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    System for cardiac procedures
    11.
    发明授权
    System for cardiac procedures 失效
    心脏手术系统

    公开(公告)号：US5868702A

    公开(公告)日：1999-02-09

    申请号：US819455

    申请日：1997-03-17

    申请人： John H. Stevens ,  Wesley D. Sterman ,  Hanson S. Gifford, III ,  Timothy R. Machold

    发明人： John H. Stevens ,  Wesley D. Sterman ,  Hanson S. Gifford, III ,  Timothy R. Machold

    IPC分类号： A61B17/00 ,  A61B17/28 ,  A61B17/32 ,  A61F2/24 ,  A61F2/958 ,  A61M1/36 ,  A61M25/00 ,  A61M25/01 ,  A61M25/06 ,  A61M29/02 ,  A61M31/00

    CPC分类号： A61F2/2427 ,  A61B17/29 ,  A61F2/2433 ,  A61M1/3653 ,  A61M1/3659 ,  A61M25/0041 ,  A61M25/0147 ,  A61M25/0152 ,  A61M25/0662 ,  A61M25/10 ,  A61B17/320016 ,  A61B2017/00243 ,  A61B2018/00232 ,  A61B2018/00261 ,  A61F2/2436 ,  A61M2025/0031 ,  A61M2025/0078 ,  A61M2025/015 ,  A61M2025/0161 ,  A61M2025/028 ,  A61M2025/1047 ,  A61M2025/1052 ,  A61M2025/1077 ,  A61M2025/1095 ,  A61M2205/11 ,  A61M2205/366 ,  A61M2210/125 ,  A61M2210/127 ,  A61M25/0032 ,  A61M25/0125 ,  A61M25/1002

    摘要： A system for accessing a patient's cardiac anatomy which includes an endovascular aortic partitioning device that separates the coronary arteries and the heart from the rest of the patient's arterial system. The endovascular device for partitioning a patient's ascending aorta comprises a flexible shaft having a distal end, a proximal end, and a first inner lumen therebetween with an opening at the distal end. The shaft may have a preshaped distal portion with a curvature generally corresponding to the curvature of the patient's aortic arch. An expandable means, e.g., a balloon, is disposed near the distal end of the shaft proximal to the opening in the first inner lumen for occluding the ascending aorta so as to block substantially all blood flow therethrough for a plurality of cardiac cycles, while the patient is supported by cardiopulmonary bypass. The endovascular aortic partitioning device may be coupled to an arterial bypass cannula for delivering oxygenated blood to the patient's arterial system. The heart muscle or myocardium is paralyzed by the retrograde delivery of a cardioplegic fluid to the myocardium through patient's coronary sinus and coronary veins, or by antegrade delivery of cardioplegic fluid through a lumen in the endovascular aortic partitioning device to infuse cardioplegic fluid into the coronary arteries. The pulmonary trunk may be vented by withdrawing liquid from the trunk through an inner lumen of an elongated catheter. The cardiac accessing system is particularly suitable for removing the aortic valve and replacing the removed valve with a prosthetic valve.

    摘要翻译： 一种用于访问患者心脏解剖结构的系统，其包括将冠状动脉和心脏与患者动脉系统的其余部分分离的血管内主动脉分配装置。 用于分隔患者升主动脉的血管内装置包括具有远端，近端和其间的第一内腔的柔性轴，在远端具有开口。 轴可以具有预先形成的远端部分，其曲率通常对应于患者主动脉弓的曲率。 一个可膨胀的装置，例如气球，靠近靠近第一内腔内的开口的轴的远端设置，用于闭塞上升主动脉，从而阻止基本上所有的血流通过其中进行多个心动周期，而 患者由体外循环支持。 血管内主动脉分配装置可以联接到动脉旁路套管，用于将氧合血液输送到患者的动脉系统。 通过患者的冠状窦和冠状静脉逆行递送心脏停搏液到心肌，或者通过血管内主动脉分配装置的内腔顺序递送心脏停跳液，将心肌或心肌瘫痪，将心脏停搏液注入冠状动脉 。 可以通过从细长的导管的内腔中抽出液体来排出肺动脉干。 心脏存取系统特别适用于去除主动脉瓣并用假体瓣替换去除的瓣膜。

    System for cardiac procedures
    13.
    发明授权
    System for cardiac procedures 失效
    心脏手术系统

    公开(公告)号：US5702368A

    公开(公告)日：1997-12-30

    申请号：US453333

    申请日：1995-05-30

    申请人： John H. Stevens ,  Wesley D. Sterman ,  Hanson S. Gifford, III ,  Timothy R. Machold

    发明人： John H. Stevens ,  Wesley D. Sterman ,  Hanson S. Gifford, III ,  Timothy R. Machold

