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公开(公告)号：US10383576B2
公开(公告)日：2019-08-20
申请号：US15284936
申请日：2016-10-04
申请人： David R. Hall , Dan Allen , Andrew Davis , Daniel Hendricks , Justin Robinson
发明人： David R. Hall , Dan Allen , Andrew Davis , Daniel Hendricks , Justin Robinson
IPC分类号： A61B5/02 , A61B5/00 , A61B5/026 , A61B5/0205 , A47K13/24 , A61B5/024 , A61B5/11 , A61B5/021 , A61B5/1455 , A61B5/053 , A61B90/00
摘要： A synthetic aperture photoplethysmography (PPG) sensor is disclosed. A group or matrix of contiguous PPG sensors located on a toilet seat are conditionally combined based on sensor measurements. Conditional combinations may be based on timing data and signal-to-noise ratio data of each of the PPG measurements. Measurements associated with the conditional combinations are then used to determine a cardiac function of a toilet user.
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公开(公告)号：US10012660B2
公开(公告)日：2018-07-03
申请号：US15834441
申请日：2017-12-07
申请人： David R. Hall , Conrad Rosenbrock , Ben Swenson , Daniel Hendricks , Joe Fox , Terrece Pearman
发明人： David R. Hall , Conrad Rosenbrock , Ben Swenson , Daniel Hendricks , Joe Fox , Terrece Pearman
CPC分类号： G01N33/94 , A61B10/007 , E03D11/025 , E03D11/11 , E03D11/13 , G01N21/6428 , G01N21/645 , G01N33/493 , G01N2021/6417 , G01N2201/061
摘要： The present disclosure describes a toilet apparatus for detecting a drug marker in a urine sample. The drug markers are fluorophores each of which emits a unique fluorescence spectrum. Accordingly, the toilet does not detect the drug but rather, the drug marker. The user consumes a drug composition which includes a drug and a fluorescent drug marker. The user urinates normally into the toilet and fluorescence spectrometer within the toilet analyzes the urine for drug markers based on their unique fluorescent spectra. Computer software associated with the toilet identifies, and in some embodiments, quantifies the fluorescent spectra by comparing the detected spectra to known spectra of fluorescent markers associated with the drug.
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23.发明申请公开(公告)号：US20180334669A1
公开(公告)日：2018-11-22
申请号：US15597633
申请日：2017-05-17
申请人： David R. Hall , Steven J.M. Butala , Dan Allen , Andrew Nguyen , Conrad Rosenbrock , Ben Swenson , Daniel Hendricks , Joe Fox
发明人： David R. Hall , Steven J.M. Butala , Dan Allen , Andrew Nguyen , Conrad Rosenbrock , Ben Swenson , Daniel Hendricks , Joe Fox
IPC分类号： C12N15/10
CPC分类号： C12N15/1065
摘要： We disclose a method of tagging a variety of pharmaceutical or nutritional products in which well-studied chemicals may be added to the products in unique ratios. The identities of the chemicals and their relative ratios comprise unique taggants. The taggants may identify which of multiple distinct categories the product falls within. The method includes the step of systematically varying the relative concentrations of the chemicals resulting in multiple ratios of the chemicals. The plurality of ratios of a defined set of chemicals may be collected to form a library of taggants associated with specified items or categories. As the number of chemicals added per product increases, the library supports more categories and the system is less likely to produce a false positive. The method may result in a series of taggants for each item which is single fault tolerant or double fault tolerant.
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公开(公告)号：US20180306826A1
公开(公告)日：2018-10-25
申请号：US15496407
申请日：2017-04-25
申请人： David R. Hall , Dan Allen , Conrad Rosenbrock , Daniel Hendricks , Andrew Nguyen , Steven J.M. Butala , Travis Niederhauser , Terrece Pearman , Joe Fox
发明人： David R. Hall , Dan Allen , Conrad Rosenbrock , Daniel Hendricks , Andrew Nguyen , Steven J.M. Butala , Travis Niederhauser , Terrece Pearman , Joe Fox
CPC分类号： G01N33/94 , A47K17/00 , A61B5/15 , A61B10/0038 , A61B10/0051 , A61B10/007 , A61B2010/0061 , A61B2010/0077 , A61B2010/0087 , G01N33/15 , G01N33/493 , G01N2458/00
摘要： We disclose a method of using taggants to assess how and to what extent a drug in a drug composition that a user has consumed has decayed in response to storage conditions and time. The taggants may decay in response to environmental conditions which cause different drugs to lose their efficacy. These environmental conditions may include light, temperature, oxidation, moisture, and age. The taggants may be detected in biological samples, including urine and feces. By identifying the taggants, the drug composition and other information relating to the drug may be identified. Additionally, quantification of the different taggants may be used to determine whether the drug in the drug composition has been exposed to environmental conditions which may reduce its efficacy.
