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563 条记录 (耗时 0.039 秒)

    CRYSTALLINE FORMS OF AN ADRENERGIC AGONIST
    14.
    发明申请
    CRYSTALLINE FORMS OF AN ADRENERGIC AGONIST 审中-公开
    ADRENERGIC AGONIST的晶体形式

    公开(公告)号：US20150111934A1

    公开(公告)日：2015-04-23

    申请号：US14505528

    申请日：2014-10-03

    申请人： DIPHARMA FRANCIS S.R.L.

    发明人： Alessio BOVE ,  Pietro ALLEGRINI ,  Emanuele ATTOLINO

    IPC分类号： C07D277/40

    CPC分类号： C07D277/40

    摘要： The present invention relates to the acetate salt of Mirabegron, in particular in two novel crystalline forms, a process for their preparation and the use of said salt and its crystalline forms in the synthesis of Mirabegron with high yields and chemical purity.

    摘要翻译： 本发明涉及Mirabegron的乙酸盐，特别是两种新的结晶形式，它们的制备方法以及所述盐及其结晶形式在Mirabegron合成中的高产率和化学纯度的用途。

    RIBONUCLEOTIDE REDUCTASE INHIBITORS AND METHODS OF USE
    15.
    发明申请
    RIBONUCLEOTIDE REDUCTASE INHIBITORS AND METHODS OF USE 有权
    RIBONUCLEOTIDE还原抑制剂及其使用方法

    公开(公告)号：US20150087844A1

    公开(公告)日：2015-03-26

    申请号：US14444172

    申请日：2014-07-28

    申请人： City of Hope

    发明人： David Horne ,  Christopher Lincoln

    IPC分类号： C07D277/46 ,  C07D277/40 ,  C07C45/68

    CPC分类号： C07D277/46 ,  C07C45/68 ,  C07D277/40 ,  C07D417/12

    摘要： Provided herein are novel compounds that inhibit ribonucleotide reductase (RR) by binding to RRM2 and interfering with the activity of the RRM1/RRM2 holoenzyme, as well as methods of synthesizing these novel compounds. The compounds may be used to inhibit RR activity and to treat various conditions associated with RRM2 expression, such as for example certain cancer types, mitochondrial diseases, or degenerative diseases.

    摘要翻译： 本文提供了通过与RRM2结合并干扰RRM1 / RRM2全酶的活性以及合成这些新化合物的方法来抑制核糖核苷酸还原酶（RR）的新型化合物。 所述化合物可用于抑制RR活性并治疗与RRM2表达相关的各种病症，例如某些癌症类型，线粒体疾病或退行性疾病。

    Insecticidal 2-acylaminothiazole-4-carboxamides
    19.
    发明授权
    Insecticidal 2-acylaminothiazole-4-carboxamides 失效
    杀虫剂2-酰基氨基噻唑-4-甲酰胺

    公开(公告)号：US07799738B2

    公开(公告)日：2010-09-21

    申请号：US12091895

    申请日：2006-10-26

    申请人： Akihiko Yanagi ,  Yukiyoshi Watanabe ,  Jun Mihara ,  Katsuhiko Shibuya ,  Eiichi Shimojo ,  Akira Emoto

    发明人： Akihiko Yanagi ,  Yukiyoshi Watanabe ,  Jun Mihara ,  Katsuhiko Shibuya ,  Eiichi Shimojo ,  Akira Emoto

    IPC分类号： A01N25/26 ,  A01N43/40 ,  A01N43/78 ,  C07D417/02 ,  C07D277/40 ,  C07D277/38 ,  C07D277/56

    CPC分类号： A01N43/78 ,  C07D277/56

    摘要： 2-Acylaminothiazole-4-carboxamides of the formula (I) and application thereof as an insecticide. wherein R1 represents phenyl which may be optionally substituted, or a 5- or 6-membered heterocyclic group containing at least one hetero atom selected from a group consisting of N, O and S which may be optionally substituted, R2 represents halogen, C1-6 alkyl or C1-6 haloalkyl, R3 represents C1-6 haloalkyl, C1-6 haloalkoxy, C1-6 haloalkylthio, C1-6 haloalkylsulfinyl or C1-6 haloalkylsulfonyl, R4 represents halogen, C1-6 alkyl or C1-6 haloalkyl, and X represents hydrogen, halogen, C1-6 alkyl or C1-6 haloalkyl, and the use of the new compounds as insecticides.

    摘要翻译： 式（I）的2-酰基氨基噻唑-4-甲酰胺及其作为杀虫剂的应用。 其中R1表示可以任意取代的苯基，或含有至少一个选自N，O和S的杂原子的5或6元杂环基团，其可任选被取代，R 2表示卤素，C 1-6 烷基或C 1-6卤代烷基，R 3表示C 1-6卤代烷基，C 1-6卤代烷氧基，C 1-6卤代烷硫基，C 1-6卤代烷基亚磺酰基或C 1-6卤代烷基磺酰基，R 4表示卤素，C 1-6烷基或C 1-6卤代烷基，X 表示氢，卤素，C 1-6烷基或C 1-6卤代烷基，以及使用新化合物作为杀虫剂。