公开(公告)号：US07871762B2

公开(公告)日：2011-01-18

申请号：US10616323

申请日：2003-07-09

Applicant: Laurence A. Cole

Inventor： Laurence A. Cole

IPC: C12Q1/00 ,  G01N33/53 ,  G01N33/574 ,  C12P21/08

CPC classification number: G01N33/57442 ,  G01N33/74 ,  G01N33/76

Abstract: The invention provides methods for detecting the presence or absence of invasive trophoblast cells. In addition, the invention provides methods for distinguishing quiescent trophoblast diseases from invasive trophoblast diseases and methods for monitoring progression of quiescent trophoblast diseases. The invention provides methods for detecting the presence or absence of germ cell tumors.

Abstract translation: 本发明提供了用于检测侵入性滋养细胞存在或不存在的方法。 此外，本发明提供了将静止滋养层疾病与侵入性滋养层疾病区分开来的方法以及监测静息滋养层疾病进展的方法。 本发明提供了用于检测生殖细胞肿瘤的存在或不存在的方法。

公开(公告)号：US07785900B1

公开(公告)日：2010-08-31

申请号：US11652432

申请日：2007-01-11

Applicant: Peter C. Simons ,  Larry A. Sklar ,  Eric R. Prossnitz ,  Angela Wandinger-Ness ,  Mathewos Z. Tessema ,  John C. Reed ,  Dayong Zhai

Inventor： Peter C. Simons ,  Larry A. Sklar ,  Eric R. Prossnitz ,  Angela Wandinger-Ness ,  Mathewos Z. Tessema ,  John C. Reed ,  Dayong Zhai

IPC: G01N33/543 ,  G01N33/53

CPC classification number: G01N33/54393 ,  G01N33/543

Abstract: The present invention relates generally to glutathione derivatized beads which are adapted for use in conjunction with glutathione-S-transferase fusion proteins (generally, GST fusion proteins, which contain a fluorescent label such as fluorescent green protein) for use in flow cytometry. The present invention also relates to methods for detecting and/or quantifying interactions between a GST fusion protein and their binding partners, in particular, labeled binding partners such as fluorescently labeled binding partners. By creating glutathione beads with an appropriate high or increased site density, disadvantages often associated with low affinity systems and quick off-rates in solution may be resolved to provide a workable system and method. Methods of identifying potential agonists, antagonists and regulator compounds of proteins fused to GST from libraries of compounds represents another aspect of the present invention.

Abstract translation: 本发明一般涉及适用于与流式细胞术中使用的谷胱甘肽-S-转移酶融合蛋白（通常为含有荧光标记如荧光绿蛋白的GST融合蛋白）结合使用的谷胱甘肽衍生化珠粒。 本发明还涉及用于检测和/或定量GST融合蛋白与其结合配偶体，特别是标记的结合配偶体如荧光标记的结合配偶体之间的相互作用的方法。 通过产生具有适当的高或增加的位点密度的谷胱甘肽珠，可以解决通常与低亲和力系统相关的缺点和解决方案中的快速关闭速率，以提供可行的系统和方法。 从化合物文库鉴定与GST融合的蛋白质的潜在激动剂，拮抗剂和调节剂化合物的方法代表本发明的另一方面。

公开(公告)号：US07708991B2

公开(公告)日：2010-05-04

申请号：US11058542

申请日：2005-02-15

Applicant: Laurence A Cole

Inventor： Laurence A Cole

IPC: A61K39/395

CPC classification number: C07K16/26 ,  A61K2039/505 ,  C07K2317/73 ,  C07K2317/76

Abstract: The present invention relates to compositions and methods for treating cancer, especially epithelial and eutopic cancers using inhibitors of H-HCG or β-H-HCG, as well as vaccines for use in oncostasis or reducing the likelihood of recurrence of cancer after remission. In addition, the present invention provides a method for reducing the likelihood that a woman will become pregnant or that an unwanted pregnancy may be terminated.

Abstract translation: 本发明涉及使用H-HCG或HGF-HCG抑制剂治疗癌症，特别是上皮和非特异性癌症的组合物和方法，以及用于止血或降低缓解后癌症复发可能性的疫苗。 此外，本发明提供了一种降低女性怀孕或可能终止意外怀孕的可能性的方法。

公开(公告)号：US07624368B2

公开(公告)日：2009-11-24

申请号：US11267587

申请日：2005-11-04

Applicant: Sterling R. Whitaker ,  Lowell H. Miles

Inventor： Sterling R. Whitaker ,  Lowell H. Miles

IPC: G06F17/50

CPC classification number: G06F17/5045 ,  G06F17/505 ,  H04L29/06 ,  H04L67/06 ,  H04L67/10 ,  H04L69/329

Abstract: An application specific integrated circuit is optimized by translating a first representation of its digital design to a second representation. The second representation includes multiple syntactic expressions that admit a representation of a higher-order function of base Boolean values. The syntactic expressions are manipulated to form a third representation of the digital design.

