公开(公告)号：US5124476A

公开(公告)日：1992-06-23

申请号：US566590

申请日：1990-08-13

Applicant: Karl-Rudolf Gassen ,  Albrecht Marhold

Inventor： Karl-Rudolf Gassen ,  Albrecht Marhold

IPC: C07C51/09 ,  C07C51/097 ,  C07C53/21 ,  C07C67/08 ,  C07C67/317 ,  C07C69/653 ,  C07C201/06 ,  C07C201/12 ,  C07C205/02 ,  C07C205/08 ,  C07C233/05

CPC classification number: C07C51/097 ,  C07C67/317

Abstract: .alpha.-Fluoroacryloyl derivatives are prepared by reacting a dihalogenopropene with an anhydrous mixture of nitric acid and hydrofluoric acid to give a 1-nitro-2,2-fluorohalogeno-3-halogenopropane, converting this in the presence of a strong acid and a little water at elevated temperature to a 2,2-fluorohalogeno-3-halogenopropanoic acid, converting this into an ester or an amide and finally treating this with a dehalogenating agent.

Abstract translation: α-氟丙烯酰基衍生物通过使二卤代丙烯与硝酸和氢氟酸的无水混合物反应得到1-硝基-2,2-氟卤代-3-卤代丙烷，在强酸和少量水的存在下进行转化 在高温下加热至2,2-氟卤代-3-卤代丙酸，将其转化为酯或酰胺，最后用脱卤剂处理。

公开(公告)号：US09340486B2

公开(公告)日：2016-05-17

申请号：US13854491

申请日：2013-04-01

Applicant: ANGUS Chemical Company

Inventor： Mahesh Sawant ,  Daniel M. Trauth ,  John G. Pendergast, Jr.

IPC: B01J19/00 ,  C07C201/08 ,  C07C201/16 ,  C07C201/06 ,  B01J10/00

CPC classification number: C07C201/06 ,  B01J10/00 ,  B01J19/00 ,  C07C201/08 ,  C07C201/16 ,  C07C205/02

Abstract: Disclosed are a process and an apparatus for synthesizing nitroalkanes by reaction of a hydrocarbon feedstock with aqueous nitric acid. Energy and capital costs may be reduced by recycling a majority of the aqueous phase back to the reactor.

公开(公告)号：US20160130295A1

公开(公告)日：2016-05-12

申请号：US14941164

申请日：2015-11-13

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Nagichettiar Satyamurthy ,  Jorge R. Barrio ,  Bernard Amarasekera ,  R. Michael Van Dam ,  Sebastian Olma ,  Dirk Williams ,  Mark Eddings ,  Clifton Kwang-Fu Shen

IPC: C07H19/16 ,  C07C201/06 ,  B01J19/00 ,  C07D207/46 ,  C07B59/00 ,  C07H19/06 ,  C07H5/02

CPC classification number: C07H19/16 ,  B01J19/004 ,  B01J19/126 ,  B01J2219/00049 ,  B01J2219/24 ,  C07B59/001 ,  C07B59/002 ,  C07B59/005 ,  C07B2200/05 ,  C07C201/06 ,  C07D207/46 ,  C07H5/02 ,  C07H19/06 ,  Y10T436/115831 ,  Y10T436/12

Abstract: A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote location. One embodiment comprises a reaction vessel including a moveable heat source with the position thereof relative to the reaction vessel being controllable from a remote position. Alternatively the heat source may be fixed in location and the reaction vial is moveable into and out of the heat source. The reaction vessel has one or more sealing plugs, the positioning of which in relationship to the reaction vessel is controllable from a remote position. Also the one or more reaction vessel sealing plugs can include one or more conduits there through for delivery of reactants, gases at atmospheric or an elevated pressure, inert gases, drawing a vacuum and removal of reaction end products to and from the reaction vial, the reaction vial with sealing plug in position being operable at elevated pressures. The modular chemical production system is assembled from modules which can each include operating condition sensors and controllers configured for monitoring and controlling the individual modules and the assembled system from a remote position. Other modules include, but are not limited to a Reagent Storage and Delivery Module, a Cartridge Purification Module, a Microwave Reaction Module, an External QC/Analysis/Purification Interface Module, an Aliquotting Module, an F-18 Drying Module, a Concentration Module, a Radiation Counting Module, and a Capillary Reactor Module.

公开(公告)号：US20150218194A1

公开(公告)日：2015-08-06

申请号：US14683910

申请日：2015-04-10

Applicant: AbbVie Inc.

