公开(公告)号：US06989232B2

公开(公告)日：2006-01-24

申请号：US09939853

申请日：2001-08-27

申请人： Catherine E. Burgess ,  Pamela B. Conley ,  William M. Grosse ,  Matthew Hart ,  Ramesh Kekuda ,  Richard A. Shimkets ,  Kimberly A. Spytek ,  Edward Szekeres, Jr. ,  James E. Tomlinson ,  James N. Topper ,  Ruey-Bin Yang

发明人： Catherine E. Burgess ,  Pamela B. Conley ,  William M. Grosse ,  Matthew Hart ,  Ramesh Kekuda ,  Richard A. Shimkets ,  Kimberly A. Spytek ,  Edward Szekeres, Jr. ,  James E. Tomlinson ,  James N. Topper ,  Ruey-Bin Yang

IPC分类号： C12Q1/68

CPC分类号： C07K14/47 ,  A61K38/00

摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：US20090264361A1

公开(公告)日：2009-10-22

申请号：US12317046

申请日：2008-12-18

申请人： Ruey-Bing Yang ,  Chi Kin Domingos Ng ,  James E. Tomlinson ,  Laszlo G. Komuves ,  James N. Topper ,  Keith E. Robison

发明人： Ruey-Bing Yang ,  Chi Kin Domingos Ng ,  James E. Tomlinson ,  Laszlo G. Komuves ,  James N. Topper ,  Keith E. Robison

IPC分类号： A61K38/16 ,  C07H21/04 ,  C12N15/63 ,  C12N5/10 ,  C12P21/02 ,  C07K14/00 ,  C07K16/00 ,  C12Q1/68 ,  G01N33/53 ,  A61P9/10 ,  A61P7/00 ,  A61P13/00

CPC分类号： C07K14/47 ,  G01N2333/485

摘要： The invention relates to SCUBE molecules and generally to gene expression in vascular endothelial cells. The invention specifically relates to the discovery of a novel gene family containing the genes and proteins referred to herein as SCUBE1, SCUBE2 and SCUBE3 which can be expressed in endothelial cells. SCUBE proteins may be involved in the development of cardiovascular disease, hemostasis, thrombosis, inflammatory disease, bone metabolism disorders, urinary bladder disorders and breast disorders.

摘要翻译： 本发明涉及SCUBE分子，通常涉及血管内皮细胞中的基因表达。 本发明具体涉及含有本文所述的可在内皮细胞中表达的SCUBE1，SCUBE2和SCUBE3的基因和蛋白质的新基因家族的发现。 SCUBE蛋白可能参与心血管疾病，止血，血栓形成，炎性疾病，骨代谢障碍，膀胱疾病和乳腺疾病的发展。

公开(公告)号：US07258988B2

公开(公告)日：2007-08-21

申请号：US10406073

申请日：2003-04-03

申请人： Ruey-Bing Yang ,  Chi Kin Domingos Ng ,  James E. Tomlinson ,  Laszlo G. Komuves ,  James N. Topper ,  Keith E. Robison

发明人： Ruey-Bing Yang ,  Chi Kin Domingos Ng ,  James E. Tomlinson ,  Laszlo G. Komuves ,  James N. Topper ,  Keith E. Robison

IPC分类号： G01N33/53 ,  C07K14/435 ,  C07K16/30

CPC分类号： C07K14/47 ,  G01N2333/485

摘要： The invention relates to SCUBE molecules and generally to gene expression in vascular endothelial cells. The invention specifically relates to the discovery of a novel gene family containing the genes and proteins referred to herein as SCUBE1, SCUBE2 and SCUBE3 which can be expressed in endothelial cells. SCUBE proteins may be involved in the development of cardiovascular disease, hemostasis, thrombosis, inflammatory disease, bone metabolism disorders, urinary bladder disorders and breast disorders.

