公开(公告)号：US06241745B1

公开(公告)日：2001-06-05

申请号：US09603588

申请日：2000-06-26

Applicant: David Rosenthal

Inventor： David Rosenthal

IPC: A61B1722

CPC classification number: A61B17/00008 ,  A61B2017/320741

Abstract: A surgical apparatus and a method to restore blood flow capacity to occluded and partially occluded arterial vessels is disclosed. More particularly, the invention is an endarterectomy instrument and a method associated with its use. The instrument combines a separation ring with a wire loop at the distal end of a resilient, flexible catheter. The separation ring separates the plaque and the inner wall from a segment of an occluded artery. The wire loop is then constricted around the undesired material. IN a preferred embodiment the wire loop of the endarterectomy instrument is used to sever, snare and remove the separated inner arterial wall with the occlusion. In an alternative embodiment, the wire loop of the endarterectomy instrument is heated by passing a current therethrough in order to sever the undesired material from the arterial wall. The undesired occlusion is removed along with the inner layers of the artery by snaring the material with the wire loop and removing the instrument from the vessel in a single step.

Abstract translation: 公开了一种手术装置和一种恢复闭塞和部分闭塞的动脉血管的血流量的方法。 更具体地，本发明是一种内膜切除术仪器和与其使用相关的方法。 该仪器在弹性柔性导管的远端结合了分离环和线环。 分离环将斑块和内壁与闭塞动脉的一段分隔开。 然后线环绕不想要的材料收缩。 在优选实施例中，内膜切除术仪器的线环用于切断，圈套并且随着闭塞移除分离的内动脉壁。 在替代实施例中，通过使电流通过其来加热内膜切除器械的线环，以便从动脉壁切断不需要的材料。 通过用导线环缠绕材料并且在单个步骤中将器械从容器中取出来，通过动脉的内层将不想要的闭塞除去。

公开(公告)号：US5947994A

公开(公告)日：1999-09-07

申请号：US910944

申请日：1997-08-08

Applicant: Frank Louw ,  Stephen A. Sosnowski ,  David Rosenthal

Inventor： Frank Louw ,  Stephen A. Sosnowski ,  David Rosenthal

IPC: A61B17/12 ,  A61B29/00

CPC classification number: A61B17/12022 ,  A61B17/12109 ,  A61B17/1214 ,  A61B2017/22097 ,  A61M2025/018

Abstract: The device for blocking (e.g., embolizing) the side branches of an anatomical passageway under endoscopic guidance. The device comprises an elongate catheter body having a side branch blocking apparatus, such as an embolization catheter, disposed therein and further incorporating an endoscope (e.g., an angioscope). The incorporated endoscope is useable to A) visually locate side branches which emanate from the anatomical passageway and b) visually observe the operation of the side branch blocking apparatus. Also disclosed are methods for utilizing a device of the forgoing character, including methods for performing in situ embolization of the side branches of a vein, under angioscopic visualization. The endoscopic component of the device may also be utilized to visually observe the use and/or effect of one or more separate device, such as valvulotome(s) used for cutting venous valves located within the lumen of a vein.

Abstract translation: 用于在内窥镜引导下阻塞（例如，栓塞）解剖通道的侧分支的装置。 该装置包括细长导管体，其具有设置在其中并进一步结合内窥镜（例如，血管造影仪）的侧分支阻塞装置，例如栓塞导管。 所配置的内窥镜可用于A）可视地定位从解剖通道发出的侧分支，以及b）目视观察侧支阻断装置的操作。 还公开了用于利用前述特征的装置的方法，包括在血管视觉可视化下进行静脉侧枝的原位栓塞的方法。 该装置的内窥镜部件也可以用于目视观察一个或多个分离装置（例如用于切割位于静脉内腔内的静脉瓣）的瓣膜切开的使用和/或效果。

