公开(公告)号：US11767326B2

公开(公告)日：2023-09-26

申请号：US18176653

申请日：2023-03-01

申请人： AbbVie Inc.

发明人： Aileen L. Pangan ,  Henrique D. Teixeira ,  Mohamed-Eslam F. Mohamed ,  Ahmed A. Othman ,  Ben Klünder ,  Jeffrey W. Voss ,  Robert J. Padley ,  Heidi S. Camp

IPC分类号： A61K31/4985 ,  A61K47/12 ,  A61K47/38 ,  C07D487/14 ,  A61K9/00 ,  A61K9/20

CPC分类号： C07D487/14 ,  A61K9/0053 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2054 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38 ,  C07B2200/13

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3Himidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis and atopic dermatitis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US11767310B2

公开(公告)日：2023-09-26

申请号：US17882709

申请日：2022-08-08

申请人： AbbVie Inc.

发明人： Kevin Patrick Cusack ,  Michael Zeller Hoemann ,  David Andrew Kinsman ,  Sami Osman ,  James Patrick Stambuli ,  Maria Anastasia Argiriadi ,  Ciaran O'Reilly ,  Hannah Dexter ,  Euan Fordyce ,  Steve St. Gallay

IPC分类号： C07D401/06 ,  A61P1/04 ,  C07D405/14 ,  C07D413/06 ,  C07D417/06 ,  C07D498/04

CPC分类号： C07D401/06 ,  A61P1/04 ,  C07D405/14 ,  C07D413/06 ,  C07D417/06 ,  C07D498/04

摘要： Provided herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, useful as RIPK1 inhibitors, and pharmaceutical compositions comprising same. Further provided are methods of use and preparation. Also provided are methods of treating Ulcerative Colitis using a compound of Formula (I).

公开(公告)号：US20230271974A1

公开(公告)日：2023-08-31

申请号：US18176651

申请日：2023-03-01

申请人： AbbVie Inc.

发明人： Aileen L. Pangan ,  Henrique D. Teixeira ,  Ayman D. Allian ,  Thomas B. Borchardt ,  Jayanthy Jayanth ,  Patrick J. Marroum ,  Fredrik Lars Nordstrom ,  Ahmad Y. Sheikh ,  Mohamed-Eslam F. Mohamed ,  Ahmed A. Othman ,  Peter T. Mayer ,  Ben Klünder

IPC分类号： C07D487/14 ,  A61K47/38 ,  A61K47/12 ,  A61K31/4985 ,  A61K9/00 ,  A61K9/20

CPC分类号： C07D487/14 ,  A61K9/0053 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2054 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38 ,  C07B2200/13

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment(including treatment of rheumatoid arthritis and atopic dermatitis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US20230255968A1

公开(公告)日：2023-08-17

申请号：US18168221

申请日：2023-02-13

申请人： AbbVie Inc. ,  Neurocrine Biosciences, Inc.

发明人： Jayanthy Jayanth ,  Kevin C. Spence ,  Gregory A. McClelland ,  Anna V. Stepanenko ,  Kristof Chwalisz ,  Charlotte D. Owens ,  James W. Thomas ,  Jane Castelli-Haley ,  Keith Gordon ,  Michael C. Snabes ,  Ahmed M. Soliman ,  Geoff Zhang ,  David Metzger ,  Yanxia Li ,  Tzuchi R. Ju ,  Xi Shao ,  Oscar Antunez Flores ,  Rita Jain ,  Juki Wing-Keung Ng ,  Janine D. North ,  Hannah Palac ,  Paul M. Peloso

IPC分类号： A61K31/513 ,  A61K9/20 ,  A61P5/30 ,  A61P15/00

CPC分类号： A61K31/513 ,  A61K9/2009 ,  A61K9/2018 ,  A61P5/30 ,  A61K9/2059 ,  A61P15/00 ,  A61K9/2027

摘要： The present disclosure relates to pharmaceutical compositions comprising a gonadotropin-releasing hormone (GnRH) antagonist and methods of preparing and using such compositions. The disclosure also relates to methods of facilitating release of a GnRH antagonist from a pharmaceutical composition.

公开(公告)号：US20230255959A1

公开(公告)日：2023-08-17

申请号：US18191810

申请日：2023-03-28

申请人： GENENTECH, INC. ,  HOFFMANN-LA ROCHE INC. ,  ABBVIE INC.

发明人： Deepak SAMPATH ,  Christian KLEIN ,  Wayne John FAIRBROTHER

IPC分类号： A61K31/496 ,  A61K31/02 ,  A61K31/04 ,  A61K31/10 ,  A61K31/18 ,  A61K31/33 ,  A61K31/436 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/45 ,  A61K31/505 ,  A61K31/63 ,  A61K39/395

CPC分类号： A61K31/496 ,  A61K31/02 ,  A61K31/04 ,  A61K31/10 ,  A61K31/18 ,  A61K31/33 ,  A61K31/436 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/45 ,  A61K31/505 ,  A61K31/63 ,  A61K39/39558 ,  A61K2039/545

摘要： The present invention is directed to a combination therapy involving a type II anti-CD20 antibody and a selective Bcl-2 inhibitor for the treatment of a patient suffering from cancer, particularly, a CD20-expressing cancer.

