes applying to the substrate a first coating which includes an aqueous dispersion or emulsion of a polymer containing an organic acid functional group and an excess of a polyfunctional cross-linking agent which is reactive with the organic acid groups of the polymer. A continuous bio-active surface coating is then formed over the dried first coating by applying thereover a bio-active agent containing an organic acid functional group or metal salt thereof. The first and second coatings are then dried to covalently bond the organic acid functional groups of the bio-active agent to the polymer through the excess unreacted polyfunctional cross-linking agent.

    摘要翻译： 公开了通过向基材提供连续的生物活性表面涂层来提高基底的生物相容性的方法。 该方法包括向基材施加第一涂层，该涂层包括含有有机酸官能团的聚合物的水性分散体或乳液，以及过量的与聚合物的有机酸基团反应的多官能交联剂。 然后通过在其上施加含有有机酸官能团或其金属盐的生物活性剂，在干燥的第一涂层上形成连续的生物活性表面涂层。 然后干燥第一和第二涂层，以通过过量的未反应的多官能交联剂将生物活性剂的有机酸官能团与聚合物共价键合。

    Medical devices visible by magnetic resonance imaging
    17.
    发明授权
    Medical devices visible by magnetic resonance imaging 有权
    磁共振成像可见的医疗器械

    公开(公告)号：US08620406B2

    公开(公告)日：2013-12-31

    申请号：US10763690

    申请日：2004-01-23

    申请人： Scott R. Smith ,  Steven E. Walak ,  Lixiao Wang ,  Jan Weber ,  Sheng-Ping Zhong

    发明人： Scott R. Smith ,  Steven E. Walak ,  Lixiao Wang ,  Jan Weber ,  Sheng-Ping Zhong

    IPC分类号： A61B5/05

    CPC分类号： G01R33/285 ,  A61B2090/3954 ,  A61M25/0043 ,  A61M25/0127 ,  G01R33/286

    摘要： Medical devices that are visible by magnetic resonance imaging (MRI), and optionally, other imaging techniques, are described. In some embodiments, a medical device adapted for insertion into the body includes an elongated shaft and an electrically conductive path extending spirally about a portion of the shaft. The conductive path is capable of being connected to a current source. The medical device can further include one or more contrast agents (such as MRI contrast agents, radiopaque materials, and/or ultrasound visible materials), which can be arranged in a predetermined manner.

    摘要翻译： 描述了通过磁共振成像（MRI）可视的医疗装置，以及可选的其他成像技术。 在一些实施例中，适于插入到本体中的医疗装置包括细长轴和围绕轴的一部分螺旋地延伸的导电路径。 导电路径能够连接到电流源。 医疗装置还可以包括一种或多种可以以预定方式布置的造影剂（例如MRI造影剂，不透射线材料和/或超声可见材料）。

    Low profile emboli capture device
    18.
    发明授权
    Low profile emboli capture device 失效
    薄型栓塞捕获装置

    公开(公告)号：US08236024B2

    公开(公告)日：2012-08-07

    申请号：US10975851

    申请日：2004-10-28

    申请人： Ulf Harry Stanford ,  Yem Chin ,  John A Griego ,  Sheng-Ping Zhong

    发明人： Ulf Harry Stanford ,  Yem Chin ,  John A Griego ,  Sheng-Ping Zhong

    IPC分类号： A61M29/00

    CPC分类号： A61F2/013 ,  A61B2017/00336 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0008 ,  A61F2230/0019 ,  A61F2230/0067 ,  A61F2230/0097 ,  A61M25/0119 ,  B29C53/66

    摘要： A low profile emboli capture device is provided for use in angioplasty and other intravascular procedures. A standard guidewire is utilized having a reduced cross-sectional area formed near its distal end. A filter and self-expanding stent are packaged on the reduced cross-sectional area of the guidewire. A movable sleeve extends over the guidewire and holds the self-expanding stent and filter in their retracted positions while the device is being positioned in the artery. The sheath is moved relative to the self-expanding stent and filter, whereupon the self-expanding stent and filter become deployed.

    摘要翻译： 提供了一种用于血管成形术和其他血管内手术的低调栓塞捕获装置。 使用在其远端附近形成的具有减小的横截面积的标准导丝。 过滤器和自扩张支架被包装在导丝的减小的横截面面积上。 可移动的套筒延伸穿过导丝，并且将自扩张支架和过滤器保持在其缩回位置，同时该装置被定位在动脉中。 护套相对于自扩张支架和过滤器移动，随后展开自扩张支架和过滤器。

    Medical devices with magnetic resonance visibility enhancing material
    20.
    发明申请
    Medical devices with magnetic resonance visibility enhancing material 审中-公开
    具有磁共振可见度增强材料的医疗器械

    公开(公告)号：US20050255046A1

    公开(公告)日：2005-11-17

    申请号：US11151044

    申请日：2005-06-13

    申请人： Sheng-Ping Zhong ,  Ronald Sahatjian

    发明人： Sheng-Ping Zhong ,  Ronald Sahatjian

    IPC分类号： G01R33/28 ,  A61B5/055 ,  A61L29/18 ,  A61L31/18 ,  A61B5/05

    CPC分类号： A61L29/18 ,  A61L31/18

    摘要： The present invention relates to an elongated medical device for intralumenal manipulation during a process of magnetic resonance imaging. The device includes an elongated body. An extrusion material is integrated with the elongated body and includes a hydrophilic polymer that incorporates a substance having a plurality of paramagnetic ions. The extrusion material is configured to enhance magnetic resonance visibility during said process of magnetic resonance imaging.

    摘要翻译： 本发明涉及一种用于在磁共振成像过程中进行腔内操作的细长医疗装置。 该装置包括细长体。 挤出材料与细长体结合在一起并且包括含有具有多个顺磁离子的物质的亲水聚合物。 挤出材料构造成在磁共振成像的所述过程期间增强磁共振可见度。