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    Energy-transfer nanocomposite materials and methods of making and using same
    11.
    发明授权
    Energy-transfer nanocomposite materials and methods of making and using same 失效
    能量转移纳米复合材料及其制造和使用方法

    公开(公告)号：US07538329B2

    公开(公告)日：2009-05-26

    申请号：US11262470

    申请日：2005-10-28

    申请人： Wei Chen ,  Shaopeng Wang ,  Sarah Westcott ,  Jun Zhang

    发明人： Wei Chen ,  Shaopeng Wang ,  Sarah Westcott ,  Jun Zhang

    IPC分类号： G01T1/20

    CPC分类号： A61B5/0059 ,  A61B6/00 ,  G01N21/76 ,  G01N2021/6495 ,  G01T1/10 ,  Y10S436/904 ,  Y10S977/904 ,  Y10S977/905

    摘要： The presently claimed and disclosed inventions relate, in general, to methods of radiation dosimetry and imaging using scintillation luminescence. More particularly, materials having a scintillation luminescence response to radiation that varies with total radiation dose received can be used for dosimetry monitoring, including, but not limited to nanoparticles for in vivo, real-time dosimetry. Energy-transfer nanocomposite materials as well as methods of making and using such materials in various applications including, but not limited to, in vivo radiation dosimetry and imaging, are disclosed. More particularly, the presently claimed and disclosed inventions relate to nanoparticle scintillation luminescence particles encapsulated in hosts of the general formula BaFX and BaFX:Eu2+ where X=Cl, Br and I.

    摘要翻译： 目前权利要求和公开的发明一般涉及使用闪烁发光的放射剂量测定法和成像方法。 更具体地，具有随所接收的总辐射剂量变化的对辐射的闪烁发光响应的材料可用于剂量测定监测，包括但不限于用于体内实时剂量测定的纳米颗粒。 公开了能量转移纳米复合材料以及在各种应用中制造和使用这些材料的方法，包括但不限于体内辐射剂量测定和成像。 更具体地说，本发明涉及包封在通式BaFX和BaFX：Eu2 +的主体中的纳米颗粒闪烁发光粒子，其中X = Cl，Br和I.

    3D tissue constructs on the basis of colloidal crystals surface modified by sequential layering
    12.
    发明授权
    3D tissue constructs on the basis of colloidal crystals surface modified by sequential layering 失效
    基于通过顺序分层修饰的胶体晶体的3D组织构建体

    公开(公告)号：US07534610B1

    公开(公告)日：2009-05-19

    申请号：US10460059

    申请日：2003-06-12

    申请人： Nicholas A. Kotov ,  Shaopeng Wang

    发明人： Nicholas A. Kotov ,  Shaopeng Wang

    IPC分类号： C12N5/00

    CPC分类号： C12N5/0669 ,  C12N2533/40 ,  C12N2533/54

    摘要： A cell growth matrix for optimizing 3D organization nutrient delivery, controlling release of differentiation factors and facilitating attachment of cells to a scaffold Colloidal crystals and inverted colloidal crystals are used to form an ordered structure for use as a scaffold for tissue engineering. The porosity of the cell growth matrix may be modified by the selection of particles of appropriate diameter. Further, the surface of colloidal crystals can be easily modified to accommodate many organic species including biomolecules. Layer-by-layer materials are used for tissue engineering to control cell development by using sequential layering of bioactive species wherein the number and order of LBL layers deposited between layers containing a particular protein are controlled. LBL may also be used for timed release of bioactive species. Increased control differentiation factors release and control of cell attachments to the scaffold are achieved to better mimic natural tissue development.

    摘要翻译： 用于优化3D组织营养物质输送，控制分化因子的释放和促进细胞附着到支架的细胞生长矩阵使用胶体晶体和反胶体晶体来形成用作组织工程的支架的有序结构。 可以通过选择适当直径的颗粒来修饰细胞生长基质的孔隙率。 此外，胶体晶体的表面可以容易地改性以适应包括生物分子在内的许多有机物质。 层叠材料用于组织工程以通过使用生物活性物质的顺序分层来控制细胞发育，其中沉积在含有特定蛋白质的层之间的LBL层的数量和顺序被控制。 LBL也可用于定时释放生物活性物质。 实现增加控制分化因子释放和控制细胞附着到支架以更好地模拟天然组织发育。

    ENERGY-TRANSFER NANOCOMPOSITE MATERIALS AND METHODS OF MAKING AND USING SAME
    15.
    发明申请
    ENERGY-TRANSFER NANOCOMPOSITE MATERIALS AND METHODS OF MAKING AND USING SAME 审中-公开
    能量转移纳米复合材料及其制备和使用方法

    公开(公告)号：US20100176343A1

    公开(公告)日：2010-07-15

    申请号：US12435957

    申请日：2009-05-05

    申请人： Wei Chen ,  Shaopeng Wang ,  Sarah L. Westcott ,  Jun Zhang

    发明人： Wei Chen ,  Shaopeng Wang ,  Sarah L. Westcott ,  Jun Zhang

    IPC分类号： C09K11/02 ,  C09K11/54 ,  C09K11/78 ,  C09K11/59

    CPC分类号： A61B5/0059 ,  A61B6/00 ,  A61B6/485 ,  G01N21/76 ,  G01N2021/6495 ,  G01T1/10

    摘要： The presently claimed and disclosed inventions relate, in general, to methods of radiation dosimetry and imaging using scintillation luminescence. More particularly, materials having a scintillation luminescence response to radiation that varies with total radiation dose received can be used for dosimetry monitoring, including, but not limited to nanoparticles for in vivo, real-time dosimetry. Energy-transfer nanocomposite materials as well as methods of making and using such materials in various applications including, but not limited to, in vivo radiation dosimetry and imaging, are disclosed. More particularly, the presently claimed and disclosed inventions relate to nanoparticle scintillation luminescence particles encapsulated in hosts of the general formula BaFX and BaFX:Eu2+ where X═Cl, Br and I.

