公开(公告)号：US20150079004A1

公开(公告)日：2015-03-19

申请号：US14397240

申请日：2013-04-19

申请人： NESTEC S.A.

发明人： Michael Jedwab ,  Adam Burbidge ,  Kala Marie Kaspar ,  Julie Ann Swanson

IPC分类号： A61K31/723 ,  A23L2/52 ,  A23L1/054

CPC分类号： A61K31/723 ,  A23L2/52 ,  A23L29/27 ,  A23L33/10 ,  A23V2002/00 ,  A61K31/718 ,  A61K2300/00 ,  A23V2200/32 ,  A23V2250/5086

摘要： In a general embodiment, a method for increasing efficacy of a swallow response is provided. The method includes providing a thickened composition having a xanthan gum thickening component, and orally administering the composition to an individual having, or at risk of having, a swallowing impairment. In an embodiment, the efficacy of the swallow response is increased by reducing an amount of pharyngeal residue in the individual's piriform sinuses, valleculae, and/or pharyngeal wall during or after the individual swallows the composition.

摘要翻译： 在一般的实施方案中，提供了一种增加吞咽反应功效的方法。 该方法包括提供具有黄原胶增稠组分的增稠组合物，并将该组合物口服给具有或具有吞咽损伤风险的个体。 在一个实施方案中，通过在个体吞咽组合物期间或之后减少个体的梨状鼻窦，胆囊和/或咽壁中的咽残留量来增加吞咽反应的功效。

公开(公告)号：US20130309266A1

公开(公告)日：2013-11-21

申请号：US13993712

申请日：2011-12-16

申请人： Jonathan Albert Margossian ,  Nicolas Pradeau ,  Yannick Fallourd

发明人： Jonathan Albert Margossian ,  Nicolas Pradeau ,  Yannick Fallourd

IPC分类号： A23L1/29 ,  A61K31/717 ,  A61K31/723 ,  A61K31/732

CPC分类号： A61K31/732 ,  A23L29/231 ,  A23L29/238 ,  A23L29/262 ,  A23L29/27 ,  A23L33/21 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/717 ,  A61K31/723 ,  A23V2200/244 ,  A23V2250/50724 ,  A23V2250/5086

摘要： The invention relates to compositions intended for reducing, ideally for eliminating, regurgitation and/or gastro-oesophageal reflux phenomena affecting a subject. Anti-regurgitation and/or anti-reflux infant formulas and milks intended for feeding newborn babies, infants and young children are more particularly described.

公开(公告)号：US08563029B2

公开(公告)日：2013-10-22

申请号：US12049546

申请日：2008-03-17

申请人： Wai Cheuk ,  Christina Khoo

发明人： Wai Cheuk ,  Christina Khoo

IPC分类号： A61K47/00

CPC分类号： A61K31/715 ,  A23K20/163 ,  A23K50/40 ,  A61K31/716 ,  A61K31/717 ,  A61K31/719 ,  A61K31/721 ,  A61K31/723 ,  A61K31/734 ,  A61K31/736 ,  A61K45/06 ,  A61K47/36 ,  H04L25/03834 ,  H04L27/2017

摘要： Compositions (including pharmaceutical compositions, foods, supplements, toys and treats) comprising a microbial exopolysaccharide are provided as well as methods for preventing or reducing diarrhea in a mammal wherein the method comprises administering a therapeutically amount of a microbial exopolysaccharide to a mammal in need thereof.

摘要翻译： 提供了包含微生物外多糖的组合物（包括药物组合物，食品，补充剂，玩具和治疗剂）以及用于预防或减少哺乳动物腹泻的方法，其中所述方法包括向有需要的哺乳动物施用治疗量的微生物外多糖 。

公开(公告)号：US08445461B2

公开(公告)日：2013-05-21

申请号：US12448804

申请日：2007-01-10

申请人： Setsuko Takeda

发明人： Setsuko Takeda

IPC分类号： A61K31/715 ,  A61K31/723 ,  A61K31/729 ,  A61K31/732

CPC分类号： A61K9/0046 ,  A61K9/06 ,  A61K31/047 ,  A61K31/702 ,  A61K31/715 ,  A61K31/717 ,  A61K31/723 ,  A61K31/729 ,  A61K31/731 ,  A61K31/732 ,  A61K31/734 ,  A61K45/06 ,  A61K47/26 ,  A61K47/36

摘要： The present invention provides pharmaceutical composition for treating Meniere's disease, comprising saccharides or sugar alcohols as an active ingredient and polysaccharides, wherein the ratio by weight of the saccharides or sugar alcohols to the polysaccharides is about 100:2 to 100:50. The pharmaceutical composition of the present invention may eliminate the cathartic effect caused by saccharides or sugar alcohols to ensure the endolymphatic hydrops decompression effect. Therefore the effect of the therapeutic composition of the present invention is improved. The pharmaceutical composition may provide in gel, powder, granule form or the like.

