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    Treatment of hypertension by renal vascular delivery of guanethidine
    11.
    发明授权
    Treatment of hypertension by renal vascular delivery of guanethidine 有权
    用胍乙啶肾血管分泌治疗高血压

    公开(公告)号：US08399443B2

    公开(公告)日：2013-03-19

    申请号：US12765708

    申请日：2010-04-22

    申请人： Kirk Patrick Seward

    发明人： Kirk Patrick Seward

    IPC分类号： A01N43/00 ,  A61K31/33

    CPC分类号： A61M25/1002 ,  A61K9/0019 ,  A61K31/155 ,  A61K31/395 ,  A61K45/06 ,  A61M5/00 ,  A61M5/007 ,  A61M5/44 ,  A61M25/00 ,  A61M25/0084 ,  A61M2025/009 ,  A61K2300/00

    摘要： Sympathetic nerves run through the adventitia surrounding renal arteries and are critical in the modulation of systemic hypertension. Hyperactivity of these nerves can cause renal hypertension, a disease prevalent in 30-40% of the adult population. Hypertension can be treated with neuromodulating agents (such as angiotensin converting enzyme inhibitors, angiotensin II inhibitors, or aldosterone receptor blockers), but requires adherence to strict regimens and often does not reach target blood pressure threshold to reduce risk of major cardiovascular events. A minimally invasive solution is presented here to reduce the activity of the sympathetic nerves surrounding the renal artery by locally delivering neurotoxic or sympathetic nerve-blocking agents into the adventitia. Extended elution of these agents may also be accomplished in order to tailor the therapy to the patient.

    摘要翻译： 交感神经穿过肾动脉周围的外膜，对调节系统性高血压至关重要。 这些神经的多动症可引起肾性高血压，一种普遍存在于成年人群中的30-40％的疾病。 高血压可以用神经调节剂（例如血管紧张素转换酶抑制剂，血管紧张素II抑制剂或醛固酮受体阻断剂）治疗，但需要遵守严格的方案，并且通常不达到目标血压阈值以降低主要心血管事件的风险。 这里介绍一种微创溶液，通过局部输送神经毒性或交感神经阻滞剂到外膜中来减少肾动脉周围交感神经的活动。 这些试剂的延长洗脱也可以完成，以便对患者进行定制。

    DUAL MODULUS BALLOON FOR INTERVENTIONAL PROCEDURES
    12.
    发明申请
    DUAL MODULUS BALLOON FOR INTERVENTIONAL PROCEDURES 有权
    双模块气球用于传统程序

    公开(公告)号：US20110313353A1

    公开(公告)日：2011-12-22

    申请号：US13222977

    申请日：2011-08-31

    申请人： Kirk Patrick Seward ,  Isidro M. Gandionco ,  David Gandionco

    发明人： Kirk Patrick Seward ,  Isidro M. Gandionco ,  David Gandionco

    IPC分类号： A61M29/00

    CPC分类号： A61M25/0012 ,  A61M5/007 ,  A61M5/158 ,  A61M25/0045 ,  A61M25/1002 ,  A61M2025/0096 ,  A61M2025/018 ,  A61M2025/1004 ,  A61M2025/1084 ,  A61M2025/1086

    摘要： A device for interventional surgical or medical procedures is presented. The device is generally in the form of a balloon and is used to position itself or other working elements up against or through lumen walls in the body. The balloon is comprised of at least two materials of different elastic modulus, which allows for a flexible but relatively non-distensible, unfolding component of the balloon as well as an elastomeric, inflatable component of the balloon. The elastomeric component is fixedly attached to the flexible but relatively non-distensible component and together they form a pressure vessel that can be inflated within the lumens of the body.

