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公开(公告)号：US11358959B2
公开(公告)日：2022-06-14
申请号：US16480861
申请日：2018-01-25
申请人： Araxes Pharma LLC
发明人： Liansheng Li , Jun Feng , Yuan Liu , Pingda Ren , Yi Liu
IPC分类号： C07D333/54 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , A61P35/00 , C07D405/04 , C07D405/14
摘要： Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I) or a pharmaceutically acceptable salt, stereoisomer or prodrug thereof, wherein B, Z, Ra, Rb, Rc, R1, L, L1 and E are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.
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公开(公告)号：US11281099B2
公开(公告)日：2022-03-22
申请号：US16420956
申请日：2019-05-23
IPC分类号： G03F7/004 , C07C381/12 , G03F7/039 , C07C309/12 , C07C303/22 , C07D339/08 , C07D333/54 , C07D327/04 , G03F7/038 , G03F7/32 , G03F7/16 , G03F7/20 , G03F7/38
摘要： A resist composition including a compound represented by formula (b1) in which Rb1 represents an aryl group which may have a substituent; Rb2 and Rb3 each independently represents an aryl group which may have a substituent or an alkyl group which may have a substituent; provided that at least one of the aryl group represented by Rb1 and the aryl group or the alkyl group represented by Rb2 or Rb3 has a substituent containing a halogen atom, and at least one of the aryl group represented by Rb1 and the aryl group or the alkyl group represented by Rb2 or Rb3 has a substituent containing a sulfonyl group; and X− represents a counteranion.
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公开(公告)号：US11274110B2
公开(公告)日：2022-03-15
申请号：US16759139
申请日：2018-10-18
发明人： Jörg Gries , Johannes Platzek
IPC分类号： C07D333/54 , C07F5/02 , C07D333/72 , C07D487/04
摘要： A process for preparing the benzothiophen-2-yl boronate of formula (VI) which serves as an intermediate for production of medicaments and for production of medicaments for treatment and/or prophylaxis of proliferative disorders, such as cancer and tumor diseases.
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公开(公告)号：US20210122761A1
公开(公告)日：2021-04-29
申请号：US16634827
申请日：2018-06-29
发明人： Xiong CAI , Changgeng QIAN , Chunqiang YE , Qijie HE
IPC分类号： C07D495/04 , C07D333/54 , C07D263/56 , C07D307/80 , C07D307/85 , C07D277/64 , C07D327/04 , C07D327/06 , C07D317/54 , C07D307/83 , C07D491/048
摘要： Provided are a 1,3-di-substituted ketene compound having a structure as represented by formula (I) and an application thereof. Such a type of compound primarily activates peroxisome proliferator-activated receptor (PPAR) α, and also activates PPPAδ and PPPAγ. The compound may be used to treat various diseases associated with PPAR regulation and control abnormality, such as non-alcoholic fatty liver disease, and especially in treating non-alcoholic hepatitis, and may potentially be used in the treatment of diseases comprising diabetes, obesity, fibrotic diseases, cardiovascular diseases (comprising heart failure, atherosclerosis, and so on), kidney diseases (comprising chronic kidney disease, renal failure, and so on), and brain degenerative diseases (comprising Alzheimer's disease and so on), having great application value.
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公开(公告)号：US10959986B2
公开(公告)日：2021-03-30
申请号：US16555634
申请日：2019-08-29
发明人： James Aaron Balog , Steven P. Seitz , Susheel Jethanand Nara , Saumya Roy , Srinivasan Thangathirupathy , Soodamani Thangavel , Ramesh Kumar Sistla
IPC分类号： A61K31/415 , A61K31/5377 , C07D231/12 , C07D401/12 , C07D403/12 , C07D261/08 , C07D277/22 , C07D285/08 , C07D211/60 , C07D317/50 , C07D307/36 , C07D333/54 , C07D231/56 , C07D221/22 , C07D471/04 , C07D487/04 , A61K31/17 , A61K31/4439 , A61K31/506 , A61K31/42 , A61K31/426 , A61K31/433 , A61K31/357 , A61K31/341 , A61K31/381 , C07C275/42
摘要： There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the disclosure.
