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11.发明授权Implantable medical device comprising copolymer of L-lactide with improved fracture toughness 有权可植入医疗装置，其包含具有改善的断裂韧性的L-丙交酯的共聚物公开(公告)号：US08119704B2
公开(公告)日：2012-02-21
申请号：US12506881
申请日：2009-07-21
Applicant: Yunbing Wang , James Oberhauser , Manish Gada , Thierry Glauser , Vincent Gueriguian , Bethany Steichen , Lothar Kleiner , Xiao Ma
Inventor： Yunbing Wang , James Oberhauser , Manish Gada , Thierry Glauser , Vincent Gueriguian , Bethany Steichen , Lothar Kleiner , Xiao Ma
Abstract: The present invention relates to implantable medical devices comprising a L-lactide-constitutional unit-containing copolymer having a wt % percent crystallinity of 40% or less.
Abstract translation: 本发明涉及包含具有40％或更低的重量百分比％结晶度的含L-丙交酯结构单元的共聚物的可植入医疗器械。
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公开(公告)号：US20110244112A1
公开(公告)日：2011-10-06
申请号：US13162937
申请日：2011-06-17
Applicant: Jason Van Sciver , Yung-Ming Chen , Lothar Kleiner
Inventor： Jason Van Sciver , Yung-Ming Chen , Lothar Kleiner
IPC: B05D1/00
CPC classification number: B05D1/002
Abstract: A stent is coated by ejecting droplets of a coating substance from a reservoir containing a coating substance. A reservoir housing can have a plurality of reservoir compartments. A transducer is used to eject the coating substance from the reservoir. Energy from the transducer is focused at a meniscus or an interface between the coating substance and another coating substance in the reservoir.
Abstract translation: 通过从包含涂层物质的储存器喷射涂层物质的液滴来涂覆支架。 储存器壳体可以具有多个储存室。 传感器用于从储存器中喷射涂层物质。 传感器的能量集中在弯液面或涂层物质与储层中另一种涂料之间的界面。
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公开(公告)号：US07632307B2
公开(公告)日：2009-12-15
申请号：US11015313
申请日：2004-12-16
Applicant: Stephen Dirk Pacetti , Jessica DesNoyer , Yung-Ming Chen , Lothar Kleiner , Syed F. A. Hossainy
Inventor： Stephen Dirk Pacetti , Jessica DesNoyer , Yung-Ming Chen , Lothar Kleiner , Syed F. A. Hossainy
IPC: A61F2/06
CPC classification number: A61L31/10 , A61L31/16 , A61L2300/608 , A61L2420/08
Abstract: Embodiments of coatings for implantable medical devices, such as stents, are disclosed. The devices may include at least one structural element having an abluminal side, luminal side, and sidewalls between the abluminal and luminal sides. The coating may include at least two continuous coating layers. In some embodiments, the luminal side, and all or a majority of the sidewalls are free of at least two of the coating layers.
Abstract translation: 公开了用于可植入医疗装置（例如支架）的涂层的实施例。 所述装置可以包括至少一个结构元件，所述至少一个结构元件具有腔外侧，腔侧和在腔侧和腔侧之间的侧壁。 涂层可以包括至少两个连续的涂层。 在一些实施例中，腔侧和全部或大部分侧壁不含至少两层涂层。
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公开(公告)号：US20080177008A1
公开(公告)日：2008-07-24
申请号：US12056197
申请日：2008-03-26
Applicant: Jessica Renee DesNoyer , Stephen Dirk Pacetti , Lothar Kleiner
Inventor： Jessica Renee DesNoyer , Stephen Dirk Pacetti , Lothar Kleiner
IPC: C08L77/06 , A61K31/436
CPC classification number: A61L31/10 , A61L31/16 , A61L2300/606 , C08L77/12 , C08L2666/14
Abstract: Provided herein is a poly(ester amide) (PEA) polymer blend and a polymeric coating containing the PEA polymer blend. The PEA polymer blend has a Tg above the Tg of poly(ester amide benzyl ester) (PEA-Bz) or the Tg of poly(ester amide TEMPO). The PEA polymer blend can form a coating on an implantable device, one example of which is a stent. The coating can optionally include a biobeneficial material and/or optionally with a bioactive agent. The implantable device can be used to treat or prevent a disorder such as one of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.
