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公开(公告)号：US5714643A
公开(公告)日：1998-02-03
申请号：US596131
申请日：1996-02-09
申请人： Kiyoshi Sato , Makoto Yoshida , Kenji Kanbe , Kiyoshi Hirazawa , Tomio Takeuchi
发明人： Kiyoshi Sato , Makoto Yoshida , Kenji Kanbe , Kiyoshi Hirazawa , Tomio Takeuchi
CPC分类号： C07C35/16 , C07C29/10 , C07B2200/07 , C07C2101/14
摘要： An aqueous solution of kasugamycin or its salt is either mixed with a strongly acidic ion-exchange resin of the H.sup.+ -form in a reaction vessel, or is brought into contact with a strongly acidic ion-exchange resin of the H.sup.+ -form in a column containing said resin, followed by heating said aqueous solution and the resin under an atmospheric pressure or an elevated pressure, thereby to effect hydrolytic reaction of kasugamycin. By this reaction, an acidic reaction solution containing D-chiro-inositol is produced. This acidic reaction solution containing D-chiro-inositol is separated from the strongly acidic ion-exchange resin. Subsequently, D-chiro-inositol is recovered from the reaction solution. For this recovery, the acidic reaction solution is passed successively through a column of a strongly acidic ion-exchange resin of the H.sup.+ -form and through a column of a strongly basic ion exchange resin of the OH.sup.- -form, so that a neutral aqueous eluate containing D-chiro-inositol is obtained. This neutral aqueous eluate is then concentrated and crystals of D-chiro-inositol are made to deposit, whereby D-chiro-inositol of a high purity can be harvested with high efficiency.
摘要翻译： PCT No.PCT / JP94 / 01304第 371日期1996年2月9日 102（e）日期1996年2月9日PCT 1994年8月8日PCT PCT。 公开号WO95 / 04711 日期1995年2月16日将春日霉素或其盐的水溶液与H +型的强酸性离子交换树脂在反应容器中混合，或与H +型强酸离子交换树脂接触， - 在含有所述树脂的柱中，然后在大气压或高压下加热所述水溶液和树脂，从而进行春日霉素的水解反应。 通过该反应，生成含有D-手性肌醇的酸性反应液。 从强酸性离子交换树脂中分离含有D-手性肌醇的酸性反应溶液。 随后，从反应溶液中回收D-手性肌醇。 对于这种回收，酸性反应溶液依次通过H +型强酸性离子交换树脂柱，并通过OH-形式的强碱性离子交换树脂柱，使得中性水性 得到含有D-手性肌醇的洗脱液。 然后将该中性水性洗脱液浓缩，并使D-手性肌醇晶体沉积，从而高效率地收获高纯度的D-手性肌醇。
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公开(公告)号：US5600014A
公开(公告)日：1997-02-04
申请号：US410477
申请日：1995-03-24
申请人： Tomas Hudlicky , Martin Mandel
发明人： Tomas Hudlicky , Martin Mandel
IPC分类号： C07D317/64 , C07C29/10 , C07C29/145 , C07C35/16 , C07C45/42 , C07C45/59 , C07C49/497 , C07D317/46 , C07D493/04 , C07D493/14
CPC分类号： C07D493/04 , C07C29/145 , C07C35/16 , C07D317/46 , C07D493/14 , C07C2101/14
摘要： There are described novel biocatalytic and chemical processes for the synthesis of various oxygenated compounds. Particularly, there are described processes for the synthesis of a useful synthon 12 made by reacting a protected diol (acetonide) with permaganate under appropriate conditions. Such synthon is useful of the synthesis of various pharmaceutically important compounds such as D-chiro-inositol and D-chiro-3-inosose. Also, there are disclosed novel compounds, including specifically the synthon 12 and compounds derived therefrom.