    IPC分类号： A61B17/00 ,  A61B17/28 ,  A61B17/32 ,  A61F2/24 ,  A61F2/958 ,  A61M1/36 ,  A61M25/00 ,  A61M25/01 ,  A61M25/06 ,  A61M29/02 ,  A61M5/00 ,  A61M37/00

    CPC分类号： A61F2/2427 ,  A61B17/29 ,  A61F2/2433 ,  A61M1/3653 ,  A61M1/3659 ,  A61M25/0041 ,  A61M25/0147 ,  A61M25/0152 ,  A61M25/0662 ,  A61M25/10 ,  A61B17/320016 ,  A61B2017/00243 ,  A61B2018/00232 ,  A61B2018/00261 ,  A61F2/2436 ,  A61M2025/0031 ,  A61M2025/0078 ,  A61M2025/015 ,  A61M2025/0161 ,  A61M2025/028 ,  A61M2025/1047 ,  A61M2025/1052 ,  A61M2025/1077 ,  A61M2025/1095 ,  A61M2205/11 ,  A61M2205/366 ,  A61M2210/125 ,  A61M2210/127 ,  A61M25/0032 ,  A61M25/0125 ,  A61M25/1002

    摘要： A system for accessing a patient's cardiac anatomy which includes an endovascular aortic partitioning device that separates the coronary arteries and the heart from the rest of the patient's arterial system. The endovascular device for partitioning a patient's ascending aorta comprises a flexible shaft having a distal end, a proximal end, and a first inner lumen therebetween with an opening at the distal end. The shaft may have a preshaped distal portion with a curvature generally corresponding to the curvature of the patient's aortic arch. An expandable means, e.g. a balloon, is disposed near the distal end of the shaft proximal to the opening in the first inner lumen for occluding the ascending aorta so as to block substantially all blood flow therethrough for a plurality of cardiac cycles, while the patient is supported by cardiopulmonary bypass. The endovascular aortic partitioning device may be coupled to an arterial bypass cannula for delivering oxygenated blood to the patient's arterial system. The heart muscle or myocardium is paralyzed by the retrograde delivery of a cardioplegic fluid to the myocardium through patient's coronary sinus and coronary veins, or by antegrade delivery of cardioplegic fluid through a lumen in the endovascular aortic partitioning device to infuse cardioplegic fluid into the coronary arteries. The pulmonary trunk may be vented by withdrawing liquid from the trunk through an inner lumen of an elongated catheter. The cardiac accessing system is particularly suitable for removing the aortic valve and replacing the removed valve with a prosthetic valve.

    摘要翻译： 一种用于访问患者心脏解剖结构的系统，其包括将冠状动脉和心脏与患者动脉系统的其余部分分离的血管内主动脉分配装置。 用于分隔患者升主动脉的血管内装置包括具有远端，近端和其间的第一内腔的柔性轴，在远端具有开口。 轴可以具有预先形成的远端部分，其曲率通常对应于患者主动脉弓的曲率。 可膨胀装置，例如 靠近靠近第一内腔中的开口的轴的远端附近的气囊，用于闭塞升主动脉，以便阻止基本上所有的血液通过其进行多个心动周期，同时患者由体外循环 。 血管内主动脉分配装置可以联接到动脉旁路套管，用于将氧合血液输送到患者的动脉系统。 通过患者的冠状窦和冠状静脉逆行递送心脏停搏液到心肌，或者通过血管内主动脉分配装置的内腔顺序递送心脏停跳液，将心肌或心肌瘫痪，将心脏停搏液注入冠状动脉 。 可以通过从细长的导管的内腔中抽出液体来排出肺动脉干。 心脏存取系统特别适用于去除主动脉瓣并用假体瓣替换去除的瓣膜。

    System for cardiac procedures
    14.
    发明授权
    System for cardiac procedures 失效
    心脏手术系统

    公开(公告)号：US06866650B2

    公开(公告)日：2005-03-15

    申请号：US09776336

    申请日：2001-02-02

    申请人： John H. Stevens ,  Wesley D. Sterman ,  Hanson S. Gifford, III ,  Timothy R. Machold

    发明人： John H. Stevens ,  Wesley D. Sterman ,  Hanson S. Gifford, III ,  Timothy R. Machold

    IPC分类号： A61B17/00 ,  A61F2/24 ,  A61F2/958 ,  A61M1/36 ,  A61M25/00 ,  A61M25/01 ,  A61M25/06 ,  A61M29/02 ,  A61M29/00

    CPC分类号： A61M25/0147 ,  A61B2017/00243 ,  A61B2018/00232 ,  A61B2018/00261 ,  A61F2/2427 ,  A61M1/3653 ,  A61M1/3659 ,  A61M25/0032 ,  A61M25/0041 ,  A61M25/0125 ,  A61M25/0152 ,  A61M25/0662 ,  A61M25/10 ,  A61M25/1002 ,  A61M2025/0031 ,  A61M2025/0078 ,  A61M2025/015 ,  A61M2025/0161 ,  A61M2025/028 ,  A61M2025/1047 ,  A61M2025/1052 ,  A61M2025/1077 ,  A61M2025/1095 ,  A61M2202/047 ,  A61M2205/11 ,  A61M2205/366 ,  A61M2210/125 ,  A61M2210/127

