公开(公告)号：US20220057362A1

公开(公告)日：2022-02-24

申请号：US17407667

申请日：2021-08-20

Applicant: Meso Scale Technologies, LLC

Inventor： Mark Billadeau ,  Nicholas Carbone ,  Charles Clinton ,  Scott Dowdell ,  Manish Kochar ,  Nicholas Fox-Lyon ,  Bandele Jeffrey-Coker ,  Alexander Tucker-Schwartz ,  George Sigal ,  Gisbert Spieles ,  Jules Vandersarl ,  Jacob Wohlstadter

IPC: G01N27/49 ,  G01N27/327

Abstract: An electrochemical cell includes a plurality of working electrode zones disposed, and defining a pattern, on a surface of the cell and at least one auxiliary electrode disposed on the surface. The auxiliary electrode may have a defined interfacial potential.

公开(公告)号：US11231417B2

公开(公告)日：2022-01-25

申请号：US16815598

申请日：2020-03-11

Applicant: Meso Scale Technologies, LLC.

Inventor： Sudeep Kumar ,  George Sigal ,  Michael Tsionsky

IPC: G01N33/543 ,  G01N33/53 ,  C12Q1/6823 ,  C12Q1/6832 ,  C12Q1/6834

Abstract: The invention relates to methods for conducting binding assays in an assay device that includes one or more storage and use zone. The storage zones of the assay device are configured to house one or more reagents used in an assay conducted in the use zone of the device.

公开(公告)号：US20220019053A1

公开(公告)日：2022-01-20

申请号：US17492187

申请日：2021-10-01

Applicant: Meso Scale Technologies, LLC.

Inventor： Ian CHAMBERLIN ,  Charles M. CLINTON ,  Eli N. GLEZER ,  Bandele JEFFREY-COKER ,  Manish KOCHAR ,  Sandor KOVACS ,  D.T. Le ,  Aaron LEIMKUEHLER ,  George SIGAL ,  Leo TABAKIN ,  Jon WILLOUGHBY

IPC: G02B7/36 ,  G01N21/25 ,  G01N21/64 ,  G01N35/02

Abstract: Apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation are described. They are particularly well suited for conducting automated analysis in a multi-well plate assay format.

公开(公告)号：US20210373033A1

公开(公告)日：2021-12-02

申请号：US17169805

申请日：2021-02-08

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  John Kenten ,  Galina Nikolenko

IPC: G01N33/68

Abstract: The present invention relates to methods of diagnosing glomerulonephritis (GN) in a patient, as well as methods of monitoring the progression of GN and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

公开(公告)号：US11135594B2

公开(公告)日：2021-10-05

申请号：US16292521

申请日：2019-03-05

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Kenneth Page ,  Sandor Kovacs ,  Sudeep Kumar ,  Kristian Roth

IPC: B01L3/00 ,  F16K11/074

Abstract: Assay cartridges are described that have a plurality of chambers and a fluidic network that includes fluidic conduits and a multi-port valve designed to selectively connect the valve inlet and one valve outlet through a fluidic connector in the valve as the remaining valve outlets are sealed.

公开(公告)号：US11105799B2

公开(公告)日：2021-08-31

申请号：US15813411

申请日：2017-11-15

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Anu Mathew

IPC: G01N33/574 ,  G01N33/543

Abstract: The present invention relates to methods of diagnosing a kidney disorder in a patient, as well as methods of monitoring the progression of a kidney disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

公开(公告)号：US11065615B2

公开(公告)日：2021-07-20

申请号：US15882914

申请日：2018-01-29

Applicant: MESO SCALE TECHNOLOGIES, LLC

Inventor： Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Jeffery D. Debad ,  Sudeep M. Kumar ,  George B. Sigal ,  Gisbert Spieles ,  Michael Tsionsky ,  Michael Warnock

IPC: G01N33/543 ,  B01L3/00 ,  G01N33/53

Abstract: We describe assay modules (e.g., assay plates, cartridges, multi-well assay plates, reaction vessels, etc.), processes for their preparation, and method of their use for conducting assays. Reagents may be present in free form or supported on solid phases including the surfaces of compartments (e.g., chambers, channels, flow cells, wells, etc.) in the assay modules or the surface of colloids, beads, or other particulate supports. In particular, dry reagents can be incorporated into the compartments of these assay modules and reconstituted prior to their use in accordance with the assay methods. A desiccant material may be used to maintain and stabilize these reagents in a dry state.

公开(公告)号：US20210182346A1

公开(公告)日：2021-06-17

申请号：US17185293

申请日：2021-02-25

Applicant: Meso Scale Technologies, LLC.

Inventor： Xinri Cong ,  Jerome Jackson ,  Carl Stevens ,  Michael Vock ,  Jacob N. Wohlstadter

IPC: G06F16/951 ,  G16H10/40 ,  G06F16/21 ,  G06Q10/10 ,  G06Q10/06 ,  G07C9/27 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10 ,  G06Q30/02 ,  G06Q30/06

Abstract: The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such information in the conduct of an assay by an assay system.

公开(公告)号：US20210172937A1

公开(公告)日：2021-06-10

申请号：US17026561

申请日：2020-09-21

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Kent Johnson ,  Michael Tsionsky ,  John H. Kenten ,  Jeff D. Debad ,  Robert M. Umek ,  Paula Denney Eason ,  Hans Biebuyck ,  Jacob N. Wohlstadter ,  James Wilbur ,  George Sigal ,  Niranjan Y. Sardesai

IPC: G01N33/53 ,  C12Q1/48 ,  G01N33/543 ,  G01N33/68 ,  G01N33/569 ,  G01N33/573

Abstract: Multiplexed test measurements are conducted using an assay module having a plurality of assay domains. In preferred embodiments, these measurements are conducted in assay modules having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.

公开(公告)号：USD918415S1

公开(公告)日：2021-05-04

申请号：US29711873

申请日：2019-11-04

Applicant: Meso Scale Technologies, LLC.

Designer： Eric Jones ,  Jennifer Parker ,  Manish Kochar ,  Nicholas Sammons