公开(公告)号：US20210403953A1

公开(公告)日：2021-12-30

申请号：US17351451

申请日：2021-06-18

Applicant: GENENTECH, INC.

Inventor： Amy SHEN ,  Shahram MISAGHI

IPC: C12N15/90 ,  C12N15/85

Abstract: The presently disclosed subject matter relates to targeted integration (TI) host cells suitable for the expression of recombinant proteins wherein those TI host cells have been subjected to supertransfection resulting in the random integration (RI) of exogenous nucleic acids encodes into their genome, as well as methods of producing and using said supertransfected TI host cells.

公开(公告)号：US11203572B2

公开(公告)日：2021-12-21

申请号：US17011355

申请日：2020-09-03

Applicant: GENENTECH, INC. ,  XENON PHARMACEUTICALS INC.

Inventor： Sultan Chowdhury ,  Christoph Martin Dehnhardt ,  Thilo Focken ,  Michael Edward Grimwood ,  Ivan William Hemeon ,  Steven McKerrall ,  Daniel Sutherlin

IPC: C07C381/10 ,  C07D401/12 ,  C07D205/04 ,  C07D211/22 ,  C07D211/42 ,  C07D213/69 ,  A61P25/04

Abstract: The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables RA, RAA, subscript n, ring A, X2, L, subscript m, X1, ring B, R1, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

公开(公告)号：US20210363230A1

公开(公告)日：2021-11-25

申请号：US17139493

申请日：2020-12-31

Applicant: GENENTECH, INC.

Inventor： Jillian Smith ,  Janice Smith ,  Geoff Kerchner

IPC: C07K16/18 ,  C07K16/00 ,  A61P25/28 ,  A61K9/00 ,  A61K31/13 ,  A61K31/185 ,  A61K31/405 ,  A61K31/4418 ,  A61K31/455 ,  A61K31/4745 ,  A61K31/519 ,  A61K39/395 ,  A61K45/06

Abstract: Methods of treating Alzheimer's Disease (AD) in patients suffering from early AD, including amyloid positive patients, ApoE4 positive patients, and patients suffering from prodromal or mild AD are provided.

公开(公告)号：US11168070B2

公开(公告)日：2021-11-09

申请号：US16886541

申请日：2020-05-28

Applicant: GENENTECH, INC. ,  CONSTELLATION PHARMACEUTICALS, INC.

Inventor： Patrick Cyr ,  Sarah Bronner ,  F. Anthony Romero ,  Steven Magnuson ,  Vickie Hsiao-Wei Tsui ,  John Wai ,  Kwong Wah Lai ,  Fei Wang

IPC: C07D401/04 ,  A61K31/47 ,  A61P25/00 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D243/14 ,  C07D413/04 ,  C07D267/14 ,  C07D413/10 ,  A61K31/435 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/5513 ,  A61K45/06 ,  C07D487/22

Abstract: The present invention relates to compounds of formula (I) and formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R5-R6 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II), or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.

公开(公告)号：US20210338778A1

公开(公告)日：2021-11-04

申请号：US17162924

申请日：2021-01-29

Applicant: Genentech, Inc.

Inventor： Alexander R. ABBAS ,  Nico P. GHILARDI ,  Zora MODRUSAN ,  Dimitry M. DANILENKO ,  Frederic J. DE SAUVAGE ,  Wenjun OUYANG ,  Patricia A. VALDEZ ,  Yan ZHENG

IPC: A61K38/19 ,  A61K38/20 ,  A61K38/17

Abstract: The present invention relates to compositions and methods for treatment of microbial disorder by modulation of the host immune response. More particularly, the present invention relates to compositions that mediate an anti-microbial immune response, and methods of treating a microbial infection using such compositions.

公开(公告)号：US20210332114A1

公开(公告)日：2021-10-28

申请号：US17110969

申请日：2020-12-03

Applicant: Genentech, Inc. ,  AC Immune SA

Inventor： Oskar Adolfsson ,  Gai Ayalon ,  Isidro Hotzel ,  Danielle Marie Di Cara

IPC: C07K16/18 ,  G01N33/68 ,  A61K39/395 ,  A61K45/06

Abstract: The invention provides anti-Tau antibodies and methods of using the same.

公开(公告)号：US11155777B2

公开(公告)日：2021-10-26

申请号：US16728733

申请日：2019-12-27

Applicant: Genentech, Inc.

Inventor： Ekta Mahajan ,  Kelsey Dent ,  Edward Chan ,  Terry Hudson ,  Neria Daniel

IPC: C12M3/00 ,  C12M1/00 ,  C12M1/06 ,  B01F7/16 ,  B01F15/00 ,  B01F13/08 ,  C12M1/02 ,  C12M1/36 ,  B01F15/06

Abstract: Described herein are bioreactor support structures configured to be used with containers having different designs, and methods for making and using such bioreactors. The support structures described herein may include two or more agitator motors and control systems or an adjustable-position agitator motor, a removable spacer and/or lid, multiple configurations for ports and probes, and multiple exhaust filter heating blankets. Also described herein are methods of manufacturing a multi-agitator motor or adjustable-position agitator motor bioreactor, as well as methods of modifying an existing support structure to be used with a container not originally designed to be used with the existing support structure, and methods for operating these bioreactors.

公开(公告)号：US11155591B2

公开(公告)日：2021-10-26

申请号：US16196829

申请日：2018-11-20

Applicant: Genentech, Inc.

Inventor： Justin Scheer ,  Wenjun Ouyang ,  Eric Gary Stefanich ,  Richard Vandlen ,  Philip E. Hass ,  Xiaoting Wang

IPC: C07K14/54 ,  C07K16/28 ,  A61K38/20 ,  A61K47/38 ,  A61K38/00

Abstract: The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.

公开(公告)号：US11155557B2

公开(公告)日：2021-10-26

申请号：US16452058

申请日：2019-06-25

Applicant: Genentech, Inc.

Inventor： F. Anthony Romero ,  Mark Zak ,  Guiling Zhao ,  Paul Gibbons ,  Wei Li ,  Yun-Xing Cheng ,  Po-Wai Yuen ,  Limin Cheng

IPC: C07D487/04 ,  C07D498/10

Abstract: Compounds of Formula (IA), or a pharmaceutically acceptable salt thereof, and methods of use as Janus kinase inhibitors are described herein.

公开(公告)号：US20210322426A1

公开(公告)日：2021-10-21

申请号：US17223105

申请日：2021-04-06

Applicant: Genentech, Inc.

Inventor： Susan Greene ,  Stephanie Joo ,  Jennifer Schutzman

IPC: A61K31/5377 ,  A61K31/4745 ,  A61K31/4439 ,  A61K31/553 ,  A61K31/501 ,  A61K31/519 ,  A61K31/444 ,  A61K31/437 ,  A61K31/427 ,  A61K31/565 ,  A61K31/155 ,  A61K31/506 ,  A61K31/337 ,  A61K31/675 ,  A61K31/704 ,  A61K31/4196 ,  A61K31/7068 ,  A61K31/138 ,  A61K31/395 ,  A61P35/00

Abstract: Described herein are methods of treating PIK3CA-mutant cancer patients by administering metformin and a PI3K alpha inhibitor.