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公开(公告)号：US08158825B2
公开(公告)日：2012-04-17
申请号：US11922740
申请日：2006-06-21
申请人： Jonathan Grimm , Paul Harrington , Richard Heidebrecht, Jr. , Thomas Miller , Karin Otte , Phieng Siliphaivanh , David Sloman , Matthew Stanton , Kevin Wilson , David Witter , Solomon Kattar , Paul Tempest
发明人： Jonathan Grimm , Paul Harrington , Richard Heidebrecht, Jr. , Thomas Miller , Karin Otte , Phieng Siliphaivanh , David Sloman , Matthew Stanton , Kevin Wilson , David Witter , Solomon Kattar , Paul Tempest
IPC分类号： C07C233/02 , C07C255/60 , C07C311/46 , C07C311/08 , C07C235/84 , A61K31/519 , A61K31/44 , C07D265/30 , C07D495/04 , C07D215/06 , C07D211/06 , C07D213/82
CPC分类号： C07C235/78 , C07C233/75 , C07C233/80 , C07C235/42 , C07C235/56 , C07C235/74 , C07C235/84 , C07C255/60 , C07C311/08 , C07C311/16 , C07C311/46 , C07C2602/08 , C07D207/06 , C07D207/327 , C07D209/14 , C07D209/20 , C07D211/06 , C07D213/40 , C07D213/56 , C07D213/82 , C07D215/06 , C07D215/12 , C07D215/40 , C07D231/40 , C07D249/08 , C07D261/14 , C07D265/30 , C07D277/28 , C07D277/46 , C07D277/56 , C07D295/135 , C07D295/155 , C07D295/185 , C07D307/68 , C07D319/16 , C07D319/18 , C07D333/20 , C07D333/38 , C07D333/70 , C07D413/14 , C07D495/04
摘要： The present invention relates to a novel class of modified malonate derivatives. The modified malonate compounds can be used to treat cancer. The modified malonate compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the modified malonate derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the modified malonate derivatives in vivo.
摘要翻译： 本发明涉及一类新型改性丙二酸衍生物。 修饰的丙二酸酯化合物可用于治疗癌症。 修饰的丙二酸酯化合物还可以抑制组蛋白脱乙酰酶，并且适用于选择性诱导末端分化，并阻止肿瘤细胞的细胞生长和/或凋亡，从而抑制这些细胞的增殖。 因此，本发明的化合物可用于治疗具有以肿瘤细胞增殖为特征的肿瘤的患者。 本发明的化合物还可用于预防和治疗TRX介导的疾病，例如自身免疫性，过敏性和炎性疾病，以及预防和/或治疗中枢神经系统（CNS）的疾病，例如 神经退行性疾病 本发明还提供包含改性丙二酸酯衍生物和这些药物组合物的安全给药方案的药物组合物，其易于遵循，并且其在体内导致治疗有效量的修饰的丙二酸酯衍生物。
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公开(公告)号：US20100160327A1
公开(公告)日：2010-06-24
申请号：US11922740
申请日：2006-06-21
申请人： Jonathan Grimm , Paul Harrington , Richard Heidebrecht, JR. , Thomas Miller , Karin Otte , Phieng Siliphaivanh , David Sloman , Matthew Stanton , Kevin Wilson , David Witter , Solomon Kattar , Paul Tempest
发明人： Jonathan Grimm , Paul Harrington , Richard Heidebrecht, JR. , Thomas Miller , Karin Otte , Phieng Siliphaivanh , David Sloman , Matthew Stanton , Kevin Wilson , David Witter , Solomon Kattar , Paul Tempest
IPC分类号： A61K31/5375 , A61K31/519 , A61K31/47 , A61K31/4453 , A61K31/44 , A61K31/4409 , A61K31/426 , A61K31/42 , A61K31/4196 , A61K31/404 , A61K31/402 , A61K31/381 , A61K31/357 , A61K31/34 , A61K31/277 , A61K31/18 , A61K31/167 , C07D265/30 , C07D495/04 , C07D215/06 , C07D211/06 , C07D213/82 , C07D213/56 , C07D277/46 , C07D277/56 , C07D261/14 , C07D249/08 , C07D209/20 , C07D207/327 , C07D333/70 , C07D319/16 , C07D307/68 , C07C255/60 , C07C311/46 , C07C311/08 , C07C235/84 , A61P35/00
CPC分类号： C07C235/78 , C07C233/75 , C07C233/80 , C07C235/42 , C07C235/56 , C07C235/74 , C07C235/84 , C07C255/60 , C07C311/08 , C07C311/16 , C07C311/46 , C07C2602/08 , C07D207/06 , C07D207/327 , C07D209/14 , C07D209/20 , C07D211/06 , C07D213/40 , C07D213/56 , C07D213/82 , C07D215/06 , C07D215/12 , C07D215/40 , C07D231/40 , C07D249/08 , C07D261/14 , C07D265/30 , C07D277/28 , C07D277/46 , C07D277/56 , C07D295/135 , C07D295/155 , C07D295/185 , C07D307/68 , C07D319/16 , C07D319/18 , C07D333/20 , C07D333/38 , C07D333/70 , C07D413/14 , C07D495/04
摘要： The present invention relates to a novel class of modified malonate derivatives. The modified malonate compounds can be used to treat cancer. The modified malonate compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the modified malonate derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the modified malonate derivatives in vivo.
