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公开(公告)号:US11972347B2
公开(公告)日:2024-04-30
申请号:US17049651
申请日:2019-04-22
Inventor: Chaim Baskin , Eliyahu Schwartz , Evgenii Zheltonozhskii , Alexander Bronstein , Natan Liss , Abraham Mendelson
IPC: G06N3/08 , G06F18/211 , G06F18/23 , G06N3/048
CPC classification number: G06N3/08 , G06F18/211 , G06F18/23 , G06N3/048
Abstract: A system for training a quantized neural network dataset, comprising at least one hardware processor adapted to: receive input data comprising a plurality of training input value sets and a plurality of target value sets; in each of a plurality of training iterations: for each layer, comprising a plurality of weight values, of one or more of a plurality of layers of a neural network: compute a set of transformed values by applying to a plurality of layer values one or more emulated non-uniformly quantized transformations by adding to each of the plurality of layer values one or more uniformly distributed random noise values; and compute a plurality of output values; compute a plurality of training output values; and update one or more of the plurality of weight values to decrease a value of a loss function; and output the updated plurality of weight values of the plurality of layers.
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公开(公告)号:US11948295B2
公开(公告)日:2024-04-02
申请号:US17256373
申请日:2019-06-27
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor: Natan Tzvi Shaked , Alon Shalev , Yoav Nahum Nygate
CPC classification number: G06T7/0012 , G06T7/13 , G06V20/698 , G06T2207/10056 , G06T2207/20192 , G06T2207/30024
Abstract: Systems and methods for visualizing an unstained sperm cell are presented, the system comprises a data input utility that receives measured data comprising at least one quantitative phase microscopy image of the unstained sperm cell; a data processing utility comprising an image analyzer module that utilizes characteristic refractive index information of one or more organelles of the sperm cell, to process the at least one quantitative phase microscopy image and generate at least one corresponding gradient image that includes edge enhancement of the one or more organelles, and a virtual staining module that applies one or more predetermined virtual staining functions to the at least one quantitative phase microscopy image and at least one corresponding gradient image, thereby virtually stain at least one of the one or more organelles of the sperm cell and generate virtually stained image data of the sperm cell; and an output utility that utilizes the virtually stained image data of the sperm cell and generates one or more stained images of the unstained sperm cell, each stained image emulating an image of the sperm cell should the sperm cell has been actually stained with one or more actual stains.
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公开(公告)号:US11904307B2
公开(公告)日:2024-02-20
申请号:US17885622
申请日:2022-08-11
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor: Moshe Kol , Tomer Rosen , Yanay Popowski
IPC: B01J31/00 , B01J31/22 , C08G63/82 , C07D401/14 , C07D213/36
CPC classification number: B01J31/2243 , C07D213/36 , C07D401/14 , C08G63/823 , B01J2231/54 , B01J2531/004 , B01J2531/0241 , B01J2531/22 , B01J2531/26
Abstract: A new family of mononuclear organometallic complexes of a divalent metal bound to sequential tetradentate monoanionic {ONNN}-type ligands, and polymerization of cyclic esters such as lactides utilizing same are provided. Novel tetradentate monoanionic {ONNN}-type ligands usable for forming these complexes are also provided.
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214.
公开(公告)号:US20240052315A1
公开(公告)日:2024-02-15
申请号:US18278100
申请日:2022-03-20
Applicant: RAMOT AT TEL AVIV UNIVERSITY LTD.
Inventor: Iftach NACHMAN , Gaya SAVYON
IPC: C12N5/077
CPC classification number: C12N5/0658 , C12N2506/02 , C12N2500/25 , C12N2501/155 , C12N2501/415 , C12N2501/12 , C12N2501/105 , C12N2501/115
Abstract: Provided herein are artificially cultured somites comprising mature muscle progenitor cells and/or mature muscle cells, methods of obtaining same and methods for fast, large scale production of cultured meat comprising mature muscle cells.
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215.
公开(公告)号:US20240043561A1
公开(公告)日:2024-02-08
申请号:US18254255
申请日:2021-11-23
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor: Vered PADLER-KARAVANI , Ron AMON
CPC classification number: C07K16/3076 , A61K39/4631 , A61K39/461 , C07K2317/24 , C07K2317/565 , C07K2317/567 , C07K2317/92 , C07K2317/622 , A61K2239/21 , A61K2239/13
Abstract: The present invention discloses humanized monoclonal antibodies that specifically bind to SLeA carbohydrate antigen with high specificity and selectivity, functional fragments of the humanized monoclonal antibodies such as scFv, and chimeric antigen receptors comprising the humanized monoclonal antibodies or the fragment thereof such as scFv. The invention further provides cells and compositions comprising the antibodies, fragments thereof or CARs as well as their use in diagnostics and treatment of cancer.
