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公开(公告)号：US09362099B2
公开(公告)日：2016-06-07
申请号：US14369121
申请日：2013-01-03
Applicant: Danielle Toutoungi , Matthew Hart , John Somerville , Jon Pearson , Max Allsworth , Richard Orrell , Antoni Negri , Jeremy Spinks , Martin Holden , Andrew H. Koehl , Alastair Taylor
Inventor： Danielle Toutoungi , Matthew Hart , John Somerville , Jon Pearson , Max Allsworth , Richard Orrell , Antoni Negri , Jeremy Spinks , Martin Holden , Andrew H. Koehl , Alastair Taylor
CPC classification number: H01J49/061 , G01N27/624 , H01J49/0018 , H01J49/068 , Y10T29/49147 , Y10T29/49149
Abstract: Ion filter for FAIMS fabricated using the LIGA technique. The ion filter is manufactured using a metal layer to form the ion channels and an insulating support layer to hold the structure rigidly together after separation of the metal layer into two electrodes.
Abstract translation: 使用LIGA技术制造的FAIMS离子过滤器。 使用金属层制造离子过滤器以形成离子通道和绝缘支撑层，以将金属层分离成两个电极之后将结构刚性地保持在一起。
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2.发明申请Novel nucleic acids and polypeptides related to a guanine exchange factor of Rho GTPase 失效与Rho GTP酶的鸟嘌呤交换因子相关的新型核酸和多肽公开(公告)号：US20070161021A1
公开(公告)日：2007-07-12
申请号：US11603491
申请日：2006-11-22
Applicant: Matthew Hart
Inventor： Matthew Hart
CPC classification number: C07K16/18 , A61K38/00 , A61K48/00 , C07K14/82 , C12Q1/6876
Abstract: The present invention relates to all aspects of a guanine exchange factor (GEF), for example, a Rho-GEF, such as p115 Rho-GEF. A GEF modulates cell signaling pathways, both in in vitro and in vivo, by modulating the activity of a GTPase. By way of illustration, a p115 Rho-GEF, which modulates the activity of a Rho GTPase, is described. However, the present invention relates to other GEFs, especially other Rho-GEFs. The present invention particularly relates to an isolated p115 Rho-GEF polypeptide or fragments of it, a nucleic acid coding for p115 Rho-GEF or fragments of it, and derivatives of the polypeptide and nucleic acid. The invention also relates to methods of using such polypeptides, nucleic acids, or derivatives thereof, e.g., in therapeutics, diagnostics, and as research tools. Another aspect of the present invention involves antibodies and other ligands which recognize p115 Rho-GEF, regulators of p115 Rho-GEF activity, and methods of treating pathological conditions associated or related to a Rho GTPase.
Abstract translation: 本发明涉及鸟嘌呤交换因子（GEF），例如Rho-GEF，例如p15Rho-GEF的所有方面。 通过调节GTP酶的活性，GEF在体外和体内调节细胞信号通路。 作为说明，描述了调节Rho GTP酶的活性的p115Rho-GEF。 然而，本发明涉及其他GEF，特别是其他Rho-GEF。 本发明特别涉及分离的p115Rho-GEF多肽或其片段，编码p115Rho-GEF或其片段的核酸，以及多肽和核酸的衍生物。 本发明还涉及使用此类多肽，核酸或其衍生物的方法，例如在治疗学，诊断学和研究工具中。 本发明的另一方面涉及识别p115Rho-GEF，p115Rho-GEF活性的调节剂以及治疗与Rho GTP酶相关或相关的病理学病症的方法的抗体和其它配体。
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公开(公告)号：US20050267207A1
公开(公告)日：2005-12-01
申请号：US11155345
申请日：2005-06-17
Applicant: Thomas Scanlan , Matthew Hart , David Grandy , James Bunzow
Inventor： Thomas Scanlan , Matthew Hart , David Grandy , James Bunzow
IPC: A61K31/137 , A61K31/277 , A61K31/35 , C07C211/27 , C07C233/77 , C07C323/32
CPC classification number: C07C215/52 , C07C217/16 , C07C217/54 , C07C235/50 , C07C255/37 , C07C271/16 , C07C271/20
Abstract: Thyronamine derivatives and analogs, methods of using such compounds, and pharmaceutical compositions containing them are disclosed. Methods of preparing such compounds are also disclosed.
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公开(公告)号：US09366649B2
公开(公告)日：2016-06-14
申请号：US13852675
申请日：2013-03-28
Applicant: Ashley Wilks , Matthew Hart , Stephen Hartwell , Alison Hart , Lara Jamieson , Max Allsworth , John Somerville
Inventor： Ashley Wilks , Matthew Hart , Stephen Hartwell , Alison Hart , Lara Jamieson , Max Allsworth , John Somerville
CPC classification number: G01N27/624 , G01N27/622
Abstract: An apparatus, system and method for detecting, identifying, classifying and/or quantifying chemical species in a gas flow using a micro-fabricated ion filter coupled to a system adapted to apply drive signals to the ion filter. Coupled to the ion filter is a system adapted to measure the output of the ion filter, which in turn is coupled to a system adapted to extract numerical parameters from the measured output of the ion filter to facilitate chemical detection, identification, classification and/or quantification of the gas flow.