摘要翻译： 本发明涉及一类新型改性丙二酸衍生物。 修饰的丙二酸酯化合物可用于治疗癌症。 修饰的丙二酸酯化合物还可以抑制组蛋白脱乙酰酶，并且适用于选择性诱导末端分化，并阻止肿瘤细胞的细胞生长和/或凋亡，从而抑制这些细胞的增殖。 因此，本发明的化合物可用于治疗具有以肿瘤细胞增殖为特征的肿瘤的患者。 本发明的化合物还可用于预防和治疗TRX介导的疾病，例如自身免疫性，过敏性和炎性疾病，以及预防和/或治疗中枢神经系统（CNS）的疾病，例如 神经退行性疾病 本发明还提供包含改性丙二酸酯衍生物和这些药物组合物的安全给药方案的药物组合物，其易于遵循，并且其在体内导致治疗有效量的修饰的丙二酸酯衍生物。
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公开(公告)号：US08119685B2
公开(公告)日：2012-02-21
申请号：US12226628
申请日：2007-04-20
IPC分类号： A61K31/381 , A61K31/166 , C07C233/02 , C07C311/08 , C07D333/24
CPC分类号： C07D333/20 , C07C229/60 , C07C237/04 , C07C237/40
摘要： The present invention relates to a novel class of disubstituted aniline compounds. These compounds can inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the compounds of the instant invention and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of these compounds in vivo.
摘要翻译： 本发明涉及一类新的二取代苯胺化合物。 这些化合物可以抑制组蛋白脱乙酰酶，适用于选择性诱导终末分化，阻止肿瘤细胞的细胞生长和/或细胞凋亡，从而抑制这些细胞的增殖。 因此，本发明的化合物可用于治疗具有以肿瘤细胞增殖为特征的肿瘤的患者。 本发明的化合物还可用于预防和治疗TRX介导的疾病，例如自身免疫性，过敏性和炎性疾病，以及预防和/或治疗中枢神经系统（CNS）的疾病，例如 神经退行性疾病 本发明进一步提供包含本发明化合物和易于遵循的这些药物组合物的安全给药方案的药物组合物，并且其在体内导致治疗有效量的这些化合物。
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公开(公告)号：US20090069391A1
公开(公告)日：2009-03-12
申请号：US11918912
申请日：2006-04-14
申请人： Jed Lee Hubbs , Sam Kattar , Joey Methot , Thomas Miller , Phieng Siliphaivanh , Matthew Stanton , Kevin Wilson , David J. Witter
发明人： Jed Lee Hubbs , Sam Kattar , Joey Methot , Thomas Miller , Phieng Siliphaivanh , Matthew Stanton , Kevin Wilson , David J. Witter
IPC分类号： A61K31/381 , C07D333/52 , A61K31/4245 , A61P25/00 , A61P35/00 , C07D271/10
CPC分类号： C07D333/70 , A61K31/38 , A61K31/381 , A61K31/41
摘要： The present invention relates to a novel class of hydroxamic acid derivatives. The hydroxamic acid compounds can be used to treat cancer. The hydroxamic acid compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention are also useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo.
