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1.发明授权公开(公告)号：US10241122B2
公开(公告)日：2019-03-26
申请号：US15472989
申请日：2017-03-29
申请人： David R. Hall , Steven Butala , Dan Allen , Daniel Hendricks , Andrew Nguyen , Conrad Rosenbrock , Terrece Pearman
发明人： David R. Hall , Steven Butala , Dan Allen , Daniel Hendricks , Andrew Nguyen , Conrad Rosenbrock , Terrece Pearman
IPC分类号： G01N33/58 , G01N33/94 , G01N33/493 , A61B5/00 , G01N21/64 , A61B10/00 , A61B5/145 , A61B5/1455 , A61B5/20
摘要： We disclose a drug tracking system and method of use which may be used to screen a subject's bodily waste in order to assess whether the subject has consumed a drug. The system includes a drug composition which is tagged with at least one artificial sweetener that may be detected in the subject's bodily waste. The subject may consume the tagged drug and a user may obtain a sample of the subject's bodily waste. The bodily waste sample may be analyzed to detect the artificial sweetener or its metabolite. In some embodiments, the result of the analysis of bodily waste may be entered into a database, compared to standards that comprises analyses of a plurality of drug tags, and the identity of the drug tag, and consequently the drug composition, determined.
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公开(公告)号：US09927448B1
公开(公告)日：2018-03-27
申请号：US15465939
申请日：2017-03-22
申请人： David R. Hall , Steven Butala , Dan Allen , Daniel Hendricks , Andrew Nguyen , Terrece Pearman
发明人： David R. Hall , Steven Butala , Dan Allen , Daniel Hendricks , Andrew Nguyen , Terrece Pearman
IPC分类号： G01N33/94 , G01N33/493 , G01N21/25 , G01N33/58
CPC分类号： G01N33/94 , G01N21/31 , G01N33/493 , G01N33/583 , G01N2021/3196 , Y10T436/13
摘要： We disclose a drug tracking system and method of use which may be used to screen a subject's bodily waste and to identify the drug the subject has consumed. The system includes a drug that is tagged with a food dye that may be detected in the subject's bodily waste using absorption spectroscopic analysis. The subject consumes the tagged drug and a user obtains a sample of the subject's bodily waste. The user may analyze the subject's urine using an absorption spectroscopic technique. The user may enter the emission spectrum obtained from the absorption spectroscopic analysis into a database that includes the signature emission spectra from multiple food dyes that are used as drug tags. The emission spectra may be compared and the identity of the food dye and its associated drug may be determined.
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3.发明申请公开(公告)号：US20180284144A1
公开(公告)日：2018-10-04
申请号：US15472989
申请日：2017-03-29
申请人： David R. Hall , Steven Butala , Dan Allen , Daniel Hendricks , Andrew Nguyen , Conrad Rosenbrock , Terrece Pearman
发明人： David R. Hall , Steven Butala , Dan Allen , Daniel Hendricks , Andrew Nguyen , Conrad Rosenbrock , Terrece Pearman
IPC分类号： G01N33/94 , G01N33/493 , G01N33/58
CPC分类号： G01N33/94 , G01N33/493 , G01N33/58 , G01N2458/00 , G01N2800/52
摘要： We disclose a drug tracking system and method of use which may be used to screen a subject's bodily waste in order to assess whether the subject has consumed a drug. The system includes a drug composition which is tagged with at least one artificial sweetener that may be detected in the subject's bodily waste. The subject may consume the tagged drug and a user may obtain a sample of the subject's bodily waste. The bodily waste sample may be analyzed to detect the artificial sweetener or its metabolite. In some embodiments, the result of the analysis of bodily waste may be entered into a database, compared to standards that comprises analyses of a plurality of drug tags, and the identity of the drug tag, and consequently the drug composition, determined.
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公开(公告)号：US20180313805A1
公开(公告)日：2018-11-01
申请号：US15497501
申请日：2017-04-26
申请人： David R. Hall , Dan Allen , Conrad Rosenbrock , Daniel Hendricks , Andrew Nguyen , Steven J.M. Butala , Travis Niederhauser , Joe Fox , Terrece Pearman
发明人： David R. Hall , Dan Allen , Conrad Rosenbrock , Daniel Hendricks , Andrew Nguyen , Steven J.M. Butala , Travis Niederhauser , Joe Fox , Terrece Pearman
摘要： We disclose a method of using taggants to assess how and to what extent a drug in a drug composition has decayed in response to environmental conditions and time. The taggants may decay in response to environmental conditions which cause drugs to lose their efficacy. The decay may occur due to improper storage or excursions into certain environmental conditions. These environmental conditions may include light, temperature, moisture, oxidation, and age. By including taggants that have different decay characteristics, the environmental condition that caused the decay may be determined. The amount of time the drug composition was exposed to the environmental condition and the amount of effective drug remaining may also be determined. The disclosed method may reduce the need for a unique assay for each drug to assess decay and determine shelf life. The disclosed method may also be used as a quality control technique for pharmaceutical products.
