公开(公告)号：US08696723B2

公开(公告)日：2014-04-15

申请号：US13771226

申请日：2013-02-20

Applicant: Zoll Circulation, Inc.

Inventor： Stelica Stelea ,  David Searl Kimball ,  Lynn Miyeko Shimada ,  Kenneth A. Collins ,  Grant Palmer

IPC: A61F7/08

CPC classification number: A61F7/10 ,  A61B2017/00026 ,  A61B2017/00119 ,  A61F7/0085 ,  A61F7/02 ,  A61F2007/0001 ,  A61F2007/0054 ,  A61F2007/0056

Abstract: An externally-applied heat exchange pad has three layers laminated together, an inner and outer non-conductive layer and a middle conductive layer. A leak in the inner layer causes coolant to contact the middle layer and change impedance, which can be sensed and used as an indication of an impending total leak of the pad.

Abstract translation: 外部施加的热交换垫具有层压在一起的三层，内部和外部非导电层和中间导电层。 内层中的泄漏使得冷却剂接触中间层并改变阻抗，其可以被感测并用作对即将到来的垫的总泄漏的指示。

公开(公告)号：US20140094882A1

公开(公告)日：2014-04-03

申请号：US13653565

申请日：2012-10-17

Applicant: ZOLL CIRCULATION, INC.

Inventor： ALEX L. LIM

IPC: A61F7/12

CPC classification number: A61F7/12 ,  A61F2007/126

Abstract: A catheter has a hollow conduit through which working fluid from a heat exchange system flows. The conduit in turn is configured to extend along a longitudinal central axis in a continuously varying non-constant azimuthal orientation so that it defines a non-round enclosed passageway through which blood can flow to exchange heat through a wall of the conduit with the working fluid flowing within the conduit.

Abstract translation: 导管具有中空导管，来自热交换系统的工作流体通过该导管流动。 导管又被配置为沿着纵向中心轴线以连续变化的非恒定方位角方向延伸，使得其限定非圆形封闭通道，血液可以通过该通道流动以通过导管的壁与工作流体交换热量 在导管内流动。

公开(公告)号：US20140094880A1

公开(公告)日：2014-04-03

申请号：US13653648

申请日：2012-10-17

Applicant: ZOLL CIRCULATION, INC.

Inventor： Alex L. LIM ,  Masouneh MAFI ,  Venkata Vishnu GURUKULA

IPC: A61F7/12

CPC classification number: A61F7/12 ,  A61F7/123 ,  A61F2007/0054 ,  A61F2007/0056 ,  A61F2007/0091 ,  A61F2007/126

Abstract: A catheter has a series of hollow loops arranged along a tube for carrying working fluid from a heat exchange system to exchange heat with a patient in whom the catheter is advanced. The loops when inflated are transverse to the catheter axis and parallel to each other, and circumscribe a hollow passageway through which blood can flow. Blood also flows around the outer perimeters of the loops.

Abstract translation: 导管具有沿着管布置的一系列中空环，用于承载来自热交换系统的工作流体，以与导管进入的患者进行热交换。 当充气时的环横向于导管轴线并且彼此平行，并且环绕血液可以流过的中空通道。 血液也流过环路的外围。

公开(公告)号：US20130325090A1

公开(公告)日：2013-12-05

申请号：US13961058

申请日：2013-08-07

Applicant: Zoll Circulation Inc.

Inventor： Wayne Noda ,  Stelica Stelea

IPC: A61F7/00

Abstract: A cooling system for an indwelling heat exchange catheter includes a heat exchange bath that is configured to receive a conduit that carries saline to and from the catheter. A heating/cooling fluid is in the bath and exchanges heat with the saline. The heating/cooling fluid flows through a heat exchanger that includes a refrigerant and two variable speed DC compressor for removing heat from the refrigerant. A gear pump circulates the working fluid to and from the catheter and is removably engaged with a pump support platform.

Abstract translation: 用于留置热交换导管的冷却系统包括热交换浴，其被配置为接收将导管和/或从该导管携带的导管。 加热/冷却液在浴中并与盐水交换热量。 加热/冷却流体流过包括制冷剂的热交换器和用于从制冷剂中除去热量的两个变速直流压缩机。 齿轮泵将工作流体循环到导管和从导管流出并且可移除地与泵支撑平台接合。

公开(公告)号：US20130281869A1

公开(公告)日：2013-10-24

申请号：US13925401

申请日：2013-06-24

Applicant: Zoll Circulation, Inc.