Abstract translation: 通过将其数字设计的第一表示转换为第二表示来优化专用集成电路。 第二种表示方法包括允许基本布尔值的高阶函数的表示的多个句法表达式。 句法表达式被操纵以形成数字设计的第三表示。

公开(公告)号：US07617081B2

公开(公告)日：2009-11-10

申请号：US11157474

申请日：2005-06-21

Applicant: Gregory Von Winckel ,  Evangelos A. Coutsias ,  Sanjay Krishna

Inventor： Gregory Von Winckel ,  Evangelos A. Coutsias ,  Sanjay Krishna

IPC: G06F17/10

CPC classification number: G06F17/13

Abstract: Methods are provided to generate eigenvalues and eigenfunctions for structures that include inhomogeneous media. In embodiments, eigenvalues and eigenfunctions generated as solutions to differential equations provide parameters for analyzing and constructing structures modeled by the differential equations.

Abstract translation: 提供了用于为包括不均匀介质的结构生成特征值和本征函数的方法。 在实施例中，作为微分方程解的特征值和本征函数提供用于分析和构造由微分方程建模的结构的参数。

公开(公告)号：US07572639B2

公开(公告)日：2009-08-11

申请号：US11144091

申请日：2005-06-02

Applicant: Laurence A. Cole ,  Jaime M. Riley ,  Francis W. Byrn

Inventor： Laurence A. Cole ,  Jaime M. Riley ,  Francis W. Byrn

IPC: G01N33/48

CPC classification number: G01N33/76 ,  G01N33/54366 ,  G01N33/689 ,  G01N33/743 ,  G01N2800/368

Abstract: A method for predicting pregnancy outcome includes measuring blood levels of hCG-hg and progesterone in a pregnant woman, determining a rate of change of progesterone levels from the blood measurements, determining at least a qualitative direction of change of hCG-hg levels from the blood measurements, comparing the determined rate of change of progesterone levels with a pre-established reference value, and determining at least a qualitative likelihood of a term pregnancy and a failed pregnancy for the woman from the qualitative direction of change of hCG-hg levels and the determined rate of change of progesterone levels relative to the pre-established reference value. The rate of change of progesterone is determined by formula as a number of days for progesterone to double.

Abstract translation: 预测妊娠结局的方法包括测量孕妇中hCG-hg和孕酮的血液水平，从血液测量中确定孕酮水平的变化率，确定hCG-hg水平从血液中至少定性的变化方向 测量，将确定的孕酮水平的变化率与预先确定的参考值进行比较，以及从hCG-hg水平的变化的定性方向确定妇女的术语怀孕和失败的怀孕的至少定性可能性，以及 孕酮水平相对于预先确定的参考值的确定的变化率。 孕酮的变化率由公式确定为孕酮倍数的天数。

公开(公告)号：US07429728B2

公开(公告)日：2008-09-30

申请号：US11360872

申请日：2006-02-23

Applicant: Christie G. Enke

Inventor： Christie G. Enke

IPC: H01J49/40

CPC classification number: H01J49/40 ,  G01N27/622 ,  H01J49/0045

Abstract: A distance of flight (DOF) approach to mass spectroscopy in which the resolution among the various ion masses is accomplished in space rather than time. A separate detector is associated with each ion mass resolution element. The DOF mass spectrometer can serve as one element in a tandem arrangement which has the capability to produce a full two-dimensional precursor/product spectrum for each bunch of ions extracted from the source. A “distance-of-flight” (DOF) mass analyzer is used in combination with time-of-flight (TOF) mass analysis for precursor and product dispersion. All the precursor ions can undergo a mass changing reaction simultaneously, while still retaining the essential information about the particular precursor m/z value from which each product ion m/z value emanated. Through the use of a two-dimensional detector, all the products ions from all the precursors can be detected for each batch of ions analyzed.

Abstract translation: 距离飞行（DOF）方法到质谱法，其中各种离子质量的分辨率在空间而不是时间内完成。 单独的检测器与每个离子质量分辨率元件相关联。 DOF质谱仪可以作为串联布置的一个元件，其能够为从源提取的每束离子产生完整的二维前体/产物光谱。 使用“飞行距离”（DOF）质谱仪与飞行时间（TOF）质量分析结合使用前体和产品分散。 所有前体离子可以同时进行质量变化反应，同时仍然保留关于每个产物离子m / z值发射的特定前体m / z值的基本信息。 通过使用二维检测器，可以对分析的每批离子检测来自所有前体的所有产物离子。

公开(公告)号：US07371359B2

公开(公告)日：2008-05-13

申请号：US11673849

申请日：2007-02-12

Applicant: Robert T. Paine, Jr.