公开(公告)号：US20230220061A1

公开(公告)日：2023-07-13

申请号：US18105316

申请日：2023-02-03

申请人： AbbVie Inc.

发明人： Gregg Timony ,  Sheila Gujrathi ,  Robert Peach ,  Allan Olson

IPC分类号： C07K16/24 ,  A61P37/06 ,  A61P1/00 ,  A61K31/436 ,  A61K31/519 ,  A61K31/58 ,  A61K38/13 ,  A61K39/395 ,  A61K45/06

CPC分类号： C07K16/244 ,  A61P37/06 ,  A61P1/00 ,  A61K31/436 ,  A61K31/519 ,  A61K31/58 ,  A61K38/13 ,  A61K39/3955 ,  A61K45/06 ,  C07K2317/56

摘要： The present invention is directed to methods for treating diseases in which IL-13 activity is detrimental, including eosinophilic esophagitis (EoE) and asthma, by administering to a subject in need of such treatment, a composition containing an interleukin-13 (IL-13) antibody, or an antigen binding fragment, thereof.

公开(公告)号：US20230183239A1

公开(公告)日：2023-06-15

申请号：US17702597

申请日：2022-03-23

申请人： AbbVie Inc.

发明人： William Michael GALLATIN ,  Joshua ODINGO ,  Gregory N. DIETSCH ,  Vincent FLORIO ,  Chandregowda VENKATESHAPPA ,  Athisayamani Jeyaraj DURAISWAMY

IPC分类号： C07D471/10 ,  C07D211/28 ,  C07D215/233 ,  C07D215/44 ,  C07D239/88 ,  C07D239/94 ,  C07D241/42 ,  C07D307/81 ,  C07D311/22 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/12 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00 ,  C07F5/02

CPC分类号： C07D471/10 ,  C07D211/28 ,  C07D215/44 ,  C07D215/233 ,  C07D239/88 ,  C07D239/94 ,  C07D241/42 ,  C07D307/81 ,  C07D311/22 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/12 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00 ,  C07F5/025

摘要： Disclosed herein are methods and compounds of augmenting and enhancing the production of type I IFNs in vivo. In some embodiments, the compounds disclosed herein are ENPP-1 inhibitors, pharmaceutical compositions, and methods for the treatment of cancer or a viral infection.

公开(公告)号：US11639393B2

公开(公告)日：2023-05-02

申请号：US17815505

申请日：2022-07-27

申请人： AbbVie Inc.

发明人： Andrew J. McCluskey ,  Amanda M. Schmidt Paustian ,  Jane Seagal ,  Julie L. Wilsbacher

IPC分类号： C07K16/28 ,  A61P35/00 ,  C12N15/85 ,  A61K39/00

摘要： The present disclosure provides anti-CCR8 antibodies, including compositions and methods of using such antibodies.

公开(公告)号：US11639390B2

公开(公告)日：2023-05-02

申请号：US17378565

申请日：2021-07-16

申请人： AbbVie Inc.

发明人： Jing Min ,  Teresa (Iok-Chan) Ng ,  Lorenzo Benatuil ,  Jacqueline Bixby ,  Tatyana Dekhtyar ,  Feng Dong ,  Axel Hernandez, Jr. ,  Preethi Krishnan ,  Liangjun Lu ,  Federico Mensa ,  Renee Miller ,  Gautam Sahu

IPC分类号： C12N5/02 ,  C12N5/20 ,  C12N1/20 ,  C12N15/00 ,  C07K16/46 ,  C07K16/00 ,  C07H21/04 ,  C07K16/28 ,  A61P31/18 ,  C12N15/63 ,  A61K39/00

摘要： The present disclosure provides anti-α4β7 antibodies that bind human α4β7, their methods of making, and their uses to treat patients with HIV infection.

公开(公告)号：US20230129413A1

公开(公告)日：2023-04-27

申请号：US17817191

申请日：2022-08-03

申请人： AbbVie Inc.

发明人： Alexandru DEAC ,  Ye HUANG ,  John M. LIPARI ,  Alexander RUGGLES ,  Thin Yu TUN

IPC分类号： A61K31/198 ,  A61K47/32 ,  A61K47/10 ,  A61K47/38 ,  A61K9/10 ,  A61K9/00 ,  A61K31/195

摘要： The present disclosure provides (a) a pharmaceutical composition comprising a levodopa active agent and a carbidopa active agent and (b) methods of treating Parkinson's disease and associated conditions comprising administering the pharmaceutical composition to a subject with Parkinson's disease.