    摘要： A system for accessing a patient's cardiac anatomy which includes an endovascular aortic partitioning device that separates the coronary arteries and the heart from the rest of the patient's arterial system. The endovascular device for partitioning a patient's ascending aorta comprises a flexible shaft having a distal end, a proximal end, and a first inner lumen therebetween with an opening at the distal end. The shaft may have a preshaped distal portion with a curvature generally corresponding to the curvature of the patient's aortic arch. An expandable means, e.g. a balloon, is disposed near the distal end of the shaft proximal to the opening in the first inner lumen for occluding the ascending aorta so as to block substantially all blood flow therethrough for a plurality of cardiac cycles, while the patient is supported by cardiopulmonary bypass. The endovascular aortic partitioning device may be coupled to an arterial bypass cannula for delivering oxygenated blood to the patient's arterial system. The heart muscle or myocardium is paralyzed by the retrograde delivery of a cardioplegic fluid to the myocardium through patient's coronary sinus and coronary veins, or by antegrade delivery of cardioplegic fluid through a lumen in the endovascular aortic partitioning device to infuse cardioplegic fluid into the coronary arteries. The pulmonary trunk may be vented by withdrawing liquid from the trunk through an inner lumen of an elongated catheter. The cardiac accessing system is particularly suitable for removing the aortic valve and replacing the removed valve with a prosthetic valve.

    摘要翻译： 一种用于访问患者心脏解剖结构的系统，其包括将冠状动脉和心脏与患者动脉系统的其余部分分离的血管内主动脉分配装置。 用于分隔患者升主动脉的血管内装置包括具有远端，近端和其间的第一内腔的柔性轴，在远端具有开口。 轴可以具有预先形成的远端部分，其曲率通常对应于患者主动脉弓的曲率。 可膨胀装置，例如 靠近靠近第一内腔中的开口的轴的远端附近的气囊，用于闭塞升主动脉，以便阻止基本上所有的血液通过其进行多个心动周期，同时患者由体外循环 。 血管内主动脉分配装置可以联接到动脉旁路套管，用于将氧合血液输送到患者的动脉系统。 通过患者的冠状窦和冠状静脉逆行递送心脏停搏液到心肌，或者通过血管内主动脉分配装置的内腔顺序递送心脏停跳液，将心肌或心肌瘫痪，将心脏停搏液注入冠状动脉 。 可以通过从细长的导管的内腔中抽出液体来排出肺动脉干。 心脏存取系统特别适用于去除主动脉瓣并用假体瓣替换去除的瓣膜。

    Methods and apparatus for perfusion of isolated tissue structure
    15.
    发明授权
    Methods and apparatus for perfusion of isolated tissue structure 有权
    分离组织结构灌注的方法和装置

    公开(公告)号：US06699231B1

    公开(公告)日：2004-03-02

    申请号：US09223229

    申请日：1998-12-30

    申请人： Wesley D. Sterman ,  John H. Stevens ,  Hanson S. Gifford, III ,  Lawrence C. Siegel ,  Joe B. Putnam

    发明人： Wesley D. Sterman ,  John H. Stevens ,  Hanson S. Gifford, III ,  Lawrence C. Siegel ,  Joe B. Putnam

    IPC分类号： A61M3100

    CPC分类号： A61B17/12136 ,  A61B17/12045 ,  A61B17/12109 ,  A61B2017/12127 ,  A61M25/1011 ,  A61M2025/1052

    摘要： Organs and other tissue structures are isolated and perfused with a therapeutic agent. Isolation is effected by endovascularly positioning catheters having occlusion balloons within the arteries or other blood vessels which supply blood to the organ. Similarly, blood flow from the organ back to the patient's circulatory system is blocked by endovascularly positioning one or more catheters carrying occlusion members within the veins or other blood vessels leading from the organ. The therapeutic agent may then be perfused through the organ in either an antegrade or retrograde fashion using the endovascularly positioned catheters while maintaining isolation.

    摘要翻译： 器官和其他组织结构被分离并用治疗剂灌注。 通过血管内定位具有在动脉或其他血管中向患者提供血液的阻塞球囊的导管进行分离。 类似地，从器官返回到患者的循环系统的血液流动通过血管内定位将携带闭塞构件的一个或多个导管从器官导向的静脉或其他血管内被阻断。 然后治疗剂可以使用血管内定位的导管在顺行或逆行方式中通过器官灌注，同时保持隔离。