Inventor： Robert T. Paine, Jr.

IPC: C01B35/10 ,  C01B21/064

CPC classification number: C01B21/064 ,  C01B21/0646 ,  C01B21/0828 ,  C01B35/146 ,  C01P2004/03 ,  C01P2004/32 ,  C01P2004/34 ,  C01P2004/61 ,  C01P2004/62 ,  C01P2006/12 ,  C01P2006/60 ,  C01P2006/80 ,  C04B35/583 ,  C04B38/009 ,  Y10T428/2982 ,  C04B38/068

Abstract: A non-aqueous route and process for preparation of boron nitride utilizing aerosol assisted vapor phase synthesis (AAVS) wherein boron precursors are nitrided in one or two heating steps, and wherein a boron oxide nitride carbide intermediary composition is formed after the first heating step and may be further nitrided to form resultant spheroidal boron nitride powders including dense or hollow spheroidal particles that are smooth, bladed, dense or hollow, have protruding whiskers, and are of turbostratic or hexagonal crystalline structure, specifically wherein the boron precursor is dissolved in a non-aqueous solution prior to aerosolization.

Abstract translation: 一种非水路线和利用气溶胶辅助气相合成（AAVS）制备氮化硼的方法，其中硼前体在一个或两个加热步骤中被氮化，并且其中在第一加热步骤之后形成氧化硼氮化碳中间体组合物， 可以进一步氮化以形成球形氮化硼粉末，其包括平滑，叶片，致密或中空的致密或中空球形颗粒，具有突出的晶须，并且具有涡流或六方晶结构，其中硼前体溶解在非 - - 雾化前的水溶液。

公开(公告)号：US20080006816A1

公开(公告)日：2008-01-10

申请号：US11780933

申请日：2007-07-20

Applicant: Sanjay Krishna ,  John P. David ,  Majeed Hayat

Inventor： Sanjay Krishna ,  John P. David ,  Majeed Hayat

IPC: H01L31/0352

CPC classification number: H01L31/1075 ,  B82Y10/00 ,  B82Y20/00 ,  H01L31/0352

Abstract: A photodetector for use at wavelengths of 2 μm and longer has an intersubband absorption region to provide absorption at wavelengths beyond 2 μm, integrated with an avalanche multiplier region to provide low-rise gain. In one particular design, the intersubband absorption region is a quantum-confined absorption region (e.g., based on quantum wells and/or quantum dots).

Abstract translation: 用于2μm和更长波长的光电检测器具有跨带吸收区域，以在超过2μm的波长处提供吸收，与雪崩倍增器区域集成以提供低增益增益。 在一个特定设计中，子带间吸收区域是量子限制吸收区域（例如，基于量子阱和/或量子点）。

公开(公告)号：US07288423B2

公开(公告)日：2007-10-30

申请号：US11326433

申请日：2006-01-06

Applicant: Diana L. Huffaker ,  Sandy Birodavolu

Inventor： Diana L. Huffaker ,  Sandy Birodavolu

IPC: H01L21/00

CPC classification number: H01L21/02639 ,  H01L21/02395 ,  H01L21/02463 ,  H01L21/02546 ,  H01L21/0262 ,  H01L21/02642 ,  H01L21/02647

Abstract: A method for removing a mask in a selective area epitaxy process is provided. The method includes forming a first layer on a substrate and oxidizing the first layer. A patterned photoresist can be formed on the oxidized first layer. A portion of the oxidized first layer can then be removed using a wet chemical etch to form a mask. After removing the patterned photoresist a second layer can be epitaxially grown in a metal organic chemical vapor deposition (MOCVD) chamber or a chemical beam epitaxy (CBE) chamber on a portion of the first layer exposed by the mask. The mask can then be removed the mask in the MOCVD/MBE chamber. The disclosed in-situ mask removal method minimizes both the atmospheric exposure of a growth surface and the number of sample transfers.

Abstract translation: 提供了一种在选择性区域外延工艺中去除掩模的方法。 该方法包括在衬底上形成第一层并氧化第一层。 可以在氧化的第一层上形成图案化的光致抗蚀剂。 然后可以使用湿化学蚀刻来去除氧化的第一层的一部分以形成掩模。 在去除图案化的光致抗蚀剂之后，可以在由掩模暴露的第一层的部分上的金属有机化学气相沉积（MOCVD）室或化学束外延（CBE）室中外延生长第二层。 然后可以在MOCVD / MBE室中去除掩模。 所公开的现场掩模去除方法使生长表面的大气暴露和样品转移的数量最小化。