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公开(公告)号：US20180149666A1
公开(公告)日：2018-05-31
申请号：US15834441
申请日：2017-12-07
申请人： David R. Hall , Conrad Rosenbrock , Ben Swenson , Daniel Hendricks , Joe Fox , Terrece Pearman
发明人： David R. Hall , Conrad Rosenbrock , Ben Swenson , Daniel Hendricks , Joe Fox , Terrece Pearman
CPC分类号： G01N33/94 , A61B10/007 , E03D11/025 , E03D11/11 , E03D11/13 , G01N21/6428 , G01N21/645 , G01N33/493 , G01N2021/6417 , G01N2201/061
摘要： The present disclosure describes a toilet apparatus for detecting a drug marker in a urine sample. The drug markers are fluorophores each of which emits a unique fluorescence spectrum. Accordingly, the toilet does not detect the drug but rather, the drug marker. The user consumes a drug composition which includes a drug and a fluorescent drug marker. The user urinates normally into the toilet and fluorescence spectrometer within the toilet analyzes the urine for drug markers based on their unique fluorescent spectra. Computer software associated with the toilet identifies, and in some embodiments, quantifies the fluorescent spectra by comparing the detected spectra to known spectra of fluorescent markers associated with the drug.
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公开(公告)号：US09970949B1
公开(公告)日：2018-05-15
申请号：US15612071
申请日：2017-06-02
申请人： David R. Hall , Joe Fox , Steven J. M. Butala , Dan Allen , Andrew Nguyen , Daniel Hendricks , Terrece Pearman
发明人： David R. Hall , Joe Fox , Steven J. M. Butala , Dan Allen , Andrew Nguyen , Daniel Hendricks , Terrece Pearman
CPC分类号： G01N33/02 , G01N33/15 , Y10T436/13
摘要： We disclose a method of tagging pharmaceutical and nutritional products with nanoparticles which include noble metals. The disclosure describes a plurality of nanoparticles each with either a different size and/or shape. The nanoparticles of different sizes and shapes are distinguishable using spectroscopic techniques because each is associated with different optical properties and have a different spectral signature. The different optical properties are at least due to the unique size or shape of the nanoparticles. Each of the plurality of nanoparticles may be associated with a different characteristic of the tagged pharmaceutical or nutritional product. The method includes mixing the nanoparticles with or adhering the nanoparticles to the tagged pharmaceutical or nutritional product. Two or more of the plurality of nanoparticles may be mixed with or adhered to the tagged pharmaceutical or nutritional product in a ratio and the ratio may be associated with a characteristic of the product.
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公开(公告)号：US09927448B1
公开(公告)日：2018-03-27
申请号：US15465939
申请日：2017-03-22
申请人： David R. Hall , Steven Butala , Dan Allen , Daniel Hendricks , Andrew Nguyen , Terrece Pearman
发明人： David R. Hall , Steven Butala , Dan Allen , Daniel Hendricks , Andrew Nguyen , Terrece Pearman
IPC分类号： G01N33/94 , G01N33/493 , G01N21/25 , G01N33/58
CPC分类号： G01N33/94 , G01N21/31 , G01N33/493 , G01N33/583 , G01N2021/3196 , Y10T436/13
摘要： We disclose a drug tracking system and method of use which may be used to screen a subject's bodily waste and to identify the drug the subject has consumed. The system includes a drug that is tagged with a food dye that may be detected in the subject's bodily waste using absorption spectroscopic analysis. The subject consumes the tagged drug and a user obtains a sample of the subject's bodily waste. The user may analyze the subject's urine using an absorption spectroscopic technique. The user may enter the emission spectrum obtained from the absorption spectroscopic analysis into a database that includes the signature emission spectra from multiple food dyes that are used as drug tags. The emission spectra may be compared and the identity of the food dye and its associated drug may be determined.
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公开(公告)号：US09766257B1
公开(公告)日：2017-09-19
申请号：US15497638
申请日：2017-04-26
申请人： David R. Hall , Conrad Rosenbrock , Ben Swenson , Daniel Hendricks , Joe Fox , Terrece Pearman
发明人： David R. Hall , Conrad Rosenbrock , Ben Swenson , Daniel Hendricks , Joe Fox , Terrece Pearman
CPC分类号： G01N33/94 , A61B10/007 , E03D11/025 , E03D11/11 , E03D11/13 , G01N21/6428 , G01N21/645 , G01N33/493 , G01N2021/6417 , G01N2201/061
摘要： The present disclosure describes a method of detecting a drug marker in urine a urine sample using a toilet. The drug markers are fluorophores each of which emits a unique fluorescence spectra. Accordingly, the method does not detect the drug but rather, the drug marker. The drug marker may include quantum dots which may be functionalized by connecting the quantum dot to a biomolecule. The biomolecule may be cleavable by a peptidase, a protease, or a nuclease to release the drug. Alternatively, the composition may include a liposome carrier. A user who has consumed the drug composition urinates into the toilet and a urine sample is captured. The toilet includes a mechanism for fluid handling which diverts urine into a fluorescence spectrometer. The fluorescence spectrometer screens the urine for drug markers based on their unique fluorescent spectra.
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