公开(公告)号：US08240521B2

公开(公告)日：2012-08-14

申请号：US11351716

申请日：2006-02-10

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65D5/72

CPC classification number: B65D83/0055 ,  A61F9/0008 ,  B05B11/00412 ,  B05B11/0072 ,  B05B11/0097 ,  B05B11/3004 ,  B05B11/3074 ,  B05B11/3077 ,  B05B11/3092 ,  B05B11/3094 ,  B65D81/245

Abstract: A dispenser for dispensing a fluid includes a rigid vial that has a main fluid chamber containing a fluid, and a pump assembly that is in fluid communication with the main fluid chamber and is configured to dispense a predetermined quantity of fluid from the main fluid chamber. A flexible bladder is provided which is located within the main fluid chamber and is configured to expand to fill the ullage created within the main fluid chamber during dispensing of fluid by the pump assembly. The resilient bladder tends to force itself outwardly toward the rigid vial and, in turn, increases the pressure within the main fluid chamber in comparison to the interior of the bladder to thereby prevent the ingress of air or vapors through the bladder or otherwise into the main fluid chamber.

Abstract translation: 用于分配流体的分配器包括具有包含流体的主流体室的刚性小瓶和与主流体室流体连通并被构造成从主流体室分配预定量的流体的泵组件。 提供柔性囊，其位于主流体室内并且构造成膨胀以填充由泵组件分配流体期间在主流体室内产生的空位。 弹性气囊趋于朝向刚性小瓶向外强制，并且与气囊的内部相比增加了主流体室内的压力，从而防止空气或蒸气进入气囊或以其它方式进入主体 流体室。

公开(公告)号：US08220507B2

公开(公告)日：2012-07-17

申请号：US12874744

申请日：2010-09-02

Applicant: Daniel Py ,  Norbert M. Assion ,  Julian V. Chan

Inventor： Daniel Py ,  Norbert M. Assion ,  Julian V. Chan

IPC: B65B1/04

CPC classification number: B65D51/002 ,  A45D34/04 ,  A45D2200/055 ,  A61J1/1406 ,  A61J7/0053 ,  B05B11/02 ,  B67D99/00 ,  G01F11/027

Abstract: A dispenser is provided for the delivery of controlled, metered amounts of any of numerous different substances to humans or animals, such as medicaments, pharmaceuticals, cosmetics, and food products, or to deliver materials that may react upon exposure to air, such as glue. Means are provided in the dispenser to effect controlled delivery of a pre-determined amount of the substance contained in the dispenser. A one-way valve is provided to hermetically seal the portion of the dispenser containing the substance to be dispensed.

Abstract translation: 提供分配器用于向人或动物（例如药物，药物，化妆品和食品）递送受控量的计量量的任何不同物质，或者输送在暴露于空气中可能反应的材料，例如胶 。 在分配器中提供装置以实现预定量的包含在分配器中的物质的受控输送。 提供单向阀以气密地密封包含待分配物质的分配器的部分。

公开(公告)号：USRE43329E1

公开(公告)日：2012-04-24

申请号：US10410911

申请日：2003-04-10

Applicant: Daniel Py

Inventor： Daniel Py

IPC: A61M5/178

CPC classification number: B05B11/3011 ,  A61F9/0026 ,  A61M11/00 ,  B05B11/3076 ,  B05B11/3092 ,  B05B11/3095

Abstract: A medicament-dispensing system includes a cartridge for housing and actuating an accordion-like vial-dispenser for dispensing a calibrated amount of medicament by means of a single actuation motion which sequentially loads the vial-dispenser and dispenses the loaded medicament. The vial-dispenser has a front bellows portion, a rear bellows portion, an internal piston mechanism, a medicament storage chamber and a dosage cavity. The cartridge has a trigger mechanism which acts in concert with a notched lever and a wedge-shaped arm internally located in the cartridge to sequentially load the dosage cavity with medicament and discharge it. Depression of the trigger mechanism simultaneously extends, by means of the notched lever, the front bellows portion and compresses the rear bellows portion to load the dosage cavity with medicament. Once the notched lever has extended the front bellows portion a predetermined distance, the notched lever is disengaged from the front bellows portion by the wedge-shaped arm extending from the rear wall of the housing, thereby releasing the front and rear bellows portions, along with the internal piston mechanism, to return to original position and force the medicament from the dosage cavity via a nozzle of the vial-dispenser.

