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21.发明授权公开(公告)号：US11723529B2
公开(公告)日：2023-08-15
申请号：US17882682
申请日：2022-08-08
发明人： Kirill V. Larin , Achuth Nair , Manmohan Singh , Salavat Aglyamov
CPC分类号： A61B3/0025 , A61B3/102 , A61B3/16 , A61B3/165 , A61B5/0051 , A61B5/0053 , A61B5/0066 , A61B5/0093 , A61B8/10 , A61B8/485 , A61B5/0097 , A61B2576/00
摘要： A system and method for measuring biomechanical properties of tissues without external excitation are capable of measuring and quantifying these parameters of tissues in situ and in vivo. The system and method preferably utilize a phase-sensitive optical coherence tomography (OCT) system for measuring the displacement caused by the intrinsic heartbeat. The method allows noninvasive and nondestructive quantification of tissue mechanical properties. Preferably, the method is used to detect tissue stiffness and to evaluate its stiffness due to intrinsic pulsatile motion from the heartbeat. This noninvasive method can evaluate the biomechanical properties of the tissues in vivo for detecting the onset and progression of degenerative or other diseases and evaluating the efficacy of therapies.
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公开(公告)号：US20230218708A1
公开(公告)日：2023-07-13
申请号：US18157648
申请日：2023-01-20
摘要： Described herein are pharmaceutical compositions containing peptoids of general formula (I), (II), or (III) capable of reducing proliferation of cancer stem cells in a subject and methods of treatment or prophylactic administration of these pharmaceutical compositions to treat cancer. Also provided herein are method of detecting and treating cancerous cell masses by use of peptoids of general formula (I), (II), or (III).
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23.发明公开公开(公告)号：US20230210371A1
公开(公告)日：2023-07-06
申请号：US18072838
申请日：2022-12-01
发明人： Kirill V. Larin , Manmohan Singh , Jiasong Li , Zhaolong Han , Michael D. Twa
CPC分类号： A61B3/18 , A61B3/165 , A61B3/102 , A61B5/7289 , A61B5/7246
摘要： Provided herein are systems and methods to measure the intraocular pressure, ocular tissue geometry and the biomechanical properties of an ocular tissue, such as an eye-globe or cornea, in one instrument. The system is an optical coherence tomography subsystem and an applanation tonometer subsystem housed as one instrument and interfaced with a computer for at least data processing and image display. The system utilizes an air-puff and a focused micro air-pulse to induce deformation and applanation and displacement in the ocular tissue. Pressure profiles of the air puff with applanation times are utilized to measure intraocular pressure. Temporal profiles of displacement and/or spatio-temporal profiles of a displacement-generated elastic wave are analyzed to calculate biomechanical properties.
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公开(公告)号：US11692155B1
公开(公告)日：2023-07-04
申请号：US17745714
申请日：2022-05-16
发明人： Zhifeng Ren
CPC分类号： C11D3/14 , C11D7/20 , C11D7/26 , C11D11/0047 , C11D17/0004 , C11D17/0013 , B82Y40/00
摘要： A cleaning composition is provided herein. The cleaning composition includes a plurality of metal particles and a base fluid. The plurality of metal particles have an average size in a range of from about 1 nanometer (nm) to about 10,000 micrometers (μm), and are dispersed in the base fluid. The cleaning composition is configured to generate an exothermic reaction when contacted with one or more components on a surface and water to facilitate removal of the one or more components from the surface. Methods of making and utilizing the cleaning composition are also provided.
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公开(公告)号：US20230181728A1
公开(公告)日：2023-06-15
申请号：US17925082
申请日：2021-05-25
CPC分类号： A61K39/385 , A61K39/0013 , A61K39/39 , A61K47/42 , A61K47/6415 , A61K47/646 , A61P25/36 , A61P37/04 , A61K2039/6037 , A61K2039/55544 , A61K2039/575 , A61K2039/541 , A61K2039/543
摘要： The adjuvanted conjugate opioid vaccine described herein is a conjugate of a protein carrier and at least one opioid backbone component or hapten conjugated thereto, admixed with at least one adjuvant. Anti-opioid effects are demonstrated after administration of a vaccine made up of the CRM197 protein carrier linked to a FEN backbone, combined with adjuvants such as dmLT or LTA1.
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公开(公告)号：US11660325B2
公开(公告)日：2023-05-30
申请号：US16334528
申请日：2017-09-19
摘要： Described herein are pharmaceutical compositions containing peptoids of general formula (I), (II), or (III) capable of reducing proliferation of cancer stem cells in a subject and methods of treatment or prophylactic administration of these pharmaceutical compositions to treat cancer. Also provided herein are method of detecting and treating cancerous cell masses by use of peptoids of general formula (I), (II), or (III).
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公开(公告)号：US20230121081A1
公开(公告)日：2023-04-20
申请号：US17962597
申请日：2022-10-10
发明人： Pranav J. Parikh
摘要： A hand function testing device includes a base having a number of rigid wires protruding from a surface thereof, each rigid wire having a stationary bead affixed at a predetermined position along the rigid wire, a moving bead movably mounted on the rigid wire and movable along a working region of the rigid wire defined between a base-end of the rigid wire and the stationary bead, the moving bead being mounted on the rigid wire via reception of the rigid wire through a lumen in the moving bead, and at least one force sensing element for measuring a force input to the moving bead. A method of testing hand function includes using the hand function testing device to measure a force input to a moving bead as the moving bead is moved within a working region on the rigid wire.
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公开(公告)号：US11627691B2
公开(公告)日：2023-04-11
申请号：US15999846
申请日：2017-02-17
发明人： Zhifeng Ren , Jing Shuai
IPC分类号： H10N10/852 , C22C12/00 , H10N10/853 , C22C28/00 , B22F3/15 , B22F1/054 , B22F9/04
摘要： Systems and methods discussed herein relate to Zintl-type thermoelectric materials, including a p-type thermoelectric material according to the formula AMyXy, and includes at least one of calcium (Ca), europium (Eu), ytterbium (Yb), and strontium (Sr), and has a ZT of the above about 0.60 above 675K. The n-type thermoelectric component includes magnesium (Mg), tellurium (Te), antimony (Sb), and bismuth (Bi) according to the formula Mg3.2Sb1.3Bi0.5-xTex that has an average ZT above 0.8 from 400K to 800K. The p-type and n-type materials discussed herein may be used alone, in combination with other materials, or in combination with each other in various configurations.
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公开(公告)号：US20230088763A1
公开(公告)日：2023-03-23
申请号：US17932889
申请日：2022-09-16
IPC分类号： C09D11/52 , G01N33/543
摘要： The present disclosure describes a new resin which can be fabricated into conductive and bioactive microstructures via two-photon polymerization. The direct incorporation of conductive poly (3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS) and/or multi-walled carbon nanotubes (MWCNTs) in a poly(ethylene glycol) diacrylate (PEGDA)-based blend remarkably enhances the electrical conductivity of microstructures over 10 orders of magnitude. Including biomaterials in the resin can promote cellular adhesion and create functional biosensors made of hybrid non-conductive and conductive structures for sensitive detection. Applications include development cost effective microelectronics in a broad range of biomedical research, electronics and sensors.
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公开(公告)号：US20230054218A1
公开(公告)日：2023-02-23
申请号：US17980185
申请日：2022-11-03
摘要： Systems and methods for the ultrasonic disruption of biofilm and algae growth on underwater structures utilize an ultrasonic actuator that produces a natural frequency in the ultrasonic range. In some embodiments, the ultrasonic actuator includes one or more piezoelectric transducers.
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