Inventor： Denise R. Barbut ,  Peter T. Keith ,  Steven W. Berhow ,  Jon P. St. Germain

IPC: A61B5/0215

CPC classification number: A61B17/12045 ,  A61B5/0215 ,  A61B5/4076 ,  A61B6/481 ,  A61B17/12036 ,  A61B17/12109 ,  A61B17/12136 ,  A61B17/12145 ,  A61B17/1219 ,  A61B2017/22054 ,  A61B2090/3966 ,  A61F7/12 ,  A61F2002/068 ,  A61F2007/126 ,  A61M25/00 ,  A61M25/003 ,  A61M25/0032 ,  A61M25/0068 ,  A61M25/0069 ,  A61M25/0074 ,  A61M25/008 ,  A61M25/0082 ,  A61M25/0147 ,  A61M25/0662 ,  A61M25/1011 ,  A61M2025/0002 ,  A61M2025/0034 ,  A61M2025/0073 ,  A61M2025/0081 ,  A61M2025/1052 ,  A61M2210/127 ,  A61M2230/005 ,  A61M2230/30

Abstract: Methods are provided for partial aortic obstruction for cerebral perfusion augmentation in patients suffering from global or focal cerebral ischemia. Alternatively, the methods can be used to partially obstruct aortic blood flow to condition the spinal cord to secrete neuroprotective agents prior to abdominal aortic aneurysm repair. Partial obstruction of a vessel can be accomplished by a device comprising an elongate catheter and a distally mounted expandable member. The expandable member may comprise one or two balloons. Other medical devices, such as an angioplasty, stent, or atherectomy catheter, can be inserted distal the expandable member to provide therapeutic intervention.

Abstract translation: 为全脑或局灶性脑缺血患者提供局部主动脉阻塞用于脑灌注增强的方法。 或者，所述方法可用于部分阻塞主动脉血流以调节脊髓以在腹主动脉瘤修复之​​前分泌神经保护剂。 容器的部分阻塞可以通过包括细长导管和远侧安装的可扩张构件的装置来实现。 可膨胀构件可以包括一个或两个气囊。 诸如血管成形术，支架或粥样斑块切除术导管的其它医疗装置可以在可扩张构件的远端插入以提供治疗干预。

公开(公告)号：US20130150930A1

公开(公告)日：2013-06-13

申请号：US13758854

申请日：2013-02-04

Applicant: ZOLL CIRCULATION, INC.

Inventor： Timothy R. Machold ,  Nicole Denise Bloom ,  Alex T. Roth ,  Dave J. Scott ,  Jose Alejandro ,  Edward A. Oliver

IPC: A61F7/00

CPC classification number: A61F7/12 ,  A61B2017/00119 ,  A61B2017/00123 ,  A61B2017/22051 ,  A61F7/0085 ,  A61F7/10 ,  A61F7/123 ,  A61F2007/0054 ,  A61F2007/0096 ,  A61F2007/126 ,  A61M5/44 ,  A61M25/1011 ,  A61M2025/1072 ,  A61M2025/1086 ,  A61M2205/127

Abstract: A heat exchange fluid supply system for supplying a heat exchange fluid to an intravascular heat exchange catheter includes a disposable cassette having a bulkhead and an external heat exchanger, and which is configured to operate in combination with a reusable master control unit. The bulkhead includes a reservoir section and a pump section. The reservoir section is provided with a means to monitor the amount of heat exchange fluid that is in the system. The bulkhead provides the mechanism for priming the system with heat exchange fluid from an external source and for circulating fluid to the catheter in a closed circuit. The pump section is configured to allow for pumping of heat exchange fluid at a constant pressure.

Abstract translation: 用于将热交换流体供应到血管内热交换导管的热交换流体供应系统包括具有隔板和外部热交换器的一次性盒，其被配置为与可重复使用的主控制单元结合操作。 舱壁包括储存段和泵段。 储存器部分设置有用于监测系统中的热交换流体的量的装置。 隔板提供了使用来自外部源的热交换流体并且用于在闭合回路中将流体循环到导管的系统引发系统的机构。 泵部分构造成允许在恒定压力下泵送热交换流体。

公开(公告)号：US20130090708A1

公开(公告)日：2013-04-11

申请号：US13631324

申请日：2012-09-28

Applicant: ZOLL Circulation Inc.