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公开(公告)号：US5574180A
公开(公告)日：1996-11-12
申请号：US284826
申请日：1994-08-01
申请人： Donald McQuigg , Charles Marston , Gina Fitzpatrick , Ernest Crowe , Susan Vorhies , Ramiah Murugan , Thomas D. Bailey
发明人： Donald McQuigg , Charles Marston , Gina Fitzpatrick , Ernest Crowe , Susan Vorhies , Ramiah Murugan , Thomas D. Bailey
IPC分类号： C07C29/09 , C07C35/16 , C07C51/43 , C07C51/47 , C07C59/08 , C07F9/117 , C07C51/42 , C07C59/48 , C07C65/10
摘要： Described is a process for recovering phytic acid or phytic acid salt from a medium in which it is contained. This process includes contacting the medium with a solid-phase free base polymer having tertiary amine functions to adsorb the phytic acid or salt thereof. In one preferred mode, the medium to be treated also contains lactic acid, and separate fractions predominant in (i) lactic acid and (ii) phytic acid or phytic acid salt, respectively, are recovered. Also described are preferred processes for treating mediums to recover lactic acid therefrom, and a favored process for obtaining inositol directly by hydrolyzing phytic acid or phytic acid salt while adsorbed on a pyridine-containing polymer.
摘要翻译： 描述了从其所含的培养基中回收植酸或植酸盐的方法。 该方法包括使培养基与具有叔胺官能团的固相游离碱基聚合物接触以吸附植酸或其盐。 在一种优选方式中，待处理的培养基还含有乳酸，分别在（i）乳酸和（ii）植酸或植酸盐中分别占优势的分离馏分。 还描述了用于处理介质以回收乳酸的优选方法，以及用于通过在吸附在含吡啶的聚合物上水解植酸或植酸盐直接获得肌醇的有利方法。
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公开(公告)号：US20240158824A1
公开(公告)日：2024-05-16
申请号：US18422779
申请日：2024-01-25
申请人： Sweet Sense Inc.
发明人： Daryl THOMPSON
IPC分类号： C12P19/12 , A23L29/30 , A23L33/125 , A61K31/047 , A61K31/7016 , A61P3/10 , C07C35/16 , C13K1/00 , C13K11/00 , C13K13/00
CPC分类号： C12P19/12 , A23L29/30 , A23L33/125 , A61K31/047 , A61K31/7016 , A61P3/10 , C07C35/16 , C13K1/00 , C13K11/00 , C13K13/00 , A23V2002/00
摘要： A composition includes a sugar source and inositol. The sugar source is one more sugars select from the group consisting of glucose, sucrose, sucrolose, tagatose, galactose, high fructose corn syrup, fructose, isoglucose, and rhamnose. The composition of sugar and inositol has an unique properties that prevents or limits the signaling of TNF-α and associated pro-inflammatory cytokines when metabolized by an individual consuming the composition. Accordingly, the composition can be advantageously used to control blood glucose levels, treat diabetes and related conditions as well as treat diseases based on an inflammatory response.
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公开(公告)号：US20110263878A1
公开(公告)日：2011-10-27
申请号：US13108651
申请日：2011-05-16
IPC分类号： C07D311/80 , C07C315/00 , C07F9/02 , C07C381/00 , C07F7/02 , C07C43/18
CPC分类号： C07C29/00 , C07C37/16 , C07C67/343 , C07C2601/16 , C07C35/16 , C07C39/23 , C07C69/94
摘要： The present invention relates to a process for preparation of a delta-9-tetrahydrocannabinol compound or derivative thereof involving treating a first intermediate compound with an organoaluminum-based Lewis acid catalyst, under conditions effective to produce the delta-9-tetrahydrocannabinol compound or derivative thereof. Another aspect of the present invention relates to a process for preparation of a cannabidiol or cannabidiolate compound involving reacting a first starting compound with a second starting compound in the presence of a metal triflate catalyst, under conditions effective to form the cannabidiol or cannabidiolate compound. The present invention also relates to a compound of the formula: where R8, R9, and R10 are the same or different and independently selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or halo, with R1, R2, and R3 defined herein.
