公开(公告)号：US20150204827A1

公开(公告)日：2015-07-23

申请号：US14419108

申请日：2013-08-05

Applicant: Commissariat a L'Energie Atomique et aux Energies Alternatives ,  Analytical Pixels Technology-Apix Technology

Inventor： Laurent Duraffourg ,  Philippe Andreucci ,  Charles-Marie Tassetti ,  Eric Colinet ,  Pierre Puget ,  Joshua Whiting ,  Peter Thomas Stevens ,  Mélanie Petitjean

IPC: G01N30/72 ,  H01J49/00 ,  H01J49/40

CPC classification number: G01N30/7206 ,  G01N2030/025 ,  H01J49/0018 ,  H01J49/405

Abstract: The invention relates to a gas analysis system comprising, from upstream to downstream: a module (SEP) for separating at least a portion of the species contained in the gas to be analysed, comprising at least one microcapillary column (GC) for gas phase chromatography, and a time-of-flight mass spectrometer (TOFMS) coupled to said separation module, said spectrometer comprising a ion source (MS1, MS2) adapted to ionise at least a portion of said species and to emit a ion beam, and a free-flight zone (MS4) for said ions, said mass spectrometer (TOFMS) being arranged in the volume of at least one substrate and comprising a micro-reflectron (R) arranged between the source (MS1, MS2) and the free-flight zone (MS4), a wall (R1) of said micro-reflectron comprising a layer made from a resistive material designed to be polarised between at least two regions so as to create a continuous electrostatic field gradient in said reflectron.

Abstract translation: 本发明涉及一种气体分析系统，包括从上游到下游：用于分离包含在待分析气体中的物质的至少一部分的模块（SEP），其包括用于气相色谱的至少一个微毛细管柱（GC） ，以及耦合到所述分离模块的飞行时间质谱仪（TOFMS），所述光谱仪包括适于离子化所述物质的至少一部分并且发射离子束的离子源（MS1，MS2） （MS4），所述质谱仪（TOFMS）布置在至少一个衬底的体积中，并且包括布置在源（MS1，MS2）和自由飞行区之间的微反射器（R） （MS4），所述微反射器的壁（R1）包括由电阻材料制成的层，其被设计为在至少两个区域之间极化，以便在所述反射器中产生连续的静电场梯度。

公开(公告)号：US08552367B2

公开(公告)日：2013-10-08

申请号：US13366701

申请日：2012-02-06

Applicant: Jean-Sebastien Danel ,  Laurent Duraffourg ,  Frederic Progent ,  Charles-Marie Tassetti

Inventor： Jean-Sebastien Danel ,  Laurent Duraffourg ,  Frederic Progent ,  Charles-Marie Tassetti

IPC: H01J49/00

CPC classification number: H01J49/405 ,  B05D3/10 ,  B81C1/00119 ,  B81C2201/0133 ,  B81C2203/031 ,  H01J49/0018

Abstract: A micro-reflectron for a time-of-flight mass spectrometer including a substrate and integrated with the volume of the substrate, means for application of a potential gradient in a volume suitable for constituting a flight zone of the ions. The means of application includes at least two polarization electrodes and a wall of at least one resistive material that can be polarized between these electrodes so as to generate a continuous potential gradient, itself providing the function of reflectron, this flight zone, these electrodes and this wall being obtained by the technology of microelectromechanical systems (MEMS) and this micro-reflectron having a thickness of less than 5 millimeters while its other dimensions are less than 10 times this thickness.