公开(公告)号：US08211640B2

公开(公告)日：2012-07-03

申请号：US12317046

申请日：2008-12-18

申请人： Ruey-Bing Yang ,  Chi Kin Domingos Ng ,  James E. Tomlinson ,  Laszlo G. Komuves ,  James N. Topper ,  Keith E. Robison

发明人： Ruey-Bing Yang ,  Chi Kin Domingos Ng ,  James E. Tomlinson ,  Laszlo G. Komuves ,  James N. Topper ,  Keith E. Robison

IPC分类号： C12Q1/68 ,  C12Q1/02 ,  C12P21/06 ,  C12N5/00 ,  C12N5/02 ,  C12N1/20 ,  C12N15/12

CPC分类号： C07K14/47 ,  G01N2333/485

摘要： The invention relates to SCUBE molecules and generally to gene expression in vascular endothelial cells. The invention specifically relates to the discovery of a novel gene family containing the genes and proteins referred to herein as SCUBE1, SCUBE2 and SCUBE3 which can be expressed in endothelial cells. SCUBE proteins may be involved in the development of cardiovascular disease, hemostasis, thrombosis, inflammatory disease, bone metabolism disorders, urinary bladder disorders and breast disorders.

摘要翻译： 本发明涉及SCUBE分子，通常涉及血管内皮细胞中的基因表达。 本发明具体涉及含有本文所述的可在内皮细胞中表达的SCUBE1，SCUBE2和SCUBE3的基因和蛋白质的新基因家族的发现。 SCUBE蛋白可能参与心血管疾病，止血，血栓形成，炎性疾病，骨代谢障碍，膀胱疾病和乳腺疾病的发展。

公开(公告)号：US07485431B2

公开(公告)日：2009-02-03

申请号：US11726543

申请日：2007-03-22

申请人： Ruey-Bing Yang ,  Chi Kin Domingos Ng ,  James E. Tomlinson ,  Laszlo G. Komuves ,  James N. Topper ,  Keith E. Robison

发明人： Ruey-Bing Yang ,  Chi Kin Domingos Ng ,  James E. Tomlinson ,  Laszlo G. Komuves ,  James N. Topper ,  Keith E. Robison

IPC分类号： G01N33/53 ,  C07K16/00 ,  C07K16/18 ,  C07K16/46

CPC分类号： C07K14/47 ,  G01N2333/485

摘要： The invention relates to SCUBE molecules and generally to gene expression in vascular endothelial cells. The invention specifically relates to the discovery of a novel gene family containing the genes and proteins referred to herein as SCUBE1, SCUBE2 and SCUBE3 which can be expressed in endothelial cells. SCUBE proteins may be involved in the development of cardiovascular disease, hemostasis, thrombosis, inflammatory disease, bone metabolism disorders, urinary bladder disorders and breast disorders.

公开(公告)号：US5891652A

公开(公告)日：1999-04-06

申请号：US460490

申请日：1995-06-02

申请人： David Wolf ,  James E. Tomlinson ,  Larry J. Fretto ,  Neill A. Giese ,  Jaime A. Escobedo ,  Lewis Thomas Williams

发明人： David Wolf ,  James E. Tomlinson ,  Larry J. Fretto ,  Neill A. Giese ,  Jaime A. Escobedo ,  Lewis Thomas Williams

IPC分类号： A61K39/395 ,  A61K38/00 ,  C07K7/04 ,  C07K14/00 ,  C07K14/705 ,  C07K14/71 ,  C07K16/00 ,  C07K16/28 ,  C12N5/10 ,  C12N15/02 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/566 ,  G01N33/50

CPC分类号： C07K16/2863 ,  C07K14/71 ,  A61K38/00 ,  C07K2319/00

摘要： Defined constructs of modified human platelet-derived growth factor receptor polypeptides are provided. Extracellular region domain structures are identified and modifications and combinatorial rearrangements of the receptor segments are provided. Both cell bound and soluble forms of modified segments are made available, as are methods for assays using them, allowing for screening of ligand analogues.