摘要翻译： 本发明涉及一种制备δ-9-四氢大麻酚化合物或其衍生物的方法，包括在有效制备δ-9-四氢大麻酚化合物或其衍生物的条件下，用有机铝基路易斯酸催化剂处理第一中间体化合物 。 本发明的另一方面涉及制备大麻二醇或大麻二酸化合物的方法，包括在金属三氟甲磺酸酯催化剂存在下，在有效形成大麻二醇或大麻二醇化合物的条件下使第一起始化合物与第二起始化合物反应。 本发明还涉及下式化合物：其中R 8，R 9和R 10相同或不同且独立地选自H，取代或未取代的烷基，取代或未取代的芳基，取代或未取代的杂芳基，或 卤素，其中R 1，R 2和R 3定义如下。
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公开(公告)号：US20070093665A1
公开(公告)日：2007-04-26
申请号：US11529147
申请日：2006-09-28
申请人： David Burdick , Steven Collier , Frederic Jos , Betina Biolatto , Bernhard Paul , Harold Meckler , Mark Helle , Alicia Habershaw
发明人： David Burdick , Steven Collier , Frederic Jos , Betina Biolatto , Bernhard Paul , Harold Meckler , Mark Helle , Alicia Habershaw
IPC分类号： C07D311/80
CPC分类号： C07C29/00 , C07C37/16 , C07C67/343 , C07C2601/16 , C07C35/16 , C07C39/23 , C07C69/94
摘要： The present invention relates to a process for preparation of a delta-9-tetrahydrocannabinol compound or derivative thereof involving treating a first intermediate compound with an organoaluminum-based Lewis acid catalyst, under conditions effective to produce the delta-9-tetrahydrocannabinol compound or derivative thereof. Another aspect of the present invention relates to a process for preparation of a cannabidiol or cannabidiolate compound involving reacting a first starting compound with a second starting compound in the presence of a metal triflate catalyst, under conditions effective to form the cannabidiol or cannabidiolate compound. The present invention also relates to a compound of the formula: where R8, R9, and R10 are the same or different and independently selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or halo, with R1, R2, and R3 defined herein.
摘要翻译： 本发明涉及一种制备δ-9-四氢大麻酚化合物或其衍生物的方法，包括在有效制备δ-9-四氢大麻酚化合物或其衍生物的条件下，用有机铝基路易斯酸催化剂处理第一中间体化合物 。 本发明的另一方面涉及制备大麻二醇或大麻二酸化合物的方法，包括在金属三氟甲磺酸酯催化剂存在下，在有效形成大麻二醇或大麻二醇化合物的条件下使第一起始化合物与第二起始化合物反应。 本发明还涉及下式的化合物：其中R 8，R 9和R 10是相同或不同的且独立地 选自H，取代或未取代的烷基，取代或未取代的芳基，取代或未取代的杂芳基或卤素，R 1，R 2和R 2， 本文定义的SUB> 3 。
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公开(公告)号：US06770757B2
公开(公告)日：2004-08-03
申请号：US09967183
申请日：2001-09-28
申请人： Hannu Paananen , Jarmo Kuisma , Vili Ravanko , Nina Mayra , Heikki Heikkila , Jari Lewandowski
发明人： Hannu Paananen , Jarmo Kuisma , Vili Ravanko , Nina Mayra , Heikki Heikkila , Jari Lewandowski
IPC分类号： C07G1700
CPC分类号： C13B35/06 , B01J39/07 , B01J39/26 , C07C29/76 , C07C227/28 , C07C2601/14 , C13B20/144 , C13B30/02 , C13K13/00 , C07C229/12 , C07C31/225 , C07C31/24 , C07C31/26 , C07C35/16
摘要： The invention relates to a method comprising a multistep process for recovering betaine, erythritol, inositol, sucrose, mannitol, glycerol and amino acids from corresponding starting materials. The invention comprises the use of a weakly acid cation exchange resin in chromatographic column in the multistep process. The starting materials are especially beet molasses, betaine molasses, syrups, thick juices, raw juices, corn steep cane based solutions and glycerol.
