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公开(公告)号：US20130085112A1
公开(公告)日：2013-04-04
申请号：US13699346
申请日：2011-05-25
IPC分类号： C12N15/113 , C07K2/00
CPC分类号： C12N15/113 , A61K31/7125 , A61K31/713 , C07K2/00 , C12N2310/11 , C12N2310/111 , C12N2310/113 , C12N2310/312 , C12N2310/313 , C12N2310/314 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/3521 , C12N2310/3525 , C12N2310/3533 , Y02A50/401 , C12N2330/10
摘要： The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Atonal homolog 1 (ATOH1), in particular, by targeting natural antisense polynucleotides of Atonal homolog 1 (ATOH1). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of ATOH1.
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22.发明申请TREATMENT OF PYRROLINE-5-CARBOXYLATE REDUCTASE 1 (PYCR1) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO PYCR1 有权通过抑制PYCR1自然抗体转录物治疗吡咯烷-5-羧酸还原酶1（PYCR1）相关疾病公开(公告)号：US20120309814A1
公开(公告)日：2012-12-06
申请号：US13580488
申请日：2011-02-21
IPC分类号： A61K31/713 , A61K31/7088 , C07H21/02 , A61P19/10 , A61P19/08 , A61P19/00 , A61P35/00 , A61P19/02 , A61P1/16 , A61P35/02 , A61P25/28 , A61P25/00 , A61P25/16 , A61P27/02 , G01N33/53 , C12N5/071
CPC分类号： C12Q1/6876 , A61K31/7088 , C12N15/113 , C12N15/1137 , C12N2310/11 , C12N2310/113 , C12N2310/14 , C12N2310/315 , C12N2320/30 , C12Q1/68 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178 , C12Y105/01002
摘要： The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Pyrroline-5-carboxylate reductase 1 (PYCR1), in particular, by targeting natural antisense polynucleotides of Pyrroline-5-carboxylate reductase 1 (PYCR1). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of PYCR1.
摘要翻译： 本发明涉及通过靶向吡咯啉-5-羧酸还原酶1（PYCR1）的天然反义多核苷酸来调节吡咯啉-5-羧酸还原酶1（PYCR1）的表达和/或功能的反义寡核苷酸。 本发明还涉及这些反义寡核苷酸的鉴定及其在治疗与PYCR1表达相关的疾病和病症中的用途。
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23.发明申请TREATMENT OF INSULIN RECEPTOR SUBSTRATE 2 (IRS2) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO IRS2 AND TRANSCRIPTION FACTOR E3 (TFE3) 审中-公开通过抑制自然抗原转录物到IRS2和转录因子E3（TFE3）来治疗胰岛素受体底物2（IRS2）相关疾病公开(公告)号：US20120289583A1
公开(公告)日：2012-11-15
申请号：US13519518
申请日：2010-12-30
IPC分类号： A61K31/7088 , A61K31/7115 , A61K31/712 , A61K31/7125 , A61K31/711 , A61K31/713 , C07H21/00 , C07H21/04 , A61P3/10 , A61P3/04 , A61P3/08 , A61P3/00 , A61P15/00 , A61P9/10 , A61P35/00 , A61P25/28 , A61P25/16 , G01N21/64 , C12N5/071
CPC分类号： C12N15/113 , A61K31/711 , C12N2310/11 , C12N2310/113 , C12N2310/17 , C12N2310/312 , C12N2310/313 , C12N2310/314 , C12N2310/315 , C12N2310/316 , C12N2310/3181 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/3231
摘要： The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Insulin Receptor Substrate 2 (IRS2) polynucleotides, in particular, by targeting natural antisense polynucleotides of Insulin Receptor Substrate 2 (IRS2) polynucleotides and Transcription factor E3 (TFE3). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of IRS2.
摘要翻译： 本发明涉及调节胰岛素受体底物2（IRS2）多核苷酸的表达和/或功能的反义寡核苷酸，特别是通过靶向胰岛素受体底物2（IRS2）多核苷酸和转录因子E3（TFE3）的天然反义多核苷酸， 。 本发明还涉及这些反义寡核苷酸的鉴定及其在治疗与IRS2表达相关的疾病和病症中的用途。
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公开(公告)号：US10995334B2
公开(公告)日：2021-05-04
申请号：US15270752
申请日：2016-09-20
申请人： CuRNA, Inc.