Abstract translation: 用于包括衬底并与衬底的体积整合的飞行时间质谱仪的微反射器是在适于构成离子的飞行区域的体积中施加电位梯度的装置。 施加装置包括至少两个极化电极和至少一个电阻材料的壁，其可以在这些电极之间极化，以便产生连续的电势梯度，其本身提供反射器的功能，该飞行区域，这些电极和这些电极 通过微机电系统（MEMS）的技术获得壁，该微反射器的厚度小于5毫米，而其它尺寸小于该厚度的10倍。

公开(公告)号：US20130187043A1

公开(公告)日：2013-07-25

申请号：US13790760

申请日：2013-03-08

Applicant: Alexander A. MAKAROV ,  Dmitry E. GRINFIELD ,  Mikhail A. MONASTYRSKIY

Inventor： Alexander A. MAKAROV ,  Dmitry E. GRINFIELD ,  Mikhail A. MONASTYRSKIY

IPC: H01J49/40 ,  H01J49/06

CPC classification number: H01J49/406 ,  H01J49/061 ,  H01J49/405

Abstract: A method of reflecting ions in a multireflection time of flight mass spectrometer is disclosed. The method includes guiding ions toward an ion mirror having multiple electrodes, and applying a voltage to the ion mirror electrodes to create an electric field that causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror and to exit the ion mirror, wherein the ion are spatially focussed by the mirror to a first location and temporally focused to a second location different from the first location. Apparatus for carrying out the method is also disclosed.

公开(公告)号：US20110220786A1

公开(公告)日：2011-09-15

申请号：US13026496

申请日：2011-02-14

Applicant: Takaya Satoh

Inventor： Takaya Satoh

IPC: H01J49/40

CPC classification number: H01J49/408 ,  H01J49/004 ,  H01J49/405

Abstract: A tandem time-of-flight (TOF) mass spectrometer is offered whose first mass analyzer is a TOF mass spectrometer having a flight distance smaller than the flight distance sufficient to impart a desired mass resolution to the first mass analyzer. When a mass spectrum is measured with the first mass analyzer, a reflectron field is activated. When precursor ions are selected by the first mass analyzer, the reflectron field is deactivated to permit ions to pass through without being reflected.

Abstract translation: 提供串联飞行时间质谱仪（TOF）质谱仪，其第一质量分析仪是具有小于飞行距离的飞行距离的TOF质谱仪，足以使第一质量分析仪具有所需的质量分辨率。 当使用第一质量分析器测量质谱时，激活反射场。 当通过第一质量分析器选择前体离子时，反射器场被去激活以允许离子通过而不被反射。

公开(公告)号：US07605377B2

公开(公告)日：2009-10-20

申请号：US11550241

申请日：2006-10-17

Applicant: Guido Fridolin Verbeck, IV ,  Kenneth Tsui

Inventor： Guido Fridolin Verbeck, IV ,  Kenneth Tsui

IPC: H01J3/14 ,  H01J23/04 ,  H01J9/00 ,  G09G1/04

CPC classification number: H01J49/0018 ,  H01J49/405 ,  H01J49/406

Abstract: A microelectronics apparatus comprising a substrate, a pair of grid electrodes coupled to the substrate on opposing sides of a central axis, wherein the grid electrodes are substantially parallel to each other and extend substantially perpendicular from the substrate, and a plurality of ion reflection lenses each coupled to the substrate, wherein each ion reflection lens: (1) is substantially perpendicular to each of the grid electrodes; (2) extends substantially perpendicular from the substrate; and (3) has an aperture aligned with the central axis.

Abstract translation: 一种微电子设备，包括基板，在中心轴线的相对侧耦合到所述基板的一对网格电极，其中所述栅电极基本上彼此平行并且从所述基板大致垂直延伸，并且每个所述多个离子反射透镜 耦合到所述衬底，其中每个离子反射透镜：（1）基本上垂直于每个所述栅极; （2）基本上垂直于基底延伸; 和（3）具有与中心轴对准的孔。

公开(公告)号：US07589319B2

公开(公告)日：2009-09-15

申请号：US11742703

申请日：2007-05-01

Applicant: Marvin L. Vestal

Inventor： Marvin L. Vestal

IPC: B01D59/44 ,  H01J49/00

CPC classification number: H01J49/164 ,  H01J49/405

Abstract: Many applications in the study of metabolics and proteomics require measurements on peptides and small molecules with high resolving power and mass accuracy. These are often present in complex mixtures and sensitivity over a relatively broad mass range, speed of analysis, reliability, and ease of use are very important. The present invention is a time-of-flight mass spectrometer providing optimum performance for these and similar applications.

