公开(公告)号：US20190117382A1

公开(公告)日：2019-04-25

申请号：US16228623

申请日：2018-12-20

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Malik Y. KAHOOK

IPC: A61F2/16

Abstract: The present disclosure relates generally to the fields of medical devices, ophthalmology, and cataract surgery, and more particularly to, for example, a capsular tension ring. The capsular tension ring can include an inner ring section, and an outer ring section at least partially enveloping the inner ring section. The outer ring section can have an outer ring surface, an inner ring surface, and a plurality of raised polygon features on the inner ring surface, wherein each of the raised polygon features is radially symmetric

公开(公告)号：US20190112354A1

公开(公告)日：2019-04-18

申请号：US16094006

申请日：2017-04-21

Applicant: Xalud Therapeutics, Inc. ,  The Regents of the University of Colorado, a Body Corporate

Inventor： John Forsayeth ,  Raymond Chavez ,  Linda Watkins ,  Peter Grace

IPC: C07K14/715 ,  A61P25/00 ,  C07K14/54 ,  A61K38/20 ,  A61K38/17 ,  C12N7/00 ,  A61K9/00 ,  A61K35/17 ,  A61K35/30

Abstract: This invention relates to methods and compositions for overcoming the dose-dependent down regulation of interleukin 10 (IL-10) by expressing, in addition to an interleukin 10 (IL-10) peptide, an IL-10 receptor type 1 (IL-10R1) peptide. The methods have use in treating a variety of diseases and symptoms, including but not limited to neuropathic or chronic pain; symptoms and physiological damage associated with multiple sclerosis, spinal cord injury, ALS, neuroinflammation, arthritis and other diseases of the joint; and autoimmune diseases.

公开(公告)号：US10233235B2

公开(公告)日：2019-03-19

申请号：US14571102

申请日：2014-12-15

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Joshua M. Thurman ,  V. Michael Holers

IPC: C07K16/18 ,  A61K38/17 ,  C07K14/47 ,  C12N9/88 ,  A61K38/00

Abstract: Provided herein are compositions, including pharmaceutical compositions, and methods for modulating, i.e., stimulating or inhibiting, activity of the alternative complement pathway, and methods of identifying factor H-binding proteins.

公开(公告)号：US10226194B2

公开(公告)日：2019-03-12

申请号：US14867938

申请日：2015-09-28

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Gregory Zlatko Grudic ,  Steven Lee Moulton ,  Isobel Jane Mulligan

IPC: A61B5/03 ,  G06F19/00 ,  G16H50/50 ,  G16H40/63 ,  A61B5/1455 ,  A61B5/021 ,  A61B5/024 ,  A61B5/0402 ,  A61B5/083 ,  A61B5/145 ,  A61B5/0205 ,  A61B8/08 ,  A61B5/00

Abstract: Tools and techniques for the rapid, continuous, invasive and/or noninvasive measurement, estimation, and/or prediction of a patient's physiological state. In an aspect, some tools and techniques can estimate predict the onset of conditions intracranial pressure, an amount of blood volume loss, cardiovascular collapse, and/or dehydration. Some tools can recommend (and, in some cases, administer) a therapeutic treatment for the patient's condition. In another aspect, some techniques employ high speed software technology that enables active, long term learning from extremely large, continually changing datasets. In some cases, this technology utilizes feature extraction, state-of-the-art machine learning and/or statistical methods to autonomously build and apply relevant models in real-time.

公开(公告)号：US20190072570A1

公开(公告)日：2019-03-07

申请号：US15580968

申请日：2016-06-07

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Michael P. CHAPMAN

IPC: G01N33/86 ,  G01N33/49 ,  G01N11/02 ,  A61B5/02

Abstract: In some embodiments, the invention provides an in vitro method for identifying a patient as likely as likely to require a transfusion of at least six units of blood in six hours or less. The method comprise, consists essentially of, or consists of (a) analyzing a sample of blood from a patient with a viscoelastic analysis assay to obtain a coagulation characteristic value that is independent of time of the patient; and (b) comparing the coagulation characteristic value of the patient to a coagulation characteristic value that is independent of time of a control, wherein the coagulation characteristic value of the patient that is lower than the coagulation characteristic value of the control identifies the patient as likely to require a transfusion of at least six units of blood in six hours or less.

公开(公告)号：US10213342B2

公开(公告)日：2019-02-26

申请号：US15389328

申请日：2016-12-22

Applicant: The Regents of the University of Colorado, a body corporate ,  New World Medical, Inc.

Inventor： Malik Kahook ,  Khalid Mansour ,  Suhail Abdullah ,  Eric Porteous

IPC: A61F9/013 ,  A61F9/007

Abstract: The present invention relates to an ophthalmic knife and methods of its use for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. The invention relates to a multi-blade device for cutting the tissues within the eye, for example, a trabecular meshwork (TM).

公开(公告)号：US20190055654A1

公开(公告)日：2019-02-21

申请号：US16049258

申请日：2018-07-30

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： STEVEN MCCLELLAN GEORGE ,  NICHOLAS RAY JOHNSON ,  JAIME WILLADEAN DUMONT ,  AMY ELIZABETH MARQUARDT ,  YOUNGHEE LEE ,  DAVID RICHARD ZYWOTKO ,  AZIZ ABDULAGATOV

IPC: C23F4/00

Abstract: The invention includes a method of promoting atomic layer etching (ALE) of a surface. In certain embodiments, the method comprises sequential reactions with a metal precursor and a halogen-containing gas. In other embodiments, the etching rate is increased by removing residual species bound to and/or adsorbed onto the surface.

公开(公告)号：US20190055537A1

公开(公告)日：2019-02-21

申请号：US16178024

申请日：2018-11-01

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Richard Carrillo ,  Jan P. Kraus ,  Tomas Majtan ,  David Naveh

IPC: C12N9/88 ,  B01D15/38 ,  B01D15/36 ,  A61K38/51

Abstract: This invention provides chromatographic methods for the purification of a cystathionine β-Synthase (CBS) protein, particularly truncated variants thereof and compositions and pharmaceutical compositions prepared therefrom.

公开(公告)号：US10202397B2

公开(公告)日：2019-02-12

申请号：US15324629

申请日：2015-07-10

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate

Inventor： Dan Theodorescu ,  Michael Fitzpatrick Wempe ,  David Ross ,  Chao Yan ,  Phillip Reigan

IPC: C07D491/052 ,  A61K31/4162 ,  A61K45/06

Abstract: Methods of inhibiting the growth or metastasis of a cancer in a subject by inhibiting a Ral GTPase in the subject, and small molecule inhibitors of Ral GTPases useful in the methods of the invention. Pharmaceutical compositions containing the compounds of the invention, and methods of using the same.

公开(公告)号：US20180371117A1

公开(公告)日：2018-12-27

申请号：US15995680

申请日：2018-06-01

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Kristi Anseth ,  Alexander Caldwell

IPC: C08F6/24 ,  C07F7/18 ,  C08F222/38 ,  C12N5/0775

Abstract: This invention is in the field of medicinal chemistry. The present invention provides cell-laden hydrogels and hydrogel assemblies thereof for use in tissue engineering. The present invention provides methods of producing various hydrogels and hydrogel assemblies and pharmaceutical compositions thereof. The present invention provides for a microgel comprising an encapsulated population of live primary human cells in a hydrogel comprising a polymeric network.