Abstract translation: 本文提供了聚（酯酰胺）（PEA）聚合物共混物和含有PEA聚合物共混物的聚合物涂层。 PEA聚合物共混物在聚（酯酰胺苄酯）（PEA-Bz）或T N g N T T上方具有T N' 的聚（酯酰胺TEMPO）。 PEA聚合物共混物可以在可植入装置上形成涂层，其一个实例是支架。 涂层可任选地包括生物有益材料和/或任选地含有生物活性剂。 可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔之一，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍 导管阻塞，输尿管阻塞，肿瘤阻塞及其组合。
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公开(公告)号：US20070202323A1
公开(公告)日：2007-08-30
申请号：US11365392
申请日：2006-02-28
Applicant: Lothar Kleiner , Jessica DesNoyer , Thierry Glauser , Stephen Pacetti , Syed Hossainy
Inventor： Lothar Kleiner , Jessica DesNoyer , Thierry Glauser , Stephen Pacetti , Syed Hossainy
CPC classification number: A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/422 , A61L2300/606 , Y10T428/265 , Y10T428/31855 , Y10T428/31935 , Y10T428/31938 , C08L29/04
Abstract: A method of forming a surface layer that includes a hydroxyl polymer on a substrate coating on a medical device is provided.
Abstract translation: 提供了一种在医疗装置上的基底涂层上形成包含羟基聚合物的表面层的方法。
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Patent Agency Ranking
公开(公告)号：US07166680B2
公开(公告)日：2007-01-23
申请号：US10960381
申请日：2004-10-06
Applicant: Jessica Renee DesNoyer , Stephen Dirk Pacetti , Lothar Kleiner
Inventor： Jessica Renee DesNoyer , Stephen Dirk Pacetti , Lothar Kleiner
CPC classification number: A61L31/10 , A61L31/16 , A61L2300/606 , C08L77/12 , C08L2666/14
Abstract: Provided herein is a poly(ester amide) (PEA) polymer blend and a polymeric coating containing the PEA polymer blend. The PEA polymer blend has a Tg above the Tg of poly(ester amide benzyl ester) (PEA-Bz) or the Tg of poly(ester amide TEMPO). The PEA polymer blend can form a coating on an implantable device, one example of which is a stent. The coating can optionally include a biobeneficial material and/or optionally with a bioactive agent. The implantable device can be used to treat or prevent a disorder such as one of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.
Abstract translation: 本文提供了聚（酯酰胺）（PEA）聚合物共混物和含有PEA聚合物共混物的聚合物涂层。 PEA聚合物共混物在聚（酯酰胺苄酯）（PEA-Bz）或T N g N T T上方具有T N' 的聚（酯酰胺TEMPO）。 PEA聚合物共混物可以在可植入装置上形成涂层，其一个实例是支架。 涂层可任选地包括生物有益材料和/或任选地含有生物活性剂。 可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔之一，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍 导管阻塞，输尿管阻塞，肿瘤阻塞及其组合。
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17.发明申请公开(公告)号：US20060093842A1
公开(公告)日：2006-05-04
申请号：US10976551
申请日：2004-10-29
Applicant: Jessica DesNoyer , Stephen Pacetti , Syed Hossainy , Lothar Kleiner , Yiwen Tang , Gina Zhang
Inventor： Jessica DesNoyer , Stephen Pacetti , Syed Hossainy , Lothar Kleiner , Yiwen Tang , Gina Zhang
CPC classification number: C09D177/12 , A61L31/06 , A61L31/10 , Y10S623/90 , Y10T428/31725 , Y10T428/31786 , C08L77/12
Abstract: Provided herein is a PEA polymer blend and coatings or implantable devices formed therefrom. The PEA polymer blend is formed of a PEA polymer and a material capable of hydrogen bonding with the PEA. The PEA polymer blend can form a coating on an implantable device, one example of which is a stent. The coating can optionally include a biobeneficial material and/or optionally with a bioactive agent. The implantable device can be used to treat or prevent a disorder such as one of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.