摘要翻译： 本发明涉及一类新型异羟肟酸衍生物。 异羟肟酸化合物可用于治疗癌症。 异羟肟酸化合物也可以抑制组蛋白脱乙酰酶，适用于选择性诱导终末分化，阻止肿瘤细胞的细胞生长和/或凋亡，从而抑制这些细胞的增殖。 因此，本发明的化合物可用于治疗具有以肿瘤细胞增殖为特征的肿瘤的患者。 本发明的化合物还可用于预防和治疗TRX介导的疾病，例如自身免疫性，过敏性和炎性疾病，以及预防和/或治疗中枢神经系统（CNS）的疾病，例如神经变性 疾病 本发明进一步提供包含异羟肟酸衍生物和这些药物组合物的安全投药方案的药物组合物，它们易于遵循，并且其在体内导致治疗有效量的异羟肟酸衍生物。
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公开(公告)号：US07772238B2
公开(公告)日：2010-08-10
申请号：US11918912
申请日：2006-04-14
申请人： Jed Lee Hubbs , Sam Kattar , Joey Methot , Thomas Miller , Phieng Siliphaivanh , Matthew Stanton , Kevin Wilson , David J. Witter
发明人： Jed Lee Hubbs , Sam Kattar , Joey Methot , Thomas Miller , Phieng Siliphaivanh , Matthew Stanton , Kevin Wilson , David J. Witter
IPC分类号： A61K31/496 , A61K31/381 , C07D405/04 , C07D333/56
CPC分类号： C07D333/70 , A61K31/38 , A61K31/381 , A61K31/41
摘要： The present invention relates to a novel class of hydroxamic acid derivatives. The hydroxamic acid compounds can be used to treat cancer. The hydroxamic acid compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention are also useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo.
摘要翻译： 本发明涉及一类新型异羟肟酸衍生物。 异羟肟酸化合物可用于治疗癌症。 异羟肟酸化合物也可以抑制组蛋白脱乙酰酶，适用于选择性诱导终末分化，阻止肿瘤细胞的细胞生长和/或凋亡，从而抑制这些细胞的增殖。 因此，本发明的化合物可用于治疗具有以肿瘤细胞增殖为特征的肿瘤的患者。 本发明的化合物还可用于预防和治疗TRX介导的疾病，例如自身免疫性，过敏性和炎性疾病，以及预防和/或治疗中枢神经系统（CNS）的疾病，例如神经变性 疾病 本发明进一步提供包含异羟肟酸衍生物和这些药物组合物的安全投药方案的药物组合物，它们易于遵循，并且其在体内导致治疗有效量的异羟肟酸衍生物。
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公开(公告)号：US20110098268A1
公开(公告)日：2011-04-28
申请号：US12912094
申请日：2010-10-26
IPC分类号： A61K31/438 , C07D471/10 , C07D487/10 , C07D498/10 , A61P35/00
CPC分类号： C07D471/10 , C07D487/10 , C07D491/10 , C07D491/107 , C07D498/10
摘要： The present invention relates to a novel class of substituted spirocyclic compounds. These compounds can inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the compounds of the instant invention and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of these compounds in vivo.
摘要翻译： 本发明涉及一类新的取代的螺环化合物。 这些化合物可以抑制组蛋白脱乙酰酶，适用于选择性诱导终末分化，阻止肿瘤细胞的细胞生长和/或细胞凋亡，从而抑制这些细胞的增殖。 因此，本发明的化合物可用于治疗具有以肿瘤细胞增殖为特征的肿瘤的患者。 本发明的化合物还可用于预防和治疗TRX介导的疾病，例如自身免疫性，过敏性和炎性疾病，以及预防和/或治疗中枢神经系统（CNS）的疾病，例如 神经退行性疾病 本发明进一步提供包含本发明化合物和易于遵循的这些药物组合物的安全给药方案的药物组合物，并且其在体内导致治疗有效量的这些化合物。
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17.发明授权公开(公告)号：US09901828B2
公开(公告)日：2018-02-27
申请号：US12963585
申请日：2010-12-08
申请人： Thomas Miller , George Weising
发明人： Thomas Miller , George Weising
IPC分类号： G09G5/00 , A63F13/655 , A63F13/5255 , A63F13/213 , A63F13/211 , A63F13/92 , G06T19/00
CPC分类号： A63F13/655 , A63F13/211 , A63F13/213 , A63F13/5255 , A63F13/92 , A63F2300/105 , A63F2300/1093 , A63F2300/204 , A63F2300/6607 , A63F2300/6676 , A63F2300/69 , G06F3/011 , G06F3/013 , G06F3/017 , G06F3/0304 , G06T19/006 , G09G2340/12 , G09G2340/125 , G09G2340/14 , G09G2354/00
摘要： Methods and systems for enabling an augmented reality character to maintain and exhibit awareness of an observer are provided. A portable device held by a user is utilized to capture an image stream of a real environment, and generate an augmented reality image stream which includes a virtual character. The augmented reality image stream is displayed on the portable device to the user. As the user maneuvers the portable device, its position and movement are continuously tracked. The virtual character is configured to demonstrate awareness of the user by, for example, adjusting its gaze so as to look in the direction of the portable device.
