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    Quadruplex stabilizer
    231.
    发明授权
    Quadruplex stabilizer 有权
    四重稳定剂

    公开(公告)号：US06979738B2

    公开(公告)日：2005-12-27

    申请号：US10690984

    申请日：2003-10-22

    Applicant: Ta-Chau Chang ,  Cheng-Chung Chang ,  Jin-Yi Wu

    Inventor： Ta-Chau Chang ,  Cheng-Chung Chang ,  Jin-Yi Wu

    IPC: A61K31/4178 ,  A61K31/4439 ,  A61K31/501 ,  A61K49/00 ,  C07D401/14 ,  C07D403/14 ,  C12Q1/00

    CPC classification number: C07D403/14 ,  C07D401/14

    Abstract: This invention relates to carbazole compounds of the following formula: In the above formula, each of rings A and B, independently, is heteroaryl containing at least one nitrogen atom; each of X and Y, independently, is CH or N; each of R1–R6, independently, is H, C1–C8 alkyl, C2–C8 alkenyl, C2–C8 alkynyl, C3–C8 cycloalkyl, C3–C8 heterocycloalkyl, aryl, heteroaryl, OH, C1–C6 alkoxy, aryloxy, heteroaryloxy, NH2, C1–C6 alkylamino, C1–C12 dialkylamino, arylamino, diarylamino, or halogen; R7 is H, C1–C8 alkyl, C2–C8 alkenyl, C2–C8 alkynyl, C3–C8 cycloalkyl, C3–C8 heterocycloalkyl, aryl, heteroaryl; and

    Abstract translation: 本发明涉及下式的咔唑化合物：在上式中，环A和B各自独立地为含有至少一个氮原子的杂芳基; X和Y各自独立地是CH或N; R 1 -R 6中的每一个独立地是H，C 1 -C 8烷基，C 1 -C 6烷基， C 2 -C 8亚烷基，C 2 -C 8炔基，C 3 - C 8环烷基，C 3 -C 8杂环烷基，芳基，杂芳基，OH，C 1 -C 3烷基， 烷氧基，芳氧基，杂芳氧基，NH 2，C 1 -C 6烷基氨基，C 1 -C 6烷基氨基， C 1 -C 12二烷基氨基，芳基氨基，二芳基氨基或卤素; R 7是H，C 1 -C 8烷基，C 2 -C 8烷基，C 2 -C 8烷基， 亚烷基，C 2 -C 8炔基，C 3 -C 8环烷基，C 1 -C 3烷基， 杂环烷基，芳基，杂芳基; 和m和n各自独立地是1,2或3。

    Novel antimicrobial peptide isolated from penaeus monodon
    234.
    发明申请
    Novel antimicrobial peptide isolated from penaeus monodon 审中-公开
    从单子对虾中分离的新型抗菌肽

    公开(公告)号：US20040235738A1

    公开(公告)日：2004-11-25

    申请号：US10842005

    申请日：2004-05-10

    Applicant: Academia Sinica

    Inventor： Jenn-Kan Lu ,  Jen-Leih Wu ,  Tze-Ting Chiou

    IPC: A61K038/17 ,  C07K014/435

    CPC classification number: A61K45/06 ,  A01K2217/05 ,  A61K38/17 ,  C07K14/43509 ,  A61K2300/00

    Abstract: The present invention provides an antimicrobial peptide, monodoncin, which is isolated and purified from Penaeus monodon and is capable of being mass produced by molecular cloning techniques in a heterologous expression system, such as yeast. Monodoncin demonstrates a wide-range of bacteriostatic and bactericidal effects on G(null) and G(null) bacteria as well as fungicidal activities, and can be used in combination with conventional antibiotics as nullcocktail therapynull to improve the therapeutic effects of the conventional antibiotics.

    Abstract translation: 本发明提供了一种抗微生物肽单链，其由对白对虾分离和纯化，并且能够通过异源表达系统如酵母中的分子克隆技术大规模生产。 Monodoncin对G（ - ）和G（+）细菌以及杀真菌活性具有广泛的抑菌和杀菌作用，可与常规抗生素联合使用，作为“鸡尾酒疗法”，以提高常规抗菌素的治疗效果 抗生素。

    Monoclonal antibody for analysis and clearance of polyethylene glycol and polyethylene glycol-modified molecules
    235.
    发明申请
    Monoclonal antibody for analysis and clearance of polyethylene glycol and polyethylene glycol-modified molecules 有权
    用于分析和清除聚乙二醇和聚乙二醇改性分子的单克隆抗体

    公开(公告)号：US20010028881A1

    公开(公告)日：2001-10-11

    申请号：US09810379

    申请日：2001-03-16

    Applicant: Academia Sinica

    Inventor： Steve Roffler ,  Tian-Lu Cheng ,  Pin Yi Wu

    IPC: A61K039/395 ,  C12P021/08 ,  G01N033/53 ,  G01N033/537 ,  G01N033/543

    CPC classification number: G01N33/5308 ,  A61K2039/505 ,  C07K16/44 ,  G01N2430/60

    Abstract: A novel anti-polyethylene glycol monoclonal antibody and its preparation are disclosed. Such an antibody can be used for determining polyethylene glycol concentration in vitro or accelerating the clearance of a polyethylene glycol containing compound from the blood circulation in the human body thereby reducing the toxicity associated with the polyethylene glycol containing conjugate. The antibody is particularly useful in cancer therapy where the therapeutic agent is selectively delivered to the tumor by increasing the tumor/blood ratio of the polyethylene glycol containing compound.

