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    DEVICE SUITABLE FOR VACUUM ASSISTED FILTRATION
    212.
    发明申请
    DEVICE SUITABLE FOR VACUUM ASSISTED FILTRATION 有权

    公开(公告)号：US20210299614A1

    公开(公告)日：2021-09-30

    申请号：US16328502

    申请日：2017-10-05

    Applicant: EMD Millipore Corporation

    Inventor： Christopher A. Scott ,  Kurt Greenizen ,  Paul Sydlowski

    IPC: B01D63/08 ,  B01D61/18 ,  B01D61/20

    Abstract: A funnel-less filtration device that attaches directly to a storage container such as a cell culture media bottle. The device includes a filter collar containing one or more membranes, an inlet with a coupling device for attaching the filter device to a supply of liquid to be filtered, an outlet at a lower portion of the collar, a vacuum port in the collar below the membrane(s) and a filtered vent in the collar above the membrane(s). Optionally, the device may include a filtrate reservoir attached to the outlet, preferably by a threaded connection. Optionally, the upper opening to the filter collar is selectively and removably sealed with a lid until used. The lid is then removed the filter device inverted over a storage container such as cell culture media bottle and the two are attached via the upper opening of the filter collar. The assembly is then inverted so the supply container is above the filter device. Upon subjecting the sample in the bottle to a driving force such as vacuum, the sample flows through the filtration element, and into a filtrate reservoir below the outlet of the filter collar.

    CONTAINER FOR SEPARATING MICROCARRIERS FROM CELL CULTURE FLUIDS
    214.
    发明申请
    CONTAINER FOR SEPARATING MICROCARRIERS FROM CELL CULTURE FLUIDS 有权

    公开(公告)号：US20210238536A1

    公开(公告)日：2021-08-05

    申请号：US16330413

    申请日：2017-10-23

    Applicant: EMD Millipore Corporation

    Inventor： Martin Morrissey

    IPC: C12M1/00 ,  C12M1/12 ,  C12M1/26

    Abstract: Containers for separating microcarriers from a cell culture fluid that offer a greater efficiency of filtration of cell culture fluids containing microcarriers relative to systems described in the art. The container may include a first compartment that may include a sterile collapsible bag, an inlet port providing a fluid path into the first compartment and an outlet port providing a fluid path exiting the first compartment; and a second compartment fluidly connected with the inlet port of the first compartment and including a plurality of independent or discrete microcarrier receiving regions defined by boundary walls which are partially or fully porous and having a porosity sufficient to retain the microcarriers inside the second compartment, while allowing the cell culture fluid to pass through the second compartment into the outlet port of the first compartment, where the cell culture fluid can be collected.

    Mixed gas integrity testing of porous materials without permeate side access
    215.
    发明授权
    Mixed gas integrity testing of porous materials without permeate side access 有权

    公开(公告)号：US10955328B2

    公开(公告)日：2021-03-23

    申请号：US16349855

    申请日：2017-11-20

    Applicant: EMD Millipore Corporation

    Inventor： Salvatore Giglia

    IPC: G01N15/08 ,  G01N33/00 ,  B01D65/10 ,  G01N15/06

    Abstract: A method of integrity testing porous materials that is non-destructive to the material being tested. The inlet gas stream includes at least two gases, wherein one of the gases has a different permeability in liquid than the other, such as oxygen and nitrogen in water. The relative permeability of the gases is measured in the retentate stream, thereby avoiding accessing the permeate stream and potentially introducing contaminants to the material being tested. The integrity test is capable of detecting the presence of oversized pores or defects that can compromise the retention capability of the porous material.

    Single Use Container Including a Collapsible Baffle Having Channels
    216.
    发明申请
    Single Use Container Including a Collapsible Baffle Having Channels 有权

    公开(公告)号：US20210054327A1

    公开(公告)日：2021-02-25

    申请号：US16964646

    申请日：2019-03-13

    Applicant: EMD Millipore Corporation

    Inventor： Jeffrey Pearsons ,  Amy Wood ,  David Kraus

    IPC: C12M1/00 ,  C12M3/00 ,  C12M1/06 ,  C12M1/34

    Abstract: A collapsible container for a fluid that includes a flexible material, defining an internal working volume; at least one collapsible baffle adhered within the working volume of said collapsible container, the at least one baffle having one or more channels for delivering one or more fluids into the working volume via at least one hole in said one or more channels, one or more channels in said container for exiting or venting fluids from the working volume, and an impeller assembly disposed at least partially within said working volume of said container.

    EMBOSSED FILM BIOPROCESSING CONTAINERS AND INTEGRITY TESTING OF BIOPROCESSING CONTAINERS
    218.
    发明申请
    EMBOSSED FILM BIOPROCESSING CONTAINERS AND INTEGRITY TESTING OF BIOPROCESSING CONTAINERS 审中-公开

    公开(公告)号：US20200209098A1

    公开(公告)日：2020-07-02

    申请号：US16644109

    申请日：2018-09-27

    Applicant: EMD Millipore Corporation

    Inventor： Brian Pereira ,  Stephen Proulx

    IPC: G01M3/32 ,  B01L3/00

    Abstract: A testing method that includes the steps of evacuating air from a container to a negative atmospheric pressure, the container being a collapsible, flexible container, and comprising at least two opposing flexible walls, wherein a surface of at least one of the walls internal to the container comprises a plurality of channels or recessed features on said at least one wall and monitoring a mass flow or a state of vacuum so as to determine the integrity of the container. The container can be of any size or conformation, with or without attached fittings.

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