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公开(公告)号:US20240012078A1
公开(公告)日:2024-01-11
申请号:US18021577
申请日:2021-08-17
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor: Uri NEVO , David CORCOS
CPC classification number: G01R33/5608 , A61B5/055 , A61B5/0042 , G06T7/0012 , G06T2207/10088 , G06T2207/30016 , A61B2576/026
Abstract: A method of scanning an object in a FOV by acquiring an MRI signal from the object at different projections of a spatially encoding magnetic field, using a plurality of receiving antennas, and reconstructing an MRI image of the object, comprising:
a) at each projection, acquiring the MRI signal from the receiving antennas;
b) filtering the received signal, for at least some of the projections, by applying different time windows to different components of the signal in different frequency bands, and/or received by different receiver antennas, resulting in a filtered received signal vector whose components describe the filtered received signal as a function of time, at each projection, for one or more receiver antennas; and
c) reconstructing an image as a vector whose components describe a weighted or unweighted net magnetization at each voxel in the FOV, that would be expected to produce the filtered received signal vector.-
公开(公告)号:US20230365491A1
公开(公告)日:2023-11-16
申请号:US18352955
申请日:2023-07-14
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor: Yoram Cohen , Micha Fridman , Roymon Joseph , Alissa Naugolny , Mark Feldman , Ido M. Herzog , Dana Kaizerman
IPC: C07C217/54 , A61K31/138 , A61K31/4178 , A61K31/66 , A61K45/06 , C02F1/50 , C07D233/60 , C07F9/54 , C09D5/16
CPC classification number: C07C217/54 , A61K31/138 , A61K31/4178 , A61K31/66 , A61K45/06 , C02F1/50 , C07D233/60 , C07F9/5407 , C09D5/1687 , C02F2303/20
Abstract: Cationic pillar[n]arenes, e.g., positively charged poly-ammonium, poly-phosphonium and poly-imidazolium pillar[5-6]arene derivatives are capable of inhibiting or preventing biofilm formation, and facilitating existing biofilm decomposition. A composition for inhibiting or disrupting biofilm, e.g., bacterial or fungal biofilm, formation, or reducing biofilm, can include a pharmaceutically acceptable carrier, and a cationic pillar[n]ene.
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公开(公告)号:US20230360220A1
公开(公告)日:2023-11-09
申请号:US18223106
申请日:2023-07-18
Applicant: Ramot at Tel-Aviv University Ltd. , Tel HaShomer Medical Research Infrastructure and Services Ltd.
Inventor: Ygal ROTENSTREICH , Ifat SHER ROSENTHAL , Haim SUCHOWSKI , Michael MREJEN , Shahar KATZ
CPC classification number: G06T7/0016 , A61B5/026 , A61B3/11 , G06T2207/10024 , G06T2207/20081 , G06T2207/30041 , G06T2207/30104
Abstract: A method of diagnosing a condition of a subject, comprises: receiving image data of an anterior of an eye of the subject, and analyzing the image data to detect at least one of: flow of individual blood cells in libmal or conjunctival blood vessels of the eye, morphology of limbal or conjunctival blood vessels. The method also comprises determining the condition of the subject based on the detection(s).
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公开(公告)号:US20230340070A1
公开(公告)日:2023-10-26
申请号:US18085632
申请日:2022-12-21
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor: Yaron CARMI , Peleg RIDER , Diana RASOULOUNIRIANA , Lior TAL
IPC: C07K14/735 , C12N5/0783 , A61P37/04
CPC classification number: C07K14/70535 , A61P37/04 , C12N5/0636 , C07K2319/03 , C07K2319/30
Abstract: Multi subunit protein modules are provided. Accordingly, there is provided a multi subunit protein module comprising at least three cell membrane polypeptides each comprising an amino acid sequence of an Fc receptor common gamma chain (FcRgamma), said amino acid sequence is capable of transmitting an activating signal; wherein at least one but not all of said at least three polypeptides comprises an extracellular binding domain capable of binding a target that is presented on a cell surface of a target cell of an immune cell, such that upon binding of said extracellular binding domain to said target said activating signal is transmitted in an immune cell expressing said multi subunit protein module. Also provided are cells expressing the multi subunit protein modules and uses thereof.
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公开(公告)号:US20230306276A1
公开(公告)日:2023-09-28
申请号:US17938131
申请日:2022-10-05
Applicant: International Business Machines Corporation , Trustees of Tufts College , Ramot at Tel-Aviv University Ltd.
Inventor: Lior Horesh , Elizabeth Newman , Misha E. Kilmer , Haim Avron
Abstract: Techniques for generating and managing, including simulating and training, deep tensor neural networks are presented. A deep tensor neural network comprises a graph of nodes connected via weighted edges. A network management component (NMC) extracts features from tensor-formatted input data based on tensor-formatted parameters. NMC evolves tensor-formatted input data based on a defined tensor-tensor layer evolution rule, the network generating output data based on evolution of the tensor-formatted input data. The network is activated by non-linear activation functions, wherein the weighted edges and non-linear activation functions operate, based on tensor-tensor functions, to evolve tensor-formatted input data. NMC trains the network based on tensor-formatted training data, comparing output training data output from the network to simulated output data, based on a defined loss function, to determine an update. NMC updates the network, including weight and bias parameters, based on the update, by application of tensor-tensor operations.
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