    Abstract translation: 公开了一种新的抗聚乙二醇单克隆抗体及其制备方法。 这样的抗体可以用于体外测定聚乙二醇浓度，或加速来自人体血液循环的含聚乙二醇的化合物的清除，从而降低与含聚乙二醇的缀合物相关的毒性。 抗体特别可用于癌症治疗，其中治疗剂通过增加含聚乙二醇的化合物的肿瘤/血液比选择性递送至肿瘤。

    Cell line derived from Penaeus monodon and a method of growing virus using the same
    237.
    发明授权
    Cell line derived from Penaeus monodon and a method of growing virus using the same 有权
    源自对虾单核细胞的细胞系和使用该细胞生长病毒的方法

    公开(公告)号：US6143547A

    公开(公告)日：2000-11-07

    申请号：US323093

    申请日：1999-06-01

    Applicant: Ya-Li Hsu

    Inventor： Ya-Li Hsu

    IPC: C12N5/06 ,  C12N7/00

    CPC classification number: C12N7/00 ,  C12N2710/14011 ,  C12N2710/14051 ,  C12N2710/18051 ,  C12N2750/14051

    Abstract: The present invention relates to the establishment of an immortal shrimp cell line (PMO) derived from Penaeus monodon. This cell line is susceptible to and capable of mass producing virus, which includes, but not limited to, white spot syndrome virus (WSSV), Panaeus monodon baculovirus (MBV), infectious hypodermal and hematopoietic necrosis virus (IHHNV), and infectious pancreatic necrosis virus (IPNV). This invention also relates to the method of mass producing virus using PMO as a host.

    Abstract translation: 本发明涉及建立源自对虾（Monica）的永生虾细胞系（PMO）。 该细胞系易感并能够大规模生产病毒，其包括但不限于白点综合征病毒（WSSV），单翅目杆状杆菌病毒（MBV），感染性皮下和造血坏死病毒（IHHNV）和感染性胰腺坏死 病毒（IPNV）。 本发明还涉及使用PMO作为宿主大量生产病毒的方法。

    Production of biologically active recombinant insulin-like growth factor II polypeptides
    238.
    发明授权
    Production of biologically active recombinant insulin-like growth factor II polypeptides 失效
    生物活性重组胰岛素样生长因子II多肽的生产

    公开(公告)号：US6010882A

    公开(公告)日：2000-01-04

    申请号：US3708

    申请日：1998-01-07

    Applicant: Jen-Leih Wu ,  Jyh-Yih Chen ,  Chi-Yao Chang

    Inventor： Jen-Leih Wu ,  Jyh-Yih Chen ,  Chi-Yao Chang

    IPC: C07K14/65 ,  C12N15/12 ,  C12N15/18 ,  C12N15/70 ,  C12N15/79 ,  C12N15/81 ,  C12N15/86 ,  C12N5/00 ,  C12N15/63

    CPC classification number: C07K14/65

    Abstract: The present invention relates to the finding and construction of fish insulin-like growth factor II (IGF-II) cDNAs which can be cloned and expressed in cells. This invention also relates to the production of biologically active fish IGF-II polypeptides by a gene expression system using fish IGF-II cDNAs. The fish IGF-II cDNAs have 1977 bp which transcribe into a prepeptide (signal peptide), and B, C, A, D, E domain peptides. The fish mature IGF-II is a single polypeptide containing the NH.sub.2 -B-C-A-D-COOH domains. The mature IGF-II polypeptide is 7 kDa in weight and has 70 amino acids. The fish recombinant IGF-II CDNA can be cloned and expressed in E. coli, yeast, baculovirus, and fish cells.

    Abstract translation: 本发明涉及可以在细胞中克隆和表达的鱼类胰岛素样生长因子II（IGF-II）cDNA的发现和构建。 本发明还涉及通过使用鱼IGF-II cDNA的基因表达系统生产生物活性鱼IGF-II多肽。 鱼IGF-II cDNA具有1977bp，其转录成前肽（信号肽），以及B，C，A，D，E结构域肽。 鱼成熟IGF-II是含有NH2-B-C-A-D-COOH结构域的单一多肽。 成熟的IGF-II多肽的重量为7kDa，具有70个氨基酸。 鱼重组IGF-II CDNA可以在大肠杆菌，酵母，杆状病毒和鱼细胞中克隆并表达。

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