    摘要翻译： 目前权利要求和公开的发明一般涉及使用闪烁发光的放射剂量测定法和成像方法。 更具体地，具有随所接收的总辐射剂量变化的对辐射的闪烁发光响应的材料可用于剂量测定监测，包括但不限于用于体内实时剂量测定的纳米颗粒。 公开了能量转移纳米复合材料以及在各种应用中制造和使用这些材料的方法，包括但不限于体内辐射剂量测定和成像。 更具体地，本发明涉及通过包封在通式BaFX和BaFX：Eu 2+的主体中的纳米颗粒闪烁发光颗粒，其中X = Cl，Br和I.

    Nanoparticle thermometry and pressure sensors
    16.
    发明申请
    Nanoparticle thermometry and pressure sensors 审中-公开
    纳米颗粒温度计和压力传感器

    公开(公告)号：US20070189359A1

    公开(公告)日：2007-08-16

    申请号：US11728908

    申请日：2007-03-27

    申请人： Wei Chen ,  Shaopeng Wang ,  Sarah Westcott

    发明人： Wei Chen ,  Shaopeng Wang ,  Sarah Westcott

    IPC分类号： G01K11/00

    CPC分类号： G01K11/20 ,  B82Y30/00 ,  G01L11/02

    摘要： A nanoparticle fluorescence (or upconversion) sensor comprises an electromagnetic source, a sample and a detector. The electromagnetic source emits an excitation. The sample is positioned within the excitation. At least a portion of the sample is associated with a sensory material. The sensory material receives at least a portion of the excitation emitted by the electromagnetic source. The sensory material has a plurality of luminescent nanoparticles luminescing upon receipt of the excitation with luminance emitted by the luminescent nanoparticles changing based on at least one of temperature and pressure. The detector receives at least a portion of the luminance emitted by the luminescent nanoparticles and outputs a luminance signal indicative of such luminance. The luminescence signal is correlated into a signal indicative of the atmosphere adjacent to the sensory material.

    摘要翻译： 纳米颗粒荧光（或上转换）传感器包括电磁源，样品和检测器。 电磁源发出激励。 样品位于激发状态。 至少一部分样品与感觉材料相关联。 感觉材料接收由电磁源发射的激发的至少一部分。 感官材料具有多个发光纳米粒子，其在接收到激发时发光，发光纳米粒子发射的亮度基于温度和压力中的至少一个而改变。 检测器接收由发光纳米粒子发出的亮度的至少一部分，并输出指示这种亮度的亮度信号。 发光信号与表示与感官材料相邻的大气的信号相关。

    Nanoparticle thermometry and pressure sensors
    20.
    发明申请
    Nanoparticle thermometry and pressure sensors 审中-公开
    纳米颗粒温度计和压力传感器

    公开(公告)号：US20060274813A9

    公开(公告)日：2006-12-07

    申请号：US10460531

    申请日：2003-06-12

    申请人： Wei Chen ,  Shaopeng Wang ,  Sarah Westcott

    发明人： Wei Chen ,  Shaopeng Wang ,  Sarah Westcott

    IPC分类号： G01K11/00 ,  G01K13/00 ,  G01K1/14

    CPC分类号： G01K11/3213 ,  G01K11/20 ,  G01K2211/00

    摘要： A nanoparticle fluorescence (or upconversion) sensor comprises an electromagnetic source, a sample and a detector. The electromagnetic source emits an excitation. The sample is positioned within the excitation. At least a portion of the sample is associated with a sensory material. The sensory material receives at least a portion of the excitation emitted by the electromagnetic source. The sensory material has a plurality of luminescent nanoparticles luminescing upon receipt of the excitation with luminance emitted by the luminescent nanoparticles changing based on at least one of temperature and pressure. The detector receives at least a portion of the luminance emitted by the luminescent nanoparticles and outputs a luminance signal indicative of such luminance. The luminescence signal is correlated into a signal indicative of the atmosphere adjacent to the sensory material.

    摘要翻译： 纳米颗粒荧光（或上转换）传感器包括电磁源，样品和检测器。 电磁源发出激励。 样品位于激发状态。 至少一部分样品与感觉材料相关联。 感觉材料接收由电磁源发射的激发的至少一部分。 感官材料具有多个发光纳米粒子，其在接收到激发时发光，发光纳米粒子发射的亮度基于温度和压力中的至少一个而改变。 检测器接收由发光纳米粒子发出的亮度的至少一部分，并输出指示这种亮度的亮度信号。 发光信号与表示与感官材料相邻的大气的信号相关。