摘要翻译： 本发明提供用于治疗梅尼埃病的药物组合物，其包含糖或糖醇作为活性成分和多糖，其中糖类或糖醇与多糖的重量比为约100:2至100:50。 本发明的药物组合物可以消除由糖或糖醇引起的通气作用，以确保内淋巴水肿减压作用。 因此，本发明的治疗组合物的效果提高。 药物组合物可以提供凝胶，粉末，颗粒形式等。

公开(公告)号：US08445044B2

公开(公告)日：2013-05-21

申请号：US12596217

申请日：2008-05-06

申请人： Douglas A. Stetzer

发明人： Douglas A. Stetzer

IPC分类号： A23B7/157 ,  A23L1/05

CPC分类号： A23L1/0541 ,  A23B7/157 ,  A23L2/52 ,  A23L29/20 ,  A23L29/27 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/723 ,  A61K47/02 ,  C12C5/02 ,  C12G1/00 ,  C12G3/04 ,  C12G2200/21 ,  A23V2200/242 ,  A23V2250/5086 ,  A23V2200/10 ,  A23V2250/51086 ,  A23V2200/32

摘要： The invention provides a food and water thickener and a method for preparing the food and water thickener. The food thickener comprises pretreated mineral water, xanthan, food preservative, a first antimicrobial and chelating agent, and a sequestering agent, wherein the food thickener has a density of between 750 and 1250 grams per liter. The method for producing the thickener incorporates pretreatment of mineral water and xanthan, and specific heating steps. Also provided is method for producing thickened alcoholic beverages. The invention further provides a method for invoking a swallow response in dysphagic patients, the method comprising increasing the mass of food to between 750 mg per liter and 1500 mg per liter; and orally administering the food to dysphagic patients.

摘要翻译： 本发明提供食品和水增稠剂及其制备方法。 食品增稠剂包括预处理的矿泉水，黄原胶，食品防腐剂，第一抗微生物剂和螯合剂和螯合剂，其中食品增稠剂的密度为750至1250克/升。 生产增稠剂的方法包括矿泉水和黄原胶的预处理，以及特定的加热步骤。 还提供了生产增稠酒精饮料的方法。 本发明还提供了一种在吞咽障碍患者中调用吞咽反应的方法，该方法包括将食物的质量提高至750mg /升至1500mg /升; 并将食物口服给吞咽障碍患者。

公开(公告)号：US07875271B2

公开(公告)日：2011-01-25

申请号：US12225255

申请日：2007-03-23

申请人： Koji Doi ,  Hiroshi Aki

发明人： Koji Doi ,  Hiroshi Aki

IPC分类号： A61K31/74

CPC分类号： A61K9/0048 ,  A61K31/7004 ,  A61K31/723 ,  A61K2300/00

摘要： The present invention provides an ophthalmic composition containing xanthan gum and glucose, which has a superior corneal epithelial disorder-treating effect.

摘要翻译： 本发明提供含有黄原胶和葡萄糖的眼用组合物，其具有优异的角膜上皮病症治疗作用。

公开(公告)号：US20080139502A1

公开(公告)日：2008-06-12

申请号：US12031483

申请日：2008-02-14

申请人： Maria Grazia Mazzone ,  Grazia Paladino ,  Clara Marino ,  Ornella Peri ,  Vincenzo Enea

发明人： Maria Grazia Mazzone ,  Grazia Paladino ,  Clara Marino ,  Ornella Peri ,  Vincenzo Enea

IPC分类号： A61K31/723 ,  A61P17/02

CPC分类号： A61K31/723 ,  A61K9/0048 ,  A61K9/06 ,  A61K31/573 ,  A61K31/661 ,  A61K31/7036 ,  A61K31/715 ,  A61K31/728 ,  A61K47/36 ,  A61K2300/00

摘要： The present invention relates to the use of xanthan gum as re-epithelializing agent and, in particular, to a pharmaceutical formulation comprising xanthan gum as a re-epithelializing active principle eventually mixed with hyaluronic acid. Said use and composition speed up and improve advantageously the formation of newly grown epithelium.

摘要翻译： 本发明涉及黄原胶作为再上皮剂，尤其涉及包含黄原胶作为最终与透明质酸混合的再上皮化活性成分的药物制剂的用途。 所述使用和组合物加速并有利地改善新生的上皮的形成。

公开(公告)号：US20050202983A1

公开(公告)日：2005-09-15

申请号：US10799521

申请日：2004-03-12

申请人： Erning Xia ,  Joseph Salamone ,  David McCanna

发明人： Erning Xia ,  Joseph Salamone ,  David McCanna

IPC分类号： A61K9/00 ,  A61K31/70 ,  A61K31/7004 ,  A61K31/7016 ,  A61K31/702 ,  A61K31/715 ,  A61K31/717 ,  A61K31/721 ,  A61K31/723 ,  A61K31/726 ,  A61K31/728 ,  A61K31/729 ,  A61K31/731 ,  A61K31/732 ,  A61K31/734 ,  A61K31/736 ,  C11D3/00 ,  C11D3/22 ,  G02B1/12