Abstract translation: 本文提供了由其形成的PEA聚合物共混物和涂层或可植入装置。 PEA聚合物共混物由PEA聚合物和能够与PEA氢键合的材料形成。 PEA聚合物共混物可以在可植入装置上形成涂层，其一个实例是支架。 涂层可任选地包括生物有益材料和/或任选地含有生物活性剂。 可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔之一，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍 导管阻塞，输尿管阻塞，肿瘤阻塞及其组合。
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公开(公告)号：US4800253A
公开(公告)日：1989-01-24
申请号：US89093
申请日：1987-08-25
Applicant: Lothar Kleiner , Martin Matthiesen
Inventor： Lothar Kleiner , Martin Matthiesen
CPC classification number: B01D35/06 , H01C1/1406 , H01C7/027 , F02B3/06
Abstract: Electrical devices which comprise at least one metal electrode and a conductive polymer element in contact therewith, wherein the metal surface which contacts the conductive polymer has a roughened or otherwise treated surface to improve its adhesion to the conductive polymer. The metal electrode is preferably an electrodeposited foil. The conductive polymer preferably exhibits PTC behavior. The devices include heaters and circuit protection devices. The improved adhesion results in improved physical and electrical stability, and broadens the range of conductive polymer compositions which can be used in a number of important applications.
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公开(公告)号：US08501215B2
公开(公告)日：2013-08-06
申请号：US10628984
申请日：2003-07-28
Applicant: Guohua Chen , Paul Houston , Lothar Kleiner , Jeremy Wright
Inventor： Guohua Chen , Paul Houston , Lothar Kleiner , Jeremy Wright
CPC classification number: A61K47/34 , A61K9/0024 , A61K9/2013 , A61K47/12 , A61K47/14
Abstract: Injectable depot compositions are provided that include a polymer matrix having a plurality of bioerodible, biocompatible polymers wherein each polymer of the plurality of polymers has a specified average molecular weight, and the polymer matrix has a broad molecular weight distribution of the plurality of polymers; a solvent having a miscibility in water of less than or equal to 7 wt % at 25° C., in an amount effective to plasticize the polymer and form a gel therewith; and a beneficial agent. The compositions have substantially improved shear thinning behavior and reduced injection force, rendering the compositions readily implanted beneath a patient's body surface by injection.
Abstract translation: 提供了可注射的储库组合物，其包括具有多个生物可腐蚀的生物相容性聚合物的聚合物基质，其中所述多种聚合物中的每种聚合物具有指定的平均分子量，并且所述聚合物基质具有所述多种聚合物的宽分子量分布; 在25℃下在水中具有小于或等于7重量％的混溶性的溶剂，其量有效塑化聚合物并与其形成凝胶; 和有益的代理人。 组合物具有显着改善的剪切稀化行为和降低的注射力，使组合物通过注射容易地植入患者体表下方。
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公开(公告)号：US08318236B2
公开(公告)日：2012-11-27
申请号：US13162937
申请日：2011-06-17
Applicant: Jason Van Sciver , Yung-Ming Chen , Lothar Kleiner
Inventor： Jason Van Sciver , Yung-Ming Chen , Lothar Kleiner
CPC classification number: B05D1/002
Abstract: A stent is coated by ejecting droplets of a coating substance from a reservoir containing a coating substance. A reservoir housing can have a plurality of reservoir compartments. A transducer is used to eject the coating substance from the reservoir. Energy from the transducer is focused at a meniscus or an interface between the coating substance and another coating substance in the reservoir.
Abstract translation: 通过从包含涂层物质的储存器喷射涂层物质的液滴来涂覆支架。 储存器壳体可以具有多个储存室。 传感器用于从储存器中喷射涂层物质。 传感器的能量集中在弯液面或涂层物质与储层中另一种涂料之间的界面。
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