Inventor： Jeremy Thomas Dabrowiak ,  Frederick Faller

IPC: A61F7/12

Abstract: Devices and methods for cooling all or part of the body of a human or animal subject by inserting a heat exchange catheter into the subject's body and infusing into or through the catheter a heat exchange medium that contains liquid phase matter and frozen solid phase matter, wherein at least some of the solid phase matter melts while in the catheter.

Abstract translation: 通过将热交换导管插入到受试者的身体中并将包含液相物质和冷冻的固相物质的热交换介质输入或穿过导管来冷却人或动物受试者的全部或部分身体的装置和方法，其中 在导管中至少有一些固相物质熔化。

公开(公告)号：US20130073014A1

公开(公告)日：2013-03-21

申请号：US13622104

申请日：2012-09-18

Applicant: Zoll Circulation, Inc.

Inventor： Alex L. Lim ,  Venkata Vishnu Gurukula ,  Jeremy T. Dabrowiak ,  Richard A. Helkowski

IPC: A61F7/12

CPC classification number: A61F7/12 ,  A61F7/0085 ,  A61F2007/0054 ,  A61F2007/0056 ,  A61F2007/0094 ,  A61F2007/0096 ,  A61F2007/126 ,  A61M25/00 ,  A61M2025/0004 ,  A61M2205/18 ,  A61M2205/3368

Abstract: A catheter has an inner sleeve through which refrigerant circulates to and from a source of refrigerant. The catheter also has an outer sleeve surrounding the inner sleeve, including a distal end thereof. The outer sleeve is filled with a frozen biocompatible substance. The refrigerant is separated from the biocompatible substance by one or more walls of the inner sleeve such that the refrigerant is isolated from a patient in whom the catheter is positioned by both the inner sleeve and the frozen biocompatible substance. The refrigerant circulates through the catheter when the catheter is positioned in the patient to maintain the biocompatible substance frozen as heat is transferred from the patient to the biocompatible substance.

Abstract translation: 导管具有内套筒，制冷剂通过该内套筒从制冷剂源流出。 导管还具有围绕内套筒的外套筒，包括其远端。 外套筒装有冷冻的生物相容性物质。 制冷剂通过内套筒的一个或多个壁与生物相容性物质分离，使得制冷剂与内套筒和冷冻生物相容性物质由导管定位的患者隔离。 当导管位于患者体内时，制冷剂通过导管循环，以便当热量从患者转移到生物相容性物质时，使生物相容性物质保持冷冻。

公开(公告)号：US20240390224A1

公开(公告)日：2024-11-28

申请号：US18668856

申请日：2024-05-20

Applicant: ZOLL Circulation, Inc.

Inventor： Nikhil S. Joshi ,  Melanie L. Harris ,  Byron J. Reynolds

IPC: A61H31/00 ,  A61H11/00

Abstract: A device for compressing the chest of a cardiac arrest victim.

公开(公告)号：US20240238117A1

公开(公告)日：2024-07-18

申请号：US18620410

申请日：2024-03-28

Applicant: Zoll Circulation, Inc.

Inventor： George L. Walls ,  Richard A. Helkowski ,  Jeremy Thomas Dabrowiak ,  Byron Reynolds ,  IIjong Lee ,  Michael W. Dae ,  Sean W. YIP

IPC: A61F7/00 ,  A61F7/08 ,  G16H40/63 ,  A61F7/12

CPC classification number: A61F7/0085 ,  A61F7/08 ,  G16H40/63 ,  A61F2007/0054 ,  A61F2007/0093 ,  A61F2007/0096 ,  A61F2007/126

Abstract: A temperature management system controls a temperature of a body of a patient and determines a value indicative of a thermoregulatory activity of the patient. The system includes a heat exchange system configured to exchange heat with a body of a patient and to record operational data while controlling the temperature of the body of the patient. The temperature management system receives temperature data from a sensor, controls the heat exchange system to maintain the temperature of the body of the patient within a target temperature range, receives, in response to the controlling, operational data, determines, based on the temperature data and the operational data, a value indicative of a thermoregulatory activity of the patient, and generates, based on the value, an alert through the user interface indicating the thermoregulatory activity of the patient.