IPC分类号： C12N15/113 , C12Q1/6876 , G01N25/04
摘要： The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Nuclear factor (erythroid-derived 2)-like 2 (NRF2), in particular, by targeting natural antisense polynucleotides of Nuclear factor (erythroid-derived 2)-like 2 (NRF2). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of NRF2.
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公开(公告)号：US10696966B2
公开(公告)日：2020-06-30
申请号：US14922954
申请日：2015-10-26
申请人： CuRNA, Inc.
IPC分类号： C12N15/113 , A61K31/7088
摘要： The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Sex Hormone Binding Globulia (SHBG), in particular, by targeting natural antisense polynucleotides of Sex Hormone Binding Globulin (SHBG). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of SHBG.
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公开(公告)号：US10583128B2
公开(公告)日：2020-03-10
申请号：US14343890
申请日：2012-08-28
IPC分类号： A61K31/7048 , A61K31/4545 , A61K31/496 , A61K31/58 , A61K31/495 , A61K31/5513 , A61K31/436 , A61K31/5375 , A61K31/519 , A61K31/4985 , A61K31/4409 , A61K31/4439 , A61K31/4422 , A61K31/365 , A61K31/64 , A61K31/41 , A61K31/135 , A61K31/165 , A61K31/4245
摘要： Small compounds that modulate the expression of and/or function of sodium channel, voltage-gated, alpha subunit (SCNxA) are presented. Pharmaceutical compositions containing such small molecules and their use in treating diseases and disorders associated with the expression of SCNxA are also presented.
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公开(公告)号：US10316317B2
公开(公告)日：2019-06-11
申请号：US15913233
申请日：2018-03-06
申请人： CuRNA, Inc.
IPC分类号： C07H21/04 , C12N15/113 , A61K31/7088 , C12Q1/6876 , C12Q1/6883
摘要： The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of an Adiponectin (ADIPOQ), in particular, by targeting natural antisense polynucleotides of an Adiponectin (ADIPOQ). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of Adiponectins (ADIPOQ)s.
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公开(公告)号：US10280421B2
公开(公告)日：2019-05-07
申请号：US15798999
申请日：2017-10-31
申请人： CuRNA, Inc.
IPC分类号： C12N15/113 , A61K31/7088 , C12Q1/68 , C12Q1/6876
摘要： The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Interferon Regulatory Factor 8 (IRF8), in particular, by targeting natural antisense polynucleotides of Interferon Regulatory Factor 8 (IRF8). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of IRF8.
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29.发明授权公开(公告)号：US10113166B2
公开(公告)日：2018-10-30
申请号：US14552726
申请日：2014-11-25
申请人： CuRNA, Inc.
IPC分类号： C12N15/11 , C12N15/113 , A61K31/7088 , A61K31/713 , A61K45/06 , A61K31/135 , A61K31/325 , A61K31/357 , A61K31/4406 , A61K31/4439 , A61K31/444 , A61K31/5415
摘要： The present invention relates to antisense oligonucleotides and/or compounds that modulate the expression of and/or function of Filaggrin (FLG), in particular, by targeting natural antisense polynucleotides of Filaggrin (FLG). The invention also relates to the identification of these antisense oligonucleotides and/or compounds and their use in treating diseases and disorders associated with the expression of FLG.
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公开(公告)号：US09902995B2
公开(公告)日：2018-02-27
申请号：US15175633
申请日：2016-06-07
申请人： CuRNA, Inc.
IPC分类号： C12N15/11 , A61K48/00 , C12Q1/68 , A61K31/7088 , C12N15/113
CPC分类号： C12Q1/6876 , A61K31/7088 , C12N15/113 , C12N15/1137 , C12N2310/11 , C12N2310/113 , C12N2310/14 , C12N2310/315 , C12N2320/30 , C12Q1/68 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178 , C12Y105/01002
摘要： The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Pyrroline-5-carboxylate reductase 1 (PYCR1), in particular, by targeting natural antisense polynucleotides of Pyrroline-5-carboxylate reductase 1 (PYCR1). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of PYCR1.
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