公开(公告)号：US5897573A

公开(公告)日：1999-04-27

申请号：US837710

申请日：1997-04-22

Applicant: David Rosenthal ,  Stephen A. Sosnowski

Inventor： David Rosenthal ,  Stephen A. Sosnowski

IPC: A61B17/04 ,  A61B17/06 ,  A61B19/00 ,  A61L17/00 ,  A61N5/10

CPC classification number: A61N5/1001 ,  A61B17/06166 ,  A61B2090/392 ,  A61N2005/1019 ,  A61N2005/1089

Abstract: A radioactive suture for inhibiting an intimal hyperplastic response comprises a needle and a suture material having a radioactive beta-emitting element. This radioactive element is preferably chemically bonded to an organic substrate of the suture material. It is preferred that the radioactive suture material generates a beta radiation greater than 0.0002 uCi/cm. A first preferred method for producing the radioactive suture comprises the steps of placing the suture needle and the suture material in a sealed reaction chamber. Once the suture is in the reaction chamber, an ionized beta radiation emitting element, preferably ionized tritium, is introduced into the chamber. While in the chamber, an entropic exchange process begins wherein the beta radiation emitting element is exchanged for hydrogen molecules in the organic suture material. Once the desired level of tritium or other beta radiation emitting element is incorporated in the suture material, the reaction chamber is flushed. The suture is then rinsed, dried, removed from the reaction chamber, and packaged. In another aspect, a radioactive suture may be fabricated from an organic polypropylene material. A beta radiation emitting element, preferably tritium, is incorporated directly into a backbone of the organic polypropylene material. The now radioactive polypropylene material is extruded into a suture thread, which is attached to a suture needle and packaged for shipment and later use. Although not required by the present inventive method, the preferred embodiment of the organic polypropylene material comprises carbon 12.

Abstract translation: 用于抑制内膜增生反应的放射性缝线包括具有放射性β发射元件的针和缝线材料。 该放射性元素优选化学键合到缝合材料的有机基底上。 放射性缝合材料优选产生大于0.0002μCi/ cm的β辐射。 用于生产放射性缝合线的第一优选方法包括以下步骤：将缝合针和缝合材料放置在密封的反应室中。 一旦缝合线在反应室中，电离的β辐射发射元件，优选离子化的氚被引入腔室。 在腔室中，开始熵交换过程，其中β辐射发射元件被交换为有机缝合材料中的氢分子。 一旦将所需水平的氚或其它β辐射发射元件并入缝合材料中，则反应室被冲洗。 然后将缝合线冲洗，干燥，从反应室中取出并包装。 另一方面，放射性缝线可由有机聚丙烯材料制成。 β辐射发射元件，优选氚直接掺入有机聚丙烯材料的主链。 现在的放射性聚丙烯材料被挤出成缝合线，其被连接到缝合针上并被包装用于运输和稍后使用。 虽然本发明方法不是必需的，但有机聚丙烯材料的优选实施方案包括碳12。

公开(公告)号：US4103183A

公开(公告)日：1978-07-25

申请号：US732785

申请日：1976-10-15

Applicant: Bruce David Rosenthal ,  Andrew Gordon Francis Dingwall

Inventor： Bruce David Rosenthal ,  Andrew Gordon Francis Dingwall

IPC: G04G99/00 ,  H02M3/07 ,  H03K5/02 ,  H03K23/42 ,  H03K19/40 ,  H03K19/08

CPC classification number: G04G99/003 ,  H02M3/07 ,  H03K23/42 ,  H03K5/023

Abstract: A circuit, whose operating potential includes complementary pulsating signals, functions to produce quasi-static output signals which are virtually independent of the pulsations. An inverter circuit includes a first transistor connected between a first, fixed, operating voltage level and an output terminal and second and third transistors whose conduction paths are connected between the output terminal and, respectively, first and second sources of complementary pulsating signals whose voltages vary, in amplitude, between the first level and a second level. The same input signal is applied to the control electrodes of the second and third transistors whereby one of them always can, when turned on, clamp the output terminal to the second voltage level. The first transistor, when turned on, clamps the output to the first voltage level.