Abstract translation: 一种用于使用耦合到适于将驱动信号施加到离子过滤器的系统的微制造离子过滤器来检测，识别，分类和/或定量气流中的化学物质的装置，系统和方法。 耦合到离子过滤器的系统是适于测量离子过滤器的输出的系统，该系统又耦合到适于从离子过滤器的测量输出提取数值参数的系统，以促进化学检测，识别，分类和/或 气流量化。
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公开(公告)号：US09177769B2
公开(公告)日：2015-11-03
申请号：US12442921
申请日：2007-09-25
Applicant: Matthew Hart , Andrew Koehl
Inventor： Matthew Hart , Andrew Koehl
CPC classification number: H01J49/061 , G01N27/622 , H01J49/0018 , H01J49/421
Abstract: An ion filter (10) for use in ion mobility spectrometry is described, together with a method for manufacturing the filter. The filter (10) is manufactured by removing portions from a monolithic structure to form a pair of electrodes which remain mechanically connected. The connecting portion (22) provides sufficient electrical impedance between the electrodes to effectively electrically separate the electrodes. The connecting portion may be doped or chemically modified to obtain a desired impedance, or this may be obtained through appropriate selection of physical dimensions.
Abstract translation: 与用于制造过滤器的方法一起描述了用于离子迁移谱的离子过滤器（10）。 过滤器（10）通过从单片结构中移除部分以形成保持机械连接的一对电极来制造。 连接部分（22）在电极之间提供足够的电阻抗以有效地电分离电极。 连接部分可以被掺杂或化学修饰以获得期望的阻抗，或者这可以通过适当选择物理尺寸来获得。
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Patent Agency Ranking
公开(公告)号：US07981365B2
公开(公告)日：2011-07-19
申请号：US11229431
申请日：2005-09-15
Applicant: Matthew Hart , Horn Bond Lin , Jay Eversole
Inventor： Matthew Hart , Horn Bond Lin , Jay Eversole
IPC: G01N30/96
CPC classification number: G01N33/54386 , G01N15/1459 , G01N2015/0046
Abstract: A device having an air sampler, an electrospray apparatus, and a fluorescence excitation and detection system. The air sampler is capable of moving air suspected of containing a biological or chemical aerosol particle into a chamber. The electrospray apparatus is capable of spraying a charged solution into the chamber to coat the aerosol particles with a coating. The solution has a fluorescent-labeled biological or chemical marker capable of specific binding to the aerosol particle. The fluorescence system is capable of detecting fluorescence of the fluorescent label in the coating. A method of detecting the aerosol particle by: moving air suspected of containing the aerosol particle into a chamber; spraying the charged solution into the chamber with an electrospray apparatus, such that a coating of the solution is formed around the particle; exciting the fluorescent label; and detecting fluorescence of the fluorescent label.
Abstract translation: 具有空气采样器，电喷射装置和荧光激发和检测系统的装置。 空气取样器能够将怀疑含有生物或化学气溶胶颗粒的空气移动到室中。 电喷射装置能够将带电溶液喷射到室中以用涂层涂覆气溶胶颗粒。 该溶液具有能够特异性结合气溶胶颗粒的荧光标记的生物或化学标记。 荧光系统能够检测涂层中荧光标记的荧光。 一种通过以下步骤检测气溶胶颗粒的方法：将怀疑含有气溶胶颗粒的空气移动到室中; 用电喷雾装置将带电溶液喷射到室中，使得在颗粒周围形成溶液的涂层; 激发荧光标签; 并检测荧光标记物的荧光。
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7.发明申请NOVEL NUCLEIC ACIDS AND POLYPEPTIDES RELATED TO A GUANINE EXCHANGE FACTOR OF RHO GTPASE 失效与RHO GTPASE的交换因子相关的新型核酸和多肽公开(公告)号：US20060275755A9
公开(公告)日：2006-12-07
申请号：US10448162
申请日：2003-05-27
Applicant: Matthew Hart
Inventor： Matthew Hart
CPC classification number: C07K16/18 , A61K38/00 , A61K48/00 , C07K14/82 , C12Q1/6876
Abstract: The present invention relates to all aspects of a guanine exchange factor (GEF), for example, a Rho-GEF, such as p115 Rho-GEF. A GEF modulates cell signaling pathways, both in in vitro and in vivo, by modulating the activity of a GTPase. By way of illustration, a p115 Rho-GEF, which modulates the activity of a Rho GTPase, is described. However, the present invention relates to other GEFs, especially other Rho-GEFs. The present invention particularly relates to an isolated p115 Rho-GEF polypeptide or fragments of it, a nucleic acid coding for p115 Rho-GEF or fragments of it, and derivatives of the polypeptide and nucleic acid. The invention also relates to methods of using such polypeptides, nucleic acids, or derivatives thereof, e.g., in therapeutics, diagnostics, and as research tools. Another aspect of the present invention involves antibodies and other ligands which recognize p115 Rho-GEF, regulators of p115 Rho-GEF activity, and methods of treating pathological conditions associated or related to a Rho GTPase.
