Abstract:
AAV expression vectors and recombinant virions produced using these vectors, which include genes coding for enzymes defective or missing in lysosomal storage disorders, are described. These recombinant AAV virions are useful in the treatment of a variety of lysosomal storage disorders and the methods described herein provide for long-term, sustained expression of the defective or missing enzyme.
Abstract:
In a method for error correcting a data signal that is transmitted via a channel and contains data blocks with associated error checking information, the data signal is first equalized, with calculated soft-bit information. In a subsequent step, the error checking information is evaluated with respect to the data block. If the evaluation of the error checking information shows that a single bit error is present in one message bit, the single bit error is corrected only when a condition that is dependent on the soft-bit information is satisfied.
Abstract:
The disclosed invention relates to a process for making a multiphase mixture, comprising: flowing a first fluid stream through a process microchannel, the first fluid stream comprising at least one liquid and/or at least one gas, the process microchannel having an apertured section; flowing a second fluid stream through the apertured section into the process microchannel in contact with the first fluid stream to form the multiphase mixture, the second fluid stream comprising at least one gas and/or at least one microbody-forming material, the first fluid stream forming a continuous phase in the multiphase mixture, the second fluid stream forming a discontinuous phase dispersed in the continuous phase.
Abstract:
Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
Abstract:
A method for channel equalization of received data includes steps of: receiving the received data in a received data packet; calculating filter setting coefficients for an input filter and calculating equalizer setting coefficients for an equalizer; setting the input filter using the filter setting coefficients and setting the equalizer using the equalizer setting coefficients; equalizing the received data using the input filter and using the equalizer; determining channel parameters for the transmission channel from the received data Xk; storing the channel parameters in a data field; and performing the step of calculating the filter setting coefficients for the input filter and calculating the equalizer setting coefficients for the equalizer by performing a GIVENS rotation of the data field.
Abstract:
A mixed-signal-controlled phase-locked loop is provided. This loop includes a mixed-signal-controlled oscillator circuit for generating an oscillating signal having an oscillating frequency and a phase in response to a digital control signal and an analog control signal, a phase-frequency detector circuit electrically connected to the mixed-signal-controlled oscillator circuit, detecting the phase and the oscillating frequency of the oscillating signal and comparing the phase and the oscillating frequency with those of a reference signal to generate an error signal after the phase and oscillating frequency are detected, and a mixed-control-signal-producing circuit electrically connected to the mixed-signal-controlled oscillator circuit and the phase-frequency detector circuit for receiving the error signal to output the analog control signal and the digital control signal to the mixed-signal-controlled oscillator circuit.
Abstract:
In a method for producing a sintered metallic product, a green compact of a powdery metallic alloy is enclosed and constrained in a rigid mold to suppress the swelling of the green compact during sintering.
Abstract:
A method for increasing bulkiness of reconstituted tobacco by adding tobacco stem particles includes (1) pulverizing a first portion of tobacco stems to obtain tobacco stem particles; (2) classifying the tobacco stem particles with mesh sieves and selecting the tobacco stem particles with a predetermined mesh size; (3) extracting a second portion of the tobacco stems with water and grinding to form a tobacco stem slurry that has a beating degree of 12-14° SR, and mixing the tobacco stem slurry with tobacco leaves in a weight ratio of 6:4 and grinding to obtaining a tobacco slurry that has a beating degree of 18-20° SR; (4) cutting plant fiber pulp boards and dispersing in water to form a plant fiber pulp; (5) preparing a filler solution that contains 10 wt % of a mineral filler; (6) mixing, rolling and drying to obtain the reconstituted tobacco.
Abstract:
A method of preparing an aramid paper coated with aramid nanofibers includes the following steps: (1) mixing a meta-aramid fibrid slurry and a chopped meta-aramid fiber slurry, filtering, pressing and drying to obtain a meta-aramid paper; (2) mixing potassium hydroxide, deionized water, dimethyl sulfoxide, and para-aramid nanofibers in a container, and stirring to obtain a para-aramid nanofiber coating solution; and (3) applying the para-aramid nanofiber coating solution to a first side of the meta-aramid paper, washing with deionized water, and drying; applying the para-aramid nanofiber coating solution to a second side of the meta-aramid paper, washing with deionized water, and drying; and hot pressing to obtain the aramid paper coated with aramid nanofibers.