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    SYSTEMS AND METHODS FOR MEASURING OXYGENATION
    233.
    发明申请
    SYSTEMS AND METHODS FOR MEASURING OXYGENATION 审中-公开
    用于测量氧化的系统和方法

    公开(公告)号：US20160007892A1

    公开(公告)日：2016-01-14

    申请号：US14794022

    申请日：2015-07-08

    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

    Inventor： Rinat ESENALIEV ,  Donald S. PROUGH ,  Yuriy PETROV ,  Irene PETROV ,  George SAADE ,  Gayle L. OLSON

    IPC: A61B5/145 ,  A61B5/1455 ,  A61B5/00

    CPC classification number: A61B5/14542 ,  A61B5/0095 ,  A61B5/14553 ,  A61B5/1459 ,  A61B5/1464 ,  A61B5/6814 ,  A61B5/6875 ,  A61B5/742 ,  A61B2562/0271

    Abstract: Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.

    Abstract translation: 描述了光声诊断系统，装置和方法。 系统可以包括控制台单元和手持式探头。 控制台单元包括控制器，处理器，光电二极管阵列，声学处理子系统和冷却子系统。 探针将来自光电二极管阵列的光信号引导到患者组织。 光信号各自具有基于感兴趣的生理参数选择的不同波长。 探头还包括声学换能器，其接收响应于定向光信号而产生的声信号。 探针可以包括手指保持的工作端，其可以在劳动期间被引导到子宫内的胎儿的头骨。 然后，探针可以准确地确定胎儿的血氧饱和度，以确定是否需要剖腹产。

    RAPAMYCIN ANALOGS TARGETING PROTEASOME FUNCTION IN THE TREATMENT OF CANCER
    236.
    发明申请
    RAPAMYCIN ANALOGS TARGETING PROTEASOME FUNCTION IN THE TREATMENT OF CANCER 有权
    RAPAMYCIN模拟靶向治疗癌症的功能

    公开(公告)号：US20150328192A1

    公开(公告)日：2015-11-19

    申请号：US14652825

    申请日：2013-12-24

    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

    Inventor： Maria E. GACZYNSKA ,  Pawel A. OSMULSKI

    IPC: A61K31/436 ,  A61K45/06

    CPC classification number: A61K31/436 ,  A61K31/453 ,  A61K31/69 ,  A61K45/06 ,  A61K2300/00

    Abstract: The invention provides for treatment of cancers using a rapamycin analog, optionally including bortezomib. In particular, the invention addresses the treatment of bortezomib-resistant cancers using seco-rapamycin and optionally a second proteasome inhibitor. This invention relates to oncology and medicine, and more particularly to treatment of cancer. In particular, rapamycin analogs such as seco-rapamycin may be used advantageously to target the proteasome in cancer cells, optionally in conjunction with proteasome inhibitors such as bortezomib.

    Abstract translation: 本发明提供了使用雷帕霉素类似物（任选地包括硼替佐米）治疗癌症。 特别地，本发明涉及使用次雷帕霉素和任选的第二蛋白酶体抑制剂治疗硼替佐米耐药性癌症。 本发明涉及肿瘤学和药物，更具体地涉及癌症的治疗。 特别地，雷帕霉素类似物例如雷帕霉素可有利地用于靶向癌细胞中的蛋白酶体，任选地与蛋白酶体抑制剂如硼替佐米结合。

    METHOD TO IMPROVE PHARMACOKINETICS OF DRUGS
    238.
    发明申请
    METHOD TO IMPROVE PHARMACOKINETICS OF DRUGS 审中-公开
    改善药物药代动力学的方法

    公开(公告)号：US20150209442A1

    公开(公告)日：2015-07-30

    申请号：US14425105

    申请日：2013-08-30

    Applicant: The Board of Regents of the University of Texas System

    Inventor： Kenneth M. Hargreaves

    IPC: A61K47/48 ,  A61K45/06 ,  A61K39/395 ,  C07K16/44 ,  C07K14/46

    CPC classification number: A61K47/48246 ,  A61K38/00 ,  A61K39/39533 ,  A61K45/06 ,  A61K47/64 ,  A61K47/641 ,  A61K47/643 ,  C07K14/46 ,  C07K16/44 ,  C07K2319/31

    Abstract: A compound comprises a pharmacologically active agent coupled to a plasma protein binding agent. The pharmacologically active agent, in some embodiments, may be an OLAM inhibitor. The plasma protein binding agent, in some embodiments, is a compound that is pharmacologically active in inflamed/injured tissue. A pharmaceutical composition that includes these compounds may be used to treat pain, shock, inflammatory conditions, or combinations thereof in a subject comprising administering to a subject who would benefit from such treatment a therapeutically effective amount of the pharmaceutical composition.

    Abstract translation: 化合物包含与血浆蛋白结合剂偶联的药理学活性剂。 在一些实施方案中，药理活性剂可以是OLAM抑制剂。 在一些实施方案中，血浆蛋白结合剂是在炎性/损伤组织中具有药理活性的化合物。 包括这些化合物的药物组合物可用于治疗受试者的疼痛，休克，炎性病症或其组合，包括向受试者提供治疗有效量的药物组合物。

    COMBINED BRANCH TARGET AND PREDICATE PREDICTION
    239.
    发明申请
    COMBINED BRANCH TARGET AND PREDICATE PREDICTION 有权
    组合分支目标和预测预测

    公开(公告)号：US20150199199A1

    公开(公告)日：2015-07-16

    申请号：US14668300

    申请日：2015-03-25

    Applicant: The Board of Regents of the University of Texas System

    Inventor： DOUGLAS C. BURGER ,  STEPHEN W. KECKLER

    IPC: G06F9/38 ,  G06F9/30

    CPC classification number: G06F9/3806 ,  G06F9/30058 ,  G06F9/30072 ,  G06F9/38 ,  G06F9/3804 ,  G06F9/3836 ,  G06F9/45516

    Abstract: Embodiments provide methods, apparatus, systems, and computer readable media associated with predicting predicates and branch targets during execution of programs using combined branch target and predicate predictions. The predictions may be made using one or more prediction control flow graphs which represent predicates in instruction blocks and branches between blocks in a program. The prediction control flow graphs may be structured as trees such that each node in the graphs is associated with a predicate instruction, and each leaf associated with a branch target which jumps to another block. During execution of a block, a prediction generator may take a control point history and generate a prediction. Following the path suggested by the prediction through the tree, both predicate values and branch targets may be predicted. Other embodiments may be described and claimed.

    Abstract translation: 实施例提供了在使用组合分支目标和谓词预测的程序执行期间与预测谓词和分支目标相关联的方法，装置，系统和计算机可读介质。 可以使用表示程序中的指令块中的谓词和块之间的分支的一个或多个预测控制流程图来进行预测。 预测控制流图可以被构造为树，使得图中的每个节点与谓词指令相关联，并且每个叶与跳转到另一块的分支目标相关联。 在块的执行期间，预测发生器可以采取控制点历史并产生预测。 按照通过树的预测建议的路径，可以预测谓词值和分支目标。 可以描述和要求保护其他实施例。

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