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公开(公告)号：US08367990B2
公开(公告)日：2013-02-05
申请号：US12783938
申请日：2010-05-20
申请人： Thomas Miller , Robert A. Schulte , Kami Poppen , Deborah Parenza
发明人： Thomas Miller , Robert A. Schulte , Kami Poppen , Deborah Parenza
IPC分类号： H05B6/80
CPC分类号： H05B6/6426
摘要： A microwave oven cabinet is ergonomic designed to provide for both stacking and jigsaw-type back-to-back interlining of multiple units of the microwave ovens. In particular, the cabinet configuration advantageously establishes a reduced footprint, ergonomically designed microwave oven which can be effectively employed in various fields, including fast food chains wherein multiple such ovens may need to be functionally positioned in a limited area, while still being easily accessible.
摘要翻译： 微波炉柜符合人体工程学设计，可提供多台微波炉的堆叠和拼图型背对背衬布。 特别地，橱柜配置有利地建立了减少的占地面积，符合人体工程学设计的微波炉，其可以有效地用于各种领域，包括快餐食品链，其中多个这样的烤箱可能需要在有限的区域中功能地定位，同时仍然易于接近。
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公开(公告)号：US08272325B2
公开(公告)日：2012-09-25
申请号：US12450137
申请日：2008-03-14
IPC分类号： F42B3/113
摘要： A detonator free blasting system, which comprises: a bulk explosive; a confined explosive; a fiber optic adapted to deliver laser light to the confined explosive, wherein the confined explosive is provided relative to the bulk explosive such that detonation of the confined explosive causes initiation of the bulk explosive.
摘要翻译： 爆炸器自由爆破系统，包括：爆炸物; 限制爆炸物 适用于向受限制的炸药传送激光的光纤，其中所述密封的爆炸物相对于大量爆炸物提供，使得限制的爆炸物的爆炸引起爆炸物的爆发。
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20.发明申请公开(公告)号：US20120225793A1
公开(公告)日：2012-09-06
申请号：US13409416
申请日：2012-03-01
申请人： Louis M. Staudt , George Wright , Sandeep Dave , Bruce Tan , John I. Powell , Wyndham Wilson , Elaine Jaffe , Wing C. Chan , Timothy C. Greiner , Dennis Weisenburger , James Armitage , Kai Fu , Richard I. Fisher , Lisa Rimsza , Thomas Miller , Thomas Grogan , Elias Campo , Silvia M. Bea , Itziar Salaverria , Armando Lopez-Guillermo , Emili Montserrat , Victor Moreno , Andreas Zetti , German Ott , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , Julie Vose , Randy Gascoyne , Joseph Connors , Erlend Smeland , Stein Kvaloy , Harald Holte , Jan Delabie , T. Andrew Lister
发明人： Louis M. Staudt , George Wright , Sandeep Dave , Bruce Tan , John I. Powell , Wyndham Wilson , Elaine Jaffe , Wing C. Chan , Timothy C. Greiner , Dennis Weisenburger , James Armitage , Kai Fu , Richard I. Fisher , Lisa Rimsza , Thomas Miller , Thomas Grogan , Elias Campo , Silvia M. Bea , Itziar Salaverria , Armando Lopez-Guillermo , Emili Montserrat , Victor Moreno , Andreas Zetti , German Ott , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , Julie Vose , Randy Gascoyne , Joseph Connors , Erlend Smeland , Stein Kvaloy , Harald Holte , Jan Delabie , T. Andrew Lister
IPC分类号： C40B30/04
CPC分类号： G01N33/6842 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N2333/51 , G16B25/00 , G16B40/00 , Y02A90/26
摘要： Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.
摘要翻译： 基因表达数据为更准确地鉴定和诊断淋巴组织增生性疾病提供了基础。 此外，基因表达数据可用于开发更准确的生存预测因子。 本发明公开了基于基因表达模式鉴定，诊断和预测淋巴瘤或淋巴组织增生性疾病存活的方法。 本发明公开了一种用于从淋巴瘤样品获得基因表达数据的新型微阵列Lymph Dx微阵列。 本发明还公开了多种利用淋巴瘤基因表达数据来确定特定淋巴瘤的身份并预测患有特定淋巴瘤的受试者的存活的方法。 该信息将有助于开发与特定受试者一起使用的治疗方法。
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