Inventor： Mary E. Bellizzi ,  David A. Betebenner ,  Jean C. Califano ,  Daniel D. Caspi ,  David A. DeGoey ,  Pamela L. Donner ,  Charles A. Flentge ,  Yi Gao ,  Charles W. Hutchins ,  Douglas K. Hutchinson ,  Tammie K. Jinkerson ,  Warren M. Kati ,  Ryan G. Keddy ,  Allan C. Krueger ,  Wenke Li ,  Dachun Liu ,  Clarence J. Maring ,  Mark A. Matulenko ,  Christopher E. Motter ,  Lissa T. Nelson ,  Sachin V. Patel ,  John K. Pratt ,  John T. Randolph ,  Todd W. Rockway ,  Kathy Sarris ,  Michael D. Tufano ,  Seble H. Wagaw ,  Rolf Wagner ,  Kevin R. Woller

IPC: C07F9/6558 ,  C07D405/14 ,  C07D403/14 ,  C07D401/14 ,  C07D207/09 ,  C07D491/113 ,  C07D413/14 ,  C07D471/04 ,  C07C201/06 ,  C07D207/08 ,  C07D207/16 ,  C07D417/14

CPC classification number: C07F9/65583 ,  C07C33/26 ,  C07C201/06 ,  C07C205/19 ,  C07D207/08 ,  C07D207/09 ,  C07D207/16 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D453/00 ,  C07D471/04 ,  C07D491/113 ,  C07K5/06

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

Abstract translation: 描述了有效抑制丙型肝炎病毒（“HCV”）复制的化合物。 本发明还涉及制备这种化合物的方法，包含这些化合物的组合物，以及使用这些化合物治疗HCV感染的方法。

公开(公告)号：US09006477B2

公开(公告)日：2015-04-14

申请号：US14131106

申请日：2012-07-04

Applicant: Shinki Tani ,  Nami Yadomatsu ,  Akiko Ikumi ,  Yuuki Hirano ,  Takuya Ido

Inventor： Shinki Tani ,  Nami Yadomatsu ,  Akiko Ikumi ,  Yuuki Hirano ,  Takuya Ido

IPC: C07C205/06 ,  C07C201/06

CPC classification number: C07C201/06 ,  C07C205/06 ,  C07C205/58

Abstract: A method for producing a nitrobenzene compound represented by general formula (2),wherein R1 and R5 are the same or different, and each is a halogen atom or another functional group, and R2, R3, and R4 are the same or different, and each is a hydrogen atom or another functional group, comprises oxidizing an aniline compound represented by general formula (1), wherein R1, R2, R3, R4, and R5 are the same as described above, with hydrogen peroxide in the presence of a tungsten compound under an acidic condition, followed by oxidation with hydrogen peroxide under a neutral to alkaline condition.

Abstract translation: 一种制备由通式（2）表示的硝基苯化合物的方法，其中R1和R5相同或不同，并且各自为卤素原子或其它官能团，R2，R3和R4相同或不同， 各自为氢原子或另一官能团，包括将氧化由通式（1）表示的苯胺化合物，其中R1，R2，R3，R4和R5与上述相同，与过氧化氢在钨存在下 在酸性条件下，然后在中性至碱性条件下用过氧化氢氧化。

公开(公告)号：US20050107646A1

公开(公告)日：2005-05-19

申请号：US10979949

申请日：2004-11-02

Applicant: Hans-Peter Schal ,  Vera Popkova ,  Boris Laskin ,  Alexander Malin ,  Sofia Volkova

Inventor： Hans-Peter Schal ,  Vera Popkova ,  Boris Laskin ,  Alexander Malin ,  Sofia Volkova

IPC: C07C201/08 ,  C07C201/06 ,  C07C205/06 ,  C07C25/06

CPC classification number: C07C201/08 ,  C07C205/06

Abstract: The invention is directed to a process for the production of 1,5-dinitronaphthalene wherein naphthalene is nitrated by nitric acid in the absence of sulfuric acid at temperatures of from 30 to 80° C., wherein the nitric acid has a concentration of from 72 to 87 wt.-%, the reaction mixture obtained is filtered at temperatures of from 5 to 20° C. and the solid precipitate obtained is washed with water, and 1,5-dinitronaphthalene is isolated from the washed precipitate by washing with acetone.