摘要翻译： 提供修饰的人血小板衍生生长因子受体多肽的定义构建体。 鉴定细胞外区域结构，并提供受体区段的修饰和组合重排。 修饰片段的细胞结合和可溶形式均可获得，使用它们的测定方法也可用，允许筛选配体类似物。

公开(公告)号：US20090241165A1

公开(公告)日：2009-09-24

申请号：US12051474

申请日：2008-03-19

申请人： David S. Tyree ,  James E. Tomlinson

发明人： David S. Tyree ,  James E. Tomlinson

IPC分类号： G06F21/00

CPC分类号： G06Q10/06 ,  G06F21/10

摘要： In an exemplary system, a compliance policy processing subsystem is selectively and communicatively coupled to a rules management subsystem. The rules management subsystem is configured to maintain a rules database. The compliance policy processing subsystem is configured to facilitate selection by a user of a section of text within a compliance policy, direct the rules management subsystem to identify one or more rules within the rules database that are relevant to the section of text, and display a representation of the relevant rules.

摘要翻译： 在示例性系统中，合规策略处理子系统被选择性地和通信地耦合到规则管理子系统。 规则管理子系统被配置为维护规则数据库。 合规策略处理子系统被配置为便于用户在合规策略中选择一段文本，指导规则管理子系统识别规则数据库内与文本部分相关的一个或多个规则，并且显示一个 代表相关规则。

公开(公告)号：US06864081B2

公开(公告)日：2005-03-08

申请号：US10201000

申请日：2002-07-24

申请人： James E. Tomlinson

发明人： James E. Tomlinson

IPC分类号： C12N1/21 ,  C12N5/08 ,  C12N9/88 ,  C07K1/00 ,  C12N1/20 ,  C12N15/00 ,  C12Q1/68

CPC分类号： C12N9/88

摘要： A DNA sequence encoding a human adenylyl cyclase is described. The amino acid sequence of the adenylyl cyclase is also described.

公开(公告)号：US06436672B1

公开(公告)日：2002-08-20

申请号：US09473716

申请日：1999-12-29

申请人： James E. Tomlinson

发明人： James E. Tomlinson

IPC分类号： C12N988

CPC分类号： C12N9/88

摘要： A DNA sequence encoding a human type V adenylyl cyclase is described. The amino acid sequence of the adenylyl cyclase is also described. This adenylyl cyclase is expressed at increased levels in heart and brain tissue, relative to other tissues.

摘要翻译： 描述了编码人V型腺苷酸环化酶的DNA序列。 还描述了腺苷酸环化酶的氨基酸序列。 相对于其他组织，该腺苷酸环化酶在心脏和脑组织中以增加的水平表达。

公开(公告)号：US4842128A

公开(公告)日：1989-06-27

申请号：US123068

申请日：1987-11-16

申请人： James E. Tomlinson

发明人： James E. Tomlinson

IPC分类号： B65G19/28

CPC分类号： B65G19/285

摘要： The inspection line pan has an opening (11), in its deck plate (10) and a three-piece door (12) located in the opening. The door is formed of three rectangular panels (15, 16, 17) of similar length and width which are disposed transversely of each other. The outer panels (15, 17) are pivotally connected to the center panel (16) and the center panel has transverse grooves (18) which are supported on tongues on central portions of the opening (10) for transverse movement. In use, one or other outer panel can be pivotally raised for inspection below the line pan. If access to the area below the line pan is required, the center panel can be slid transversely into the space created by the raised outer panel and after the center panel is free of the tongues, it can be lifted clear of the opening. If the outer panels are attached to the center panel, they are lifted clear of the opening with the center panel; otherwise they are removed separately.

摘要翻译： PCT No.PCT / GB87 / 00069 Sec。 371日期1987年11月16日 102（e）1987年11月16日PCT PCT公开1987年2月2日PCT公布。 出版物WO87 / 04687 日期1987年8月13日。检查线盘在其甲板（10）和位于开口中的三件式门（12）上具有开口（11）。 门由相互长度和宽度相似的三个矩形板（15,16,17）形成，它们彼此横向设置。 外板（15,17）可枢转地连接到中心面板（16），并且中心面板具有横向槽（18），横向槽（18）支撑在开口（10）的中心部分上用于横向移动的舌部。 在使用中，可以将一个或其它外部面板枢转地提升以在线盘下方进行检查。 如果需要进入线盘下面的区域，则中心面板可以横向滑动到由凸起的外板产生的空间中，并且在中心面板没有舌头之后，可以将其从开口抬起。 如果将外板连接到中央面板，则将它们从中心面板抬起而离开开口; 否则它们被单独删除。