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16.发明申请公开(公告)号：US20210047285A1
公开(公告)日：2021-02-18
申请号：US17087926
申请日：2020-11-03
发明人： Shannon Stahl , Stephen Tereniak
IPC分类号： C07D333/22 , C07D277/32 , B01J31/18 , C07D333/54 , B01J31/24 , B01J31/04 , B01J31/22
摘要： An oxidative homocoupling method of synthesizing certain 2,2′-bithiophenes from thiophenes using oxygen as the terminal oxidant is disclosed. In non-limiting examples, the method uses oxygen along with a catalytic system that includes palladium, an assistive ligand, and a non-palladium metal additive to catalyze one of the following reactions: Associated catalytic systems and compositions are also disclosed.
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17.发明申请公开(公告)号：US20200283426A1
公开(公告)日：2020-09-10
申请号：US16702357
申请日：2019-12-03
发明人： Takuya UNO
IPC分类号： C07D409/12 , C07D307/79 , C07D413/10 , C07D405/10 , C07D405/12 , C07D407/14 , C07D407/12 , C07D407/04 , C07D409/14 , C07D417/10 , C07D333/54 , C07D409/10 , C07D409/04 , C07D405/04 , H01L51/00
摘要： An organic electroluminescence device includes a first electrode, a hole transport region disposed on the first electrode, an emission layer disposed on the hole transport region, an electron transport region disposed on the emission layer, and a second electrode disposed on the electron transport region, wherein the hole transport region includes a polycyclic compound represented by Formula 1, thereby showing high emission efficiency.
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公开(公告)号：US20200239456A1
公开(公告)日：2020-07-30
申请号：US16744728
申请日：2020-01-16
发明人： Mark E. THOMPSON , Abegail TADLE , Karim EL ROZ , Peter Ivan DJUROVICH , Daniel Sylvinson MUTHIAH RAVINSON , Jessica H. GOLDEN , Stuart W. SAWYER
IPC分类号： C07D405/14 , C07D409/14 , C07D403/14 , C07D403/04 , C07D333/54 , C07D251/24 , C07D209/82 , C07F7/08 , H01L51/00
摘要： A compound of Formula X wherein ring A is absent, or present and selected from a 5-membered or 6-membered, carbocyclic or heterocyclic ring, which is optionally substituted; ring B is absent, or present and selected from a 5-membered or 6-membered, carbocyclic or heterocyclic ring, which is optionally substituted; and at least one of ring A or ring B is present, and the hash line represents ring A fused to ring N—W1—W3 and ring B fused to ring N—W4—W6; W1, W2, W3, W4, W5, and W6 are independently selected from CR1 or N; Z is selected from CRZ or N; and Y is selected from a group consisting of C(R2)2, B(R2)2, Al(R2)2, Si(R2)2, and Ge(R2)2. An optoelectronic device selected from the group consisting of a photovoltaic device, a photodetector device, a photosensitive device, and an OLED, the optoelectronic device including an organic layer that comprises a compound of Formula X. A consumer product that includes the optoelectronic device.
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公开(公告)号：US20200231559A1
公开(公告)日：2020-07-23
申请号：US16486340
申请日：2018-02-14
申请人： MERCK PATENT GMBH
IPC分类号： C07D307/79 , A61L27/16 , C08F120/36 , C08F126/06 , C08F124/00 , C08F128/06 , C07D333/54 , C07D409/04 , C07F7/18 , C07D407/12 , C07D409/14 , C07D409/06 , C07D209/08 , C07D209/12
摘要： The present invention relates to novel compounds, particularly to compounds comprising a photoactive unit, said novel compounds being particularly suitable for compositions and ophthalmic devices as well as to compositions and ophthalmic devices comprising such compounds.
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20.发明授权公开(公告)号：US10662170B2
公开(公告)日：2020-05-26
申请号：US16174378
申请日：2018-10-30
发明人： Hui Huang , Gee-Hong Kuo , Mark R. Player , Shyh-Ming Yang , Yue-Mei Zhang
IPC分类号： C07D409/10 , C07D409/12 , C07D333/54 , C07D233/56 , C07D409/02 , C07D333/56 , C07D409/04 , C07D409/14 , C07D495/10 , A61K31/381 , A61K31/4436
摘要： Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, R5, R6, W, and A are defined herein.
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