Abstract translation: 在代谢和蛋白质组学研究中的许多应用需要对具有高分辨能力和质量精度的肽和小分子进行测量。 这些通常以复杂的混合物存在，并且在相对宽的质量范围内的灵敏度，分析速度，可靠性和易用性是非常重要的。 本发明是为这些和类似应用提供最佳性能的飞行时间质谱仪。

公开(公告)号：US07297960B2

公开(公告)日：2007-11-20

申请号：US10989646

申请日：2004-11-16

Applicant: Jeffery Mark Brown ,  Daniel James Kenny

Inventor： Jeffery Mark Brown ,  Daniel James Kenny

IPC: G21K1/08 ,  H01J3/14 ,  H01J3/26

CPC classification number: H01J49/405 ,  H01J49/421

Abstract: A mass filter is disclosed comprising an orthogonal acceleration electrode 9. Ions entering the mass filter are orthogonally accelerated by the orthogonal acceleration electrode 9 in a primary acceleration region 2 and enter a flight region 3. The ions 6,7,8 are then reflected by a reflectron 4 and are directed towards an exit region of the mass filter. Ions having a desired mass to charge ratio are arranged to arrive in the primary acceleration region 2 at a time when a voltage pulse applied to the orthogonal acceleration electrode 9 falls from a maximum to zero. Ions having a desired mass to charge ratio are orthogonally decelerated such that they have a zero component of velocity in the orthogonal direction. Accordingly, ions having a desired mass to charge ratio exit the mass filter in an axial direction.

Abstract translation: 公开了一种包括正交加速电极9的质量过滤器。 进入质量过滤器的离子通过正加速电极9在主加速区域2中正交加速并进入飞行区域3。 然后离子6,7,8被反射器4反射并且被引向质量过滤器的出口区域。 具有期望的质荷比的离子被布置成在施加到正交加速电极9的电压脉冲从最大值降到零的时刻到达主加速区域2。 具有期望的质荷比的离子正交减速，使得它们在正交方向上具有零分量的速度。 因此，具有期望质荷比的离子沿轴向离开质量过滤器。

公开(公告)号：US20070034794A1

公开(公告)日：2007-02-15

申请号：US10546323

申请日：2004-02-23

Applicant: Robert Cotter ,  Benjamin Gardner ,  Robert English ,  Serguei Ilchenko

Inventor： Robert Cotter ,  Benjamin Gardner ,  Robert English ,  Serguei Ilchenko

IPC: H01J49/00

CPC classification number: H01J49/004 ,  H01J49/405

Abstract: A tandem mass spectrometer includes a linear time-of-flight mass analyzer and curved field reflectron mass analyzer. The curved-field reflectron mass analyzer is disposed at an end of the linear time-of-flight mass analyzer such that ions having a plurality of ion masses formed in the linear time-of-flight analyzer such that ions having a plurality of ion masses formed in the linear time-of-flight analyzer enter the curved-field reflectron mass analyzer. The tandem mass spectrometer also includes a mass selection gate disposed between the time-of-flight mass analyzer and the curved-field reflectron mass analyzer. The mass selection gate selects an ion mass from the plurality of ion masses. Furthermore, the tandem mass spectrometer also includes a dissociating component located in a path of the ions formed in the linear time-of-flight analyzer. The dissociating component causes dissociation of the ions into a plurality of ion fragments.

Abstract translation: 串联质谱仪包括线性飞行时间质量分析仪和弯曲场反射体质量分析仪。 弯道反射体质量分析器设置在线性飞行时质量分析器的末端，使得在线性飞行时间分析器中形成多个离子质量的离子使得具有多个离子质量的离子 形成在线性飞行时间分析仪中进入曲面反射体质量分析仪。 串联质谱仪还包括设置在飞行时间质量分析器和弯曲场反射体质量分析器之间的质量选择门。 质量选择门从多个离子质量选择离子质量。 此外，串联质谱仪还包括位于在线性飞行时间分析仪中形成的离子的路径中的解离组分。 离解组分导致离子离解成多个离子片段。