Abstract translation: 药物分配系统包括用于容纳和致动手风琴式小瓶 - 分配器的药筒，用于通过单次致动运动分配校准量的药物，其顺序地加载小瓶分配器并分配装载的药物。 小瓶分配器具有前波纹管部分，后波纹管部分，内部活塞机构，药物储存室和剂量腔。 药筒具有触发器机构，其与位于药筒内部的缺口杠杆和楔形臂协同作用，以顺序地将药物腔装入药物并将其排出。 触发机构的凹陷同时通过切口杆延伸前波纹管部分并压缩后波纹管部分以用药物装载剂量腔。 一旦切口杆将前波纹管部分延伸了预定的距离，则切口杆通过从壳体的后壁延伸的楔形臂与前波纹管部分分离，从而释放前波纹管部分和后波纹管部分以及 内部活塞机构返回到初始位置，并且通过小瓶分配器的喷嘴迫使药物从剂量腔中。

公开(公告)号：US20120018455A1

公开(公告)日：2012-01-26

申请号：US13027401

申请日：2011-02-15

Applicant: Daniel Py

Inventor： Daniel Py

IPC: G01F11/00 ,  B67D7/58

CPC classification number: G01F11/021 ,  B05B11/3001 ,  B05B11/3015 ,  B05B11/3032 ,  B05B11/3047 ,  B05B11/3074 ,  B65D47/2031 ,  B65D83/00 ,  B65D83/0033 ,  B65D83/0072 ,  G01F11/02

Abstract: A dispenser has a housing, and a variable-volume storage chamber formed within the housing and defining a substantially fluid-tight seal between the chamber and exterior of the housing for storing a substance to be dispensed. A piston is mounted within the housing, and a one-way valve is mounted within the housing and coupled in fluid communication with the variable-volume storage chamber. A compression chamber is coupled in fluid communication between the piston and one-way valve, and at least one of the piston and valve is manually depressible relative to the other between (i) a first position in which the piston is located at least partially outside of the compression chamber for permitting substance to flow from the variable-volume storage chamber into the compression chamber, and (ii) a second position in which the piston is located at least partially within the compression chamber for pressurizing substance within the compression chamber above a valve opening pressure and, in turn, dispensing substance through the one-way valve and out of the dispenser.

Abstract translation: 分配器具有壳体和形成在壳体内的可变容积的储存室，并且在壳体的室和外部之间限定基本上流体密封的密封，用于存储待分配的物质。 活塞安装在壳体内，并且单向阀安装在壳体内并且与可变容积存储室流体连通地联接。 压缩室在活塞和单向阀之间流体连通地联接，并且活塞和阀门中的至少一个在第一位置之间相对于另一个手动地相对地被压下，其中活塞位于至少部分外部 的压缩室，用于允许物质从可变容积的储存室流入压缩室，以及（ii）第二位置，其中活塞至少部分地位于压缩室内，用于将压缩室内的物质加压在压缩室的上方 打开阀门的压力，并通过单向阀分配物质并从分配器中分出物质。

公开(公告)号：US20120011812A1

公开(公告)日：2012-01-19

申请号：US13045655

申请日：2011-03-11

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B55/04

CPC classification number: B65B3/04 ,  A61L2/08 ,  A61L2/087 ,  A61L2/24 ,  A61L2202/14 ,  B65B3/003 ,  B65B7/16 ,  B65B7/161 ,  B65B55/025 ,  B65B55/08 ,  B65B55/16