公开(公告)号：US4068182A

公开(公告)日：1978-01-10

申请号：US761374

申请日：1977-01-21

Applicant: Andrew Gordon Francis Dingwall ,  Bruce David Rosenthal

Inventor： Andrew Gordon Francis Dingwall ,  Bruce David Rosenthal

IPC: H03F1/30 ,  H03F1/02 ,  H03F3/185 ,  H03F3/45

CPC classification number: H03F1/303

Abstract: A cascade amplifier embodying the present invention includes a plurality of amplifier stages in direct-coupled cascade connection. During specified intervals interspersed with normal amplification equal potentials are imposed on the inverting and non-inverting terminals of the first amplifier stage. A direct-coupled feedback connection from the output port of the final amplifier stage to the input port of one of the amplifier stages succeeding the first includes a sample-and-hold circuit. This sample-and-hold circuit samples the signal level appearing at the output port of the final amplifier stage during said specified intervals and holds that level for the feedback connection during the intervening periods of normal amplification to provide continuing compensation against input offset potential error.

Abstract translation: 体现本发明的级联放大器包括多个直流耦合级联连接的放大器级。 在具有正常放大的指定间隔期间，等效电位施加在第一放大器级的反相和非反相端。 从最终放大器级的输出端口到第一级放大器级之一的输入端口的直接耦合反馈连接包括采样和保持电路。 该采样和保持电路在所述指定的间隔期间对出现在最终放大器级的输出端口处的信号电平进行采样，并且在正常放大的中间期期间保持用于反馈连接的电平，以提供针对输入偏移电位误差的持续补偿。

公开(公告)号：US4055812A

公开(公告)日：1977-10-25

申请号：US714122

申请日：1976-08-13

Applicant: Bruce David Rosenthal

Inventor： Bruce David Rosenthal

IPC: H03F3/45

CPC classification number: H03F3/45071

Abstract: A current subtractor circuit utilizing a current mirror amplifier (CMA) as the subtracting element. An operational amplifier converts the difference current to an output voltage proportional to this difference. The operational amplifier additionally may be utilized to equalize the voltage drop across the conduction paths of the transistors comprising the CMA and to maintain the CMA output transistor in its constant current region of operation.

Abstract translation: 利用电流镜放大器（CMA）作为减法元件的电流减法器电路。 运算放大器将差分电流转换成与该差成正比的输出电压。 运算放大器另外可以用于均衡包括CMA的晶体管的导电路径上的电压降，并且将CMA输出晶体管保持在其恒定电流操作区域中。

公开(公告)号：US4009432A

公开(公告)日：1977-02-22

申请号：US610181

申请日：1975-09-04

Applicant: Andrew Gordon Francis Dingwall ,  Bruce David Rosenthal

Inventor： Andrew Gordon Francis Dingwall ,  Bruce David Rosenthal

IPC: H02H7/20 ,  G05F3/24 ,  G05F1/56

CPC classification number: G05F3/247 ,  Y10S323/901

Abstract: A first field-effect transistorized constant current supply provides a first relatively constant output current. A second field-effect transistorized constant current supply is cascaded with, and driven by, the first current to provide a more highly regulated second constant output current. The system is self-starting and latch free. The second output current may be employed to drive a current mirror with a plurality of output current paths.

Abstract translation: 第一场效应晶体管恒流源提供第一相对恒定的输出电流。 第二场效应晶体管恒流源与第一电流级联并由第一电流驱动，以提供更高调节的第二恒定输出电流。 该系统是自启动和闩锁自由。 可以采用第二输出电流来驱动具有多个输出电流路径的电流镜。