公开(公告)号：US07148472B2

公开(公告)日：2006-12-12

申请号：US10789555

申请日：2004-02-28

Applicant: Yuri Glukhoy

Inventor： Yuri Glukhoy

IPC: H01J49/40

CPC classification number: H01J49/061 ,  H01J49/0445 ,  H01J49/405

Abstract: An aerosol TOF MS of the present invention is based on the use of quadrupole lenses with angular gradient of the electrostatic field. On the entrance side, the TOF MS contains an ion-optic system that is used for focusing, aligning, and time-modulating the ionized flow of particles and a deflector modulator that provides alternating deflections of the flow of particles between two positions for aligning the flow with two inlet openings into the TOF MS. As a result, two independently analyzed discrete flows of particles pass through the ion mass separation chamber of the TOF MS without interference with each other. The charged particles fly in direct and return paths along helical trajectories which extend the length of the flight time. The time of the collision and the magnitude of the collision pulse will contain information about the M/Z ratio for the particles being registered. Multiplication of a single flow of particles into a plurality of independent and spatially separated flows propagating in one chamber increases efficiency of the TOF MS and makes it possible to use it in continuous and high-duty applications with the duty cycle as high as 98%, which is unattainable with any known device of this class.

Abstract translation: 本发明的气溶胶TOF MS基于使用具有静电场角度梯度的四极透镜。 在入口侧，TOF MS包含用于聚焦，对准和时间调制颗粒的离子流的离子光学系统，以及在两个位置之间提供粒子流的交替偏转的偏转器调制器，用于对准 流入两个入口到TOF MS。 结果，两个独立分析的离散粒子流通过TOF MS的离子质量分离室，而不会彼此干涉。 带电粒子沿着延伸飞行时间长度的沿着螺旋轨迹的直接和返回路径飞行。 碰撞的时间和碰撞脉冲的大小将包含关于正在登记的颗粒的M / Z比的信息。 将单个流动的粒子乘以在一个腔室中传播的多个独立和空间上分离的流动提高了TOF MS的效率，并且使得可以在占空比高达98％的连续和高负荷应用中使用它， 这是该类的任何已知设备无法实现的。

公开(公告)号：US07075065B2

公开(公告)日：2006-07-11

申请号：US10925192

申请日：2004-08-24

Applicant: Alexander William Colburn ,  Peter John Derrick ,  Anastassios Giannakopulos

Inventor： Alexander William Colburn ,  Peter John Derrick ,  Anastassios Giannakopulos

IPC: H01L49/40

CPC classification number: H01J49/405 ,  H01J49/004

Abstract: Mass spectrometry apparatus 105 comprises a serial arrangement of an ion source 110, first time of flight means, a field free region 120, means to fragment the molecules, a second time of flight means and a large area detector 160. The second time of flight means includes an ion mirror 150, the ion mirror 150 being arranged to produce a reflecting substantially quadratic field. The first time of flight means is arranged to provide spatial focusing concomitant with time focusing of ions at or near the entrance to the ion mirror 150. The means provided to fragment the ions front the first time of flight means can be a collision cell 140 or in the field free region 220 or in the first time of flight means. The means to fragment the molecules has a potential which is different from the potential at the entrance to the ion mirror 150, and the detecting surface of the detector 160 is mounted in the time focal surface of the ion mirror 150.

Abstract translation: 质谱装置105包括离子源110的串行排列，第一飞行时间装置，无场区域120，分解分子的装置，第二时间飞行装置和大面积检测器160。 第二次飞行装置包括离子镜150，离子镜150被布置成产生反射基本上二次场。 第一次飞行装置被设置成提供空间聚焦，伴随着离子在离子反射镜150的入口处或附近的时间聚焦。 提供用于在飞行装置的第一时间前面分离离子的装置可以是碰撞室140或场自由区域220或在第一次飞行装置中。 分解分子的方法具有与入射到离子镜150的电位不同的电位，并且检测器160的检测表面安装在离子反射镜150的时间焦点表面中。