Abstract: A sterile filling machine and related method are provided for sterile filling a container with a substance. The container includes a resealable stopper or portion and a chamber for receiving the substance therein. The sealed, empty containers are subjected to radiation capable of penetrating through the resealable portion and chamber for sterilizing the container. The previously sterilized containers are then transported through another sterilizing chamber, such as an e-beam chamber, to sterilize the penetrable surface. A filling member is moved into engagement with the resealable portion to pierce the sterilized penetrable surface of the resealable portion and inject the substance through the filling member and into the chamber of the container. Energy is then transmitted onto the stopper to hermetically re-seal the penetration in the resealable portion.

Abstract translation: 提供了一种无菌灌装机及相关方法，用于无菌填充具有物质的容器。 容器包括可重新密封的塞子或部分和用于在其中接收物质的室。 密封的空容器经受能够穿透可再密封部分和室的辐射以对容器进行灭菌。 先前灭菌的容器然后通过另一个灭菌室，如电子束室输送，以对可穿透表面进行消毒。 填充构件被移动成与可再密封部分接合以刺穿可再密封部分的消毒的可穿透表面，并且将物质通过填充构件注入到容器的室中。 然后将能量传递到塞子上以气密地重新密封可再密封部分中的穿透。

公开(公告)号：US08096333B2

公开(公告)日：2012-01-17

申请号：US12627655

申请日：2009-11-30

Applicant: Daniel Py ,  Benoit Adamo ,  John Guthy

Inventor： Daniel Py ,  Benoit Adamo ,  John Guthy

IPC: B65B1/04

CPC classification number: B65B3/006 ,  A61L2/10 ,  A61M5/1782 ,  B29C66/80 ,  B65B3/003 ,  B65B43/00 ,  B65B51/00 ,  Y10T29/49716

Abstract: An assembly includes a support and drive assembly, a first structure and a second structure. The first structure is in operable communication with and supported by the support and drive assembly. The first structure includes at least one needle assembly and is adjustable to receive a plurality of needle assemblies. The second structure is supported by the support and drive assembly. The second structure includes at least one seal assembly and is adjustable to receive a plurality of seal assemblies. A method includes determining a number of vials that are to be filled concurrently and adjusting an assembly to include at least one needle assembly and at least one seal assembly. A number of the needle assemblies and the seal assemblies equals the number of vials.

Abstract translation: 组件包括支撑和驱动组件，第一结构和第二结构。 第一结构与支撑和驱动组件可操作地连通并由其支撑。 第一结构包括至少一个针组件，并且可调节以接收多个针组件。 第二个结构由支撑和驱动组件支撑。 第二结构包括至少一个密封组件，并且可调节以接收多个密封组件。 一种方法包括确定要同时填充的小瓶的数量并且调整组件以包括至少一个针组件和至少一个密封组件。 许多针组件和密封组件等于小瓶的数量。

公开(公告)号：USD650067S1

公开(公告)日：2011-12-06

申请号：US29332347

申请日：2009-02-13

Applicant: Daniel Py ,  Norbert M. Assion

Designer： Daniel Py ,  Norbert M. Assion

公开(公告)号：USD644334S1

公开(公告)日：2011-08-30

申请号：US29357349

申请日：2010-03-11

Applicant: Daniel Py

Designer： Daniel Py

公开(公告)号：US07980276B2

公开(公告)日：2011-07-19

申请号：US12875440

申请日：2010-09-03

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B1/20 ,  B65B51/10 ,  B65D39/00

