公开(公告)号：US10945881B1

公开(公告)日：2021-03-16

申请号：US16720094

申请日：2019-12-19

Applicant: PAOLO GOBBI FRATTINI S.R.L.

Inventor： Paolo Giuseppe Gobbi Frattini

IPC: A61F9/00 ,  A61J1/14 ,  A61J1/20

Abstract: A plural-use drop-by-drop dispenser for sterile liquid product comprises a vial (1) for containment of the liquid product (2) and a connector (4) provided with a plug (8) which is normally hermetically closed and with a cartridge (19) with sterilizing filter (24) which can be axially moved to force open said plug (8) to dispense the liquid product and allow the hermetic reclosure thereof at the end of dispensing. The cartridge (19) is provided with a filter-holding bottom element (25) provided with a dispensing spout (26), possibly in antimicrobic material, with elastically flexible converging lips (27), which open under pressure of the liquid product (2) for drop-by-drop dispensing thereof and elastically hermetically reclose at the end of the dispensing operation.

公开(公告)号：US20230147763A1

公开(公告)日：2023-05-11

申请号：US17983550

申请日：2022-11-09

Applicant: Paolo Gobbi Frattini S.R.L.

Inventor： Paolo Giuseppe GOBBI FRATTINI

IPC: A61J1/20

CPC classification number: A61J1/2096 ,  A61J1/2006 ,  A61J1/2037

Abstract: A preassembled component (1) for connectable element assembly for the reconstitution of fluid drugs and nutrients with active substances in powder, liquid or gel form, consists of a female connector (2) with a hermetic closing valve (8) openable by pressure and automatically hermetically reclosable upon the removal of the pressure, which is directly fastened to a coupling and piercing device (3) for vials or the like.

公开(公告)号：US10123939B2

公开(公告)日：2018-11-13

申请号：US15248353

申请日：2016-08-26

Applicant: PAOLO GOBBI FRATTINI S.R.L.

Inventor： Paolo Giuseppe Gobbi Frattini

IPC: A61M5/32 ,  A61J1/14 ,  B01L3/00 ,  B65D51/00 ,  A61J1/20

Abstract: A closing plug for a sealed sterile vial containing medical or nutritional active substances, which is suitable for the sterile connection to a container of liquid diluent solution. There is also described a sterile connection system between a sealed sterile vial closed by means of a plug and a tube for drawing said active substances, for mixing them with a liquid diluent solution inside a sterile container. The plug requires an internal sterile chamber in which, upon the piercing of an outer film for sealing the plug, a compressible protection cap of a piercing tip of the tube is inserted, which abuts against a seat of the sterile chamber allowing the tip to pierce the end wall of the protection cap and then the inner membrane of the closing plug. An intermediate pierceable membrane placed on the seat of the internal chamber of the vial may be included.

公开(公告)号：US09988601B2

公开(公告)日：2018-06-05

申请号：US15027709

申请日：2014-10-06

Applicant: Paolo Gobbi Frattini S.R.L.

Inventor： Paolo Giuseppe Gobbi Frattini

IPC: C12N5/00 ,  C12N5/078 ,  G01N33/50 ,  B01D21/26

CPC classification number: C12N5/0634 ,  B01D21/26 ,  G01N33/5002

Abstract: The present invention relates to a method for retrieving more numerous, viable and efficient stem cells from the blood of a patient. The method comprises a preliminary step of pre-treating blood cells using an oxygen-ozone mixture and a subsequent step of separating the stem cells from said pre-treated blood cells.

公开(公告)号：US20170100307A1

公开(公告)日：2017-04-13

申请号：US15287235

申请日：2016-10-06

Applicant: PAOLO GOBBI FRATTINI S.R.L.

Inventor： Paolo Giuseppe GOBBI FRATTINI

IPC: A61J1/20 ,  A61J1/14 ,  A61J1/10

CPC classification number: A61J1/2093 ,  A61J1/10 ,  A61J1/1406 ,  A61J1/1475 ,  A61J1/1481 ,  A61J1/1487 ,  A61J1/201 ,  A61J1/2027 ,  A61J1/2051 ,  A61J1/2055 ,  A61J1/2065 ,  A61J1/2089 ,  B65D81/3266

Abstract: There is described a package for the reconstitution and administration of fluid medicinal or nutritional substances which are infused or instillable within the body of a patient, comprising a flexible casing containing a vial of a medicinal or nutritional substance in a coupling position to a coupling and perforation device inserted into a mixing tube for the connection with a bag of liquid diluent. The casing comprises a connector provided with an openable and hermetically closable cap, adapted to introduce a mixture of sterilizing gas and oxygen into said casing.

公开(公告)号：US20170056288A1

公开(公告)日：2017-03-02

申请号：US15248353

申请日：2016-08-26

Applicant: PAOLO GOBBI FRATTINI S.R.L.

Inventor： Paolo Giuseppe GOBBI FRATTINI

IPC: A61J1/14 ,  A61J1/20

CPC classification number: A61J1/1412 ,  A61J1/1406 ,  A61J1/20 ,  A61J1/201 ,  A61J1/2055 ,  B01L3/50825 ,  B01L2300/044 ,  B65D51/002

Abstract: A closing plug for a sealed sterile vial containing medical or nutritional active substances, which is suitable for the sterile connection to a container of liquid diluent solution. There is also described a sterile connection system between a sealed sterile vial closed by means of a plug and a tube for drawing said active substances, for mixing them with a liquid diluent solution inside a sterile container. The plug requires an internal sterile chamber in which, upon the piercing of an outer film for sealing the plug, a compressible protection cap of a piercing tip of the tube is inserted, which abuts against a seat of the sterile chamber allowing the tip to pierce the end wall of the protection cap and then the inner membrane of the closing plug. An intermediate pierceable membrane placed on the seat of the internal chamber of the vial may be included.

Abstract translation: 用于密封的灭菌小瓶的封闭塞，其包含医疗或营养活性物质，其适用于与液体稀释剂溶液的容器的无菌连接。 还描述了在通过塞子封闭的密封的无菌小瓶和用于拉伸所述活性物质的管之间的无菌连接系统，以将它们与无菌容器内的液体稀释剂溶液混合。 塞子需要内部的无菌室，其中在穿过用于密封塞子的外部膜的穿孔时，插入管的穿刺尖端的可压缩保护帽，其抵靠无菌室的座，允许尖端刺穿 保护盖的端壁，然后是封闭塞的内膜。 可以包括放置在小瓶的内室的座上的中间可穿透膜。