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11.发明申请PREPARATION OF 7-DEHYDROCHOLESTEROL AND/OR THE BIOSYNTHETIC INTERMEDIATES AND/OR SECONDARY PRODUCTS THEREOF IN TRANSGENIC ORGANISMS 审中-公开7-脱氢胆甾醇和/或其生物合成中间体和/或其在转基因生物中的二次产物的制备公开(公告)号：US20150353980A1
公开(公告)日：2015-12-10
申请号：US14583418
申请日：2014-12-26
Applicant: Christine Lang , Markus Veen
Inventor： Christine Lang , Markus Veen
CPC classification number: C12P33/00 , C12N9/0004 , C12N9/0006 , C12N9/001 , C12N9/0071 , C12N9/0073 , C12N9/1007 , C12N9/90 , C12N15/52 , C12N15/81 , C12Y101/01088 , C12Y103/01072 , C12Y114/1307 , C12Y114/13132 , C12Y114/19 , C12Y201/01041 , C12Y503/03005
Abstract: The present invention relates to a method for preparing 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof by culturing organisms, in particular yeasts. Furthermore, the invention relates to the preparation of the nucleic acid constructs required for preparing the genetically modified organisms and to said genetically modified organisms, in particular yeasts, themselves.
Abstract translation: 本发明涉及通过培养生物体，特别是酵母来制备7-脱氢胆固醇和/或其生物合成中间体和/或其二次产物的方法。 此外，本发明涉及制备基因修饰生物体和所述转基因生物，特别是酵母本身所需的核酸构建体的制备。
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Patent Agency Ranking
12.发明申请PREPARATION OF 7-DEHYDROCHOLESTEROL AND/OR THE BIOSYNTHETIC INTERMEDIATES AND/OR SECONDARY PRODUCTS THEREOF IN TRANSGENIC ORGANISMS 审中-公开7-脱氢胆甾醇和/或其生物合成中间体和/或其在转基因生物中的二次产物的制备公开(公告)号：US20110151509A1
公开(公告)日：2011-06-23
申请号：US12607017
申请日：2009-10-27
Applicant: Christine Lang , Markus Veen
Inventor： Christine Lang , Markus Veen
CPC classification number: C12P33/00 , C12N9/0004 , C12N9/0006 , C12N9/001 , C12N9/0071 , C12N9/0073 , C12N9/1007 , C12N9/90 , C12N15/52 , C12N15/81 , C12Y101/01088 , C12Y103/01072 , C12Y114/1307 , C12Y114/13132 , C12Y114/19 , C12Y201/01041 , C12Y503/03005
Abstract: The present invention relates to a method for preparing 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof by culturing organisms, in particular yeasts. Furthermore, the invention relates to the preparation of the nucleic acid constructs required for preparing the genetically modified organisms and to said genetically modified organisms, in particular yeasts, themselves.
Abstract translation: 本发明涉及通过培养生物体，特别是酵母来制备7-脱氢胆固醇和/或其生物合成中间体和/或其二次产物的方法。 此外，本发明涉及制备基因修饰生物体和所述转基因生物，特别是酵母本身所需的核酸构建体的制备。
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13.发明申请公开(公告)号：US20170198328A1
公开(公告)日：2017-07-13
申请号：US15412724
申请日：2017-01-23
Applicant: Christine Lang , Markus Veen
Inventor： Christine Lang , Markus Veen
CPC classification number: C12P33/00 , C12N9/0004 , C12N9/0006 , C12N9/001 , C12N9/0071 , C12N9/0073 , C12N9/1007 , C12N9/90 , C12N15/52 , C12N15/81 , C12Y101/01088 , C12Y103/01072 , C12Y114/1307 , C12Y114/13132 , C12Y114/19 , C12Y201/01041 , C12Y503/03005
Abstract: The present invention relates to a method for preparing 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof by culturing organisms, in particular yeasts. Furthermore, the invention relates to the preparation of the nucleic acid constructs required for preparing the genetically modified organisms and to said genetically modified organisms, in particular yeasts, themselves.