CPC classification number: A61J1/2096 ,  A61J1/1406 ,  A61J1/1468 ,  A61J1/18 ,  A61L2/08 ,  B29C65/16 ,  B29C65/1616 ,  B29C65/1619 ,  B29C65/1654 ,  B29C65/1677 ,  B29C65/18 ,  B29C66/001 ,  B29C66/1222 ,  B29C66/1224 ,  B29C66/12461 ,  B29C66/1312 ,  B29C66/342 ,  B29C66/534 ,  B29C66/5344 ,  B29C66/542 ,  B29C66/612 ,  B29C66/71 ,  B29C66/73755 ,  B29C66/7392 ,  B29C66/73921 ,  B29C66/7394 ,  B29C66/8322 ,  B29C67/004 ,  B29L2031/7158 ,  B29L2031/753 ,  B65B3/003 ,  B65B7/161 ,  B65D51/002 ,  B29C65/00 ,  B29K2025/08 ,  B29K2023/00

Abstract: A device defining a chamber for receiving a substance and a thermoplastic portion in fluid communication with the chamber is provided along with a method of filling and sealing the substance within the chamber. The thermoplastic portion defines a penetrable region that is penetrable by a filling member and is heat resealable to hermetically seal an aperture therein by applying laser radiation at a predetermined wavelength and power. The thermoplastic portion comprises a thermoplastic body defining a predetermined wall thickness and includes a styrene block copolymer, an olefin and a predetermined amount of pigment allowing the body to absorb laser radiation at the predetermined wavelength, substantially prevent the passage of radiation through the predetermined wall thickness, and hermetically seal the aperture in the penetrable region in a predetermined time period. The body includes a predetermined amount of lubricant that reduces friction forces at an interface of the filling member and body during penetration thereof.

Abstract translation: 提供了一种用于接收物质的腔室和与腔室流体连通的热塑性部分的装置以及在腔室内填充和密封物质的方法。 热塑性部分限定可渗透区域，其可由填充构件穿透，并且可热再密封以通过施加预定波长和功率的激光辐射来密封其中的孔。 热塑性部分包括限定预定壁厚的热塑性本体，并且包括苯乙烯嵌段共聚物，烯烃和预定量的颜料，其允许身体吸收预定波长的激光辐射，基本上防止辐射通过预定壁厚 并且在预定时间段内气密地密封可穿透区域中的孔。 主体包括预定量的润滑剂，其减少了在穿透填充构件和主体的界面处的摩擦力。

公开(公告)号：US20110135535A1

公开(公告)日：2011-06-09

申请号：US10241249

申请日：2002-09-10

Applicant: Daniel Py

Inventor： Daniel Py

IPC: A61L2/08 ,  E06B7/16 ,  B65G47/00 ,  E06B7/28

CPC classification number: B65B31/024 ,  A61L2/04 ,  A61L2/081 ,  A61L2/087 ,  A61L2/26 ,  A61L2202/122 ,  A61L2202/182 ,  B65B5/045 ,  B65B7/02 ,  B65B55/02 ,  B65B55/08 ,  B65B55/16 ,  B65B69/0033 ,  B65B69/0066

Abstract: A sterile enclosure contains a transfer module defining a window. A port covers the window to maintain the inside of the enclosure as a sealed and sterile environment. A sliding, heated cutting element mounted on the port serves to sterilize and sever a portion of a sterile transfer bag assembly attached to the port. Preferably, the excised portion of the sterile transfer bag assembly is affixed to the port when the port opens. The sliding cutting element remains extended and heated to prevent contamination when the port is open. Further, a heating element is mounted about the window in order to sterilize around the opening when the port is open.

Abstract translation: 无菌外壳包含定义窗口的传输模块。 端口覆盖窗口，以将密封和无菌环境保持在外壳内部。 安装在端口上的滑动加热切割元件用于对连接到端口的无菌传送袋组件的一部分进行消毒和切断。 优选地，当端口打开时，无菌转移袋组件的切除部分被固定到端口。 滑动切割元件保持延伸和加热，以防止端口打开时的污染。 此外，加热元件安装在窗口周围，以便在端口打开时围绕开口消毒。