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公开(公告)号：US10408849B2
公开(公告)日：2019-09-10
申请号：US15494089
申请日：2017-04-21
申请人： David R. Hall , Dan Allen , Conrad Rosenbrock , Daniel Hendricks , Andrew Nguyen , Steven J. M. Butala , Travis Niederhauser , Terrece Pearman , Joe Fox
发明人： David R. Hall , Dan Allen , Conrad Rosenbrock , Daniel Hendricks , Andrew Nguyen , Steven J. M. Butala , Travis Niederhauser , Terrece Pearman , Joe Fox
摘要： We disclose a method of using taggants to assess how and to what extent a drug in a drug composition that a user has consumed has decayed in response to storage conditions and time. The taggants may decay in response to environmental conditions which cause different drugs to lose their efficacy. These environmental conditions may include light, temperature, oxidation, and age. The taggants may be detected in biological samples, including urine and feces. By identifying the taggants, the drug composition and other information relating to the drug may be identified. Additionally, quantification of the different taggants may be used to determine whether the drug in the drug composition has been exposed to environmental conditions which may reduce its efficacy.
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公开(公告)号：US10444144B2
公开(公告)日：2019-10-15
申请号：US15493433
申请日：2017-04-21
申请人： David R. Hall , Dan Allen , Daniel Hendricks , Andrew Nguyen , Conrad Rosenbrock , Travis Niederhauser , Joe Fox , Terrece Pearman , Steven J. M. Butala
发明人： David R. Hall , Dan Allen , Daniel Hendricks , Andrew Nguyen , Conrad Rosenbrock , Travis Niederhauser , Joe Fox , Terrece Pearman , Steven J. M. Butala
IPC分类号： G01N21/359 , A61B10/00 , G01N33/15 , A61B5/145 , G01N30/02
摘要： We disclose a method of tagging nutritional or drug compositions using chemical entities which are known to be safely consumed and which are detectable using known techniques, including near IR spectroscopy. The chemical entities used as tags may be detected in easily obtainable biological samples, including urine and feces. The biological sample may be deposited into a medical toilet which may analyze the biological sample using an analytical device associated with the medical toilet. The tag may be identified and quantified to then identify and quantify the nutritional or drug composition the subject consumed along with the tag. This system may be used to track the source of a food or drug, confirm compliance to a prescribed diet or drug treatment, confirm drug consumption in clinical trials, identify the source of contaminated food, and identify the food substances used to produce food products.
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公开(公告)号：US10209264B2
公开(公告)日：2019-02-19
申请号：US15496407
申请日：2017-04-25
申请人： David R. Hall , Dan Allen , Conrad Rosenbrock , Daniel Hendricks , Andrew Nguyen , Steven J. M. Butala , Travis Niederhauser , Terrece Pearman , Joe Fox
发明人： David R. Hall , Dan Allen , Conrad Rosenbrock , Daniel Hendricks , Andrew Nguyen , Steven J. M. Butala , Travis Niederhauser , Terrece Pearman , Joe Fox
IPC分类号： G01N33/94 , G01N33/493 , G01N33/15 , A61B5/15 , A61G10/00 , A47K17/00 , A61B10/00 , G01N33/58
摘要： We disclose a method of using taggants to assess how and to what extent a drug in a drug composition that a user has consumed has decayed in response to storage conditions and time. The taggants may decay in response to environmental conditions which cause different drugs to lose their efficacy. These environmental conditions may include light, temperature, oxidation, moisture, and age. The taggants may be detected in biological samples, including urine and feces. By identifying the taggants, the drug composition and other information relating to the drug may be identified. Additionally, quantification of the different taggants may be used to determine whether the drug in the drug composition has been exposed to environmental conditions which may reduce its efficacy.