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14.发明授权Expression of chimeric KSAC protein and method of producing soluble proteins by high pressure 有权嵌合KSAC蛋白的表达及其制备高可溶性蛋白质的方法公开(公告)号：US09315553B2
公开(公告)日：2016-04-19
申请号：US14014437
申请日：2013-08-30
Applicant: Laurent Bernard Fischer , Nicolas Pierre Yves Carboulec , Fabien Lux
Inventor： Laurent Bernard Fischer , Nicolas Pierre Yves Carboulec , Fabien Lux
IPC: C12P21/04 , C12N5/00 , C12N5/02 , C12N1/00 , C12N1/12 , C12N1/20 , C07K14/245 , A23L3/015 , A61K39/008 , A61K39/02 , A61L2/00 , C12N9/10 , C12N9/52 , C07K14/44 , C12P21/02 , A61K39/00
CPC classification number: C07K14/44 , A23L3/0155 , A61K39/008 , A61K39/0225 , A61K39/0241 , A61K39/099 , A61K2039/552 , A61L2/0011 , C07K14/245 , C07K2319/00 , C07K2319/35 , C07K2319/40 , C12N5/0031 , C12N9/1007 , C12N9/50 , C12N9/52 , C12P21/02 , C12Y201/01041 , C12Y304/22
Abstract: The present invention encompasses vaccines or compositions comprising the chimeric KSAC protein that possesses immunogenic and protective properties, and methods of use including administering to an animal the antigenic KSAC protein thereof to protect animals. The invention also encompasses methods for making and producing the soluble, disaggregated, refolded or active proteins from inclusion bodies produced from prokaryotes or eukaryotes.
Abstract translation: 本发明包括含有具有免疫原性和保护性质的嵌合KSAC蛋白质的疫苗或组合物，以及使用方法，包括向动物施用其抗原性KSAC蛋白质以保护动物。 本发明还包括从由原核生物或真核生物产生的包涵体制备和产生可溶，分解，重折叠或活性蛋白的方法。
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15.发明授权Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins 有权高压装置和用于生产灭活疫苗和重折叠/增溶重组蛋白质的方法公开(公告)号：US09169302B2
公开(公告)日：2015-10-27
申请号：US14014434
申请日：2013-08-30
Applicant: Nicolas Pierre Yves Carboulec , Gildas Merian , Rene Labatut , Lionel Gerentes
Inventor： Nicolas Pierre Yves Carboulec , Gildas Merian , Rene Labatut , Lionel Gerentes
IPC: A61L2/00 , C07K14/245 , A23L3/015 , A61K39/008 , A61K39/02 , C12N9/10 , C12N9/52 , C07K14/44 , A61K39/00
CPC classification number: C07K14/44 , A23L3/0155 , A61K39/008 , A61K39/0225 , A61K39/0241 , A61K39/099 , A61K2039/552 , A61L2/0011 , C07K14/245 , C07K2319/00 , C07K2319/35 , C07K2319/40 , C12N5/0031 , C12N9/1007 , C12N9/50 , C12N9/52 , C12P21/02 , C12Y201/01041 , C12Y304/22
Abstract: The invention relates to hyperbaric devices for inactivating microorganisms and viruses while retaining their immunogenicity and for making and producing the soluble, disaggregated, refolded or active immunogenic or therapeutic proteins from inclusion bodies produced from prokaryotes or eukaryotes. The invention encompasses hyperbaric methods for inactivating pathogenic organisms, and methods for producing vaccine compositions using the inactivated pathogens. The hyperbarically inactivated microorganisms are safer and more immunogenic than chemically inactivated microorganisms. Similarly, the solubilized proteins have superior properties compared to more heavily aggregated proteins, including reduced non-specific immune reactions.
Abstract translation: 本发明涉及用于灭活微生物和病毒的高压装置，同时保留其免疫原性并用于制备和产生可从原核生物或真核生物产生的包涵体的可溶性，分解，重折叠或活性免疫原性或治疗性蛋白质。 本发明包括用于灭活致病生物体的高压方法，以及使用灭活病原体生产疫苗组合物的方法。 高温灭活的微生物比化学灭活的微生物更安全，更具免疫原性。 类似地，与更重聚集的蛋白质相比，溶解的蛋白质具有优异的性质，包括减少的非特异性免疫反应。
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16.发明申请Preparation of 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof in transgenic organisms 有权转基因生物中7-脱氢胆固醇和/或其生物合成中间体和/或其次级产物的制备公开(公告)号：US20060240508A1
公开(公告)日：2006-10-26
申请号：US10503044
申请日：2003-01-22
Applicant: Christine Lang , Markus Veen
Inventor： Christine Lang , Markus Veen
CPC classification number: C12P33/00 , C12N9/0004 , C12N9/0006 , C12N9/001 , C12N9/0071 , C12N9/0073 , C12N9/1007 , C12N9/90 , C12N15/52 , C12N15/81 , C12Y101/01088 , C12Y103/01072 , C12Y114/1307 , C12Y114/13132 , C12Y114/19 , C12Y201/01041 , C12Y503/03005
Abstract: The present invention relates to a method for preparing 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof by culturing organisms, in particular yeasts. Furthermore, the invention relates to the preparation of the nucleic acid constructs required for preparing the genetically modified organisms and to said genetically modified organisms, in particular yeasts, themselves.
Abstract translation: 本发明涉及通过培养生物体，特别是酵母来制备7-脱氢胆固醇和/或其生物合成中间体和/或其二次产物的方法。 此外，本发明涉及制备基因修饰生物体和所述转基因生物，特别是酵母本身所需的核酸构建体的制备。
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