Abstract translation: 本发明涉及鸟嘌呤交换因子（GEF），例如Rho-GEF，例如p15Rho-GEF的所有方面。 通过调节GTP酶的活性，GEF在体外和体内调节细胞信号通路。 作为说明，描述了调节Rho GTP酶的活性的p115Rho-GEF。 然而，本发明涉及其他GEF，特别是其他Rho-GEF。 本发明特别涉及分离的p115Rho-GEF多肽或其片段，编码p115Rho-GEF或其片段的核酸，以及多肽和核酸的衍生物。 本发明还涉及使用此类多肽，核酸或其衍生物的方法，例如在治疗学，诊断学和研究工具中。 本发明的另一方面涉及识别p115Rho-GEF，p115Rho-GEF活性的调节剂以及治疗与Rho GTP酶相关或相关的病理学病症的方法的抗体和其它配体。
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公开(公告)号：US20060035980A1
公开(公告)日：2006-02-16
申请号：US11099959
申请日：2005-04-05
Applicant: Thomas Scanlan , Matthew Hart , David Grandy , James Bunzow , Motonori Miyakawa , Edwin Tan , Katherine Suchland
Inventor： Thomas Scanlan , Matthew Hart , David Grandy , James Bunzow , Motonori Miyakawa , Edwin Tan , Katherine Suchland
IPC: A61K31/137 , C07C211/27
CPC classification number: C07C217/60 , C07C215/52 , C07C217/16 , C07C217/20 , C07C217/54 , C07C235/50 , C07C235/60 , C07C255/37 , C07C271/16 , C07C271/20
Abstract: Thyronamine derivatives and analogs, methods of using such compounds, and pharmaceutical compositions containing them are disclosed. Methods of preparing such compounds are also disclosed.
Abstract translation: 公开了甲状腺胺衍生物和类似物，使用这些化合物的方法，以及含有它们的药物组合物。 还公开了制备这些化合物的方法。
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公开(公告)号：US20150028196A1
公开(公告)日：2015-01-29
申请号：US14369121
申请日：2013-01-03
Applicant: Danielle Toutoungi , Matthew Hart , John Somerville , Jon Pearson , Max Allsworth , Richard Orrell , Antoni Negri , Jeremy Spinks , Martin Holden , Andrew H. Koehl , Alistair Taylor
Inventor： Danielle Toutoungi , Matthew Hart , John Somerville , Jon Pearson , Max Allsworth , Richard Orrell , Antoni Negri , Jeremy Spinks , Martin Holden , Andrew H. Koehl , Alistair Taylor
CPC classification number: H01J49/061 , G01N27/624 , H01J49/0018 , H01J49/068 , Y10T29/49147 , Y10T29/49149
Abstract: Ion filter for FAIMS fabricated using the LIGA technique. The ion filter is manufactured using a metal layer to form the ion channels and an insulating support layer to hold the structure rigidly together after separation of the metal layer into two electrodes.
Abstract translation: 使用LIGA技术制造的FAIMS离子过滤器。 使用金属层制造离子过滤器以形成离子通道和绝缘支撑层，以将金属层分离成两个电极之后将结构刚性地保持在一起。
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公开(公告)号：US20140061459A1
公开(公告)日：2014-03-06
申请号：US13852675
申请日：2013-03-28
Applicant: Ashley Wilks , Matthew Hart , Stephen Hartwell , Alison Hart , Lara Jamieson , Max Allsworth , John Somerville
Inventor： Ashley Wilks , Matthew Hart , Stephen Hartwell , Alison Hart , Lara Jamieson , Max Allsworth , John Somerville
IPC: G01N27/62
CPC classification number: G01N27/624 , G01N27/622
Abstract: An apparatus, system and method for detecting, identifying, classifying and/or quantifying chemical species in a gas flow using a micro-fabricated ion filter coupled to a system adapted to apply drive signals to the ion filter. Coupled to the ion filter is a system adapted to measure the output of the ion filter, which in turn is coupled to a system adapted to extract numerical parameters from the measured output of the ion filter to facilitate chemical detection, identification, classification and/or quantification of the gas flow.
Abstract translation: 一种用于使用耦合到适于将驱动信号施加到离子过滤器的系统的微制造离子过滤器来检测，识别，分类和/或定量气流中的化学物质的装置，系统和方法。 耦合到离子过滤器的系统是适于测量离子过滤器的输出的系统，该系统又耦合到适于从离子过滤器的测量输出提取数值参数的系统，以促进化学检测，识别，分类和/或 气流量化。
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