    摘要翻译： 介绍了外科手术或医疗手术的装置。 该装置通常为气球的形式，并且用于将自身或其它工作元件向上或靠近身体中的腔壁定位。 气囊由至少两种不同弹性模量的材料组成，其允许气囊的柔性但相对不扩张的展开部件以及气囊的弹性的，可充气的部件。 弹性体部件固定地附接到柔性但相对不扩张的部件上，并且它们一起形成可以在体内的腔内膨胀的压力容器。

    DUAL MODULUS BALLOON FOR INTERVENTIONAL PROCEDURES
    13.
    发明申请
    DUAL MODULUS BALLOON FOR INTERVENTIONAL PROCEDURES 有权
    双模块气球用于传统程序

    公开(公告)号：US20100145307A1

    公开(公告)日：2010-06-10

    申请号：US12711141

    申请日：2010-02-23

    申请人： Kirk Patrick Seward ,  Isidro M. Gandionco ,  David Gandionco

    发明人： Kirk Patrick Seward ,  Isidro M. Gandionco ,  David Gandionco

    IPC分类号： A61M25/10

    CPC分类号： A61M25/0012 ,  A61M5/007 ,  A61M5/158 ,  A61M25/0045 ,  A61M25/1002 ,  A61M2025/0096 ,  A61M2025/018 ,  A61M2025/1004 ,  A61M2025/1084 ,  A61M2025/1086

    摘要： A device for interventional surgical or medical procedures is presented. The device is generally in the form of a balloon and is used to position itself or other working elements up against or through lumen walls in the body. The balloon is comprised of at least two materials of different elastic modulus, which allows for a flexible but relatively non-distensible, unfolding component of the balloon as well as an elastomeric, inflatable component of the balloon. The elastomeric component is fixedly attached to the flexible but relatively non-distensible component and together they form a pressure vessel that can be inflated within the lumens of the body.

    摘要翻译： 介绍了外科手术或医疗手术的装置。 该装置通常为气球的形式，并且用于将自身或其它工作元件向上或靠近身体中的腔壁定位。 气囊由至少两种不同弹性模量的材料组成，其允许气囊的柔性但相对不扩张的展开部件以及气囊的弹性的，可充气的部件。 弹性体部件固定地附接到柔性但相对不扩张的部件上，并且它们一起形成可以在体内的腔内膨胀的压力容器。

    PERIVASCULAR ANTI-INFLAMMATORY THERAPY FOR VENOUS THROMBOSIS
    15.
    发明申请
    PERIVASCULAR ANTI-INFLAMMATORY THERAPY FOR VENOUS THROMBOSIS 有权

    公开(公告)号：US20220105108A1

    公开(公告)日：2022-04-07

    申请号：US17491036

    申请日：2021-09-30

    申请人： Mercator MedSystems, Inc.

    发明人： Kirk P. SEWARD

    IPC分类号： A61K31/573 ,  A61K9/00 ,  A61P7/04

    摘要： Disclosed herein are methods, devices, systems, and kits for reducing inflammation and rate of progression to post-thrombotic syndrome (PTS) in individuals who have experienced venous thrombosis. Provided herein are approaches for local delivery of therapeutic agents to reduce inflammation and resolve clotting in affected veins in limbs. A catheter is positioned within the affected vein, and a composition comprising one or more therapeutic agents is injected into the perivenous tissue through the wall of the vein. The puncturing to inject may be achieved by an expanding balloon on the distal end of the catheter.

    Methods and systems for inhibiting vascular inflammation
    16.
    发明授权
    Methods and systems for inhibiting vascular inflammation 有权

    公开(公告)号：US10441747B2

    公开(公告)日：2019-10-15

    申请号：US14605865

    申请日：2015-01-26

    申请人： Mercator MedSystems, Inc.

    发明人： Kirk Patrick Seward

    IPC分类号： A61M25/00 ,  A61M37/00 ,  A61M25/10 ,  A61L29/16 ,  A61L31/16 ,  A61M5/158 ,  A61B5/01 ,  A61B5/021 ,  A61B5/053 ,  A61B5/145 ,  A61B5/00

    摘要： Methods and kits for delivering pharmaceutical agents to an adventitia and other regions outside an external elastic lamina (EEL) surrounding a blood vessel utilize a catheter having a needle. The needle is positioned in up to 5 mm beyond the EEL and delivers an amount of a pharmaceutical agent sufficient to circumferentially permeate around the blood vessel and, in many cases, extend longitudinally and radially along the blood vessel. Confirmation that a delivery aperture of the needle lies beyond the EEL may be required before delivering the pharmaceutical agent. In one example, catheters are used to deliver dexamethasone and other anti-inflammatory agents to a peripheral vasculature and other vasculature to treat peripheral vascular disease and other conditions.