公开(公告)号：US4000412A

公开(公告)日：1976-12-28

申请号：US578913

申请日：1975-05-19

Applicant: Bruce David Rosenthal ,  Andrew Gordon Francis Dingwall

Inventor： Bruce David Rosenthal ,  Andrew Gordon Francis Dingwall

IPC: G01R19/22 ,  G04G99/00 ,  H02M3/07 ,  H03K19/096 ,  H03K3/64 ,  H03K3/353 ,  H03K17/60

CPC classification number: G04G99/003 ,  H02M3/07

Abstract: Circuits for generating pulsating potentials and voltage levels outside the range of, and/or of greater magnitude than, the operating potential applied to the circuits. Each circuit includes first and second transistors for applying a first voltage to one plate of a capacitor and a second voltage to the other plate of the capacitor, during one time interval. During a subsequent time interval, the first and second transistors are turned off and a third transistor applies the second potential to the one plate of the capacitor. The change in the potential at the one plate of the capacitor is coupled to the other plate of the capacitor at which is produced an output potential outside the range of the first and second voltages. The potential difference between the first voltage and the output potential is greater in amplitude than the potential difference between the first and second voltages. The circuit may also include means alternately applying the first voltage and then the output potential to an output point for generating pulsating signals of greater amplitude than the magnitude of the applied potential. The outputs of two or more circuits may be combined to produce direct current (d.c.) levels. Also included are circuits which operate from a pulsating source of operating potential.

Abstract translation: 用于产生超出施加到电路的工作电位的范围之外的脉动电位和电压电平的电路和/或更大的幅度的电路。 每个电路包括用于在一个时间间隔期间将第一电压施加到电容器的一个板并且将第二电压施加到电容器的另一个板的第一和第二晶体管。 在随后的时间间隔期间，第一和第二晶体管截止，第三晶体管将第二电位施加到电容器的一个板。 在电容器的一个电极处的电位的变化被耦合到电容器的另一个板，在其上产生超出第一和第二电压范围的输出电位。 第一电压和输出电位之间的电位差在振幅上大于第一和第二电压之间的电位差。 电路还可以包括将第一电压然后输出电位交替施加到输出点的装置，用于产生比施加电位的幅度大的幅度的脉动信号。 可以组合两个或更多个电路的输出以产生直流（直流）电平。 还包括从脉动源工作电位工作的电路。

公开(公告)号：US2617222A

公开(公告)日：1952-11-11

申请号：US10361949

申请日：1949-07-08

Applicant: DAVID ROSENTHAL

Inventor： SAMUEL KATCHER

IPC: G04B45/00 ,  G09F3/18 ,  G09F7/02

CPC classification number: G04B45/0092 ,  G09F3/18 ,  G09F7/02

公开(公告)号：US20080120281A1

公开(公告)日：2008-05-22

申请号：US11943374

申请日：2007-11-20

Applicant: Carla Marceau ,  Matthew A. Stillerman ,  David Rosenthal ,  Marisa Gioioso

Inventor： Carla Marceau ,  Matthew A. Stillerman ,  David Rosenthal ,  Marisa Gioioso

IPC: G06F7/06

CPC classification number: G06F17/30893

Abstract: This disclosure describes techniques of dynamically assembling and utilizing a pedigree of a resource. A pedigree of a resource is a set of statements that describe a provenance of the resource. As described herein, a set of one or more servers may host context objects that contain the statements that make up the pedigree of the resource. In order to obtain the pedigree of the resource, a context assembly device may send queries to the servers for context objects that are likely to contain statements in the pedigree of the resource. After receiving context objects from the servers in response to the queries, the context assembly device may query the statements in the received context objects in order to identify, among the statements in the context objects, the statements that constitute the pedigree of the resource. The dynamically assembled pedigree may then be used in a variety of ways.

Abstract translation: 本公开描述了动态组合和利用资源谱系的技术。 资源的血统是描述资源来源的一组语句。 如本文所述，一组一个或多个服务器可以承载包含构成资源谱系的语句的上下文对象。 为了获得资源的血统，上下文组合设备可以向服务器发送可能包含资源血统中的语句的上下文对象的查询。 在从服务器接收到响应于查询的上下文对象之后，上下文组装装置可以查询所接收的上下文对象中的语句，以便在上下文对象中的语句之间识别构成资源谱系的语句。 然后可以以各种方式使用动态组合的谱系。