CPC分类号： A61K31/70 ,  A61K31/7004 ,  A61K31/7016 ,  A61K31/702 ,  A61K31/715 ,  A61K31/717 ,  A61K31/721 ,  A61K31/723 ,  A61K31/726 ,  A61K31/728 ,  A61K31/729 ,  A61K31/731 ,  A61K31/732 ,  A61K31/734 ,  A61K31/736 ,  C11D3/0078 ,  C11D3/222

摘要： Compositions are described which are useful in preventing the loss of tight epithelial cell junctions upon topical application. Such compositions include one or more carbohydrates in an amount effective to prevent the loss of tight cell junctions and hence improve the management of tissue health.

摘要翻译： 描述了可用于在局部施用时防止紧密上皮细胞连接丧失的组合物。 这样的组合物包括一种或多种碳水化合物，其量有效地防止紧密细胞连接的丧失，从而改善组织健康的管理。

公开(公告)号：US20180332873A1

公开(公告)日：2018-11-22

申请号：US16043899

申请日：2018-07-24

申请人： Kent Precision Foods Group, Inc.

发明人： Douglas A. Stetzer

IPC分类号： A23L2/52 ,  A61K31/723 ,  A23L33/00 ,  A23L29/20 ,  A23L29/269 ,  C12G3/04 ,  C12G1/00 ,  C12C5/02 ,  A23B7/157 ,  A61K47/02

CPC分类号： A23L2/52 ,  A23B7/157 ,  A23L29/20 ,  A23L29/27 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/723 ,  A61K47/02 ,  C12C5/02 ,  C12G1/00 ,  C12G3/04 ,  C12G2200/21 ,  A23V2200/242 ,  A23V2250/5086 ,  A23V2200/10 ,  A23V2250/51086 ,  A23V2200/32

摘要： The invention provides a food and water thickener and a method for preparing the food and water thickener. The food thickener comprises pretreated mineral water, xanthan, food preservative, a first antimicrobial and chelating agent, and a sequestering agent, wherein the food thickener has a density of between 750 and 1250 grams per liter. The method for producing the thickener incorporates pretreatment of mineral water and xanthan, and specific heating steps. Also provided is method for producing thickened alcoholic beverages. The invention further provides a method for invoking a swallow response in dysphagic patients, the method comprising increasing the mass of food to between 750 mg per liter and 1500 mg per liter; and orally administering the food to dysphagic patients.

公开(公告)号：US20180177820A1

公开(公告)日：2018-06-28

申请号：US15739229

申请日：2016-10-13

申请人： TECHNO GUARD CO. LTD.

发明人： Kiichiro NABETA

IPC分类号： A61K31/728 ,  A61K9/14 ,  A61K31/192 ,  A61K31/196 ,  A61K31/573 ,  A61K9/00

CPC分类号： A61K31/728 ,  A61K9/0007 ,  A61K9/0053 ,  A61K9/0065 ,  A61K9/143 ,  A61K9/145 ,  A61K9/146 ,  A61K9/2009 ,  A61K9/2031 ,  A61K9/485 ,  A61K9/4866 ,  A61K31/047 ,  A61K31/192 ,  A61K31/196 ,  A61K31/573 ,  A61K31/722 ,  A61K31/723 ,  A61K31/726 ,  A61K33/10 ,  A61P1/00 ,  A61K2300/00

摘要： An object of the present invention is to provide a protective composition for gastrointestinal mucosa, for example, for inhibiting occurrence of a gastrointestinal mucosa disorder when an oral drug that induces the gastrointestinal mucosa disorder is taken. The protective composition for gastrointestinal mucosa of the present invention as a resolution for achieving the object is characterized by comprising at least a macromolecular polysaccharide, sodium hydrogen carbonate and/or magnesium carbonate, and a polyhydric alcohol. According to the protective composition for gastrointestinal mucosa of the present invention, sodium hydrogen carbonate or magnesium carbonate foams through contact with a gastric juice in stomach to thereby generate diffusing power for the macromolecular polysaccharide. This power can allow the macromolecular polysaccharide to quickly dissolve or disperse in the gastric juice and allow the macromolecular polysaccharide to effectively exert a gastric mucosa protective action. In addition, the macromolecular polysaccharide dissolved or dispersed in the gastric juice moves into intestine without degradation in stomach, then dissolves in an intestinal juice having a neutral or alkaline pH, and exerts an intestinal mucosa protective action without degradation also in intestine. The polyhydric alcohol plays a role as a dispersion medium for the macromolecular polysaccharide and sodium hydrogen carbonate or magnesium carbonate which are powder, or enables formulation of the protective composition for gastrointestinal mucosa of the present invention into various dosage forms, according to the nature and use amount thereof.