Abstract translation: 本发明涉及一种生产1,5-二硝基萘的方法，其中在不存在硫酸的情况下，硝酸在30-80℃的温度下硝化硝酸，其中硝酸的浓度为72 得到的反应混合物在5至20℃的温度下过滤，所得固体沉淀物用水洗涤，用丙酮洗涤从洗涤的沉淀物中分离出1,5-二硝基萘。

公开(公告)号：US2473341A

公开(公告)日：1949-06-14

申请号：US73994847

申请日：1947-04-07

Applicant: SHELL DEV

Inventor： CORNELIS KOOIJMAN EDUARD ,  JOHAN OVERHOFF

IPC: C07C201/06 ,  C07C205/09

CPC classification number: C07C205/09

公开(公告)号：US2447504A

公开(公告)日：1948-08-24

申请号：US63354045

申请日：1945-12-07

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： HASS HENRY B ,  CHARLES WHITAKER ARTHUR

IPC: C07C201/06 ,  C07C205/08

CPC classification number: C07C205/08

公开(公告)号：US09481705B2

公开(公告)日：2016-11-01

申请号：US14941164

申请日：2015-11-13

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Nagichettiar Satyamurthy ,  Jorge R. Barrio ,  Bernard Amarasekera ,  R. Michael Van Dam ,  Sebastian Olma ,  Dirk Williams ,  Mark Eddings ,  Clifton Kwang-Fu Shen

IPC: C07H19/16 ,  B01J19/00 ,  B01J19/12 ,  C07B59/00 ,  C07C201/06 ,  C07D207/46 ,  C07H5/02 ,  C07H19/06

CPC classification number: C07H19/16 ,  B01J19/004 ,  B01J19/126 ,  B01J2219/00049 ,  B01J2219/24 ,  C07B59/001 ,  C07B59/002 ,  C07B59/005 ,  C07B2200/05 ,  C07C201/06 ,  C07D207/46 ,  C07H5/02 ,  C07H19/06 ,  Y10T436/115831 ,  Y10T436/12

Abstract: A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote location. One embodiment comprises a reaction vessel including a moveable heat source with the position thereof relative to the reaction vessel being controllable from a remote position. Alternatively the heat source may be fixed in location and the reaction vial is moveable into and out of the heat source. The reaction vessel has one or more sealing plugs, the positioning of which in relationship to the reaction vessel is controllable from a remote position. Also the one or more reaction vessel sealing plugs can include one or more conduits there through for delivery of reactants, gases at atmospheric or an elevated pressure, inert gases, drawing a vacuum and removal of reaction end products to and from the reaction vial, the reaction vial with sealing plug in position being operable at elevated pressures. The modular chemical production system is assembled from modules which can each include operating condition sensors and controllers configured for monitoring and controlling the individual modules and the assembled system from a remote position. Other modules include, but are not limited to a Reagent Storage and Delivery Module, a Cartridge Purification Module, a Microwave Reaction Module, an External QC/Analysis/Purification Interface Module, an Aliquotting Module, an F-18 Drying Module, a Concentration Module, a Radiation Counting Module, and a Capillary Reactor Module.

公开(公告)号：US20150175522A1

公开(公告)日：2015-06-25

申请号：US14415788

申请日：2013-07-23

Applicant: Bayer MaterialScience AG

Inventor： Thomas Knauf ,  Michael Merkel ,  Antoni Mairata

IPC: C07C201/06

CPC classification number: C07C201/06 ,  C07C201/08 ,  C07C205/06

Abstract: The invention provides a continuous adiabatic process for the preparation of nitrobenzene by nitrating benzene with mixtures of sulfuric and nitric acids using a stoichiometric excess of benzene, wherein the content of organic compounds in the circulating sulfuric acid, at least during the start-up period of the production plant, is always kept below 1.0 mass percent, based on the total mass of circulating sulfuric acid. This is preferably achieved by a procedure in which, either after the end or before the beginning of a production cycle, the circulating sulfuric acid is circulated at elevated temperature so that the organics contained in the sulfuric acid, preferably comprising nitrobenzene and traces of benzene, dinitrobenzene and nitrophenols, are separated off in the evaporation apparatus for concentrating the sulfuric acid.

Abstract translation: 本发明提供了一种连续的绝热方法，用于通过使用化学计量过量的苯将硫与硝酸的混合物硝化苯来制备硝基苯，其中循环硫酸中有机化合物的含量至少在启动期间 基于循环硫酸的总质量，生产厂总是保持在1.0质量％以下。 这优选通过以下程序来实现，其中，在生产周期结束或开始之前循环硫酸在升高的温度下循环，使得包含在硫酸中的有机物，优选包含硝基苯和痕量的苯， 二硝基苯和硝基苯酚在用于浓缩硫酸的蒸发装置中分离出来。