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公开(公告)号：US20180321218A1
公开(公告)日：2018-11-08
申请号：US15589403
申请日：2017-05-08
申请人： David R. Hall , Dan Allen , Conrad Rosenbrock , Daniel Hendricks , Andrew Nguyen , Steven J.M. Butala , Travis Niederhauser , Terrece Pearman , Joe Fox
发明人： David R. Hall , Dan Allen , Conrad Rosenbrock , Daniel Hendricks , Andrew Nguyen , Steven J.M. Butala , Travis Niederhauser , Terrece Pearman , Joe Fox
IPC分类号： G01N33/493 , G01N33/53 , G01N33/487 , G01N33/543 , G01N33/542 , G01N27/327 , G01N21/64 , G01N21/78 , A61B5/00 , A61B5/20
CPC分类号： G01N33/493 , A61B5/0071 , A61B5/207 , G01N21/6428 , G01N21/78 , G01N27/3276 , G01N33/48792 , G01N33/5308 , G01N33/542 , G01N33/5438 , G01N2021/6417 , G01N2021/6432 , G01N2021/6439
摘要： We disclose an in-toilet urinalysis system which includes a system for collection urine and for analysis of urine components using aptamer technology. Urine collection system may dispense urine into cuvettes, channels, or other containers that include aptamers. The aptamers may detect target molecules in urine. The aptamers may measure urine analytes, detect excreted drugs or drug metabolites, or disease markers. Upon binding to the target molecule, the aptamers may produce a signal which a sensor in the toilet may detect. In some embodiments, the signal may be electrochemical, fluorescent, or colorimetric. The measurements obtained from analysis of the urine may be used to assess a user's health or diagnose disease. In some embodiments, the measurements are stored in a controller which may transmit the measurements to a healthcare provider for assessment.
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公开(公告)号：US20180306824A1
公开(公告)日：2018-10-25
申请号：US15493433
申请日：2017-04-21
申请人： David R. Hall , Dan Allen , Daniel Hendricks , Andrew Nguyen , Conrad Rosenbrock , Travis Niederhauser , Joe Fox , Terrece Pearman , Steven J.M. Butala
发明人： David R. Hall , Dan Allen , Daniel Hendricks , Andrew Nguyen , Conrad Rosenbrock , Travis Niederhauser , Joe Fox , Terrece Pearman , Steven J.M. Butala
IPC分类号： G01N33/94 , A61B5/15 , A61B10/00 , G01N21/359
CPC分类号： G01N21/359 , A61B5/145 , A61B10/0038 , A61B10/0051 , A61B10/007 , A61B2010/0009 , A61B2010/0061 , A61B2010/0077 , A61B2010/0087 , G01N30/02 , G01N33/15 , G01N2458/15
摘要： We disclose a method of tagging nutritional or drug compositions using chemical entities which are known to be safely consumed and which are detectable using known techniques, including near IR spectroscopy. The chemical entities used as tags may be detected in easily obtainable biological samples, including urine and feces. The biological sample may be deposited into a medical toilet which may analyze the biological sample using an analytical device associated with the medical toilet. The tag may be identified and quantified to then identify and quantify the nutritional or drug composition the subject consumed along with the tag. This system may be used to track the source of a food or drug, confirm compliance to a prescribed diet or drug treatment, confirm drug consumption in clinical trials, identify the source of contaminated food, and identify the food substances used to produce food products.
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公开(公告)号：US20180306826A1
公开(公告)日：2018-10-25
申请号：US15496407
申请日：2017-04-25
申请人： David R. Hall , Dan Allen , Conrad Rosenbrock , Daniel Hendricks , Andrew Nguyen , Steven J.M. Butala , Travis Niederhauser , Terrece Pearman , Joe Fox
发明人： David R. Hall , Dan Allen , Conrad Rosenbrock , Daniel Hendricks , Andrew Nguyen , Steven J.M. Butala , Travis Niederhauser , Terrece Pearman , Joe Fox
CPC分类号： G01N33/94 , A47K17/00 , A61B5/15 , A61B10/0038 , A61B10/0051 , A61B10/007 , A61B2010/0061 , A61B2010/0077 , A61B2010/0087 , G01N33/15 , G01N33/493 , G01N2458/00
摘要： We disclose a method of using taggants to assess how and to what extent a drug in a drug composition that a user has consumed has decayed in response to storage conditions and time. The taggants may decay in response to environmental conditions which cause different drugs to lose their efficacy. These environmental conditions may include light, temperature, oxidation, moisture, and age. The taggants may be detected in biological samples, including urine and feces. By identifying the taggants, the drug composition and other information relating to the drug may be identified. Additionally, quantification of the different taggants may be used to determine whether the drug in the drug composition has been exposed to environmental conditions which may reduce its efficacy.
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