摘要翻译： 本发明涉及一种方法，该方法包括从相应起始原料中回收甜菜碱，赤藓糖醇，肌醇，蔗糖，甘露糖醇，甘油和氨基酸的多步法。 本发明包括在多步骤过程中在色谱柱中使用弱酸阳离子交换树脂。 起始材料特别是甜菜糖蜜，甜菜碱糖蜜，糖浆，浓稠果汁，生果汁，玉米枸杞子溶液和甘油。
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公开(公告)号：US5932774A
公开(公告)日：1999-08-03
申请号：US539424
申请日：1995-11-06
IPC分类号： C07C29/09 , C07C35/16 , C07C69/013
CPC分类号： C07C69/013 , C07C29/095 , C07C35/16 , C07C2101/14
摘要： A method for the preparation of D-chiro-inositol from kasugamycin, comprising the steps of: (a) reacting kasugamycin with an acetylating agent to form a crude hexa-acetate intermediate; (b) purifying the crude intermediate to form purified hexa-acetate intermediate; (c) deacetylating the purified intermediate to form D-chiro-inositol; and (d) isolating the D-chiro-inositol. The method permits efficient, large-scale preparation of D-chiro-inositol without the need for extensive chromatographic purification of the final D-chiro-inositol product.
摘要翻译： 一种从春雷霉素制备D-手性肌醇的方法，包括以下步骤：（a）使春日霉素与乙酰化试剂反应形成六醋酸中间体中间体; （b）纯化粗中间体以形成纯化的六醋酸酯中间体; （c）将纯化的中间体脱乙酰以形成D-手性肌醇; 和（d）分离D-手性肌醇。 该方法可有效，大规模地制备D-手性肌醇，而不需要对最终D-手性肌醇产品进行广泛的色谱纯化。
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公开(公告)号：US5516950A
公开(公告)日：1996-05-14
申请号：US389709
申请日：1995-02-14
IPC分类号： C07C29/10 , C07C29/143 , C07C35/16 , C07C45/00 , C07C49/497 , C07C35/18
CPC分类号： C07C49/497 , C07C29/103 , C07C29/143 , C07C35/16 , C07C45/00 , C12C11/02 , C07B2200/07 , C07C2101/14 , Y02P20/55
摘要： The present invention relates to the synthesis of D-chiroinositol from a dialdose, comprising the steps of condensing the dialdose by an acyloin condensation reaction to form an inosose, protecting the carbon atoms at the 2, 3, 4 and 5 positions, reducing the ketone of the inosose and removing the protecting groups. In addition, a method of preparing mannodialdose from mannuronic acid is disclosed.
摘要翻译： 本发明涉及由二糖合成D-二羟基肌醇，其包括以下步骤：通过偶姻缩合反应缩合二糖以形成肌苷，保护2,3,4和5位上的碳原子，还原酮 的去污保护基团。 另外，公开了从甘露糖醛酸制备甘露糖多糖的方法。
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公开(公告)号：US5463142A
公开(公告)日：1995-10-31
申请号：US337656
申请日：1994-11-10
IPC分类号： C07C29/09 , C07C35/16 , C07C69/013
CPC分类号： C07C29/09 , C07C35/16 , C07C69/013 , C07B2200/07 , C07C2101/14
摘要： A method for the preparation of D-chiro-inositol from kasugamycin, comprising the steps of:(a) reacting kasugamycin with an acetylating agent to form a crude hexa-acetate intermediate;(b) purifying the crude intermediate to form purified hexa-acetate intermediate;(c) deacetylating the purified intermediate to form D-chiro-inositol; and(d) isolating the D-chiro-inositol.The method permits efficient, large-scale preparation of D-chiro-inositol without the need for extensive chromatographic purification of the final D-chiro-inositol product.
摘要翻译： 一种从春雷霉素制备D-手性肌醇的方法，包括以下步骤：（a）使春日霉素与乙酰化试剂反应形成六醋酸中间体中间体; （b）纯化粗中间体以形成纯化的六醋酸酯中间体; （c）将纯化的中间体脱乙酰以形成D-手性肌醇; 和（d）分离D-手性肌醇。 该方法可有效，大规模地制备D-手性肌醇，而不需要对最终D-手性肌醇产品进行广泛的色谱纯化。
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